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Results 401 - 450 of 2229
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Blankstein Michael - - 2010
BACKGROUND: The objective of this study was to assess the role of pulmonary fat embolism caused by intramedullary pressurization of the femoral canal in the development of acute lung injury in the setting of acute hemorrhagic shock and resuscitation. METHODS: Thirty New Zealand White rabbits were randomly assigned to one ...
Orozco-Gutiérrez Juan José - - 2010
Background: The effect of L-arginine and L-citrulline on blood pressure and right ventricular function in heart failure patients with preserved ejection fraction (HFpEF) is unknown. We have therefore evaluated, in a randomized clinical trial, the effect of these aminoacids in chronic outstanding and stable patients with HFpEF. Methods and results: ...
Adeoye Opeolu - - 2010
Intracerebral hemorrhage remains a challenging worldwide clinical problem with no proven treatments. In the acute phase of the illness, there has been some controversy regarding the appropriate management of elevated blood pressure. Recently published and ongoing clinical trials are beginning to shed some light on appropriate blood pressure management in ...
Jones Alan E - - 2010
ABSTRACT: Arterial pressure optimization in septic shock is a critical, yet poorly understood component of resuscitation. New data suggest that, during the routine management of patients with severe sepsis, there is no association between mean arterial pressure achieved and outcome as long as the mean arterial pressure is maintained at ...
Nightingale Pamela - - 2010
This article uses national and local records of debt and evidence from coins, prices, and wages to discuss the economic effects of the gold coinage that was introduced into England in 1344. It distinguishes between the deflationary effects of gold and those of the falling population on prices and credit, ...
Li Jian-Jun - - 2010
Several previous trials from Western population studies have showed that statins may help reduce blood pressure (BP). However, randomized clinical data is limited. Xuezhikang, a partially extract of red yeast rice, contains a family of naturally occurring statins, and has a marked impact on lipids, but it is unknown whether ...
Kishi Takuya - - 2010
The phosphodiesterase III inhibitor milrinone (MIL) is considered to be effective for "wet and cold" heart failure. In some cases, however, the inotropic effects of milrinone are insufficient. A previous study suggested that baroreflex sensitivity (BRS) predicts the cases in which MIL increases left ventricular dp/dt. The aim of this ...
Myburgh John - - 2010
Septic shock causes unpredictable cardiovascular responses through adrenoreceptor-mediated changes in cardiac function and vascular responsiveness. The use of norepinephrine should be regarded as neurohormonal augmentation therapy to defend decompensating haemodynamic function rather than as a rescue therapy to treat shock. Recent trials represent a perceptible change in clinical practice to ...
Whitaker Annie M - - 2010
Trauma/hemorrhage (TxHem) is associated with an immediate pro-inflammatory response that, if exaggerated or prolonged, is thought to contribute to the subsequent immunosuppression that characterizes the period after injury. Previously we have demonstrated that chemical sympathectomy (SNSx) accentuates this immediate pro-inflammatory response to TxHem. These findings suggest that the noradrenergic system ...
Tano Takatoshi - - 2010
To investigate the impact of cataract surgery and blood pressure changes induced by one week of sodium restriction on retinal vascular diameter. Fundus photographs of 200 patients were obtained before and one week after cataract surgery. For one week after admission, 100 patients received sodium restriction and 100 patients (ie, ...
Jamshidi Nima - - 2010
This pilot study aimed to assess the differences in center of pressure trajectory in neuropathic patients with steppage gait. Steppage gait has previously been evaluated by several biomechanical methods, but plantar pressure distribution has been much less studied. The purpose of this study was to analyze the changes in center ...
Jain Gaurav - - 2010
THIS STUDY AIMS TO COMPARE TWO VASOCONSTRICTORS: - norepinephrine and phenylephrine - in the management of dopamine-resistant septic shock. We performed a randomized, prospective, controlled trial in 54 septic shock patients, with persistent hypotension despite adequate volume resuscitation and continued dopamine infusion ~25mug/kg/h. Patients were randomly allocated into two groups ...
Sallum Elias Aissar - - 2010
This study evaluated retroperitoneal hematomas produced by bilateral injury of iliac arteries (uncontrolled hemorrhage), blood volume loss, transcapillary refill, the effects of volume replacement on retroperitoneal bleeding and the hemodynamic changes with and without treatment. Initial blood volume was determined with Tc(99m)-labelled red cells, and bleeding was evaluated by means ...
Sfreddo Carla - - 2010
Working mostly at night has been suggested to be associated with upset of chronobiological rhythms and high blood pressure, but the evidence from epidemiological studies is weak. In a cross-sectional survey, we evaluated the association between shift work and blood pressure, pre-hypertension and hypertension. In total, 493 nurses, nurse technicians ...
Liao Qiuming - - 2010
Optimal manual closed chest compressions are difficult to give. A mechanical compression/decompression device, named LUCAS, is programmed to give compression according to the latest international guidelines (2005) for cardiopulmonary resuscitation (CPR). The aim of the present study was to compare manual CPR with LUCAS-CPR. 30 kg pigs were anesthetized and ...
Morgado Manuel P - - 2010
Interventions to improve blood pressure control in hypertension have had limited success in clinical practice despite evidence of cardiovascular disease prevention in randomised controlled trials.The objectives of this study were to evaluate blood pressure control and antihypertensive pharmacotherapy patterns in a population of Eastern Central Region of Portugal, attending a ...
Khosravi Alireza - - 2010
We aimed to evaluate the changes over time in the prevalence, awareness, treatment, and control rate of hypertension in intervention and reference areas of a comprehensive community trial with reference area. Data from independent sample surveys before and after implementation of the program (2001 vs.2007) were used to compare differences ...
Walcott Gregory P GP Department of Medicine-Division of Cardiovascular Diseases, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA. - - 2010
Since the initial development of the defibrillator, there has been concern that, while delivery of a large electric shock would stop fibrillation, it would also cause damage to the heart. This concern has been raised again with the development of the biphasic defibrillator. To compare defibrillation efficacy, postshock cardiac function, ...
Albaghdadi Ali S - - 2010
Pulseless electrical activity is an important cause of cardiac arrest. Our purpose was to determine if induction of hypothermia with a cold perfluorocarbon-based total liquid ventilation (TLV) system would improve resuscitation success in a swine model of asphyxial cardiac arrest/PEA. Twenty swine were randomly assigned to control (C, no ventilation, ...
Yu Tao - - 2010
AIM OF STUDY: We investigated the safety, feasibility and efficacy of a resuscitation blanket designed with the intent to protecting the rescuer from the risk of receiving electrical current during defibrillation which, would allow for uninterrupted chest compressions. METHODS: Fifteen pigs weighing between 22 and 40 kg were investigated with ...
Ohashi Hitoshi - - 2009
The present experiments were carried out to investigate the usefulness of measuring peripheral tissue metabolism for the clinical assessment of shock. Male Wistar/ST rats (8 weeks-old) were used. All rats were placed in a supine position while anesthetized. A tube for measuring arterial pressure and collecting blood samples was cannulated ...
de Oliveira Marcos Antonio - - 2009
BACKGROUND: Different hemodynamic parameters including static indicators of cardiac preload as right ventricular end-diastolic volume index (RVEDVI) and dynamic parameters as pulse pressure variation (PPV) have been used in the decision-making process regarding volume expansion in critically ill patients. The objective of this study was to compare fluid resuscitation guided ...
Lee Chih-Hsin - - 2009
INTRODUCTION:: To investigate whether the pulse pressure power spectrum (PPPS) could predict the effect of volume expansion (VE) in shock patients under mechanical ventilation without sedation. METHODS:: The PPPS within a frequency band of 0.15-0.75 Hz was developed with an animal model using nine domesticated piglets simulating acute hemorrhagic shock ...
Liu Zhaoxia - - 2011
Background: Restoration of spontaneous circulation after cardiopulmonary resuscitation in cardiac arrest patients does not always signal a completely successful outcome. Functional deficiencies of the nervous system are found in many survivors of cardiac arrest. Objectives: To study the effects of dopamine-induced elevated blood pressure on the hemodynamics, oxygen metabolism, and ...
Knudson M D - - 2009
Evaluation of models and theory of high-pressure material response is largely made through comparison with shock wave data, which rely on impedance match standards. The recent use of quartz as a shock wave standard has prompted a need for improved data. We report here on measurements of the quartz Hugoniot ...
McKinley Bruce A - - 2009
Previously, we developed a protocol for shock resuscitation of severe trauma patients to reverse shock and regain hemodynamic stability during the first 24 intensive care unit (ICU) hours. Key hemodynamic measurements of cardiac output and preload were obtained using a pulmonary artery catheter (PAC). As an alternative, we developed a ...
Tobin Joshua M - - 2009
We report the quantification of a hemodynamic profile sufficient to support consciousness during cardiopulmonary resuscitation. A 62-yr-old man experienced cardiac arrest while being evaluated for heart failure after heart transplantation. During the emergency, hemodynamic data were obtained from bedside monitors and reviewed at regular intervals. His mean arterial blood pressure ...
Nagasao Tomohisa - - 2011
Objective: This biomechanical study aims to elucidate differences in how skulls with trigonocephaly, normal skulls, and postoperative trigonocephalic skulls respond to intracranial pressure and how this affects the orbital distances. Materials and Methods: For 10 patients with trigonocephaly (8.2 ± 4.5 months), simulation models were produced based on the computed tomographic ...
Mader Timothy J - - 2009
OBJECTIVE: We sought to determine the effect of the preshock pause (PSP) on coronary perfusion pressure (CPP) decay and subsequent rescue shock (RS) outcome in porcine ventricular fibrillation (VF). METHODS: Retrospective analysis of digitally recorded CPP tracings was performed. Ventricular fibrillation was electrically induced in all animals and resuscitation was ...
Shah Shinil K - - 2011
High volume resuscitation and damage control surgical methods, while responsible for significantly decreasing morbidity and mortality from traumatic injuries, are associated with pathophysiologic derangements that lead to subsequent end organ edema and dysfunction. Alterations in hydrostatic and oncotic pressures frequently result in intestinal edema and subsequent dysfunction. The purpose of ...
Sheng Chao - - 2011
Obstetric hemorrhage remains a leading cause of maternal death internationally. Polydatin is an effective drug in ameliorating microcirculatory insufficiency and increasing survival rate in non-pregnant animal model of controlled hemorrhagic shock. In the present study, we investigated the effects of hypotensive resuscitation combined with Polydatin administration on microcirculation and survival ...
Torres Filho Ivo P IP Department of Physiology and Biophysic, Virginia Commonwealth University Reanimation Engineering Shock Center (VCURES), Virginia Commonwealth University Health System, Richmond, VA 23298-0551, USA. - - 2010
The identification of early indicators of hemorrhagic hypotension (HH) severity may support early therapeutic approaches and bring insights into possible mechanistic implications. However, few systematic investigations of physiologic variables during early stages of hemorrhage are available. We hypothesized that, in certain subjects, early physiologic responses to blood loss are associated ...
Tamura Akira - - 2010
The administration of dopamine may cause further hemodynamic deterioration in Takotsubo cardiomyopathy patients with cardiogenic shock who exhibit a high intraventricular pressure gradient. Optimal treatment for such patients remains to be elucidated.
Babbs Charles F - - 2009
OBJECTIVE: To explore in detail the expected magnitude of systemic perfusion pressure during standard CPR as a function of compression frequency for different sized people from neonate to adult. METHOD: A 7-compartment mathematical model of the human cardiopulmonary system - upgraded to include inertance of blood columns in the aorta ...
Rodriguez Cilina C Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, - - 2009
Hypertension secondary to scavenging of NO remains a limitation in the use of HBOCs (haemoglobin-based oxygen carriers). Recent studies suggest that nitrite reduction to NO by deoxyhaemoglobin supports NO signalling. In the present study we tested whether nitrite would attenuate HBOC-mediated hypertension using HBOC-201 (Biopure), a bovine cross-linked, low-oxygen-affinity haemoglobin. ...
Inal Mehmet Turan - - 2010
BACKGROUND: Hypovolemia is a common clinical entity in critical patients, and adequate volume replacement therapy seems to be essential for maintaining tissue perfusion. However, it is still uncertain which solution is most appropriate for fluid resuscitation. OBJECTIVE: The aim of this study was to investigate the effects of fluid resuscitation ...
Rokyta R R - - 2010
A higher mean arterial pressure (MAP) achieved by norepinephrine up-titration may improve organ blood flow in critically ill, whereas norepinephrine-induced afterload rise might worsen myocardial function. Our aim was to assess the effects of norepinephrine dose titration on global hemodynamics in cardiogenic shock. We prospectively evaluated 12 mechanically ventilated euvolemic ...
Tschauner Oliver - - 2009
We observed micrometer-sized grains of wadsleyite, a high-pressure phase of (Mg,Fe)(2)SiO(4,) in the recovery products of a shock experiment. We infer these grains crystallized from shock-generated melt over a time interval of <1 micros, the maximum time over which our experiment reached and sustained pressure sufficient to stabilize this phase. ...
Hauser Balázs - - 2009
OBJECTIVE: To test the hypothesis whether pure oxygen ventilation is equally safe and beneficial in fully developed fecal peritonitis-induced septic shock as hyperoxia initiated at the induction of sepsis. DESIGN: Prospective, randomized, controlled, experimental study with repeated measures. SETTING: Animal research laboratory at a university medical school. SUBJECTS: Twenty anesthetized, ...
Wang Yuan-Long - - 2009
OBJECTIVE: Previous laboratory and clinical studies have demonstrated that chest compression preceding defibrillation in prolonged ventricular fibrillation (VF) increases the likelihood of successful cardiac resuscitation. The lower limit of VF duration when preshock chest compression provides no benefit has not been specifically studied. We aimed to study the effect of ...
Aboy Mateo - - 2009
We describe an improved automatic algorithm to estimate the pulse-pressure-variation (PPV) index from arterial blood pressure (ABP) signals. This enhanced algorithm enables for PPV estimation during periods of abrupt hemodynamic changes. Numerous studies have shown PPV to be one of most specific and sensitive predictors of fluid responsiveness in mechanically ...
Cai Bolin B Laboratory of Anti-Inflammatory Signaling and Surgical Immunology, Center of Immunity and Infection, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103, - - 2009
Hemorrhage is a common cause of death despite the recent advances in resuscitation and critical care. Conventional resuscitation fluids are designed to reestablish tissue perfusion, but they fail to prevent systemic inflammation. Indeed, resuscitation can promote inflammatory responses, which can be more dangerous than the original hemorrhage. This consideration is ...
Azzopardi Ernest A - - 2009
BACKGROUND: Secondary abdominal compartment syndrome (sACS) in adults with severe burns is commonly unsuspected, can be rapidly fatal and seriously compromises the reliability of urine output as an indicator of perfusion and resuscitation status. Current literature lacks an exhaustive, evidence-based review critically appraising all retrieved literature on which clinical decisions ...
Cooper Edward S - - 2009
BACKGROUND: Enhancing plasma viscosity during fluid resuscitation results in vasodilation and improved microvascular perfusion in rodents subjected to hemorrhagic shock. We hypothesized that resuscitation with hyperviscous lactated Ringer's solution (hyperLRS) would result in improved tissue oxygenation and acid-base values in hemorrhaged dogs. METHODS: Twelve dogs were anesthetized and splenectomized. Vascular ...
Sambasivan Chitra N - - 2009
BACKGROUND: This study compared the efficacy of 3 hemostatic dressings in a severe groin injury model in swine. METHODS: Twenty-three swine received TraumaStat (OreMedix, Lebanon, OR), Chitoflex (HemCon, Inc., Portland, OR), or standard gauze for hemostasis. Complete femoral vessel transections were followed by 30 seconds of uncontrolled hemorrhage. The groin ...
Hefzy H M - - 2009
BACKGROUND AND PURPOSE: Hemorrhage is known to occur in posterior reversible encephalopathy syndrome (PRES), but the characteristics have not been analyzed in detail. The purpose of this study was to evaluate the imaging and clinical features of hemorrhage in PRES. MATERIALS AND METHODS: Retrospective assessment of 151 patients with PRES ...
Renner Jochen - - 2009
The effect of vasopressors on pulse pressure variation (PPV), stroke volume variation (SVV) and on the volumetric variable global end-diastolic volume (GEDV) during changing loading conditions is currently under debate. The aim of our study was to investigate the effect of norepinephrine (NE) on PPV, SVV and GEDV in a ...
McKinley Bruce A - - 2009
Previously, we developed a protocol for shock resuscitation of severe trauma patients to reverse shock and regain hemodynamic stability during the first 24 ICU hours. Key hemodynamic measurements of cardiac output and preload were obtained using a pulmonary artery catheter (PAC). As an alternative, we developed a protocol that used ...
Cabrales Pedro P La Jolla Bioengineering Institute, 505 Coast Boulevard South Suite #405, La Jolla, CA 92037, United States. - - 2009
This study analyzed the systemic and microvascular hemodynamic changes related to increased nitric oxide (NO) availability during the early phase of hemorrhagic shock. Hemodynamic responses to hemorrhagic shock were studied in the hamster window chamber. Exogenous NO was administered in the form of nitrosothiols (nitrosylated glutathione, GSNO) and was given ...
Ammi Azzdine Y - - 2009
Ultrasound acts synergistically with thrombolytic agents, such as recombinant tissue plasminogen activator (rt-PA), to accelerate thrombolysis. The aim of the study was to demonstrate the efficacy of 120-kHz ultrasound-enhanced rt-PA thrombolysis in a porcine hemorrhagic stroke model in vivo. Clots were formed by infusing 3 ml of autologous blood into ...
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