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Rostand Stephen G SG The Nephrology Research and Training Center, Division of Nephrology, Department of Medicine, The University of Alabama at Birmingham, 266 Paula Building, 1720 2nd Avenue South, Birmingham, AL, 35294, USA, - - 2014
Vitamin D deficiency is inversely associated with blood pressure and is felt to contribute to the genesis and maintenance of hypertension. Although well demonstrated in animal studies, in many clinical studies the association between vitamin D status and blood pressure has not been consistently observed or else has been quite ...
Fitzgerald Ciaran - - 2014
This work examined the resistance of the renin inhibitory, tridecapeptide IRLIIVLMPILMA derived previously from a Palmaria palmata papain hydrolysate, during Gastrointestinal (GI) transit. Following simulated GI digestion, breakdown products were identified using MS analysis and the known renin and angiotensin-I-converting enzyme inhibitory dipeptide IR was identified. In vivo animal studies ...
Sun Jialan J Department of Neurology, Pudong District Gongli Hospital, Shanghai, - - 2014
To study the relationship between nocturnal blood pressure (BP) variation and spontaneous intracerebral hemorrhage (ICH) among Chinese hypertensive patients and its clinical significance, the authors retrospectively screened 371 patients with primary hypertension (189 patients with ICH, 182 patients without ICH) in Shanghai and analyzed their demographics, clinical information, nocturnal blood ...
Moon-Massat Paula F - - 2014
NVX-108, a dodecafluoropentane-based perfluorocarbon (PFC) emulsion, has therapeutic potential as an oxygen-carrying fluid for emergency medical treatment for traumatic brain injury (TBI) and hemorrhagic shock. Potential cerebral vasoactive properties were assessed by directly measuring pial arteriolar vessel diameters before and after a 30 minute intravenous (IV)infusion of 1.0 ml/kg (high ...
Tanaka Eijirou E From the Department of Cerebrovascular Medicine (E.T., J.K., T.O., S.S., K.M., K.T.), Division of Stroke Care Unit (M.K., S.A.), and Department of Neurology (H.Y, K.N.), National Cerebral and Cardiovascular Center, Suita, Japan; Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan (K. Kario); Department of Neurosurgery and Stroke Center, Nakamura Memorial Hospital, Sapporo, Japan (K. Kamiyama); Department of Stroke Neurology, Kohnan Hospital, Sendai, Japan (E.F.); Department of Neurosurgery and Stroke Center, Kyorin University School of Medicine, Mitaka, Japan (Y.S.); Department of Neurology, St Marianna University School of Medicine, Kawasaki, Japan (Y.H.); Department of Neurology, NHO Nagoya Medical Center, Nagoya, Japan (S.O.); Department of Neurology, Stroke Center, Kobe City Medical Center General Hospital, Kobe, Japan (H.Y.); Department of Stroke Medicine, Kawasaki Medical School, Kurashiki, Japan (K. Kimura); and Department of Cerebrovascular Medicine, NHO Kyushu Medical Center, Fukuoka, Japan - - 2014
The associations between early blood pressure (BP) variability and clinical outcomes in patients with intracerebral hemorrhage after antihypertensive therapy, recently clarified by a post hoc analysis of Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial 2 (INTERACT2), were confirmed using the Stroke Acute Management with Urgent Risk-factor Assessment and ...
Zhang Qian Q Department of Endocrinology, Chinese PLA General Hospital, Beijing, China; Chinese PLA General Hospital, Beijing, - - 2014
In search of add-on treatments to metformin, sodium-glucose cotransporter-2 (SGLT-2) inhibitors are potential candidates. This meta-analysis examines the potential use of SGLT-2 inhibitors in combination with metformin as a therapeutic option for type 2 diabetes management in patients with inadequate control with metformin. A literature search was made in several ...
McCourt Rebecca R From the Division of Neurology (R.M., B.G., L.G., M.K., T.J., B.B., K.B.) and Department of Diagnostic Imaging (D.E.), University of Alberta, Edmonton, Canada; Division of Neurology, University of British Columbia, Vancouver, Canada (N.A.); Division of Neurology, University of Ottawa, Ottawa, Canada (D.D.); and Department of Clinical Neurosciences, University of Calgary, Calgary, Canada (S.B.C., M.D.H., - - 2014
The pathogenesis of perihematoma edema in intracerebral hemorrhage (ICH) is unknown but has been hypothesized to be ischemic. In the ICH Acutely Decreasing Arterial Pressure Trial (ICH ADAPT), perihematoma cerebral blood flow (CBF) was reduced but was unaffected by blood pressure (BP) reduction. Using ICH ADAPT data, we tested the ...
Isegawa Kengo K Department of Cardiovascular Medicine - - 2014
Abstract Abnormal elevation of blood pressure in early morning (rest-to-active phase) is suggested to cause cardiovascular events. We investigated whether azilsartan (AZL), a novel potent angiotensin receptor blocker, suppresses blood pressure elevation from the light-rest to dark-active phase in spontaneously hypertensive rats (SHRs). AZL has a sustained depressor effect around ...
Hammond Tara N TN Department of Emergency/Critical Care, Tufts Veterinary Emergency Treatment & Specialties, Walpole, - - 2014
Treatment for hemorrhagic shock secondary to a spontaneous hemoperitoneum includes restoration of IV volume and surgical control of hemorrhage. This study was designed to determine if limited fluid volume resuscitation (LFVR) with hypertonic saline (HS) and hyperoncotic fluids (hydroxyethylstarch [HES]) results in more rapid cardiovascular stabilization in dogs with spontaneous ...
Németh M M Department of Anaesthesiology and Intensive Therapy, University of Szeged, Szeged, - - 2014
Fluid resuscitation is still a major challenge. We aimed to describe changes in central venous oxygen saturation (ScvO2 ) and venous-to-arterial carbon dioxide gap (dCO2 ) during an experimental stroke volume (SV) index (SVI)-guided hemorrhage and fluid resuscitation model in pigs. Twelve anesthetized, mechanically ventilated pigs were bled till baseline ...
Mitrano M M Max Planck Institute for the Structure and Dynamics of Matter, Luruper Chaussee 149, 22761 Hamburg, - - 2014
We measure the ultrafast recombination of photoexcited quasiparticles (holon-doublon pairs) in the one dimensional Mott insulator ET-F2TCNQ as a function of external pressure, which is used to tune the electronic structure. At each pressure value, we first fit the static optical properties and extract the electronic bandwidth t and the ...
Kwan Irene I Evidence for Policy and Practice Information and Coordinating Centre (EPPI-Centre), Social Science Research Unit (SSRU), Institute of Education, University of London, 10 Woburn Square, London, UK, WC1H - - 2014
Treatment of haemorrhagic shock involves maintaining blood pressure and tissue perfusion until bleeding is controlled. Different resuscitation strategies have been used to maintain the blood pressure in trauma patients until bleeding is controlled. However, while maintaining blood pressure may prevent shock, it may worsen bleeding. To examine the effect on ...
Ebi Masahide M aDepartment of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan bVascular Biology Program, Boston Children's Hospital cDepartment of Surgery, Harvard Medical School and Boston Children's Hospital, Boston, - - 2014
Endoscopic submucosal dissection (ESD) is a useful technique for early gastric neoplasms without lymph node metastasis. However, a critical complication is unpredictable post-ESD bleeding. Some risk factors for post-ESD bleeding have been reported previously, although those risk factors have not directly contributed toward prevention of post-ESD bleeding. We retrospectively identified ...
Umanath Kausik K Division of Nephrology and Hypertension, Henry Ford Hospital, Detroit, MI; Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN; and Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, - - 2014
Hypertension is a common problem among patients with glomerular disease and CKD. Optimal blood pressure targets for these patients have been the source of much debate. Careful review of the available data supports a blood pressure target of less than 140/90 mmHg. Consideration for a lower goal of less than ...
Kragh John F JF - - 2014
Objective: The purpose of the present study is to determine the performance of tourniquet use by the placement of the tourniquet?s windlass on the extremity in four positions?medial, lateral, anterior, and posterior? to inform tourniquet instructors and develop best tourniquet practices. Methods: A HapMed™ Leg Tourniquet Trainer was used as ...
Gates Keith S - - 2014
Objective: Junctional bleeding from the groin is a leading cause of potentially preventable death on the battlefield. To address this problem, a novel device called the Junctional Emergency Treatment Tool (JETT™) was developed. The JETT was designed to stabilize pelvic ring fractures while controlling lower extremity bleeding sustained during high-energy ...
Wang Yunjie Y Faculty of Technology, Bielefeld University, Bielefeld, - - 2014
Vertebrates evolved an endothelium-lined hemostatic system and a pump-driven pressurized circulation with a finely-balanced coagulation cascade and elaborate blood pressure control over the past 500 million years. Genome analyses have identified principal components of the ancestral coagulation system, however, how this complex trait was originally regulated is largely unknown. Likewise, ...
Zardi Enrico Maria EM Department of Clinical Medicine, 'Campus Bio-Medico' University , Rome , - - 2013
Portal hypertension is a severe syndrome that may derive from pre-sinusoidal, sinusoidal, and post-sinusoidal causes. As a consequence, several complications (i.e. ascites, oesophageal varices) may develop. In sinusoidal portal hypertension, hepatic venous pressure gradient (HVPG) is a reliable method for defining the grade of portal pressure, establishing the effectiveness of ...
Puglisi Janis P - - 2013
: This article reviews the 2011 guidelines for the evaluation, treatment, and prevention of vitamin D deficiency as well as the research literature evidencing an association between vitamin D, blood pressure and depression. Studies reveal an association between vitamin D levels and both systolic blood pressure and depression.
Darbemamieh Goldis - - 2013
Abstract Haemostatic powder is an effective solution commonly used in various open surgeries. However, there is no specific intra-abdominal delivery device for application of haemostatic powder at the bleeding site during minimally invasive surgery (MIS). In this study, design, construction and test of a novel powder delivery device were carried ...
Rapp John Paul - - 2013
A perspective on interpreting data on epistatis in the context of genetics of hypertension is presented.
Saeedi Morteza M Department of Emergency Medicine, Tehran University of Medical Sciences, Tehran, Iran. - - 2013
To evaluate the effects of various fluids on uncontrolled hemorrhagic shock (UHS). Controversy exists over the appropriate doses and types of fluids for best treating UHS. This study evaluated the effects of hypertonic saline (HTS), normal saline (NS), and no fluid resuscitation (NFR) on UHS. Thirty goats were anesthetized and ...
Bahk Byung Hoo BH Department of Anesthesiology and Pain Medicine, School of Medicine, Yeungnam University, Daegu, - - 2013
Intestinal obstruction was diagnosed in two fetuses at maternal antenatal care. Both received emergency surgery on the day of their birth, at about 35 weeks gestational age. The disease progressed for a long time in both cases because prompt diagnosis and surgery are difficult to perform in utero. As a ...
Harrois Anatole A 1Laboratoire de Microcirculation, Energétique, Inflammation, Insuffisance Circulatoire Aigue, Université Paris VII-XI-XIII, Paris, France. 2Service d'Anesthésie-Réanimation Chirurgicale, Hôpital de Bicêtre, Université Paris-Sud, Hôpitaux universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France. 3BakerIDI Heart and Diabetes Institute, Monash University, Melbourne, Australia. 4Service d'Anatomie pathologique, Groupe hospitalier Paris-Seine-Saint Denis, Hopital Jean Verdier, AP-HP, Bondy, France. 5France et Universite Paris 13, Sorbonne Paris Cite, UFR SMBH, Bobigny, - - 2013
To investigate the effect of hypoxemia, hemorrhagic shock, and the association of both of these on intestinal microcirculation (microcirculatory perfusion and leukocytes-endothelium interactions in postcapillary venules), as it can be encountered in hemorrhagic shock following trauma. Prospective controlled experimental study. University research laboratory. Forty-eight anesthetized and mechanically ventilated Balb/c mice. ...
Smith L A - - 2013
Hemospray is a haemostatic agent licensed for endoscopic haemostasis of non-variceal upper gastrointestinal bleeding (NVUGIB) in Europe and Canada. Hemospray has been shown to be safe and effective in achieving haemostasis in bleeding peptic ulcers in a prospective clinical study and several further case series have described the use of ...
Inamasu Joji - - 2013
Our assumption that blood pressure (BP) in supratentorial hypertensive intracerebral hemorrhage patients does not differ significantly according to the hemispheric laterality has never been verified before. This study was carried out to explore the possibility of hemispheric BP differences and whether this might influence the outcomes. A review of the ...
Poovazhagi Varadarajan - - 2013
The authors describe an 11-y-old child with intracranial bleed due to malignant hypertension. Child presented with hypertension, right hemiparesis, feeble femoral pulses and lower limb blood pressure less than the upper limb. CT angiogram revealed narrowing of the abdominal aorta with thinned out left renal artery and hypoplasia of the ...
Li Tao - - 2013
Our previous studies demonstrated that 50-60 mmHg of mean arterial blood pressure (MAP) was the ideal target hypotension for uncontrolled hemorrhagic shock during the active hemorrhage in sexually mature rats. The ideal target resuscitation pressure for immature and elderly rats has not been determined. To elucidate this issue, using uncontrolled ...
Peterson Katherine L - - 2013
To compare the shock index (SI) in a population of healthy dogs to a population of dogs with confirmed hemorrhagic shock. Retrospective analysis of data collected prospectively from 2 previous studies. University teaching hospital. Seventy-eight healthy control dogs enrolled in a study to establish a reference interval for a tissue ...
Kato Yuko - - 2013
We identified 2,8-diazaspiro[4.5]decane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase (sEH) inhibitors and orally active agents for treating hypertension. Docking studies using human and murine sEH X-ray crystal structures revealed steric hindrance around the side chain of Phe406 of murine sEH. The trifluoromethyl moiety (11) was replaced with ...
Metzger Anja - - 2013
One approach to improve outcomes after trauma and hemorrhage is to follow the principles of permissive hypotension by avoiding intravascular overpressure and thereby preventing dislodgement of platelet plugs early in the clotting process. We hypothesized that augmentation of negative intrathoracic pressure (nITP) by treatment with an impedance threshold device would ...
Lieberman Jeremy A - - 2013
BACKGROUND:: Transcranial motor-evoked potentials (TcMEPs) monitor spinal cord motor tract integrity. Using a swine model, the authors studied the effects of vasodilatory hypotension, hemorrhage, and various resuscitation efforts on TcMEP responses. METHODS:: Twelve pigs were anesthetized with constant infusions of propofol, ketamine, and fentanyl. Animals were incrementally hemorrhaged, until bilateral ...
Saito Yuka - - 2013
In this study, hemoglobin vesicle (HbV), a type of artificial oxygen carrier, was infused in a hemorrhagic shock model, and the findings were compared with those of red blood cell (RBC) transfusion to evaluate the effects on blood pressure and renal function. In rats maintained in hemorrhagic shock for 30 min ...
Burnett Luke R - - 2013
Traumatic injury is the leading cause of death in people aged 44 or less in the US. It is also estimated that 82% of deaths from battlefield hemorrhage may be survivable with better treatment options. In this study, two biomaterial hemostats having disparate mechanisms were evaluated in a large animal ...
Ghosh Suborno M SM William Harvey Research Institute, Barts and The London Medical School, Queen Mary University of London, London, United - - 2013
Elevation of circulating nitrite (NO2(-)) levels causes vasodilatation and lowers blood pressure in healthy volunteers. Whether these effects and the underpinning mechanisms persist in hypertension is unknown. Therefore, we investigated the consequences of systemic nitrite elevation in spontaneously hypertensive rats and conducted proof-of-principle studies in patients. Nitrite caused dose-dependent blood ...
Kikidis D - - 2013
Both epistaxis and hypertension are frequent problems in the adult population. The relationship between the level of arterial pressure and incidence of epistaxis in a patient with hypertension is a question that appears frequently in the clinical practice. A systematic review of the literature regarding the relation of arterial hypertension ...
Kasotakis George - - 2013
BACKGROUND: We previously demonstrated that abdominal gas insufflation (AGI) reduces intra-abdominal bleeding. To date, this is the only method that holds promise for reducing mortality from internal bleeding in a pre-hospital setting. We aimed to assess the optimal AGI pressure and the effectiveness of a portable miniaturized insufflator in abdominal ...
Bauman David R - - 2013
In an effort to understand the origin of blood-pressure lowering effects observed in recent clinical trials with 11β-HSD1 inhibitors, we examined a set of 11β-HSD1 inhibitors in a series of relevant in vitro and in vivo assays. Select 11β-HSD1 inhibitors reduced blood pressure in our preclinical models but most or ...
Ranieri Maria M - - 2013
Understanding the kinetics of olefin polymerization with Ziegler-Natta and related catalysts means identifying the main kinetic parameters such as kp and concentration of active sites. The high-pressure quenched-flow technique could be an absolute method for counting active sites and for activation studies of molecular catalysts. A kinetic study of metallocene ...
Gröger Michael - - 2013
OBJECTIVES:: Accidental hypothermia increases mortality and morbidity after hemorrhage, but controversial data are available on the effects of therapeutic hypothermia. Therefore, we tested the hypothesis whether moderate pretreatment hypothermia would beneficially influence organ dysfunction during long-term, porcine hemorrhage and resuscitation. DESIGN:: Prospective, controlled, randomized study. SETTING:: University animal research laboratory. ...
Chugh Preeta Kaur - - 2013
While it is known that non-steroidal anti-inflammatory drugs including selective cyclooxygenase-2 (COX-2) inhibitors influence BP, the exact relationship and underlying mechanisms are still unclear. We investigated the effect of etoricoxib, a selective COX-2 inhibitor on the antihypertensive efficacy of atenolol; beta-blocker, ramipril; angiotensin converting enzyme inhibitor and telmisartan; angiotensin receptor ...
Lin Geng-Shiau - - 2013
BACKGROUND: Good outcomes have resulted from hypotensive resuscitation of hemorrhagic shock patients. We hypothesized that mean arterial pressure (MAP) 60mmHg is the target blood pressure for hypotensive resuscitation during uncontrolled hemorrhagic shock in trauma. METHODS: To determine the effective target MAP for hypotensive resuscitation during uncontrolled hemorrhagic shock, we randomly ...
Martini Wenjun Z - - 2013
This study compared coagulation function after resuscitation with Hextend and lactated Ringer's (LR) solution in pigs with tissue injury and hemorrhagic shock. Pigs were randomized into control (n = 7 each), LR, and Hextend groups. Femur fracture was induced using the captive bolt stunner at midshaft of the pigs' left ...
Tamez Hector H Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, - - 2013
Both vitamin D deficiency and hypertension are highly prevalent. It is unclear whether vitamin D modulates blood pressure and therefore whether vitamin D testing and therapy should become part of routine hypertension prevention and management. This article provides an overview of the data, with special emphasis on the work published ...
Lyden Patrick D - - 2013
BACKGROUND: Despite the increasing use of thrombolytic therapy for acute ischemic stroke, hemorrhagic transformation remains a significant complication. Transformation appears to occur more frequently with age, diabetes, and hypertension, but clinical data are mixed. In addition to risk factors, matrix metalloproteinase expression mediates hemorrhage. We sought to test the effects ...
Herath Chandana B - - 2013
Portal hypertension is responsible for the bulk of the morbidity and mortality in patients with cirrhosis. Drug therapy to reduce portal pressure involves targeting two vascular beds. The first approach is to reduce intra hepatic vascular tone induced by the activity of powerful vasocontrictors such as angiotensin II, endothelin-1 and ...
Xu Jiefeng - - 2013
ABSTRACT: To avoid aggressive fluid resuscitation during hemorrhagic shock, fluid resuscitation is best guided by a specific measurement of tissue perfusion. We investigated whether fluid resuscitation guided by sublingual PCO2 would reduce the amount of resuscitation fluid without compromising the outcomes of hemorrhagic shock.Ten male domestic pigs weighing between 34-37 ...
Astorne Figari Walter J - - 2013
Citalopram is one of the selective serotonin re-uptake inhibitors (SSRIs) most commonly prescribed for depression and many affective disorders. Abrupt cessation of this medication has been associated with dizziness, nausea, myalgias, anxiety and irritability. It is unclear whether blood pressure can be perturbed under such a circumstance. We present a ...
Anderson Craig - - 2013
The Statistical analysis plan (SAP) for the second INTEnsive blood pressure Reduction in Acute Cerebral hemorrhage Trial (INTERACT2).
Amin Osama S M - - 2013
The simultaneous development of two (or more) spontaneous, hypertensive, non-traumatic intraparenchymal cerebral haemorrhages is rare and constitutes less than 5.6% of all hypertensive cerebral haemorrhages. In addition to having a high early mortality, these haemorrhages carry a considerable morbidity figure in patients who survive the event. We report a 68-year-old hypertensive ...
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