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McCourt Rebecca R From the Division of Neurology (R.M., B.G., L.G., M.K., T.J., B.B., K.B.) and Department of Diagnostic Imaging (D.E.), University of Alberta, Edmonton, Canada; Division of Neurology, University of British Columbia, Vancouver, Canada (N.A.); Division of Neurology, University of Ottawa, Ottawa, Canada (D.D.); and Department of Clinical Neurosciences, University of Calgary, Calgary, Canada (S.B.C., M.D.H., - - 2014
The pathogenesis of perihematoma edema in intracerebral hemorrhage (ICH) is unknown but has been hypothesized to be ischemic. In the ICH Acutely Decreasing Arterial Pressure Trial (ICH ADAPT), perihematoma cerebral blood flow (CBF) was reduced but was unaffected by blood pressure (BP) reduction. Using ICH ADAPT data, we tested the ...
Isegawa Kengo K Department of Cardiovascular Medicine - - 2014
Abstract Abnormal elevation of blood pressure in early morning (rest-to-active phase) is suggested to cause cardiovascular events. We investigated whether azilsartan (AZL), a novel potent angiotensin receptor blocker, suppresses blood pressure elevation from the light-rest to dark-active phase in spontaneously hypertensive rats (SHRs). AZL has a sustained depressor effect around ...
Hammond Tara N TN Department of Emergency/Critical Care, Tufts Veterinary Emergency Treatment & Specialties, Walpole, - - 2014
Treatment for hemorrhagic shock secondary to a spontaneous hemoperitoneum includes restoration of IV volume and surgical control of hemorrhage. This study was designed to determine if limited fluid volume resuscitation (LFVR) with hypertonic saline (HS) and hyperoncotic fluids (hydroxyethylstarch [HES]) results in more rapid cardiovascular stabilization in dogs with spontaneous ...
Németh M M Department of Anaesthesiology and Intensive Therapy, University of Szeged, Szeged, - - 2014
Fluid resuscitation is still a major challenge. We aimed to describe changes in central venous oxygen saturation (ScvO2 ) and venous-to-arterial carbon dioxide gap (dCO2 ) during an experimental stroke volume (SV) index (SVI)-guided hemorrhage and fluid resuscitation model in pigs. Twelve anesthetized, mechanically ventilated pigs were bled till baseline ...
Mitrano M M Max Planck Institute for the Structure and Dynamics of Matter, Luruper Chaussee 149, 22761 Hamburg, - - 2014
We measure the ultrafast recombination of photoexcited quasiparticles (holon-doublon pairs) in the one dimensional Mott insulator ET-F2TCNQ as a function of external pressure, which is used to tune the electronic structure. At each pressure value, we first fit the static optical properties and extract the electronic bandwidth t and the ...
Kwan Irene I Evidence for Policy and Practice Information and Coordinating Centre (EPPI-Centre), Social Science Research Unit (SSRU), Institute of Education, University of London, 10 Woburn Square, London, UK, WC1H - - 2014
Treatment of haemorrhagic shock involves maintaining blood pressure and tissue perfusion until bleeding is controlled. Different resuscitation strategies have been used to maintain the blood pressure in trauma patients until bleeding is controlled. However, while maintaining blood pressure may prevent shock, it may worsen bleeding. To examine the effect on ...
Ebi Masahide M aDepartment of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan bVascular Biology Program, Boston Children's Hospital cDepartment of Surgery, Harvard Medical School and Boston Children's Hospital, Boston, - - 2014
Endoscopic submucosal dissection (ESD) is a useful technique for early gastric neoplasms without lymph node metastasis. However, a critical complication is unpredictable post-ESD bleeding. Some risk factors for post-ESD bleeding have been reported previously, although those risk factors have not directly contributed toward prevention of post-ESD bleeding. We retrospectively identified ...
Umanath Kausik K Division of Nephrology and Hypertension, Henry Ford Hospital, Detroit, MI; Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN; and Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, - - 2014
Hypertension is a common problem among patients with glomerular disease and CKD. Optimal blood pressure targets for these patients have been the source of much debate. Careful review of the available data supports a blood pressure target of less than 140/90 mmHg. Consideration for a lower goal of less than ...
Kragh John F JF - - 2014
Objective: The purpose of the present study is to determine the performance of tourniquet use by the placement of the tourniquet?s windlass on the extremity in four positions?medial, lateral, anterior, and posterior? to inform tourniquet instructors and develop best tourniquet practices. Methods: A HapMed™ Leg Tourniquet Trainer was used as ...
Gates Keith S - - 2014
Objective: Junctional bleeding from the groin is a leading cause of potentially preventable death on the battlefield. To address this problem, a novel device called the Junctional Emergency Treatment Tool (JETT™) was developed. The JETT was designed to stabilize pelvic ring fractures while controlling lower extremity bleeding sustained during high-energy ...
Zardi Enrico Maria EM Department of Clinical Medicine, 'Campus Bio-Medico' University , Rome , - - 2013
Portal hypertension is a severe syndrome that may derive from pre-sinusoidal, sinusoidal, and post-sinusoidal causes. As a consequence, several complications (i.e. ascites, oesophageal varices) may develop. In sinusoidal portal hypertension, hepatic venous pressure gradient (HVPG) is a reliable method for defining the grade of portal pressure, establishing the effectiveness of ...
Puglisi Janis P - - 2013
: This article reviews the 2011 guidelines for the evaluation, treatment, and prevention of vitamin D deficiency as well as the research literature evidencing an association between vitamin D, blood pressure and depression. Studies reveal an association between vitamin D levels and both systolic blood pressure and depression.
Darbemamieh Goldis - - 2013
Abstract Haemostatic powder is an effective solution commonly used in various open surgeries. However, there is no specific intra-abdominal delivery device for application of haemostatic powder at the bleeding site during minimally invasive surgery (MIS). In this study, design, construction and test of a novel powder delivery device were carried ...
Rapp John Paul - - 2013
A perspective on interpreting data on epistatis in the context of genetics of hypertension is presented.
Saeedi Morteza M Department of Emergency Medicine, Tehran University of Medical Sciences, Tehran, Iran. - - 2013
To evaluate the effects of various fluids on uncontrolled hemorrhagic shock (UHS). Controversy exists over the appropriate doses and types of fluids for best treating UHS. This study evaluated the effects of hypertonic saline (HTS), normal saline (NS), and no fluid resuscitation (NFR) on UHS. Thirty goats were anesthetized and ...
Bahk Byung Hoo BH Department of Anesthesiology and Pain Medicine, School of Medicine, Yeungnam University, Daegu, - - 2013
Intestinal obstruction was diagnosed in two fetuses at maternal antenatal care. Both received emergency surgery on the day of their birth, at about 35 weeks gestational age. The disease progressed for a long time in both cases because prompt diagnosis and surgery are difficult to perform in utero. As a ...
Harrois Anatole A 1Laboratoire de Microcirculation, Energétique, Inflammation, Insuffisance Circulatoire Aigue, Université Paris VII-XI-XIII, Paris, France. 2Service d'Anesthésie-Réanimation Chirurgicale, Hôpital de Bicêtre, Université Paris-Sud, Hôpitaux universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France. 3BakerIDI Heart and Diabetes Institute, Monash University, Melbourne, Australia. 4Service d'Anatomie pathologique, Groupe hospitalier Paris-Seine-Saint Denis, Hopital Jean Verdier, AP-HP, Bondy, France. 5France et Universite Paris 13, Sorbonne Paris Cite, UFR SMBH, Bobigny, - - 2013
To investigate the effect of hypoxemia, hemorrhagic shock, and the association of both of these on intestinal microcirculation (microcirculatory perfusion and leukocytes-endothelium interactions in postcapillary venules), as it can be encountered in hemorrhagic shock following trauma. Prospective controlled experimental study. University research laboratory. Forty-eight anesthetized and mechanically ventilated Balb/c mice. ...
Smith L A - - 2013
Hemospray is a haemostatic agent licensed for endoscopic haemostasis of non-variceal upper gastrointestinal bleeding (NVUGIB) in Europe and Canada. Hemospray has been shown to be safe and effective in achieving haemostasis in bleeding peptic ulcers in a prospective clinical study and several further case series have described the use of ...
Inamasu Joji - - 2013
Our assumption that blood pressure (BP) in supratentorial hypertensive intracerebral hemorrhage patients does not differ significantly according to the hemispheric laterality has never been verified before. This study was carried out to explore the possibility of hemispheric BP differences and whether this might influence the outcomes. A review of the ...
Poovazhagi Varadarajan - - 2013
The authors describe an 11-y-old child with intracranial bleed due to malignant hypertension. Child presented with hypertension, right hemiparesis, feeble femoral pulses and lower limb blood pressure less than the upper limb. CT angiogram revealed narrowing of the abdominal aorta with thinned out left renal artery and hypoplasia of the ...
Li Tao - - 2013
Our previous studies demonstrated that 50-60 mmHg of mean arterial blood pressure (MAP) was the ideal target hypotension for uncontrolled hemorrhagic shock during the active hemorrhage in sexually mature rats. The ideal target resuscitation pressure for immature and elderly rats has not been determined. To elucidate this issue, using uncontrolled ...
Peterson Katherine L - - 2013
To compare the shock index (SI) in a population of healthy dogs to a population of dogs with confirmed hemorrhagic shock. Retrospective analysis of data collected prospectively from 2 previous studies. University teaching hospital. Seventy-eight healthy control dogs enrolled in a study to establish a reference interval for a tissue ...
Kato Yuko - - 2013
We identified 2,8-diazaspiro[4.5]decane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase (sEH) inhibitors and orally active agents for treating hypertension. Docking studies using human and murine sEH X-ray crystal structures revealed steric hindrance around the side chain of Phe406 of murine sEH. The trifluoromethyl moiety (11) was replaced with ...
Metzger Anja - - 2013
One approach to improve outcomes after trauma and hemorrhage is to follow the principles of permissive hypotension by avoiding intravascular overpressure and thereby preventing dislodgement of platelet plugs early in the clotting process. We hypothesized that augmentation of negative intrathoracic pressure (nITP) by treatment with an impedance threshold device would ...
Lieberman Jeremy A - - 2013
BACKGROUND:: Transcranial motor-evoked potentials (TcMEPs) monitor spinal cord motor tract integrity. Using a swine model, the authors studied the effects of vasodilatory hypotension, hemorrhage, and various resuscitation efforts on TcMEP responses. METHODS:: Twelve pigs were anesthetized with constant infusions of propofol, ketamine, and fentanyl. Animals were incrementally hemorrhaged, until bilateral ...
Saito Yuka - - 2013
In this study, hemoglobin vesicle (HbV), a type of artificial oxygen carrier, was infused in a hemorrhagic shock model, and the findings were compared with those of red blood cell (RBC) transfusion to evaluate the effects on blood pressure and renal function. In rats maintained in hemorrhagic shock for 30 min ...
Burnett Luke R - - 2013
Traumatic injury is the leading cause of death in people aged 44 or less in the US. It is also estimated that 82% of deaths from battlefield hemorrhage may be survivable with better treatment options. In this study, two biomaterial hemostats having disparate mechanisms were evaluated in a large animal ...
Ghosh Suborno M SM William Harvey Research Institute, Barts and The London Medical School, Queen Mary University of London, London, United - - 2013
Elevation of circulating nitrite (NO2(-)) levels causes vasodilatation and lowers blood pressure in healthy volunteers. Whether these effects and the underpinning mechanisms persist in hypertension is unknown. Therefore, we investigated the consequences of systemic nitrite elevation in spontaneously hypertensive rats and conducted proof-of-principle studies in patients. Nitrite caused dose-dependent blood ...
Kikidis D - - 2013
Both epistaxis and hypertension are frequent problems in the adult population. The relationship between the level of arterial pressure and incidence of epistaxis in a patient with hypertension is a question that appears frequently in the clinical practice. A systematic review of the literature regarding the relation of arterial hypertension ...
Kasotakis George - - 2013
BACKGROUND: We previously demonstrated that abdominal gas insufflation (AGI) reduces intra-abdominal bleeding. To date, this is the only method that holds promise for reducing mortality from internal bleeding in a pre-hospital setting. We aimed to assess the optimal AGI pressure and the effectiveness of a portable miniaturized insufflator in abdominal ...
Bauman David R - - 2013
In an effort to understand the origin of blood-pressure lowering effects observed in recent clinical trials with 11β-HSD1 inhibitors, we examined a set of 11β-HSD1 inhibitors in a series of relevant in vitro and in vivo assays. Select 11β-HSD1 inhibitors reduced blood pressure in our preclinical models but most or ...
Ranieri Maria M - - 2013
Understanding the kinetics of olefin polymerization with Ziegler-Natta and related catalysts means identifying the main kinetic parameters such as kp and concentration of active sites. The high-pressure quenched-flow technique could be an absolute method for counting active sites and for activation studies of molecular catalysts. A kinetic study of metallocene ...
Gröger Michael - - 2013
OBJECTIVES:: Accidental hypothermia increases mortality and morbidity after hemorrhage, but controversial data are available on the effects of therapeutic hypothermia. Therefore, we tested the hypothesis whether moderate pretreatment hypothermia would beneficially influence organ dysfunction during long-term, porcine hemorrhage and resuscitation. DESIGN:: Prospective, controlled, randomized study. SETTING:: University animal research laboratory. ...
Chugh Preeta Kaur - - 2013
While it is known that non-steroidal anti-inflammatory drugs including selective cyclooxygenase-2 (COX-2) inhibitors influence BP, the exact relationship and underlying mechanisms are still unclear. We investigated the effect of etoricoxib, a selective COX-2 inhibitor on the antihypertensive efficacy of atenolol; beta-blocker, ramipril; angiotensin converting enzyme inhibitor and telmisartan; angiotensin receptor ...
Lin Geng-Shiau - - 2013
BACKGROUND: Good outcomes have resulted from hypotensive resuscitation of hemorrhagic shock patients. We hypothesized that mean arterial pressure (MAP) 60mmHg is the target blood pressure for hypotensive resuscitation during uncontrolled hemorrhagic shock in trauma. METHODS: To determine the effective target MAP for hypotensive resuscitation during uncontrolled hemorrhagic shock, we randomly ...
Martini Wenjun Z - - 2013
This study compared coagulation function after resuscitation with Hextend and lactated Ringer's (LR) solution in pigs with tissue injury and hemorrhagic shock. Pigs were randomized into control (n = 7 each), LR, and Hextend groups. Femur fracture was induced using the captive bolt stunner at midshaft of the pigs' left ...
Tamez Hector H Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, - - 2013
Both vitamin D deficiency and hypertension are highly prevalent. It is unclear whether vitamin D modulates blood pressure and therefore whether vitamin D testing and therapy should become part of routine hypertension prevention and management. This article provides an overview of the data, with special emphasis on the work published ...
Lyden Patrick D - - 2013
BACKGROUND: Despite the increasing use of thrombolytic therapy for acute ischemic stroke, hemorrhagic transformation remains a significant complication. Transformation appears to occur more frequently with age, diabetes, and hypertension, but clinical data are mixed. In addition to risk factors, matrix metalloproteinase expression mediates hemorrhage. We sought to test the effects ...
Herath Chandana B - - 2013
Portal hypertension is responsible for the bulk of the morbidity and mortality in patients with cirrhosis. Drug therapy to reduce portal pressure involves targeting two vascular beds. The first approach is to reduce intra hepatic vascular tone induced by the activity of powerful vasocontrictors such as angiotensin II, endothelin-1 and ...
Xu Jiefeng - - 2013
ABSTRACT: To avoid aggressive fluid resuscitation during hemorrhagic shock, fluid resuscitation is best guided by a specific measurement of tissue perfusion. We investigated whether fluid resuscitation guided by sublingual PCO2 would reduce the amount of resuscitation fluid without compromising the outcomes of hemorrhagic shock.Ten male domestic pigs weighing between 34-37 ...
Astorne Figari Walter J - - 2013
Citalopram is one of the selective serotonin re-uptake inhibitors (SSRIs) most commonly prescribed for depression and many affective disorders. Abrupt cessation of this medication has been associated with dizziness, nausea, myalgias, anxiety and irritability. It is unclear whether blood pressure can be perturbed under such a circumstance. We present a ...
Anderson Craig - - 2013
The Statistical analysis plan (SAP) for the second INTEnsive blood pressure Reduction in Acute Cerebral hemorrhage Trial (INTERACT2).
Amin Osama S M - - 2013
The simultaneous development of two (or more) spontaneous, hypertensive, non-traumatic intraparenchymal cerebral haemorrhages is rare and constitutes less than 5.6% of all hypertensive cerebral haemorrhages. In addition to having a high early mortality, these haemorrhages carry a considerable morbidity figure in patients who survive the event. We report a 68-year-old hypertensive ...
Franceschi Ruben C - - 2013
The anesthetic gas xenon is reported to preserve hemodynamic stability during general anesthesia. However, the effects of the gas during shock are unclear. The objective of this study was to evaluate the effect of Xe on hemodynamic stability and tissue perfusion in a canine model of hemorrhagic shock. Twenty-six dogs, ...
Cevik Cemal - - 2013
Blood pressure control is an important component of cardiovascular disease prevention. Despite the advances in the treatment of hypertension; effective management remains poor. The combined use of multiple drug strategies fail to regulate blood pressure and chronic use of those agents cause severe side-effects. New strategies are required to control ...
Wilson David F - - 2013
Phosphorescence quenching and visible lightguide spectrophotometry were used to measure brain cortex oxygen partial pressure and skin oxygen saturation, respectively, during stepwise haemorrhage and re-transfusion in four 4-7-day-old anaesthetised piglets. In three cases, the effect of administration of adrenalin (epinephrine) was investigated. Brain cortex partial pressure was measured using a ...
Zhang Yu-Ming - - 2013
The aim of this study was to compare the effects of hypotensive and normotensive resuscitation with a novel combination of fluids via lactate Ringer's solution (LRS), 6% hydroxyethyl starch 130/0.4 solution (HES), and 7.5% hypertonic saline solution (HSS) at early stage of uncontrolled hemorrhagic shock (UHS) before hemostasis. New Zealand ...
Thongrong Cattleya - - 2013
Hemostasis is critical for adequate anatomical visualization during endoscopic endonasal skull base surgery. Reduction of intraoperative bleeding should be considered during the treatment planning and continued throughout the perioperative period. Preoperative preparations include the optimization of comorbidities and cessation of drugs that may inhibit coagulation. Intraoperative considerations comprise anesthetic and ...
Yasaka Masahiro - - 2013
To prevent major hemorrhage during anticoagulation, it is quite important to manage controllable risk factors such as hypertension, diabetes mellitus, smoking habit, and too much alcohol intake. It is also important to avoid dual antithrombotic therapy as long as possible, which increases severe bleeding events. For patients with major bleeding ...
Huang Qi-Fang QF Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of - - 2013
We reviewed the Chinese and English literature for the efficacy and safety data of valsartan monotherapy or combination therapy in Chinese hypertensive patients. According to the data of ten randomized controlled trials, valsartan monotherapy was as efficacious as another angiotensin receptor blocker or other classes of antihypertensive drugs, excepting the ...
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