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Sturesson L W LW Section of Anaesthesiology and Intensive Care, Lund University and Skane University Hospital, SE-221 85 Lund, Sweden - - 2014
The anaesthetic conserving device AnaConDa(®) (ACD) reflects exhaled anaesthetic agents thereby facilitating the use of inhaled anaesthetic agents outside operating theatres. Expired CO2 is, however, also reflected causing a dead space effect in excess of the ACD internal volume. CO2 reflection from the ACD is attenuated by humidity. This study ...
Kovacs Gabor G Medical University of Graz, Pulmonology, Auenbruggerplatz 20., Graz, Austria, 8044, Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria ; - - 2014
The accuracy of pulmonary vascular pressure measurements is of great diagnostic and prognostic relevance. However, there is variability of zero leveling procedures, and the current recommendation of end-expiratory reading may not always be adequate. A review of physiological and anatomical data, comforted by recent imaging, leads to the practical recommendation ...
Spadaro S S Department of Morfology, Experimental Medicine and Surgery. Section of Anaesthesia andIntensive Care. Arcispedale Sant' Anna. University of Ferrara. Ferrara, Italy - - - 2014
Maximal Inspiratory Pressure (MIP) can help to evaluate inspiratory muscle strength. However its determination in ventilated patients is cumbersome and needs special equipment. We hypothesized that MIP could be obtained by using the expiratory hold knob of the ventilator. The aim of this study was to verify whether: 1) the ...
Spooner Amy J AJ Critical Care Research Group, Adult Intensive Care Services, The Prince Charles Hospital and University of Queensland, Chermside, Brisbane, Australia - - 2014
Head-of-bed elevation (HOBE) has been shown to assist in reducing respiratory complications associated with mechanical ventilation; however, there is minimal research describing changes in end-expiratory lung volume. This study aims to investigate changes in end-expiratory lung volume in a supine position and 2 levels of HOBE. Twenty postoperative cardiac surgery ...
Acker Shannon N SN Department of Pediatric Surgery, University of Colorado School of Medicine, Aurora, CO. Electronic address: - - 2014
To assess the ability of vasopressin to stabilize hemodynamics in infants with systemic hypotension secondary to congenital diaphragmatic hernia (CDH). A retrospective chart review was performed to identify 13 patients with CDH treated with vasopressin for refractory hypotension to assess the effect of vasopressin on pulmonary and systemic hemodynamics and ...
Ying Lin - - 2014
The pathogenesis of obstructive sleep apnoea/hypopnoea syndrome (OSAHS), a highly prevalent disease, is not completely understood. The purpose of this study was to investigate the contributions of Th17 cells and the Th17-associated cytokines IL-17A and IL-17 F to OSAHS. 46 male patients with a clinical suspicion of OSAHS were enrolled ...
Price Andrew P AP University of Minnesota, Pediatrics, Minneapolis, Minnesota, United States ; - - 2014
We developed an automated system that can be used to decellularize whole human-sized organs and have shown lung as an example. Lungs from 20-30kg pigs were excised en bloc with the trachea and decellularized with our established protocol of distilled water, detergents, sodium chloride and porcine pancreatic DNase. A software ...
Nonaka Paula N PN Unitat de Biofísica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Spain and Master's and Doctoral Degree Programs in Rehabilitation Sciences, Nove de Julho University, Sao Paulo, - - 2014
Lung decellularization is based on the use of physical, chemical, or enzymatic methods to break down the integrity of the cells followed by a treatment to extract the cellular material from the lung scaffold. The aim of this study was to characterize the mechanical changes throughout the different steps of ...
Blankman Paul - - 2014
This study compares different parameters derived from electrical impedance tomography (EIT) data to define 'best' positive end-expiratory pressure (PEEP) during a decremental PEEP trial in mechanically-ventilated patients. 'Best' PEEP is regarded as minimal lung collapse and overdistention in order to prevent ventilator-induced lung injury. A decremental PEEP trial (from 15 ...
Sun Xuefeng X Department of Pulmonary Medicine, Peking Union Medical College Hospital, Beijing, - - 2014
Pulmonary hypertension has been recognized as being associated with obstructive sleep apnoea (OSA). Continuous positive airway pressure (CPAP) might reduce pulmonary artery pressure in OSA patients; however, evidence from clinical studies is limited and inconsistent. This meta-analysis aims to assess whether CPAP is associated with a decrease in pulmonary artery ...
Fodor Gergely H GH Department of Physics and Informatics, University of Szeged, Szeged, - - 2014
Bronchoaspiration results in local deterioration of lung function through direct damage and/or indirect systemic effects related to neurohumoral pathways. We distinguished these effects by selectively intubating the two main bronchi in pigs while a PEEP of 4 or 10 cmH2O was maintained. Gastric juice was instilled only into the right lung. ...
Fernandez-Bustamante Ana A From the Department of Anesthesiology and Webb-Waring Center, University of Colorado School of Medicine, Aurora, Colorado (A.F.-B.); Department of Anesthesiology and iC42 Integrated Solutions in Systems Biology, University of Colorado School of Medicine, Aurora, Colorado (J.K., U.C.); Department of Medicine and Webb-Waring Center, University of Colorado School of Medicine, Aurora, Colorado (J.E.R.); Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado (A.A., T.S.); Department of Pathobiology and Lerner Research Institute (NC22), the Cleveland Clinic Foundation and Case Western Reserve University School of Medicine, Cleveland, Ohio (A.J.J., S.C.E.); Case Western Reserve University School of Medicine, Cleveland, Ohio (C.S.); Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado (M.M., I.S.D.); and Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, Colorado - - 2014
The early biological impact of short-term mechanical ventilation on healthy lungs is unknown. The authors aimed to characterize the immediate tidal volume (VT)-related changes on lung injury biomarkers in patients with healthy lungs and low risk of pulmonary complications. Twenty-eight healthy patients for knee replacement surgery were prospectively randomized to ...
Caltabeloti Fabiola Prior - - 2014
The study was designed to assess the impact of fluid loading on lung aeration, oxygenation and hemodynamics in patients with septic shock and acute respiratory distress syndrome (ARDS). During a 1-year period, a prospective observational study was performed in 32 patients with septic shock and ARDS. Cardiorespiratory parameters were measured ...
Chiva Teresa T Liver Unit Digestive Disease Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Centro de Investigación Biomédica de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón (IISGM), Madrid, - - 2014
Diagnosis of portopulmonary hypertension (POPH) is based on the presence of portal hypertension and the same haemodynamic criteria as pulmonary arterial hypertension (PAH). However, the typical hyperdynamic circulation of cirrhosis may have some impact on the diagnosis of POPH. The aim was to compare the haemodynamic pattern of the pulmonary ...
Duenwald-Kuehl Sarah E - - 2014
Background A relationship between tendon stress and strain and ultrasonic echo intensity has previously been defined in tendons, demonstrating a correlation between tissue stiffness and echo intensity. An analogous relationship between volume-dependent pressure changes and echo intensity changes in the inflating lung would indicate a correlation between lung compliance and ...
Ketabchi Farzaneh F Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, - - 2014
Background: Alveolar hypoxia induces monophasic pulmonary vasoconstriction in vivo, biphasic vasoconstriction in the isolated pulmonary artery, and controversial responses in the isolated perfused lung. Pulmonary vascular responses to sustained alveolar hypoxia have not been addressed in the isolated perfused rat lung. In this study, we investigated the effect of sustained ...
Araz Omer O Dr. Omer Araz, Assistant Professor, Department of Pulmonary Diseases, Ataturk University School of Medicine, 25240, Erzurum, - - 2014
Objective: Hemoptysis is one of the most important and challenging symptoms in pulmonary medicine. Because of the increased number of patients with hemoptysis in certain periods of the year, we aimed to investigate whether atmospheric changes have an effect on the development of hemoptysis with or without a secondary cause. ...
Lv Runxiao - - 2014
Oxygen therapy is one of the most widely used clinical interventions to counteract insufficient pulmonary oxygen delivery in patients with severe lung injury. However, prolonged exposure to hyperoxia at elevated partial pressure leads to inflammation and acute lung injury. The population at risk for this condition has markedly increased with ...
Lavizzari Anna A NICU, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico-Università degli Studi di Milano, , Milan, - - 2014
To compare the effect of heated, humidified, high-flow nasal cannula (HHHFNC) and nasal continuous positive airways pressure (NCPAP) on lung function and mechanics in preterm infants with respiratory distress syndrome (RDS) at the same level of retropharyngeal pressure (Prp). Randomised crossover trial. Neonatal intensive care unit, Ospedale Maggiore Policlinico, Milan, ...
Medarov Boris I BI Division of Pulmonary and Critical Care Medicine, Albany Medical College, MC-91, 47 New Scotland Avenue, Albany, NY 12208, - - 2014
Portopulmonary hypertension (PoPH) is an often neglected form of pulmonary hypertension where pulmonary hypertension occurs in the presence of portal hypertension. PoPH is important to diagnose and treat as it may improve the patient's quality of life and improve the outcome after liver transplantation. In this review, we discuss the ...
Formenti Paolo P Unità Operativa di Anestesia e Rianimazione, Azienda Ospedaliera San Paolo-Polo Universitario, Milano, Italy. Electronic address: - - 2014
Pleural effusion (PE) is commonly encountered in mechanically ventilated, critically ill patients and is generally addressed with evacuation or by fluid displacement using increased airway pressure (PAW). However, except when massive or infected, clear evidence is lacking to guide its management. The aim of this study was to investigate the ...
Li Y Y Department of Anesthesiology, Shaoxing People's Hospital of Zhejiang University, Shaoxing City, China; Department of Clinical and Experimental Medicine, Linköping University, Linköping, - - 2014
The way in which hyperoxia affects pulmonary ventilation and perfusion is not fully understood. We investigated how an increase in oxygen partial pressure in healthy young volunteers affects pulmonary ventilation and perfusion measured by thoracic electrical impedance tomography (EIT). Twelve semi-supine healthy male volunteers aged 21-36 years were studied while ...
Domingo Enric - - 2014
Exercise capacity is impaired in pulmonary arterial hypertension (PAH). We hypothesized that cardiovascular reserve abnormalities would be associated with impaired hemodynamic response to pharmacological stress and worse outcome in PAH. Eighteen PAH patients (p) group 1 NYHA class II/III and ten controls underwent simultaneous right cardiac catheterization and intravascular ultrasound ...
Keller Steven P SP aDepartment of Critical Care, National Institutes of Health, Bethesda bDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, - - 2014
Studies in patients with acute respiratory distress syndrome (ARDS) have been unable to demonstrate a survival advantage with higher levels of positive end-expiratory pressure (PEEP) to open atelectatic lung regions or prevent their cyclic collapse. This review will discuss the challenges of accurately measuring pleural pressure with balloon-tipped catheters in ...
Han Ling L Department of Respiration, Jilin University 1st Hospital, No. 71, Xinmin Road, Changchun, 130021, Jilin, - - 2014
The objective of the study was to investigate the effects of adaptive support ventilation (ASV) and synchronized intermittent mandatory ventilation (SIMV) on peripheral circulation of chronic obstructive pulmonary disease (COPD) patients with respiratory failure. 86 COPD patients with respiratory failure were recruited in this study. Self-control method was used to ...
Frazão M M Federal University of Rio Grande do Norte, Brazil. Electronic address: - - 2014
The aim of the study was to determine the acute effects of positive expiratory pressure (PEP) on breathing pattern, operational volumes and shortening velocity of respiratory muscles on patients with Parkinson's disease. It was evaluated 15 patients and healthy controls, by optoelectronic plethysmography, using PEP in three different levels (10, ...
Gommers Diederik D Department of Adult Intensive Care, Erasmus MC, Rotterdam, the - - 2014
To discuss the role of measuring functional residual capacity (FRC) during mechanical ventilation to improve patient ventilator settings in order to prevent ventilator-induced lung injury. Nowadays, FRC can be measured without the use of tracer gases and without disconnection from the ventilator. It is shown that FRC can provide additional ...
Moceri Pamela P Service de cardiologie, hôpital Pasteur, CHU de Nice, 30, avenue de la Voie-Romaine, BP69, CS 51069, 06001 Nice cedex 1, France. Electronic address: - - 2014
Patients with pulmonary hypertension must be evaluated using a multimodality approach to ensure a correct diagnosis and basal evaluation as well as a prognostic assessment. Beyond the assessment of pulmonary pressures, the echocardiographical examination allows the evaluation of right ventricular adaptation to elevated afterload. Numbers of variables are commonly used ...
Withers Philip C PC Animal Biology M092, University of Western Australia, Crawley, Western Australia 6009, Australia; 2Department of Biological Sciences, University of North Texas, Denton, Texas 76203; 3Department of Herpetology, California Academy of Sciences, San Francisco, California 94118; 4Department of Biology, Portland State University, Portland, Oregon - - 2014
Abstract Dehydration tolerance of anuran amphibians is directly related to their ability to mobilize lymphatic reserves, with more terrestrial species having more effective lymph mobilization dependent on specialized skeletal muscles acting directly on the lymph sacs and via pulmonary ventilation. Consequently, we tested the hypothesis that pulmonary compliance, lung volume, ...
Xia Jingen J From the Department of Intensive Care Medicine, China-Japan Friendship Hospital, Beijing, P. R. China (J.X., Q.Z.); and Beijing Institute of Respiratory Medicine, Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, P. R. China (H.Z., B.S., R.Y., - - 2014
It has been proved that spontaneous breathing (SB) with biphasic positive airway pressure (BIPAP) can improve lung aeration in acute respiratory distress syndrome compared with controlled mechanical ventilation. The authors hypothesized that SB with BIPAP would attenuate lung injury in acute respiratory distress syndrome compared with pressure-controlled ventilation. Twenty male ...
Bellani Giacomo G aDepartment of Health Science, University of Milan-Bicocca bDepartment of Emergency and Intensive Care, San Gerardo Hospital, Monza, - - 2014
Spontaneous breathing has been shown to induce both positive and negative effects on the function and on injury of lungs and diaphragm during critical illness; thus, monitoring of the breathing effort generated by the patient might be valuable for a better understanding of the mechanisms of disease and to set ...
Smith Bradford - - 2014
Mechanical ventilation of patients with acute respiratory distress syndrome (ARDS) is a necessary life support measure which may lead to ventilator induced lung injury, a complication that can be reduced or ameliorated by using appropriate tidal volumes and positive end-expiratory pressures. However, the optimal mechanical ventilation parameters are almost certainly ...
Keszler Martin M Department of Pediatrics, Women and Infants Hospital of Rhode Island, Brown University, Providence, Rhode - - 2014
Background Surgical closure of patent ductus arteriosus (PDA) is associated with adverse outcomes. Surgical exposure requires retraction of the lung, resulting in decreased aeration and compliance. Optimal respiratory support for PDA surgery is unknown. Experience with volume guarantee (VG) ventilation at our institution led us to hypothesize that surgery would be ...
van Os Sylvia S Neonatal Research Unit, Royal Alexandra Hospital, Alberta Health Services, Edmonton, - - 2014
Respiratory support in the delivery room remains challenging. Assessing chest rise is imprecise and mask leak and airway obstruction are common problems. We describe recordings of respiratory signals during delivery room resuscitations and discuss guidance on positive pressure ventilation using respiratory parameters and exhaled carbon dioxide (ECO2 ) during neonatal ...
Bruchim Y Y Koret School of Veterinary Medicine, Veterinary Teaching Hospital, The Hebrew University of Jerusalem, Rehovot, 76100, - - 2014
To assess the usefulness of clinical and clinicopathological parameters as prognostic markers of survival in dogs undergoing positive pressure ventilation. Retrospective study of case records of 58 client-owned dogs undergoing positive pressure ventilation. Dogs were divided into two groups; inadequate oxygenation due to pulmonary parenchymal disease (Group 1) and inadequate ...
Krebs Joerg - - 2014
The ideal ventilation strategy for patients with massive brain damage requires better elucidation. We hypothesized that in the presence of massive brain injury, a ventilation strategy using low (6 milliliters per kilogram ideal body weight) tidal volume (VT) ventilation with open lung positive end-expiratory pressure (LVT/OLPEEP) set according to the ...
Sutherasan Yuda Y Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, IRCCS San Martino - IST, Genoa, - - 2014
Mechanical ventilation (MV) is the main supportive treatment in respiratory failure due to different etiologies. However, MV might aggravate ventilator-associated lung injury (VALI). Four main mechanisms leading to VALI are: 1) increased stress and strain, induced by high tidal volume (VT); 2) increased shear stress, i.e. opening and closing, of ...
Rubini Alessandro A 1Department of Biomedical Sciences, Section Physiology, University of Padova , Padova , - - 2014
ABSTRACT Aim: To investigate the volume dependence of respiratory system stress relaxation in anesthetized, positive-pressure ventilated rats. Materials and methods: The effects on respiratory system stress relaxation of changing the end inflation volume while keeping tidal volume constant, and of changing the tidal volume while maintaining constant end inflation volume, ...
Pearsall Matthew F MF From the General Anesthesia Division, Children's Hospital of Philadelphia, Perelman School of Medicine/University of Pennsylvania, Philadelphia, - - 2014
Physiologic dead space is defined as the volume of the lung where gas exchange does not occur. Apparatus dead space increases dead space volume, causing either increased PaCO2 or the need to increase minute ventilation to maintain normocapnia. Children are especially vulnerable because small increases in apparatus dead space can ...
Xu Yu Y 1 Department of Respiratory Medicine, Xinqiao Hospital, Third Military Medical University , Chongqing, China - - 2014
Abstract Xu, Yu, Yuliang Liu, Junze Liu, and Guisheng Qian. Meta-analysis of clinical efficacy of sildenafil, a phosphodiesterase type-5 inhibitor on high altitude hypoxia and its complications. High Alt Med Biol. 15:46-51, 2014.-Objective: High altitude illness can be life-threatening if left untreated. Acute mountain sickness and high altitude pulmonary hypertension ...
Zieleskiewicz Laurent L From the Department of Anesthesiology and Critical Care Medicine, North Hospital, Aix Marseille University, Marseille, France (L.Z., C.C., C.B., M.T., A.V., F.A., C.M., and M.L.); Intensive Care Unit, Department of Anesthesiology and Critical Care Medicine, Nîmes University, Nîmes, France (L.M.); and North Hospital, Department of Obstetrics and Gynecology, Aix Marseille University, Marseille, France - - 2014
The role of lung ultrasound has never been evaluated in parturients with severe preeclampsia. The authors' first aim was to assess the ability of lung ultrasound to detect pulmonary edema in severe preeclampsia. The second aim was to highlight the relation between B-lines and increased left ventricular end-diastolic pressures. This ...
Lan Chou-Chin CC Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Tzuchi Hospital, The Buddhist Tzuchi Medical Foundation, New Taipei City, Republic of China ; School of Medicine, Tzuchi University, Hualien, Republic of - - 2014
Thoracotomy is a common procedure. However, thoracotomy leads to lung atelectasis and deteriorates pulmonary gas exchange in operated side. Therefore, different positions with operated side lowermost or uppermost may lead to different gas exchange after thoracotomy. Besides, PEEP (positive end-expiratory pressure) influence lung atelectasis and should influence gas exchange. The ...
Cakmak Sabit S Population Studies Division, Environmental Health Science and Research Bureau, Health Canada, 50 Columbine Driveway, Ottawa, Ontario K1A 0K9, Canada. Electronic address: - - 2014
Studying the physiologic effects of components of fine particulate mass (PM2.5) could contribute to a better understanding of the nature of toxicity of air pollution. We examined the relation between acute changes in cardiovascular and respiratory function, and PM2.5-associated-metals. Using generalized linear mixed models, daily changes in ambient PM2.5-associated metals ...
Kelly Julia L JL Sleep and Ventilation Department, NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and National Heart and Lung Institute, Imperial College London, London, - - 2014
Effective non-invasive ventilation (NIV) therapy is dependent on optimal ventilator settings to maximize clinical benefit and patient tolerance. Intelligent volume-assured pressure support (iVAPS) is a hybrid mode of servoventilation, providing constant automatic adjustment of pressure support (PS) to achieve a target ventilation determined by the patient's requirements. In a randomized ...
Pellegrino Riccardo Giovanni RG 1Allergologia e Fisiopatologia - - 2014
Obesity is associated with important decrements in lung volumes. Despite this, ventilation remains normally or near normally distributed at least for moderate decrements in functional residual capacity (FRC). We tested the hypothesis that this is because maximum flow increases presumably as a result of an increased lung elastic recoil. Forced ...
Beer Alison A University of Iowa Hospitals and Clinics, Division of Pulmonary, Critical Care and Occupational Medicine, Iowa City, Iowa, United - - 2014
Between 10-57% of lung transplant (LTx) recipients develop primary graft dysfunction (PGD) within 72 hours of LTx. PGD is clinically and histologically analogous to the acute respiratory distress syndrome (ARDS). In patients at risk for, or with ARDS, lung protective ventilation strategies (low tidal volumes and positive end expiratory pressure) ...
Alzahrany Mohammed M Department of Mechanical Engineering & Mechanics, Lehigh University, Bethlehem, PA 18015, United - - 2014
A large Eddy simulation (LES) based computational fluid dynamics study was performed to investigate gas transport and mixing in patient specific human lung models during high frequency oscillatory ventilation. Different pressure-controlled waveforms (sinusoidal, exponential and square) and ventilator frequencies (15, 10 and 6Hz) were used (tidal volume=50mL). The waveforms were ...
Quintel Michael - - 2014
Ventilator-induced lung injury and ventilator-induced diaphragmatic dysfunction are major complications in mechanically ventilated patients with acute respiratory failure. Invasive ventilation adds a further burden by increasing the risk of infections. An approach that protects both lung and diaphragm is pivotal. Mirabella and colleagues compared conventional controlled ventilation with a mode ...
Mukerji A A Division of Neonatology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, - - 2014
Objective:To examine the role of frequency in high-frequency ventilation (HFV) on carbon-dioxide (CO2) elimination and lung injury, independent of its effect on tidal volume.Study Design:An anatomically representative lung model was attached to a mechanical ventilator capable of providing HFV with a constant volume. CO2 was infused directly into the lung, ...
Limper U U Department of Anesthesiology and Surgical Intensive Care Medicine, Merheim Medical Center, Hospitals of Cologne, University Witten/Herdecke, Ostmerheimer Strasse 200, 51109, Cologne, Germany, - - 2014
Commercial parabolic flights accessible to customers with a wide range of health states will become more prevalent in the near future because of a growing private space flight sector. However, parabolic flights present the passengers' cardiovascular system with a combination of stressors, including a moderately hypobaric hypoxic ambient environment (HH) ...
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