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Ventetuolo Corey E CE Alpert Medical School of Brown University, Providence, - - 2014
-While frequently assessed in trials and clinical practice, hemodynamic response to therapy has never been validated as a surrogate endpoint for clinical events in pulmonary arterial hypertension (PAH). -We performed a patient-level pooled analysis of four randomized placebo-controlled trials to determine if treatment-induced changes in hemodynamic values at 12 weeks ...
Ryan John J JJ From the Division of Cardiovascular Medicine, Department of Medicine, University of Utah, Salt Lake City (J.J.R.); and Department of Medicine, Queen's University, Kingston, Ontario, Canada - - 2014
The right ventricle (RV) is the major determinant of functional state and prognosis in pulmonary arterial hypertension. RV hypertrophy (RVH) triggered by pressure overload is initially compensatory but often leads to RV failure. Despite similar RV afterload and mass some patients develop adaptive RVH (concentric with retained RV function), while ...
Maci Eliana E Department of Medical Oncology, University Campus Bio-Medico , - - 2014
Background: Tobacco smoke causes lung disfunction and inflammation. Methods: Twenty-two consecutive smokers with undetermined lung nodules were included. All underwent a baseline imaging, exhaled carbon monoxide level evaluation and spirometry, repeated at three months from smoking cessation therapy. Results: A significant reduction in size of the lung nodules was reported ...
Hallberg Christopher J - - 2014
Respiratory disease accounts for three of the ten leading causes of death worldwide. Many of these diseases can be treated and diagnosed using a nebulizer. Nebulizers can also be used to safely and efficiently deliver vaccines. Unfortunately, commercially available nebulizers are not designed for use in regions of the world ...
Joshi Suchita S Department of Child Health, Cardiff University, Cardiff, - - 2014
Although increased pulmonary arterial pressure is common in infancy in preterm infants who develop chronic lung disease of prematurity (CLD), it is unknown if the increase persists into childhood. We, therefore, assessed if 8-12-year-old children with documented CLD in infancy had evidence of right ventricular dysfunction or pulmonary arterial hypertension ...
Santos Cíntia Lourenco - - 2014
Mechanical ventilation with high positive end-expiratory pressure (PEEP) has been used in patients with acute respiratory distress syndrome (ARDS) and intra-abdominal hypertension (IAH), but the role of PEEP in minimizing lung injury remains controversial. We hypothesized that in the presence of acute lung injury (ALI) with IAH: 1) higher PEEP ...
LeVarge Barbara L BL Dept of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA - - 2014
Current guidelines recommend measurement of pulmonary artery wedge pressure (PAWP) at end-expiration. However, this recommendation is not universally followed and may not be physiologically appropriate. We investigated the performance of end-expiratory PAWP in the evaluation of precapillary pulmonary hypertension patients. 329 spontaneously breathing patients undergoing right heart catheterisation were retrospectively ...
Sueta Shinichi S Kidney Disease Center, Japanese Red Cross Nagoya Daini Hospital, 2-9, Myoken-cho, Showa-ku, Nagoya, 466-8650, Japan, - - 2014
Vitamin D deficiency is common among patients with chronic kidney disease (CKD). However, the benefits of vitamin D supplementation versus vitamin D receptor activator (VDRA) administration have yet to be established. Recently, an association between activated vitamin D and cardiovascular factors was reported. To evaluate the benefits of VDRA in ...
Toishi Masayuki M Department of Thoracic Surgery, Shinshu University School of Medicine, Matsumoto, - - 2014
Vessel-sealing devices (VSDs) are widely used for various surgical procedures, including thoracoscopic surgery, but very few reports have compared their safety and usefulness with human thoracoscopic lobectomy procedures not employing VSDs. Primary lung cancer patients for whom a thoracoscopic lobectomy involving mediastinal lymph node dissection was planned in our department ...
Mu Lina L Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, SUNY, 270 Farber Hall, Buffalo, NY 14214, USA. Electronic address: - - 2014
This study aims to examine whether changes in short-term exposures to particulate matter are associated with changes in lung function, breath rate, and blood pressure among healthy adults and whether smoking status modifies the association. We took advantage of the artificially controlled changes in air pollution levels that occurred during ...
Henderson Ashley G - - 2014
The pathogenesis of mucoinfective lung disease in cystic fibrosis (CF) patients likely involves poor mucus clearance. A recent model of mucus clearance predicts that mucus flow depends on the relative mucin concentration of the mucus layer compared with that of the periciliary layer; however, mucin concentrations have been difficult to ...
Titosky Jordan T F JT Department of Mechanical Engineering, University of Alberta, Edmonton, Alberta, T6G 2T8, - - 2014
The purpose of the study is to understand the effect of altitude on the performance of selected pressurized metered dose inhalers (pMDIs) and dry powder inhalers (DPIs). A testing apparatus that created consistent breath profiles through the Alberta Idealized Throat was designed to test five pMDIs and two DPIs at ...
Esquinas Antonio M AM 1Intensive Care Unit and Non Invasive Ventilatory Unit, Hospital Morales Meseguer , Murcia , - - 2014
Abstract Method to improve minute ventilation (MV) during spontaneous breathing (SB) in stable severe chronic obstructive pulmonary disease (COPD) have a great clinical relevant in long term outcome. In this scenario, recommendations of early use of high-Intensity non-invasive Positive pressure Ventilation (HI-NPPV) or intelligent Volume Assured Pressure (iVAP) Support in ...
Radcliffe Robin W - - 2014
It was observed previously that end-expired carbon dioxide (P(E)CO2) decreased when immobilized black rhinoceroses (Diceros bicornis) were moved from sternal to lateral recumbency. These experiments were designed to test whether greater alveolar ventilation or greater pulmonary dead space in lateral recumbency explains this postural difference in P(E)CO2. Twenty-one (9 male, ...
Belhadj Zoubida Z UDL Sidi Bel Abbes, Sidi Bel Abbes, - - 2014
To evaluate the influence of occupational exposure to ultrafine particles on cardiopulmonary parameters. Changes in ventilatory and haemodynamic parameters during occupational exposure to ultrafine particles summers studied using a survey-type retrospective cohort exposed unexposed conducted in a company producing agricultural equipment for a period of five month period from January ...
Shujaat Adil A Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Jacksonville, Florida, - - 2014
Pulmonary hypertension (PH) in overweight or obese patients with obstructive sleep apnea (OSA) may be multifactorial. The effect of pulmonary artery hypertension (PAH)-specific drugs on PH and exercise capacity in such patients is unknown. We performed a retrospective review of overweight or obese patients with OSA and PH who were ...
Tedford Ryan J RJ Department of Medicine, Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, Maryland, - - 2014
Right ventricular (RV) afterload consists of both resistive and capacitive (pulsatile) components. Total afterload can be measured directly with pulmonary artery input impedance spectra or estimated, either with lumped-parameter modeling or by pressure-volume analysis. However, the inverse, hyperbolic relationship between resistance and compliance in the lung would suggest that the ...
Moura Vitor Mayer de VM Faculdade de Medicina, Universidade Nove de Julho, São Paulo, - - 2014
To experimentally compare two classic techniques described for manual suture of the bronchial stump. We used organs of pigs, with isolated trachea and lungs, preserved by refrigeration. We dissected 30 bronchi, which were divided into three groups of ten bronchi each, of 3mm, 5mm, and 7mm, respectively. In each, we ...
Toney Brent M BM Department of Medicine, Division of Pulmonary, Allergy, Critical Care, Occupational and Sleep Medicine, Indiana University, Indianapolis, Indiana, - - 2014
Endothelin-1 is a potent mediator of sepsis-induced pulmonary hypertension (PH). The pulmonary vascular effects of selective blockade of endothelin receptor subtype A (ETAR) during endotoxemia remain unknown. We hypothesized that selective ETAR antagonism attenuates endotoxin-induced PH and improves pulmonary artery (PA) vasoreactivity. Adult male Sprague-Dawley rats (250-450 g) received lipopolysaccharide ...
- - 2014
The role of positive end-expiratory pressure in mechanical ventilation during general anaesthesia for surgery remains uncertain. Levels of pressure higher than 0 cm H2O might protect against postoperative pulmonary complications but could also cause intraoperative circulatory depression and lung injury from overdistension. We tested the hypothesis that a high level ...
Sturesson L W LW Section of Anaesthesiology and Intensive Care, Lund University and Skane University Hospital, SE-221 85 Lund, Sweden - - 2014
The anaesthetic conserving device AnaConDa(®) (ACD) reflects exhaled anaesthetic agents thereby facilitating the use of inhaled anaesthetic agents outside operating theatres. Expired CO2 is, however, also reflected causing a dead space effect in excess of the ACD internal volume. CO2 reflection from the ACD is attenuated by humidity. This study ...
Kovacs Gabor G Medical University of Graz, Pulmonology, Auenbruggerplatz 20., Graz, Austria, 8044, Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria ; - - 2014
The accuracy of pulmonary vascular pressure measurements is of great diagnostic and prognostic relevance. However, there is variability of zero leveling procedures, and the current recommendation of end-expiratory reading may not always be adequate. A review of physiological and anatomical data, comforted by recent imaging, leads to the practical recommendation ...
Spadaro S S Department of Morfology, Experimental Medicine and Surgery. Section of Anaesthesia andIntensive Care. Arcispedale Sant' Anna. University of Ferrara. Ferrara, Italy - - - 2014
Maximal Inspiratory Pressure (MIP) can help to evaluate inspiratory muscle strength. However its determination in ventilated patients is cumbersome and needs special equipment. We hypothesized that MIP could be obtained by using the expiratory hold knob of the ventilator. The aim of this study was to verify whether: 1) the ...
Spooner Amy J AJ Critical Care Research Group, Adult Intensive Care Services, The Prince Charles Hospital and University of Queensland, Chermside, Brisbane, Australia - - 2014
Head-of-bed elevation (HOBE) has been shown to assist in reducing respiratory complications associated with mechanical ventilation; however, there is minimal research describing changes in end-expiratory lung volume. This study aims to investigate changes in end-expiratory lung volume in a supine position and 2 levels of HOBE. Twenty postoperative cardiac surgery ...
Acker Shannon N SN Department of Pediatric Surgery, University of Colorado School of Medicine, Aurora, CO. Electronic address: - - 2014
To assess the ability of vasopressin to stabilize hemodynamics in infants with systemic hypotension secondary to congenital diaphragmatic hernia (CDH). A retrospective chart review was performed to identify 13 patients with CDH treated with vasopressin for refractory hypotension to assess the effect of vasopressin on pulmonary and systemic hemodynamics and ...
Ying Lin - - 2014
The pathogenesis of obstructive sleep apnoea/hypopnoea syndrome (OSAHS), a highly prevalent disease, is not completely understood. The purpose of this study was to investigate the contributions of Th17 cells and the Th17-associated cytokines IL-17A and IL-17 F to OSAHS. 46 male patients with a clinical suspicion of OSAHS were enrolled ...
Price Andrew P AP University of Minnesota, Pediatrics, Minneapolis, Minnesota, United States ; - - 2014
We developed an automated system that can be used to decellularize whole human-sized organs and have shown lung as an example. Lungs from 20-30kg pigs were excised en bloc with the trachea and decellularized with our established protocol of distilled water, detergents, sodium chloride and porcine pancreatic DNase. A software ...
Nonaka Paula N PN Unitat de Biofísica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Spain and Master's and Doctoral Degree Programs in Rehabilitation Sciences, Nove de Julho University, Sao Paulo, - - 2014
Lung decellularization is based on the use of physical, chemical, or enzymatic methods to break down the integrity of the cells followed by a treatment to extract the cellular material from the lung scaffold. The aim of this study was to characterize the mechanical changes throughout the different steps of ...
Blankman Paul - - 2014
This study compares different parameters derived from electrical impedance tomography (EIT) data to define 'best' positive end-expiratory pressure (PEEP) during a decremental PEEP trial in mechanically-ventilated patients. 'Best' PEEP is regarded as minimal lung collapse and overdistention in order to prevent ventilator-induced lung injury. A decremental PEEP trial (from 15 ...
Sun Xuefeng X Department of Pulmonary Medicine, Peking Union Medical College Hospital, Beijing, - - 2014
Pulmonary hypertension has been recognized as being associated with obstructive sleep apnoea (OSA). Continuous positive airway pressure (CPAP) might reduce pulmonary artery pressure in OSA patients; however, evidence from clinical studies is limited and inconsistent. This meta-analysis aims to assess whether CPAP is associated with a decrease in pulmonary artery ...
Fodor Gergely H GH Department of Physics and Informatics, University of Szeged, Szeged, - - 2014
Bronchoaspiration results in local deterioration of lung function through direct damage and/or indirect systemic effects related to neurohumoral pathways. We distinguished these effects by selectively intubating the two main bronchi in pigs while a PEEP of 4 or 10 cmH2O was maintained. Gastric juice was instilled only into the right lung. ...
Fernandez-Bustamante Ana A From the Department of Anesthesiology and Webb-Waring Center, University of Colorado School of Medicine, Aurora, Colorado (A.F.-B.); Department of Anesthesiology and iC42 Integrated Solutions in Systems Biology, University of Colorado School of Medicine, Aurora, Colorado (J.K., U.C.); Department of Medicine and Webb-Waring Center, University of Colorado School of Medicine, Aurora, Colorado (J.E.R.); Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado (A.A., T.S.); Department of Pathobiology and Lerner Research Institute (NC22), the Cleveland Clinic Foundation and Case Western Reserve University School of Medicine, Cleveland, Ohio (A.J.J., S.C.E.); Case Western Reserve University School of Medicine, Cleveland, Ohio (C.S.); Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado (M.M., I.S.D.); and Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, Colorado - - 2014
The early biological impact of short-term mechanical ventilation on healthy lungs is unknown. The authors aimed to characterize the immediate tidal volume (VT)-related changes on lung injury biomarkers in patients with healthy lungs and low risk of pulmonary complications. Twenty-eight healthy patients for knee replacement surgery were prospectively randomized to ...
Caltabeloti Fabiola Prior - - 2014
The study was designed to assess the impact of fluid loading on lung aeration, oxygenation and hemodynamics in patients with septic shock and acute respiratory distress syndrome (ARDS). During a 1-year period, a prospective observational study was performed in 32 patients with septic shock and ARDS. Cardiorespiratory parameters were measured ...
Chiva Teresa T Liver Unit Digestive Disease Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Centro de Investigación Biomédica de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón (IISGM), Madrid, - - 2014
Diagnosis of portopulmonary hypertension (POPH) is based on the presence of portal hypertension and the same haemodynamic criteria as pulmonary arterial hypertension (PAH). However, the typical hyperdynamic circulation of cirrhosis may have some impact on the diagnosis of POPH. The aim was to compare the haemodynamic pattern of the pulmonary ...
Duenwald-Kuehl Sarah E - - 2014
Background A relationship between tendon stress and strain and ultrasonic echo intensity has previously been defined in tendons, demonstrating a correlation between tissue stiffness and echo intensity. An analogous relationship between volume-dependent pressure changes and echo intensity changes in the inflating lung would indicate a correlation between lung compliance and ...
Lv Runxiao - - 2014
Oxygen therapy is one of the most widely used clinical interventions to counteract insufficient pulmonary oxygen delivery in patients with severe lung injury. However, prolonged exposure to hyperoxia at elevated partial pressure leads to inflammation and acute lung injury. The population at risk for this condition has markedly increased with ...
Ketabchi Farzaneh F Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, - - 2014
Alveolar hypoxia induces monophasic pulmonary vasoconstriction in vivo, biphasic vasoconstriction in the isolated pulmonary artery, and controversial responses in the isolated perfused lung. Pulmonary vascular responses to sustained alveolar hypoxia have not been addressed in the isolated perfused rat lung. In this study, we investigated the effect of sustained hypoxic ...
Araz Omer O Dr. Omer Araz, Assistant Professor, Department of Pulmonary Diseases, Ataturk University School of Medicine, 25240, Erzurum, - - 2014
Hemoptysis is one of the most important and challenging symptoms in pulmonary medicine. Because of the increased number of patients with hemoptysis in certain periods of the year, we aimed to investigate whether atmospheric changes have an effect on the development of hemoptysis with or without a secondary cause. The ...
Lavizzari Anna A NICU, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico-Università degli Studi di Milano, , Milan, - - 2014
To compare the effect of heated, humidified, high-flow nasal cannula (HHHFNC) and nasal continuous positive airways pressure (NCPAP) on lung function and mechanics in preterm infants with respiratory distress syndrome (RDS) at the same level of retropharyngeal pressure (Prp). Randomised crossover trial. Neonatal intensive care unit, Ospedale Maggiore Policlinico, Milan, ...
Medarov Boris I BI Division of Pulmonary and Critical Care Medicine, Albany Medical College, MC-91, 47 New Scotland Avenue, Albany, NY 12208, - - 2014
Portopulmonary hypertension (PoPH) is an often neglected form of pulmonary hypertension where pulmonary hypertension occurs in the presence of portal hypertension. PoPH is important to diagnose and treat as it may improve the patient's quality of life and improve the outcome after liver transplantation. In this review, we discuss the ...
Formenti Paolo P Unità Operativa di Anestesia e Rianimazione, Azienda Ospedaliera San Paolo-Polo Universitario, Milano, Italy. Electronic address: - - 2014
Pleural effusion (PE) is commonly encountered in mechanically ventilated, critically ill patients and is generally addressed with evacuation or by fluid displacement using increased airway pressure (PAW). However, except when massive or infected, clear evidence is lacking to guide its management. The aim of this study was to investigate the ...
Li Y Y Department of Anesthesiology, Shaoxing People's Hospital of Zhejiang University, Shaoxing City, China; Department of Clinical and Experimental Medicine, Linköping University, Linköping, - - 2014
The way in which hyperoxia affects pulmonary ventilation and perfusion is not fully understood. We investigated how an increase in oxygen partial pressure in healthy young volunteers affects pulmonary ventilation and perfusion measured by thoracic electrical impedance tomography (EIT). Twelve semi-supine healthy male volunteers aged 21-36 years were studied while ...
Domingo Enric - - 2014
Exercise capacity is impaired in pulmonary arterial hypertension (PAH). We hypothesized that cardiovascular reserve abnormalities would be associated with impaired hemodynamic response to pharmacological stress and worse outcome in PAH. Eighteen PAH patients (p) group 1 NYHA class II/III and ten controls underwent simultaneous right cardiac catheterization and intravascular ultrasound ...
Keller Steven P SP aDepartment of Critical Care, National Institutes of Health, Bethesda bDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, - - 2014
Studies in patients with acute respiratory distress syndrome (ARDS) have been unable to demonstrate a survival advantage with higher levels of positive end-expiratory pressure (PEEP) to open atelectatic lung regions or prevent their cyclic collapse. This review will discuss the challenges of accurately measuring pleural pressure with balloon-tipped catheters in ...
Han Ling L Department of Respiration, Jilin University 1st Hospital, No. 71, Xinmin Road, Changchun, 130021, Jilin, - - 2014
The objective of the study was to investigate the effects of adaptive support ventilation (ASV) and synchronized intermittent mandatory ventilation (SIMV) on peripheral circulation of chronic obstructive pulmonary disease (COPD) patients with respiratory failure. 86 COPD patients with respiratory failure were recruited in this study. Self-control method was used to ...
Frazão M M Federal University of Rio Grande do Norte, Brazil. Electronic address: - - 2014
The aim of the study was to determine the acute effects of positive expiratory pressure (PEP) on breathing pattern, operational volumes and shortening velocity of respiratory muscles on patients with Parkinson's disease. It was evaluated 15 patients and healthy controls, by optoelectronic plethysmography, using PEP in three different levels (10, ...
Gommers Diederik D Department of Adult Intensive Care, Erasmus MC, Rotterdam, the - - 2014
To discuss the role of measuring functional residual capacity (FRC) during mechanical ventilation to improve patient ventilator settings in order to prevent ventilator-induced lung injury. Nowadays, FRC can be measured without the use of tracer gases and without disconnection from the ventilator. It is shown that FRC can provide additional ...
Moceri Pamela P Service de cardiologie, hôpital Pasteur, CHU de Nice, 30, avenue de la Voie-Romaine, BP69, CS 51069, 06001 Nice cedex 1, France. Electronic address: - - 2014
Patients with pulmonary hypertension must be evaluated using a multimodality approach to ensure a correct diagnosis and basal evaluation as well as a prognostic assessment. Beyond the assessment of pulmonary pressures, the echocardiographical examination allows the evaluation of right ventricular adaptation to elevated afterload. Numbers of variables are commonly used ...
Withers Philip C PC Animal Biology M092, University of Western Australia, Crawley, Western Australia 6009, Australia; 2Department of Biological Sciences, University of North Texas, Denton, Texas 76203; 3Department of Herpetology, California Academy of Sciences, San Francisco, California 94118; 4Department of Biology, Portland State University, Portland, Oregon - - 2014
Abstract Dehydration tolerance of anuran amphibians is directly related to their ability to mobilize lymphatic reserves, with more terrestrial species having more effective lymph mobilization dependent on specialized skeletal muscles acting directly on the lymph sacs and via pulmonary ventilation. Consequently, we tested the hypothesis that pulmonary compliance, lung volume, ...
Xia Jingen J From the Department of Intensive Care Medicine, China-Japan Friendship Hospital, Beijing, P. R. China (J.X., Q.Z.); and Beijing Institute of Respiratory Medicine, Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, P. R. China (H.Z., B.S., R.Y., - - 2014
It has been proved that spontaneous breathing (SB) with biphasic positive airway pressure (BIPAP) can improve lung aeration in acute respiratory distress syndrome compared with controlled mechanical ventilation. The authors hypothesized that SB with BIPAP would attenuate lung injury in acute respiratory distress syndrome compared with pressure-controlled ventilation. Twenty male ...
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