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Limper U U Department of Anesthesiology and Surgical Intensive Care Medicine, Merheim Medical Center, Hospitals of Cologne, University Witten/Herdecke, Ostmerheimer Strasse 200, 51109, Cologne, Germany, - - 2014
Commercial parabolic flights accessible to customers with a wide range of health states will become more prevalent in the near future because of a growing private space flight sector. However, parabolic flights present the passengers' cardiovascular system with a combination of stressors, including a moderately hypobaric hypoxic ambient environment (HH) ...
Yoshinaga Keiichiro K Department of Molecular Imaging, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita-Ku, Sapporo, Hokkaido, Japan, 060-8638, - - 2014
The right ventricle (RV) has a high capacity to adapt to pressure or volume overload before failing. However, the mechanisms of RV adaptation, in particular RV energetics, in patients with pulmonary hypertension (PH) are still not well understood. We aimed to evaluate RV energetics including RV oxidative metabolism, power and ...
Hikal Walid M WM Department of Chemical Engineering, Texas Tech University, Lubbock, TX 79409, USA; Department of Physics, Faculty of Science, Assiut University, Assiut 71516, Egypt. Electronic address: - - 2014
The diffusion coefficients of explosives are crucial in their trace detection and lifetime estimation. We report on the experimental values of diffusion coefficients of three of the most important explosives in both military and industry: TNT, PETN, and RDX. Thermogravimetric analysis (TGA) was used to determine the sublimation rates of ...
Putensen Christian - - 2014
External noise is introduced by computer-generated random levels of pressure assistance during noisy pressure support ventilation (PSV). In patients, noisy PSV was associated with higher tidal volume variability but not improved cardio-pulmonary function compared with conventional PSV. The potential role of noisy PSV in the management of critically ill patients ...
Ghasemzadeh Nima N Department of Medicine, Emory University School of Medicine, Atlanta, - - 2014
Oxidative stress contributes to the development of pulmonary hypertension in experimental models, but this association in humans is unknown. We investigated the relationship between pulmonary artery systolic pressure measured by echocardiography and plasma aminothiol oxidative stress markers, with the hypothesis that oxidative stress will be higher in those with pulmonary ...
Prisk G Kim GK University of California, San Diego, - - 2014
The structure of the lung, with its delicate network of airspaces and capillaries, means that gravity has a profound influence on its function. Studies of lung function in the absence of gravity provide valuable insight into how, for we Earth-bound individuals, its unavoidable effects shape our lung function. Gravity causes ...
Ferrando Carlos C From the *Anesthesiology and Critical Care Department, Hospital Clinico Universitario of Valencia, Valencia, Spain; and †Department of Anesthesiology, Hospital Privado de Comunidad, Mar de Plata, - - 2014
We investigated whether individualized positive end-expiratory pressure (PEEP) improves oxygenation, ventilation, and lung mechanics during one-lung ventilation compared with standardized PEEP. Thirty patients undergoing thoracic surgery were randomly allocated to the study or control group. Both groups received an alveolar recruitment maneuver at the beginning and end of one-lung ventilation. ...
Heulitt Mark J MJ From the Sections of *Pediatric Critical Care Medicine and †Pediatric Emergency Medicine, Department of Pediatrics, University of Arkansas for Medical Sciences College of Medicine; and ‡Respiratory Care, Arkansas Children's Hospital, Little Rock, - - 2014
The objective of this study was to evaluate 2 transport ventilators utilizing both a test lung and a pediatric animal model. Two transport ventilators were utilized for evaluations. A test lung or intubated, sedated pigs (n = 9) with healthy and injured lungs were ventilated using control and support modes. ...
Toba A A Institute for East China Sea Research, Nagasaki University, 1551-7, Tairamachi, Nagasaki 851-2213, - - 2014
Air was stored in 90% of Boleophthalmus pectinirostris burrows in summer breeding months when fish were active on the mudflat surface during low tide but only in 50% of burrows in overwintering months when the fish confined themselves to burrows. The volume of gas recovered from the burrows ranged from ...
Crocker George H GH Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, - - 2014
We tested the hypothesis that oleic-acid (OA) infusion impairs gas exchange, decreases total cardiopulmonary O2 delivery and lowers maximal aerobic capacity (VO2max). We infused 0.05ml OA kg(-1) (∼3ml) and ∼563ml saline into the right atria of four goats [59.1±14.0 (SD) kg] prior to running them on a treadmill at VO2max ...
Moens Yves - - 2014
The use of alveolar recruitment maneuvers during general anaesthesia of horses is a potentially useful therapeutic option for the ventilatory management. While the routine application of recruitments would benefit from the availability of dedicated large animal ventilators their impact on ventilation and perfusion in the horse is not yet well ...
Syed Khalid A KA Division of Orthopaedic Surgery, Musculoskeletal Health and Arthritis Program, Toronto Western Hospital, Toronto, - - 2014
The aim of this study was to compare the effect of supine versus lateral position on clinical signs of fat embolism during orthopedic trauma surgery. Dogs served as the current study model, which could be extended and/or serve as a basis for future in vivo studies on humans. It was ...
Jauncey-Cooke Jacqui J School of Nursing & Midwifery, The University of Queensland, Australia; Paediatric Critical Care Research Group, PICU, Mater Children's Hospital, Brisbane, Australia. Electronic address: - - 2014
Lung recruitment is used as an adjunct to lung protective ventilation strategies. Lung recruitment is a brief, deliberate elevation of transpulmonary pressures beyond what is achieved during tidal ventilation levels. The aim of lung recruitment is to maximise the number of alveoli participating in gas exchange particularly in distal and ...
Navaneethan Sankar D SD Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute,, ‡Respiratory Institute,, §Medicine Institute, and, ‖Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, †Cleveland Clinic Lerner College of Medicine and, ¶Department of Nephrology, Case Western Reserve University, Cleveland, - - 2014
Pulmonary hypertension is associated with higher mortality rates. The associations of nondialysis-dependent CKD and all-cause mortality in patients with pulmonary hypertension were studied. The study population included those patients who underwent right heart catheterization for confirmation of pulmonary hypertension between 1996 and January 2011. Pulmonary hypertension was defined as the ...
Zuo Li L Radiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, The Ohio State University Wexner Medical Center, Columbus, - - 2014
Hypertension, commonly recognized as high blood pressure, is a serious disease that affects millions of people worldwide. Similar to many physiological disorders, hypertension consists of several different cellular signaling pathways that involve various molecular messengers. Recent studies have shown that reactive oxygen species (ROS) play a substantial role in the ...
Elias-Al-Mamun Md M Department of Cardiovascular Medicine, Tohoku University Graduate School of - - 2014
Background: Pulmonary hypertension (PH) is a fatal disease characterized by pulmonary artery (PA) remodeling, elevated PA pressure and right ventricular (RV) failure. It has been previously demonstrated that treatment with a Rho-kinase inhibitor, fasudil, ameliorates PH in animal models. Here, whether combination therapy with fasudil and sildenafil further ameliorates PH in ...
Räsänen Jukka J Department of Anesthesiology, H. Lee Moffitt Cancer Center, Tampa, FL, - - 2014
To evaluate the effect of positive end-expiratory pressure (PEEP) on sound propagation through injured lungs, we injected a multifrequency broad-band sound signal into the airway of eight anesthetized, intubated and mechanically ventilated pigs, while recording transmitted sound at three locations bilaterally on the chest wall. Oleic acid injections effected a ...
Krabbe Vera B VB Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, J6-S, PO Box 9600, 2300 RC, Leiden, The - - 2014
Both disposable and non-disposable T-piece resuscitator (TPR) devices are used. Accuracy of the disposable and non-disposable infant TPR was compared. Peak inspiratory pressures (PIP) and positive end-expiratory pressures (PEEP) were measured during ventilation of a test lung. Measured PIP ±1 cmH2O and PEEP ±0.5 cmH2O of the desired pressures were considered acceptable. ...
Pica Silvia S Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, - - 2014
We tested the hypothesis that analysis of longitudinal right ventricular (RV) function and analysis of transverse RV function by echocardiography provide different clinical information in patients with pulmonary hypertension (PH). Indices of longitudinal and transverse RV function were obtained with different echocardiographic techniques in 30 patients with idiopathic pulmonary arterial ...
Polglase Graeme R - - 2014
Sustained inflations (SI) are advocated for the rapid establishment of FRC after birth in preterm and term infants requiring resuscitation. However, the most appropriate way to deliver a SI is poorly understood. We investigated whether a volume-limited SI improved the establishment of FRC and ventilation homogeneity and reduced lung inflammation/injury ...
Ishimaru Kazuhiko K Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Japan, - - 2014
Patients who undergo right ventricular (RV) outflow augmentation inevitably develop RV remodeling due to pulmonary insufficiency-related volume overload (VOL). However, the reversibility of this remodeling is not fully understood. The goal of this study was to establish an animal model of VOL and unloading to characterize the functional and pathological ...
Nelson J A JA Department of Biological Sciences, Towson University, Towson, MD 21252-0001, - - 2014
Several taxonomically disparate groups of fishes have evolved the ability to extract oxygen from the air with elements of their gut. Despite perceived difficulties with balancing digestive and respiratory function, gut air breathing (GAB) has evolved multiple times in fishes and several GAB families are among the most successful fish ...
Schranz C C Institute of Technical Medicine, Furtwangen University, Jakob-Kienzle-Str. 17, 78054 Villingen-Schwenningen, - - 2014
Mechanical ventilation carries the risk of ventilator-induced-lung-injury (VILI). To minimize the risk of VILI, ventilator settings should be adapted to the individual patient properties. Mathematical models of respiratory mechanics are able to capture the individual physiological condition and can be used to derive personalized ventilator settings. This paper presents model-based ...
Kleinsasser Axel T AT From the Department of Anesthesiology, Innsbruck Medical University, Innsbruck, Austria (A.T.K., I.P., S.T., B.T.); Department of Anesthesiology and CCM II, Klinikum Wels, Wels, Austria (H.K.); and Department of Anesthesiology and CCM, Hanusch Hospital, Vienna, Austria - - 2014
During emergence from anesthesia, breathing 100% oxygen is frequently used to provide a safety margin toward hypoxemia in case an airway problem occurs. Oxygen breathing has been shown to cause pulmonary gas exchange disorders in healthy individuals. This study investigates how oxygen breathing during emergence affects lung function specifically whether ...
Meric Henri H Centre d'Investigation Clinique - Innovations Technologiques, Services de Physiologie - Explorations Fonctionnelles, Hôpital Raymond Poincaré, AP-HP; E.A. 4497, Université de Versailles-Saint Quentin en Yvelines, 92380 Garches, - - 2014
Neurally adjusted ventilator assist (NAVA) assists spontaneous breathing in proportion to diaphragmatic electrical activity (EAdi). Here, we evaluate the effects of various levels of NAVA and PSV on the breathing pattern and, thereby, on PaCO2 homeostasis in 10 healthy volunteers. For each ventilation mode, four levels of support (delivered pressure ...
Suarez-Sipmann F F Servicio de Medicina Intensiva, Hospital Universitario de Uppsala, Laboratorio Hedenstierna, Departamento de Ciencias Quirúrgicas, Universidad de Uppsala, Uppsala, Suecia. Electronic address: - - 2014
Recent major advances in mechanical ventilation have resulted in new exciting modes of assisted ventilation. Compared to traditional ventilation modes such as assisted-controlled ventilation or pressure support ventilation, these new modes offer a number of physiological advantages derived from the improved patient control over the ventilator. By implementing advanced closed-loop ...
Prunet Bertrand B *Intensive Care Unit, Sainte Anne Military Teaching Hospital, Toulon; and †UMR MD2, P2COE, University of Aix-Marseille, School of Medicine, Marseille, France; ‡U.S. Army Institute of Surgical Research, Fort Sam Houston, Texas; and §Department of Emergency Medicine and Intensive Care, Timone University Hospital, Marseille; and ∥Intensive Care Unit, Laveran Military Teaching Hospital; and ¶Department of Anesthesiology, Pique Military Teaching Hospital, Bordeaux, - - 2014
Background: This study compared three different fluid resuscitation strategies in terms of respiratory tolerance and hemodynamic efficacy in a pig model of blunt chest trauma with lung contusion and controlled hemorrhagic shock. We hypothesized that the choice of fluid resuscitation strategy (type and amount of fluids) may impact differently contused ...
Ugurlucan Murat M Department of Cardiovascular Surgery, Istanbul University Istanbul Medical Faculty, Istanbul, - - 2014
Objective: Cardiopulmonary bypass deteriorates pulmonary functions to a certain extent. Patients with chronic obstructive pulmonary disease (COPD) are associated with increased mortality and morbidity risks in the postoperative period of open-heart surgery. In this study we compared 2 different mechanical ventilation modes, pressure-controlled ventilation (PCV) and volume-controlled ventilation (VCV), in ...
Sharifian Attar Alireza A Department of Anesthesiology, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR - - 2014
Hypoxia occurs during one-lung ventilation (OLV) due to the arteriovenous shunt of unsaturated pulmonary venous blood. Hypoxic pulmonary vasoconstriction (HPV) acts as a defense mechanism against shunting. In thoracic surgery, anesthetics with minimal inhibitory effect on HPV and minimal hemodynamic changes are preferred. The present study aimed to evaluate the ...
Amorim Erica de Freitas ED Divisions of Thoracic and Cardiovascular Surgery, Hospital das Clinicas of Ribeirao Preto Medical School, University of São Paulo, São Paulo, - - 2014
To test the tolerance and safety of an alveolar recruitment manoeuvre performed in the immediate postoperative period of corrective open heart surgery in children with congenital heart disease associated with excessive pulmonary blood flow and pulmonary arterial hypertension due to left-to-right shunt. Ten infants aged 1-24 months with congenital heart ...
Akoumianaki Evangelia E Klinik für Herzchirurgie, Herzzentrum, Intensive Care Unit,, Leipzig, Germany ; - - 2014
This report summarizes current physiological and technical knowledge on esophageal pressure (Pes) measurements in patients receiving mechanical ventilation. The respiratory changes in Pes are representative of changes in pleural pressure. The difference between airway pressure (Paw)and Pes is a valid estimate of transpulmonary pressure. Pes allows to partition what fraction ...
Kang Woon-Seok WS Department of Anaesthesiology and Pain Medicine, Konkuk University Hospital, Konkuk University Medical Center; Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, - - 2014
Impaired pulmonary gas exchange after cardiac surgeries with cardiopulmonary bypass (CPB) often occurs, and the selection of mechanical ventilation mode, pressure-controlled ventilation (PCV) or volume-controlled ventilation (VCV), may be important for preventing hypoxia and improving oxygenation. The authors hypothesized that patients with PCV would show better oxygenation, compared with VCV, ...
Phillip Veit - - 2014
Ascites is a major and common complication of liver cirrhosis. Large or refractory ascites frequently necessitates paracentesis. The aim of our study was to investigate the effects of paracentesis on hemodynamic and respiratory parameters in critically ill patients. Observational study comparing hemodynamic and respiratory parameters before and after paracentesis in ...
Jha Ajay Kumar AK Department of Cardiothoracic and Vascular Anesthesia, All India Institute of Medical Sciences, New Delhi, India. Electronic address: - - 2014
The unique series arrangement of the cerebral and pulmonary circulation in bidirectional superior cavopulmonary anastomosis (BCPA) makes the pulmonary blood flow dependent upon the cerebral blood flow. Until now, several investigators have tried to correct post-BCPA hypoxemia with various methods such as induced hyperventilation, the addition of carbon dioxide, and ...
Mirabella Lucia - - 2014
Experimental work provides insight into potential lung protective strategies. The objective of this study was to evaluate markers of ventilator-induced lung injury after two different ventilation approaches: (1) a "conventional" lung-protective strategy (volume control (VC) with low tidal volume, positive end-expiratory pressure (PEEP) and paralysis), (2) a physiological approach with ...
Borges João Batista JB 1Hedenstierna Laboratory, Department of Surgical Sciences, Section of Anaesthesiology & Critical Care, Uppsala University, Uppsala, Sweden. 2Pulmonary Divison, Heart Institute (Incor) Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. 3Research and Education Institute, Hospital Sírio Libanês, São Paulo, Brazil. 4Centros de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. 5Department of Hospital Physics, Uppsala University Hospital, Uppsala, Sweden. 6Hedenstierna Laboratory, Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, - - 2014
The common denominator in most forms of ventilator-induced lung injury is an intense inflammatory response mediated by neutrophils. PET with [F]fluoro-2-deoxy-D-glucose can be used to image cellular metabolism, which, during lung inflammatory processes, mainly reflects neutrophil activity, allowing the study of regional lung inflammation in vivo. The aim of this ...
Fortis Spyridon S Department of Medicine, Bridgeport Hospital, Yale University, Bridgeport, CT, - - 2014
With increasing realization that sedatives may complicate care of mechanically ventilated patients, greater emphasis might turn to promoting comfort by titration of ventilator settings. Patients with acute on chronic respiratory failure (ACRF) with underlying chronic obstructive pulmonary disease (COPD) demonstrate different levels of comfort in response to varying ventilator settings ...
Al Shehri Abdullah M AM - - 2014
To test the effects of pressure-controlled (PCV) and volume-controlled (VCV) ventilation during one-lung ventilation (OLV) for thoracic surgery on right ventricular (RV) function. A prospective, randomized, double-blind, controlled, crossover study. A single university hospital. Fourteen pairs of consecutive patients scheduled for elective thoracotomy. Patients were assigned randomly to ventilate the ...
Haddad Jorge L JL Division of Cardiology, Department of Internal Medicine, Hospital das Clínicas - Ribeirão Preto Medical School, University of São Paulo, - - 2014
Objective: The objective of the study was to analyse the use of the pressure wire for the acquisition of intravascular pulmonary pressures in the presence of pulmonary atresia and systemic-dependent pulmonary blood flow. Methods: In this study, we included patients with pulmonary atresia and systemic-dependent pulmonary circulation referred for diagnostic ...
Tamplin J J University of Melbourne, Melbourne, Victoria, - - 2014
Study design:Systematic reviewObjectives:To determine the effect of respiratory muscle training (RMT) on pulmonary function in tetraplegia.Methods:A comprehensive search of the research literature included MEDLINE, EMBASE, CINAHL, ISI Web of Science, PubMed, the relevant Cochrane and clinical trials registers and hand-searching the reference lists of appropriate papers. There was no language ...
Paradies P P Department of Emergency and Organs Transplantations, Veterinary Section, Internal Medicine Unit, University of Bari, Strada Provinciale Per Casamassima Km 3, 70010, Valenzano, Bari, Italy, - - 2014
Pulmonary hypertension (PH) decreases resistance to fatigue and life expectancy. The aim of this study was to correlate some indirect Doppler indices of PH with tricuspid and pulmonary regurgitation criteria and to relate PH on different indices with the severity of clinical signs. Furthermore the pathogenetic mechanisms associated to PH ...
Nozoe Masafumi M Department of Rehabilitation, Hyogo College of Medicine Sasayama Medical Center, Kurooka 5, Sasayama, Hyogo, Japan; Department of Physical Therapy, Faculty of Nursing and Rehabilitation, Konan Women's University; Department of Rehabilitation, Konan Kakogawa Hospital; Department of General Medicine and Community Health Science, Hyogo College of Medicine; Department of Functional Regenerative Science, Hyogo College of Medicine; Department of Rehabilitation Medicine, Hyogo College of Medicine. Electronic address: - - 2014
To study the feasibility and the laterality of measurements of chest wall volume variation during tidal breathing in the lateral position in healthy subjects. Eighteen normal subjects were studied. Chest wall volume changes were measured by optoelectronic plethysmography in the supine and right and left lateral positions during quiet breathing. ...
Jurek Samuel C SC Boston Children's Hospital, Medicine, Boston, Massachusetts, United States ; - - 2014
Rationale: The Acute Respiratory Distress Syndrome (ARDS), a devastating lung disease that has no cure, is exacerbated by life-supportive mechanical ventilation that worsens lung edema and inflammation through the syndrome of Ventilator Induced Lung Injury (VILI). Recently, the membrane ion channel TRPV4 on alveolar macrophages was shown to mediate murine ...
Güldner Andreas A From the Pulmonary Engineering Group, Department of Anesthesiology and Intensive Care Medicine, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany (A.G., A.B., N.C., A.B., S.Z., C.U., P.M.S., T.K., and M.G.d.A.); Department of Electric Engineering, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil (A.B.); Institute of Informatics and Biometry, Dresden, Germany (B.W.); Institute of Nuclear Medicine, University Hospital Dresden, Dresden, Germany (G.W., M.A., and J.K.); and IRCCS San Martino Hospital, Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy - - 2014
Spontaneous breathing (SB) in the early phase of the acute respiratory distress syndrome is controversial. Biphasic positive airway pressure/airway pressure release ventilation (BIPAP/APRV) is commonly used, but the level of SB necessary to maximize potential beneficial effects is unknown. Experimental acute respiratory distress syndrome was induced by saline lung lavage ...
Yang Yi Y Department of Critical Care Medicine, Nanjing Zhong-Da Hospital, Southeast University, 87 Dingjiaqiao Rd, Nanjing, 210009, People's Republic of - - 2014
Lung recruitment maneuvers can help open collapsed lung units for sufficient oxygenation, and positive end expiratory pressure (PEEP) is used to keep the lung open after recruitment. However, the application of high PEEP levels may play a significant role in causing regional lung hyperinflation during mechanical ventilation. The authors sought ...
Tusman Gerardo G From the Departments of *Anesthesia and †Surgery, Hospital Privado de Comunidad, Mar del Plata, Buenos Aires; ‡Bioengineering Laboratory, Electronic Department, School of Engineering, Mar del Plata University, Mar del Plata, Argentina; §Swisstom AG, Landquart, Switzerland; ‖Department of Surgical Sciences, Clinical Physiology, Uppsala University Hospital, Uppsala, Sweden; and ¶Instituto de Investigación Santinaria, Fundación Jiménez Díaz, IIS-FJD, CIBERES, Madrid, - - 2014
We conducted this study to determine whether pulse oximetry and volumetric capnography (VCap) can determine the opening and closing pressures of lungs of anesthetized morbidly obese patients. Twenty morbidly obese patients undergoing laparoscopic bariatric surgery with capnoperitoneum were studied. A lung recruitment maneuver was performed in pressure control ventilation as ...
Mariani Alessandro Wasum AW Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, - - 2014
Lung preservation remains a challenging issue for lung transplantation groups. Along with the development of ex vivo lung perfusion, a new preservation method known as topical-ECMO (extracorporal membrane oxygenation) has been proposed. The present study compared topical-ECMO with cold ischemia (CI) for lung preservation in an ex vivo experimental model. ...
Revermann Marc M Department of Anesthesiology and Critical Care Medicine, University Hospital Mannheim, Faculty of Medicine, University of Heidelberg, Heidelberg, Germany ; Institute for Cardiovascular Physiology, Medical Faculty of the Goethe-University Frankfurt, Frankfurt, - - 2014
Right heart failure is a fatal consequence of chronic pulmonary hypertension (PH). The development of PH is characterized by increased proliferation of vascular cells, in particular pulmonary artery smooth muscle cells (PASMCs) and pulmonary artery endothelial cells. In the course of PH, an escalated right ventricular (RV) afterload occurs, which ...
Bitar Abbas A Department of Medicine, Internal Medicine Residency Program, Krannert Institute of Cardiology, Indiana University, Indianapolis, Indiana, United States of - - 2014
Accurate determination of left ventricular filling pressure is essential for differentiation of pre-capillary pulmonary hypertension (PH) from pulmonary venous hypertension (PVH). Previous data suggest only a poor correlation between left ventricular end-diastolic pressure (LVEDP) and its commonly used surrogate, the pulmonary capillary wedge pressure (PCWP). However, no data exist on ...
Oppenheimer Beno W BW André Cournand Pulmonary Physiology Laboratory, Division of Pulmonary, Critical Care and Sleep, Department of Medicine, Bellevue Hospital/New York University School of Medicine, New York, New York, United States of - - 2014
Abnormality in distal lung function may occur in obesity due to reduction in resting lung volume; however, airway inflammation, vascular congestion and/or concomitant intrinsic airway disease may also be present. The goal of this study is to 1) describe the phenotype of lung function in obese subjects utilizing spirometry, plethysmography ...
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