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Breslin Jerome W JW Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA. Electronic address: - - 2014
This review examines the current understanding of how the lymphatic vessel network can optimize lymph flow in response to various mechanical forces. Lymphatics are organized as a vascular tree, with blind-ended initial lymphatics, precollectors, prenodal collecting lymphatics, lymph nodes, postnodal collecting lymphatics and the larger trunks (thoracic duct and right ...
Xu Zhongqi Z College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, PR China; Key Laboratory of Science & Technology of Eco-Textile, Ministry of Education, Donghua University, Shanghai, PR China. Electronic address: - - 2014
Pressure-assisted electrokinetic injection (PAEKI) was applied for negatively charged verteporfin (VER) overloading and inline stacking, which targeted highly sensitive enantioseparation by CE. The essential step of PAEKI is a constant pressure used to counterbalance the electroosmotic flow (EOF), consequently, the large amount of analyte could be permitted into capillary and ...
Dudhipala Narendar N Department of Nanotechnology, University College of Pharmaceutical Sciences, Kakatiya University , Warangal, Andra Pradesh , - - 2014
Abstract Candesartan cilexetil (CC) is used in the treatment of hypertension and heart failure. It has poor aqueous solubility and low oral bioavailability. In this work, CC loaded solid lipid nanoparticles (CC-SLNs) were developed to improve the oral bioavailability. Components of the SLNs include either of trimyristin/tripalmitin/tristearin, and surfactants (Poloxamer ...
Balamurugesan Kandan K Associate Professor, Department of General Medicine, Indira Gandhi Medical College , Kadhiramam, Pondicherry, India - - 2014
We are describing a 60-year-old hypertensive lady who developed Rumpel-Leede phenomenon following the use of a tourniquet to obtain a blood sample. History revealed that she was on amlodipine therapy and that spontaneous sun-exposure related purpura was often seen since amlodipine was prescribed. Examinations and investigations provided normal results. She ...
Baki Aber Halim AH Departments of Nephrology, Faculty of Medicine, Ain Shams University, Cairo, - - 2014
Introduction: The term hypertensive nephrosclerosis has traditionally been used to describe a clinical syndrome characterized by long-term essential hypertension, hypertensive retinopathy, left ventricular hypertrophy, minimal proteinuria, and progressive renal insufficiency. In the absence of renal biopsy, the diagnosis of hypertensive nephrosclerosis is one of exclusion. Methods: We retrospectively studied 735 ...
Nathanson S David - - 2013
Clinicians have long regarded firm enlarged axillary nodes as suspicious for metastasis, and this has been confirmed to represent increased pressure in sentinel lymph nodes (SLN) in vivo in breast cancer. We hypothesized that measuring intranodal pressure (INP) in the operating room would correlate with metastasis size and be more ...
Seggers Jorien - - 2013
Background:Recent studies suggest that in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are associated with suboptimal cardiometabolic outcome in offspring. It is unknown whether preimplantation genetic screening (PGS), which involves embryo biopsy, affects blood pressure, anthropometrics and the frequency of received medical care.Method:In this prospective multi-centre follow-up study we ...
Threlfall Greg - - 2013
Experiments and theory were undertaken on the destruction of ultrasound contrast agent microbubbles on needle injection, with the aim of predicting agent loss during in vivo studies. Agents were expelled through a variety of syringe and needle combinations, subjecting the microbubbles to a range of pressure drops. Imaging of the bubbles ...
Boonsarngsuk Viboon - - 2013
BACKGROUND: Data regarding the effect of aspiration pressure over endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) on the diagnosis of intrathoracic lymphadenopathies is limited. The aim of this study was to compare the effect of three levels of aspiration pressure over EBUS-TBNA on the diagnostic yield and numbers of diagnostic cells. ...
Desai Mahesh - - 2013
Microperc is a significant advance in miniaturization of PNL procedure. The whole procedure is done in one step manner using 16 G needle. In any PNL, outer sheath (Amplatz sheath) keeps on draining the fluid from the PC system this maintaining low intra renal pressures. Microperc can have disadvantage that ...
Kwon Joon Yub - - 2013
Electrokinetic supercharging is one of the most powerful sample stacking methods that combines field amplified sample injection and transient isotachophoresis. In counter flow electrokinetic supercharging, a constant counter pressure is applied during sample injection in order to counterbalance the movement of the injected sample zone. As a result, there will ...
Gildea John J JJ University of Virginia, Charlottesville, VA 22903, United - - 2013
Salt sensitivity (SS) of blood pressure (BP) affects 25% of adults, shares comorbidity with hypertension, and has no convenient diagnostic test. We tested the hypothesis that urine-derived exfoliated renal proximal tubule cells (RPTCs) could diagnose the degree of an individual's SS of BP. Subjects were selected who had their SS ...
Marvel Sarah - - 2013
OBJECTIVE: An ex vivo comparison of thoracoscopic lung biopsy techniques in dogs. STUDY DESIGN: Experimental. SAMPLE POPULATION: Cadaveric canine lung lobes. METHODS: Lungs were inflated to 10 cmH(2) O. After collecting biopsies 3 cm from the edge of lung lobes, leak pressures were recorded as inflation pressure was increased to 40 cmH(2) O. ...
Leinonen V - - 2013
BACKGROUND AND PURPOSE: This study determined the correlation between uptake of the amyloid positron emission tomography (PET) imaging agent [(18) F]flutemetamol and amyloid-β measured by immunohistochemical and histochemical staining in a frontal cortical biopsy. METHODS: Fifteen patients with possible normal pressure hydrocephalus (NPH) and previous brain biopsy obtained during intracranial ...
Park Ellen - - 2013
This study aimed to measure the pressure generated during positive-pressure irrigation at the periapex of an in vitro tooth model using a novel method of measurement, investigating the effect of flow rate and needle design. Apical pressure was correlated with the extent of dye clearance from the end of a needle ...
Shiroyama Takayuki T Department of Thoracic Malignancy, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Osaka, - - 2013
The optimal suction pressure during endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) remains to be determined. The aim of this study was to compare suction pressures for performance in collecting sufficient tissue specimens from mediastinal and hilar lymph nodes during EBUS-TBNA. Retrospective analysis of consecutive patients with mediastinal and hilar ...
Kjaergaard Benedict B Department of Cardiothoracic Surgery, Centre for Cardiovascular Research, and Biomedical Research Laboratory, Aalborg University Hospital, Aalborg, Denmark. - - 2013
It can be difficult to perform CT guided biopsy of small pulmonary nodules especially if the position is behind a costa or close to the diaphragm and respiratory movements may hamper the procedure. During apneic oxygenation with a pulmonary standstill these movements can be hindered. Six patients with decreased lung ...
Ejike Chukwunonso E C C - - 2012
The diagnostic accuracy of blood-pressure-to-height-ratios (BPHRs) in 716 Nigerian children was studied, using standard protocols. Systolic BPHR (SBPHR) and diastolic BPHR (DBPHR) had diagnostic accuracies ranging from 0.934 to 1.000, irrespective of sex and age. Optimal thresholds of SBPHR/DBPHR are provided, and their sensitivities and specificities all exceeded 80%. BPHR ...
Türkyılmaz Meltem - - 2013
Pomegranate juice (PJ) samples were produced with three different pressing programs: (1) 1.2-4.8bar for 25min, (2) 1.2-2.4bar for 15min and (3) 1.2-1.8bar for 5.5min. Respective juice yields were 39.2%, 33.2% and 27.2%. Effects of pressing pressure-time and yield on total phenolic (TP) content, condensed tannin (CT) content, monomeric anthocyanin (MA) ...
Fischer Lorenz H - - 2012
The first fluorescent material for the referenced simultaneous RGB (red green blue) imaging of barometric pressure (oxygen partial pressure) and temperature is presented. This sensitive coating consists of two platinum(II) complexes as indicators and a reference dye, each of which is incorporated in appropriate polymer nanoparticles. These particles are dispersed ...
Mendis Buddhike - - 2012
In clinical studies of glucagon-like peptide-1 (GLP-1) agonists used in the management of patients with type 2 diabetes, there is often a small accompanying fall in blood pressure. The mechanism underlying this effect is not known, although exenatide, a GLP-1 mimetic, has acute regional vasodilator properties in rats. We have ...
Tang T-Y Dora - - 2012
Monoacylglycerol based lipids are highly important model membrane components and attractive candidates for drug encapsulation and as delivery agents. However, optimizing the properties of these lipids for applications requires a detailed understanding of the thermodynamic factors governing the self-assembled structures that they form. Here, we report on the effects of ...
Granada Juan F - - 2012
The treatment of severe hypertension by the surgical obliteration of the renal sympathetic nerves was proposed almost 80 years ago. This approach, although highly effective in reducing blood pressure was associated with a significant amount of side effects and it was rapidly replaced by better tolerated medical therapy. The rapid progress ...
Damasceno-Oliveira A - - 2012
The reproductive cycle in teleosts is timed to guarantee that eggs hatch in the right place at the right time, with environmental factors playing important roles in entraining and controlling the entire process. The effects of some environmental factors, like temperature and photoperiod, are now well understood. There are only ...
Gaede Andrea H - - 2012
This study focuses on presympathetic neurons of the rostral ventrolateral medulla (RVLM) that regulate sympathetic vasomotor tone. Many neurotransmitters are co-localized in RVLM neurons and are released under specific conditions to modulate efferent homeostatic responses. Of particular interest here, are two peptides co-localized in catecholaminergic RVLM neurons: catestatin, and pituitary ...
Merlini Marco - - 2012
Carbon-bearing solids, fluids, and melts in the Earth's deep interior may play an important role in the long-term carbon cycle. Here we apply synchrotron X-ray single crystal micro-diffraction techniques to identify and characterize the high-pressure polymorphs of dolomite. Dolomite-II, observed above 17 GPa, is triclinic, and its structure is topologically ...
Phillips Robert S - - 2012
The effects of pH and hydrostatic pressure on the reaction of H463F tryptophan indole-lyase (TIL) have been evaluated. The mutant TIL shows very low activity for elimination of indole, but is still competent to form a quinonoid intermediate from L-tryptophan (Phillips, R. S., Johnson, N. and Kamath, A. V. (2002) ...
Kojonazarov Baktybek - - 2012
BACKGROUND: Little is known about the effects of current PAH therapies and receptor tyrosine kinase inhibitors on heart remodeling. We sought to investigate the effects of the multikinase inhibitors sunitinib (PDGFR-, VEGFR- and KIT-inhibitor) and sorafenib (raf1/b-, VEGFR-, PDGFR-inhibitor) on pressure overload induced right ventricular (RV) remodeling. METHODS: We investigated ...
Bouzid Assil - - 2012
First-principles molecular dynamics (FPMD) data on the structural properties of glassy GeSe(2) under ambient conditions are produced by carefully considering and minimizing the effect of a residual pressure on the periodic system. When compared to previous FPMD results, this strategy leads to an improved agreement between theory and neutron diffraction ...
Juncos Luis I - - 2012
Hydroxy methyl glutaryl CoA inhibitors (statins) are the agents most frequently used to reduce elevated serum cholesterol. In addition to their cholesterol lowering effects, statins also have nonlipid lowering pleiotropic properties. These include reducing oxidative stress, renin-angiotensin and endothelin synthesis and activity, and improving nitric oxide (NO) synthesis and availability. ...
Belzowzki Anne - - 2012
The cutaneous hyperemic response following the release of direct pressure occlusion lasts much longer than the short-term hyperemia that occurs after proximal arterial occlusion. Post-pressure hyperemia may be an important mechanism to prevent pressure induced injury to the skin. The role of vasoactive mediators in modulating post-pressure hyperemia is unknown. ...
Zivkovic Vladimir - - 2012
Research on the effects of homocysteine on the vascular wall, especially in endothelial and smooth muscle cells, has indicated that increased homocysteine levels lead to cellular stress and cell damage. Considering the adverse effects of homocysteine on vascular function and the role of oxidative stress in these mechanisms, the aim ...
Biering S - - 2012
The pressure dependence of bulk properties for the group 12 chalcogenides MX (M = Zn, Cd, Hg; X = S, Se, Te) from density functional theory are presented. Energy-volume and corresponding enthalpy-pressure relationships are determined to obtain the transition paths and properties of various high-pressure phases. The influence of relativistic ...
Hou Shao-Zhen - - 2012
Aim of the study: Lilhocarpus polystachys Rehd. (Sweet Tea, ST) is a folk herbal medicine that has been traditionally used as a natural remedy for hypertension in China, which mechanism remains unveiled. Flavonoid fraction is considered as the major active components in ST. This study aimed to provide experimental evidence ...
Moreira Thiago S - - 2012
OBJECTIVE: Peripheral treatment with the cholinergic agonist pilocarpine increases salivary gland blood flow and induces intense salivation that is reduced by the central injection of moxonidine (α(2)-adrenoceptors/imidazoline agonist). In the present study, we investigated the effects of the intracerebroventricular (i.c.v.) injection of pilocarpine alone or combined with moxonidine also injected ...
Kao Yu-Cheng - - 2012
The high pressure induced phase transition in rhenium diselenides (ReSe(2)) and gold-doped rhenium diselenides (Au-ReSe(2)) at ambient temperature have been investigated using angular-dispersive x-ray diffraction (ADXRD) under high pressure up to around 10.50 and 9.98 GPa, respectively. In situ ADXRD measurements found that the phase transition pressures of ReSe(2) and ...
Pimenta E - - 2012
Clinical studies have shown that aldosterone and salt are independently related to hypertension, cardiovascular morbidity and mortality. More recently, studies in humans have demonstrated that, similarly to animals, endogenous aldosterone and dietary salt intake have not only separate, but also combined effects to accelerate target-organ deterioration. The aldosterone-salt interaction has ...
Papathanassoglou Elizabeth D E - - 2012
Introduction: Nurses use several forms of touch in patient encounters. Interpersonal touch elicits specific physiological and psychological responses, including neuroendocrine effects and reduction of stress. Critical illness is a state of excessive physiological and psychological stress. Aims: To critically review evidence on the effect of touch on physiological outcomes in ...
Soeki Takeshi - - 2012
Cilnidipine, an L/N-type calcium channel blocker (CCB), has been reported to have more beneficial effects on proteinuria progression in hypertensive patients than amlodipine, an L-type CCB. The N-type calcium channel blockade that inhibits renal sympathetic nerve activity might reduce glomerular hypertension by facilitating vasodilation of the efferent arterioles. However, the ...
Lin Yin-Shiou - - 2012
This study aimed to investigate the antihypertensive effects of ethanolic extracts (EE) and compounds isolated from the small-leaf grape (Vitis thunbergii var. taiwaniana, VTT). The highest anti-angiotensin-converting enzyme (anti-ACE) was found in stem-EE (IC50 was 69.5 μg/mL). In spontaneously hypertensive rats (SHRs), stem-EE effectively reduced blood pressure 24 h after ...
Bhavanani Ananda Balayogi - - 2012
Recent studies have reported differential physiological and psychological effects produced by exclusive right and left nostril breathing and clinical research is required to prove immediate and sustained efficacy of these techniques in various psychosomatic conditions such as hypertension (HT). The present study was designed to determine immediate effects of 27 ...
Waeber Bernard - - 2012
Diuretics play a pivotal role in the management of hypertension. A large experience has been accumulated with indapamide , a long-acting thiazide-like diuretic that lowers blood pressure (BP) primarily through its natriuretic diuretic effect. Some of its long-term antihypertensive efficacy may be due to calcium antagonist-like vasorelaxant activities. Indapamide has ...
Mitręga Katarzyna A - - 2012
Our previous studies have established cardio-protective effects of furnidipine and its active metabolites. We therefore decided to compare the influence of oral and intravenous administration of furnidipine, nifedipine, nitrendipine and nimodipine to examine their effects on hemodynamics and arrhythmias. Since dihydropyridines are oxidatively metabolised in the body and the oxidized ...
Borgdorff Marinus A J - - 2012
AimRight ventricular (RV) failure due to pressure or volume overload is a major risk factor for early mortality in congenital heart disease and pulmonary hypertension, but currently treatments are lacking. We aimed to demonstrate that the phosphodiesterase 5A inhibitor sildenafil can prevent adverse remodelling and improve function in chronic abnormal ...
Tiniakov Ruslan - - 2012
Administration of the 5-HT(1A) receptor agonist, 8-OH-DPAT, improves cardiovascular hemodynamics and tissue oxygenation in conscious rats subjected to hypovolemic shock. This effect is mediated by sympathetic-dependent increases in venous tone. To determine the role of splanchnic nerves in this response, effects of 8-OH-DPAT (30 nmol/kg iv) were measured following fixed-arterial ...
Rita Omar de - - 2012
BACKGROUND: In animal models, aldosterone has adverse cardiac and vascular effects independent of blood pressure, and these are ameliorated by spironolactone or eplerenone (mineralocorticoid receptor antagonists). Both agents reduce mortality in human systolic heart failure. We studied the effect of plasma aldosterone on human carotid atherosclerosis. METHODS: The effect of ...
Bae H - - 2012
We present a miniature Fabry-Perot pressure sensor fabricated at the tip of an optical fiber with a pre-written Bragg grating by using UV-molding polymer process. The mold is constructed by integrating an optical fiber of 80 μm diameter with a zirconia ferrule. The optical fiber based mold makes it possible ...
Lee Seung Ho - - 2012
The effect of the infiltration pressure on the birefringent properties of a side-hole fiber filled with indium was investigated by the fiber-optic Sagnac loop interferometry. The fiber was made at the various gas pressures during the metal infiltration process. It was found that the birefringence of the fiber strongly decreased ...
Jian Jie - - 2012
The effect of 17-methoxyl-7-hydroxy-benzene-furanchalcone isolated from the roots of Millettia pulchra (Benth.) Kurz var. Laxior (Dunn) Z. Wei on rat myocardial ischemia has been investigated. An in vitro cardiocyte apoptosis model and an in vivo myocardial ischemia model were used to elucidate the mechanism of 17-methoxyl-7-hydroxy-benzene-furanchalcone. In contrast to hydrogen ...
Vaudagna S R - - 2012
We compared the application of high hydrostatic pressure (HHP) on unfrozen carpaccio (HHP at 20°C) and on previously-frozen carpaccio (HHP at -30°C). HHP at 20°C changed the color. The pressure increase from 400 to 650MPa and the time increment from 1 to 5min at 400MPa increased L* and b*. a* ...
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