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Tierney M M Penn State Milton S. Hershey Medical Center, Hershey, - - 2014
This is a 63-year-old female hiker with normal corrected vision followed status post emergent surgery secondary to bilateral acute angle closure glaucoma (AACG). She was started on acetazolamide by a travel clinic for acute mountain sickness prophylaxis (AMS) prior to hiking Machu Picchu in Peru. Six days later, she rapidly ...
Martín-Suárez Eva E Animal Medicine and Surgery, Córdoba University, Campus Universtario de Rabanales Crt Madrid-Cádiz km 396 Córdoba, Córdoba 14014, Spain (Martín-Suárez, Molleda C, Galán, Molleda J); Clincal Sciences, Concepción University, Concepción, Chile (Tardón); Ophthalmology Service, Reina Sofía Hospital, Córdoba, Spain - - 2014
Diurnal variations in central corneal thickness (CCT) and intraocular pressure (IOP) and their relationships were studied in healthy dogs. Central corneal thickness was measured by ultrasonic pachymetry and IOP by applanation tonometry in 16 beagle dogs. Measurements were taken every 90 min over 12 h (08:00 am to 08:00 pm). ...
Zode Gulab S - - 2014
Administration of glucocorticoids induces ocular hypertension in some patients. If untreated, these patients can develop a secondary glaucoma that resembles primary open-angle glaucoma (POAG). The underlying pathology of glucocorticoid-induced glaucoma is not fully understood, due in part to lack of an appropriate animal model. Here, we developed a murine model ...
Park B-J BJ Department of Family Medicine, CHA University School of Medicine, Seoul, Republic of - - 2014
AimLeukoaraiosis and high intraocular pressure are strongly associated with cardiovascular disease, vascular angiopathy, and geriatric syndrome. Until now, little is known about the relationship between intraocular pressure and leukoaraiosis in its preclinical stage. The aim of this study was to evaluate the association between intraocular pressure and leukoaraiosis among middle-aged ...
de Oliveira Ana Paula Chaves AP Department of Ophthalmology, Irmandade da Santa Casa de Misericordia de Sao Paulo Central Hospital, Santa Casa de Sao Paulo School of Medical Sciences, Rua Sao Mauro, 292, São Paulo, SP, 02526-050, - - 2014
The aim of the study is to assess the correlation between ocular perfusion pressure (OPP) fluctuation and the severity of glaucoma. Forty-three patients with primary open-angle glaucoma (POAG) were enrolled in the study. All subjects had intraocular pressure (IOP) and blood pressure measured at three time points (7:00 a.m., 1:00 p.m. and ...
Ozkok Ahmet A Ophthalmology Department, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey, - - 2014
The objective of this study was to evaluate and compare the IOP values in the sitting and supine positions in primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG) patients. We also investigated possible relationships between the level of visual field damage and postural IOP change. Twenty-nine patients with POAG and ...
Borrego-Sanz L L Department of Ophthalmology, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Madrid, - - 2014
Purpose: To compare central corneal thickness (CCT) values obtained by Lenstar (LE), Pentacam (PC), specular microscopy (SM) and ultrasound pachymetry (UP) in healthy corneas and study their influence on intraocular pressure (IOP) readings determined by Goldmann applanation tonometry (GAT). Methods: CCT was measured in 76 healthy subjects by LE, PC, ...
Leidl Matthew C MC Nassau University Medical Center, East Meadow, New York, - - 2014
While mean intraocular pressure (IOP) has long been known to correlate with glaucomatous damage, the role of IOP fluctuation is less clearly defined. There is extensive evidence in the literature for and against the value of short-term and long-term IOP fluctuation in the evaluation and prognosis of patients with glaucoma. ...
Asejczyk-Widlicka Magdalena - - 2014
To evaluate the clinical utility of spectral analysis of intraocular pressure pulse wave in healthy eyes of a control group (CG), patients having glaucomatous optic disc appearance or ocular hypertension, and patients with primary open angle glaucoma or primary angle closure glaucoma. This is a prospective study that enrolled 296 ...
Li Guorong G Department of of Ophthalmology, Duke University, Durham, NC, 27710, United - - 2014
Purpose:The goal was to assess effects of intraocular pressure (IOP) and pilocarpine-induced ciliary muscle contraction on conventional outflow pathway tissues in living anesthetized mice. Methods:IOP was controlled by intracameral cannulation of mouse eyes while imaging using spectral domain optical coherence tomography (SD-OCT). Time-lapse sagittal SD-OCT sections through Schlemm's canal (SC) ...
Kitamura Kazuyoshi K Departments of *Ophthalmology †Health Sciences, Faculty of Medicine, University of Yamanashi, Chuo ‡Yamanashi Koseiren Health Care Center, Kofu, - - 2014
To investigate the changes in intraocular pressure (IOP) and associated factors over 10 years in subjects who participated in health examinations in 1999 and 2008. Subjects with no clear history of ocular disease and who participated in health examinations at Yamanashi Koseiren Health Care Center, Japan, in 1999 and 2008 ...
La Mancusa Antonia A Ophthalmology, Friedrich-Alexander University Erlangen-Nuremberg, Schwabachanlage 6, Erlangen, 91054, - - 2014
To examine the influence of the cold pressor test (CPT) on steady-state-pattern electroretinograms (PERG) in normal subjects and glaucoma patients. Steady state PERGs to 7.8 Hz pattern reversal stimuli were recorded in 63 subjects. Fifteen healthy control subjects, 14 patients with ocular hypertension (OHT) and 34 patients with open-angle glaucoma ...
Wadia Shernaz S Division of Pediatric Emergency Medicine, Louisville, KY. Electronic address: - - 2014
We determine the increase in intraocular pressure during pediatric procedural sedation with ketamine, and the proportion of children whose increase might be clinically important (at least 5 mm Hg). We prospectively enrolled children aged 8 to 18 years, chosen to receive ketamine sedation in a pediatric emergency department. We measured ...
Nishida S S Department of Mechanical Engineering, Osaka University, 2-1 Yamadaoka, Suita 565-0871, - - 2014
Molecular dynamics simulations of a nanoscale liquid droplet on a solid surface are carried out in order to examine the pressure tensor field around the multiphase interfaces, and to explore the validity of Young's equation. By applying the virial theorem to a hemicylindrical droplet consisting of argon molecules on a ...
Villamarin Adan A Laboratory of Hemodynamics and Cardiovascular Technology, LHTC, Swiss Federal Institute of Technology, Lausanne, EPFL, EPFL STI IBI LHTC, Building BM 5126 Station 17, Lausanne, Vaud, 1015, - - 2014
Purpose: This work is focused on the testing of a new experimental noninvasively adjustable glaucoma drainage device (AGDD) that allows for the control of its outflow resistance to modulate intraocular pressure (IOP) in a customized fashion. Methods: Six AGDDs were directly connected to a pressure transducer and a perfusion system ...
Zhang Hong H Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, 32 Gisborne Street, East Melbourne VIC 3002, Australia; Eye Hospital, Harbin Medical University, No.157 Baojian Road, Nangang District, Harbin, Heilongjiang Province, China 150001. Electronic address: - - 2014
Rabbits play a growing role in research into glaucoma surgical models and ocular drug delivery models. However, the lack of an accurate method for measuring intraocular pressure (IOP) in this animal has been a significant deficit. In this study we validated the use of the TonoVet rebound tonometer and provide ...
Hays Cassandra L CL Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE, 68198-5840, United - - 2014
Purpose: To determine outflow facility (C) in human anterior segments implanted with a novel Schlemm's canal scaffold (Hydrus™ Microstent, Ivantis, Inc.) or two trabecular micro-bypasses (iStent®, Glaukos, Inc.). Methods: Human anterior segments were isolated from 12 pairs of eyes from donors with no history of ocular disease and then perfused ...
Zhou Aimei A Department of Food Science, College of Food Science, South China Agricultural University, Guangzhou, Guangdong 510642, China. Electronic address: - - 2014
Changes of physicochemical properties in natural actomyosin (NAM) from threadfin bream (Nemipterus spp.) induced by high hydrostatic pressure (200, 400, 600MPa for 10, 30, 50min) were studied. The increase in turbidity of NAM was coincidental with the decrease in protein solubility with increasing pressure and time, suggesting the formation of ...
Dzido Tadeusz H TH Department of Physical Chemistry, Chair of Chemistry, Medical University, Lublin, Poland. Electronic address: - - 2014
We report combination of overpressured layer chromatography (OPLC) and pressurized planar electrochromatography (PPEC) techniques into a single technique in which both OPLC and PPEC processes proceed simultaneously and orthogonally. The separation process with this new technique is performed in adsorbent layer of a chromatographic plate, which is equipped with special ...
Isobe Tomoyuki T Tokyo New Drug Research Laboratories, Kowa Co., Ltd. , Tokyo , - - 2014
Abstract Purpose: To evaluate the topical instillation of K-115, a selective Rho-associated coiled coil-containing protein kinase (ROCK) inhibitor, on intraocular pressure (IOP), ocular distribution, and aqueous humor dynamics in experimental animals. Methods: Kinase inhibition by K-115 was measured by biochemical assay. IOP was monitored using a pneumatonometer in albino rabbits ...
Yoo Young-Chul YC Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, - - 2014
Intraocular pressure is increased during laparoscopic surgeries performed in a steep Trendelenburg position. This study compared the effects of propofol with those of sevoflurane on intraocular pressure in patients undergoing robot-assisted laparoscopic radical prostatectomy in a 30° Trendelenburg position. Sixty-six patients were randomly allocated to a maintenance anesthetic consisting of ...
Yoshida Masao M Department of Public Health, Kyorin University School of Medicine, Mitaka, Tokyo 181-8611, - - 2014
To clarify whether high blood pressure (BP) and high body mass index (BMI) are associated with elevated intraocular pressure (IOP), a cross-sectional and longitudinal study was conducted. This epidemiological study analyzed health examination data obtained between 2001 and 2005 from 896 Japanese individuals (aged 32-79 years) who had not undergone ...
Wang Yanbin Y Center for Advanced Radiation Sources, The University of Chicago, Chicago, Illinois 60637, - - 2014
A defining characteristic of silicate melts is the degree of polymerization (tetrahedral connectivity), which dictates viscosity and affects compressibility. While viscosity of depolymerized silicate melts increases with pressure consistent with the free-volume theory, isothermal viscosity of polymerized melts decreases with pressure up to ~3-5 GPa, above which it turns over to ...
Van de Velde Sarah S Laboratory of Ophthalmology, katholieke Universiteit Leuven, Herestraat 49 bus 1025, Leuven, 3000, - - 2014
To determine whether ROCK inhibition for the treatment of glaucoma can be improved by using novel, locally acting Rho kinase (ROCK) inhibitors, such as AMA0076, that lower intraocular pressure (IOP) without inducing hyperemia. On-target potency of AMA0076 was compared with other ROCK inhibitors (Y-27632 and Y-39983) and conversion of AMA0076 ...
Gao Peiwen P Institute of Physics and Beijing National Laboratory for Condensed Matter Physics, Chinese Academy of Sciences, Beijing, 100190, - - 2014
Pressure-induced superconductivity is oberserved in Ca10 (Pt3 As8 )(Fe2 As2 )5 by in situ high-pressure resistance and magnetic susceptibility measurements. Scaling of the pressure-induced and doping-induced superconductivity shows that the electronic phase diagrams of the pressurized and chemically doped 10-3-8 compound are similar in the moderate pressure and doping range ...
Cheng Shaoan S State Key Laboratory of Clean Energy, Department of Energy Engineering, Zhejiang University, Hangzhou 310027, PR China. Electronic address: - - 2014
Scaling up of microbial fuel cells (MFCs) without losing power density requires a thorough understanding of the effect of hydraulic pressure on MFC performance. In this work, the performance of an activated carbon air-cathode MFC was evaluated under different hydraulic pressures. The MFC under 100mmH2O hydraulic pressure produced a maximum ...
Abegão Pinto Luís L Department of Ophthalmology, Centro Hospitalar Lisboa Central, Lisbon, Portugal; Department of Pharmacology and Neurosciences, Faculty of Medicine, Lisbon University, Lisbon, - - 2014
To determine the correlation between ocular blood flow velocities and ocular pulse amplitude (OPA) in glaucoma patients using colour Doppler imaging (CDI) waveform analysis. A prospective, observer-masked, case-control study was performed. OPA and blood flow variables from central retinal artery and vein (CRA, CRV), nasal and temporal short posterior ciliary ...
Santos-Bueso E E Unidad de Neurooftalmología, Servicio de Oftalmología, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, España. Electronic address: - - 2014
An 80 year old woman operated on by trabeculectomy for primary open-angle glaucoma due to increased pressure, who started treatment with latanoprost. Monitoring of blood pressure (BP) showed a statistically significant increase in both systolic and diastolic BP, coinciding with the use of topical hypotensive, which resolved by voluntarily suspending ...
Renzo Roberta R Department of Veterinary Clinical Medicine and Surgery, Sao Paulo State University (UNESP), Via de Acesso Prof.Paulo Donato Castellane s/n, 14884-900, Jaboticabal, SP, - - 2014
This study aimed to evaluate and correlate intraocular pressure (IOP), endothelial cell density (CD), and hexagonality (HEX), and the aqueous humor prostaglandin E2 (PGE2 ) concentration in dogs with mature (MG, n = 8) and hypermature (HG, n = 8) cataracts. Eight laboratory beagles with no ocular abnormalities were included as a control group ...
Kim Mi Jeung MJ Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea; Department of Ophthalmology, Seoul National University Hospital, Seoul, - - 2014
To investigate the distribution of intraocular pressure (IOP) and its associated factors in a large Korean population based on the data from the nationwide cross-sectional survey. We obtained 2009-2010 data from the Korea National Health and Nutrition Examination Survey (KNHANES) (n = 17 901). After excluding individuals under 19 years of age, a total ...
Kara Necip N Kanuni Sultan Suleyman Education and Research Hospital, Department of Ophthalmology , Istanbul , Turkey - - 2014
Abstract Purpose: To investigate the intraocular pressure (IOP) and ocular perfusion pressure (OPP) in night shift workers. Methods: Seventy-one healthy individuals who work the night shift were evaluated. IOP and OPP were measured in the sitting position in each participant. Measurements were obtained at rest time (09:00, 12:00, 16:00) and ...
Fabbiani Francesca P A FP GZG, Abteilung Kristallographie, Georg-August-Universität Göttingen, Göttingen, 37077, Germany. - - 2014
The monohydrate form of the neurotransmitter γ-amino butyric acid (GABA) has been crystallised in the 0.4-0.8 GPa pressure range, recovered to ambient pressure and then used as a seed. Theoretical calculations indicate that this hydrate is only thermodynamically favoured over the two anhydrous forms at high pressures.
Acott Ted S TS Casey Eye Institute, Oregon Health & Science University , Portland, - - 2014
Abstract Although glaucoma is a relatively common blinding disease, most people do not develop glaucoma. A robust intraocular pressure (IOP) homeostatic mechanism keeps ocular pressures within relatively narrow acceptable bounds throughout most peoples' lives. The trabecular meshwork and/or Schlemm's canal inner wall cells respond to sustained IOP elevation and adjust ...
Kim Shin-Hyun SH 1] Department of Physics, School of Engineering and Applied Sciences, Harvard University, 29 Oxford street, Cambridge, Massachusetts 02138, USA [2] Department of Chemical and Biomolecular Engineering, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, - - 2014
Colloidal crystals are promising structures for photonic applications requiring dynamic control over optical properties. However, for ease of processing and reconfigurability, the crystals should be encapsulated to form 'ink' capsules rather than confined in a thin film. Here we demonstrate a class of encapsulated colloidal photonic structures whose optical properties ...
Tiidus Peter M PM Health Sciences Program and Department of Kinesiology Wilfrid Laurier University Waterloo, Ontario, - - 2014
To compare the intramuscular pressure (IMP) of the tibialis anterior in healthy persons under several exercise conditions with the IMP diagnostic criteria in use for diagnosing chronic exertional compartment syndrome (CECS). A search of MEDLINE for the period 1966 to March 2010 used the words "intramuscular," "intracompartment," "anterior compartment," and ...
Zhang Li-Fan LF Department of Aerospace Physiology, Fourth Military Medical University, Xi'an, China . - - 2014
Visual impairment intracranial pressure syndrome (VIIP) is considered a major risk for future human spaceflight. Loss of hydrostatic pressure gradients in vascular and cerebrospinal fluid systems due to the removal of gravity associated with subsequent intracranial and intraocular fluid shifts and the resulting intraocular/intracranial pressure mismatch might be important etiology ...
Ko Minhee K MK Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California (USC), Los Angeles, - - 2014
To describe live mouse, anterior chamber constant-pressure perfusion by an approach using feedback-controlled coupling of pressure and flow to maintain a preset pressure. We established a microperfusion system that maintains a constant preset pressure in the anterior chamber of live mice by automatically regulating the microsyringe pump flow rate with ...
Mizoue Shiro S Department of Ophthalmology, Ehime University Graduate School of Medicine, Ehime, - - 2014
This study aimed to evaluate the effect of travoprost with sofZia® preservative system for lowering the intraocular pressure (IOP) of Japanese normal tension glaucoma (NTG) patients. In this prospective, multicenter, open-label study, Japanese NTG patients with baseline IOPs <20 mmHg were enrolled after three consecutive time measurements taken at screening ...
Paschalis Eleftherios I EI Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, - - 2014
To present an autonomous intraocular pressure (IOP) measurement technique using a wireless implantable transducer (WIT) and a motion sensor. The WIT optical aid was implanted within the ciliary sulcus of a normotensive rabbit eye after extracapsular clear lens extraction. An autonomous wireless data system (AWDS) comprising of a WIT and ...
Nagayama Mikio M Nagayama Eye Clinic, Okayama, - - 2014
The purpose of this study was to assess the safety and efficacy of fixed-combination brinzolamide 1%/timolol 0.5% (BRINZ/TIM-FC) compared with concomitant brinzolamide 1% and timolol 0.5% (BRINZ + TIM) in Japanese patients with open-angle glaucoma (primary open-angle, exfoliation, pigmentary) or ocular hypertension. This randomized, double-masked, multicenter, parallel-group, positive-control, Phase III ...
Nebbioso Marcella M 0000-0002-5512-0849 Department of Sense Organs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, - - 2014
Objective. The purpose of this study focused on understanding the mechanisms underlying ocular hydrodynamics and the changes which occur in the eyes of subjects exposed to hypobaric hypoxia (HH) to permit the achievement of more detailed knowledge in glaucomatous disease. Methods. Twenty male subjects, aged 32 ± 5 years, attending ...
Fung Derrick S DS Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, - - 2014
Glaucoma is a progressive, neurodegenerative optic nerve disease that can cause significant visual morbidity and affects over 60 million people worldwide. The only known modifiable risk factor for glaucoma at this time is elevated intraocular pressure (IOP), which may be treated with medications, laser therapy, and/or incisional surgery. Topical ocular ...
Nakajima Masayuki M Nakajima Eye Clinic, Kyoto, - - 2014
The purpose of this study was to evaluate the safety and efficacy of a long-term, twice-daily brinzolamide 1%/timolol 0.5% fixed combination ophthalmic suspension (BRINZ/TIM-FC) in Japanese patients with open-angle glaucoma (primary open-angle, normal-tension, exfoliation, or pigmentary) or ocular hypertension. This was a prospective, nonrandomized, multicenter, open-label, Phase III study of ...
Chu Jiangtao J Department of Engineering Sciences, Uppsala University, Box 534, 751 21, Uppsala, - - 2013
With the interest of studying larger biomolecules by microdialysis (MD), this sampling technique has reached into the ultrafiltration region of fluid exchange, where fluid recovery (FR) has a strong dependence on pressure. Hence in this study, we focus on the fluid exchange across the high molecular weight cut off MD ...
Johnstone Murray A MA Department of Ophthalmology, University of Washington , Seattle, - - 2013
Abstract Intraocular pressure (IOP) is the only treatable risk factor in glaucoma, one of the world's leading causes of blindness. Mechanisms that maintain IOP within a normal range have been poorly understood in contrast to intrinsic mechanisms that regulate systemic blood pressure. In vessels, continuous cyclic forces involving alterations in ...
Cho H-K HK Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, - - 2013
PurposeTo investigate clinical characteristics and progression rates of the initial central scotomas (ICS) compared with the initial peripheral scotomas (IPS) in normal-tension glaucoma (NTG) patients.MethodsAmong NTG patients showing a single hemifield defect and who performed more than five reliable standard visual field (VF) tests, medical records of ICS (involvement of ...
Winkler Nelson S NS 1 Mayo Clinic College of Medicine , Rochester, - - 2013
Abstract Elevated intraocular pressure (IOP) is the most prevalent risk factor for glaucoma. All treatments, whether surgical or pharmaceutical, are aimed at lowering IOP. Prostaglandin analogues are a first line therapy for glaucoma due to their ability to reduce IOP, once-daily dosing, efficacy, and minimal side-effect profile. Whereas prostaglandin analogues ...
Su L L Graduate School of Human Life Science, Osaka City University, Sugimoto, Sumiyoshiku, Osaka 558-8585, Japan; The High Pressure Research Center of Science and Technology, Zhengzhou University of Light Industry, Zhengzhou 450002, - - 2013
In situ observation of heat-and pressure-induced gelation of methylcellulose (MC) aqueous solution has been studied by using dynamic viscoelastic and fluorescence measurements. The storage modulus G' decreased gradually first on heating, and then leveled off in the temperature range from 25°C to 75°C. Methylcellulose solutions were subjected to pressures up ...
Bogner Barbara - - 2013
Purpose: Previous experiments have shown that arginine-vasopressin (AVP) reduces intraocular pressure (IOP) dose-dependently. The present study investigated the relationships between IOP, ciliary blood flow (CilBF) and aqueous flow (AqF) responses to AVP in anaesthetized rabbits. Methods: CilBF was measured by Laser Doppler flowmetry and AqF by fluorophotometry. Mean arterial pressure ...
Guerra Yenifer - - 2013
Abstract Purpose: To determine the differential profiles of sphingomyelin, sphingoid base, sphingoid base-1-phosphate, and ceramide and their quantitative differences between trabecular meshwork (TM) derived from normotensive and hypertensive intraocular pressure states of DBA/2J mice. Methods: Normotensive and hypertensive state TM were collected from mice and analyzed. Lipid extraction was performed ...
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