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Basset Leanne L CIToxLAB North America, 445 Armand Frappier, Laval, QC, Canada, H7V - - 2014
A number of drugs in clinical trials are discontinued due to potentially life-threatening airway obstruction. As some drugs may not cause changes in core battery parameters such as tidal volume (Vt), respiratory rate (RR) or minute ventilation (MV), including measurements of respiratory mechanics in safety pharmacology studies represents an opportunity ...
Khirani Sonia S Pediatric Pulmonary Department, Assistance Publique-Hôpitaux de Paris, Hôpital Armand Trousseau, Paris, France.S2A Santé, Ivry sur Seine, - - 2014
Daytime mouthpiece ventilation is a useful adjunct to nocturnal noninvasive ventilation (NIV) in patients with neuromuscular disease. The aims of the study were to analyze the practice of mouthpiece ventilation and to evaluate the performance of ventilators for mouthpiece ventilation. Practice of mouthpiece ventilation was assessed by a questionnaire, and ...
Ganigara Anuradha A Department of Anesthesiology, Indira Gandhi Institute of Child Health, South Hospital Complex, Dharmaram College Post, Bangalore, 560029, Karnataka, India, - - 2014
Endotracheal tube cuff pressure monitoring is one of the standard degrees of care afforded to anesthetized patients in the operative theater. Traditional pressure transducer when used to monitor cuff pressure provides real time continuous sine wave pressure waveform which has not been described in literature so far. This unique waveform ...
Keenan Brendan T BT Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, PA, USA Joint first - - 2014
Obstructive sleep apnoea (OSA) is associated with cardiovascular disease. Dyslipidaemia has been implicated as a mechanism linking OSA with atherosclerosis, but no consistent associations with lipids exist for OSA or positive airway pressure treatment. We assessed the relationships between fasting lipid levels and obesity and OSA severity, and explored the ...
Iwasaki Tomonori T Field of Developmental Medicine, Health Research Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan. Electronic address: - - 2014
Recent evidence suggests that rapid maxillary expansion (RME) is an effective treatment of obstructive sleep apnea syndrome (OSAS) in children with maxillary constriction. Nonetheless, the effect of RME on pharyngeal airway pressure during inspiration is not clear. The purpose of this retrospective study was to evaluate changes induced by the ...
Kohan Mahmoud M M Kohan, BSN, MSN, Lecturer, Department of Operating Room, Alborz University of Medical Sciences, Karaj, - - 2014
To investigate the effects of expiratory ribcage compression (ERCC) before endotracheal suctioning on the arterial blood gases (ABG) in patients receiving mechanical ventilation. Endotracheal suctioning is one of the most frequently used methods for airway clearance in patients receiving mechanical ventilation. Chest physiotherapy techniques such as ERCC before endotracheal suctioning ...
Ho Amh A Department of Anesthesiology and Perioperative Medicine, Queen's University, Kingston General Hospital, Kingston, Ontario, - - 2014
If tracheal intubation is not possible using direct laryngoscopy, one option is to use a laryngeal mask airway (LMA) through which an endotracheal tube (ETT) can be passed. In children, however, the size of an uncuffed ETT that can pass through the lumen of an LMA is sometimes too small ...
Adelborg K K Department of Cardiology, Aarhus University Hospital, Aarhus, - - 2014
Thirty surf lifeguards (mean (SD) age: 25.1 (4.8) years; 21 male, 9 female) were randomly assigned to perform 2 × 3 min of cardiopulmonary resuscitation on a manikin using mouth-to-face-shield ventilation (AMBU(®) LifeKey) and mouth-to-pocket-mask ventilation (Laerdal Pocket Mask™). Interruptions in chest compressions, effective ventilation (visible chest rise) ratio, tidal volume and inspiratory time ...
Kawaguchi Atsushi A University of Alberta, Department of Pediatrics, Pediatric Critical Care Medicine, Stollery Children's Hospital, 3A3.06 Walter C MacKenzie Health Centre, 8440 112 St Edmonton, T6G 2B7, AB, Canada; University of Alberta, School of Public - - 2014
Airway Pressure Release Ventilation (APRV) is widely used in adult critical care settings. However, information on the use of APRV in the pediatric population is limited. All patients admitted to the medical-surgical pediatric intensive care unit with a diagnosis of Acute Respiratory Distress Syndrome (ARDS) who received APRV for at ...
Daoud Ehab G EG Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44106, - - 2014
No objective data directly comparing the 2 modes are available. Based on a simple mathematical model, APRV and BIPAP can presumably be set to achieve the same mean airway pressure (mPaw), end expiratory pressure, and tidal volume (VT). Herein, we tested this hypothesis when using a real ventilator and clinically ...
Geng Guiqi G Department of Anesthesiology, Obstetrics and Gynecology Hospital, Fudan University, Shenyang Road 128#, Yangpu District, Shanghai, 200090, China, - - 2014
Postoperative respiratory complications related to endotracheal intubation usually present as cough, sore throat, hoarseness. The aim of the study was to examine the effects of endotracheal tube cuff pressure changes during gynecological laparoscopic surgery on postoperative sore throat rates. Thirty patients who underwent gynecological laparoscopic surgery and 30 patients who ...
Galetke Wolfgang W Krankenhaus der Augustinerinnen Cologne, Cologne, Germany; Institute for Pneumology at the University Witten/Herdecke, Solingen, Germany. Electronic address: - - 2014
Although coexisting obstructive sleep apnea (OSA) and Cheyne-Stokes respiration (CSR) occur frequently in patients with heart diseases, optimal treatment remains unclear. Positive airway pressure (PAP) effectively treats OSA and adaptive servo-ventilation (ASV) has been shown to improve CSR. We compared a new treatment algorithm combining automatic continuous positive airway pressure ...
Harbut P P Department of Anesthesiology and Intensive Care, Danderyd Hospital, Stockholm, - - 2014
Morbidly obese patients are more prone to desaturation of arterial blood during apnea with induction of anesthesia than are non-obese. This study aimed to assess the effect of low-pressure continuous positive airway pressure (CPAP) with pressure support ventilation (PSV) during pre-oxygenation on partial oxygen pressure in arterial blood (PaO2 ) ...
Yuan George G From the Firestone Institute for Respiratory Health, Department of Medicine, McMaster University, Hamilton, Ontario, Canada (GY); and Department of Physical Medicine and Rehabilitation (JRB, LS); Department of Neurosciences (JRB, LS); and Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine (AB), Rutgers-New Jersey Medical School, University Hospital, Newark, - - 2014
Fiber-optic bronchoscopy supported by continuous or bilevel positive airway pressure has helped patients with hypoxemic or hypercapnic respiratory failure avoid respiratory complications. The authors describe a case of a 57-yr-old man with multiple sclerosis with a vital capacity of 250 ml (5% of predicted normal) who was using continuous noninvasive ...
Harcourt Edward R ER 1Neonatology, Royal Children's Hospital, Parkville, VIC, Australia. 2Clinical Technology Service, Royal Children's Hospital, Parkville, VIC, Australia. 3Neonatal Research, Royal Women's Hospital, Parkville, VIC, Australia. 4Neonatal Research, Murdoch Children's Research Institute, Parkville, VIC, Australia. 5Department of Paediatrics, Royal Hobart Hospital, Hobart, TAS, Australia. 6Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano University, Milano, Italy. 7Departments Paediatrics and Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, - - 2014
The differences in performance of early generation high-frequency oscillators have been attributed to their distinct pressure and flow waveforms. Recently, five new oscillators have been commercially released. The objective of this study was to characterize the pressure and flow waveforms of eight commercially available oscillators. In vitro benchtop study. Tertiary ...
Gouinaud Laure L a Medical Gases Group, Air Liquide Santé International, Centre de Recherche Claude Delorme , 1 Chemin de la Porte des Loges, B.P. 126, Les Loges-en-Josas 78354 , - - 2014
A numerical pressure loss model previously used for adult human airways has been modified to simulate the inhalation pressure distribution in a healthy 9-month-old infant lung morphology model. Pressure distributions are calculated for air as well as helium and xenon mixtures with oxygen to investigate the effects of gas density ...
Abboud François - - 2014
Nearly two decades ago, we evaluated ten patients with obstructive sleep apnea (OSA). We determined that alarming nocturnal oscillations in arterial pressure and sympathetic nerve activity (SNA) were caused by regulatory coupling and neural interactions among SNA, apnea, and ventilation. Patients with OSA exhibited high levels of SNA when awake, ...
Dubey Prakash Kumar PK Department of Anaesthesiology and Critical Care Medicine, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna, Bihar, - - 2014
A 3-month-old male child underwent uneventful inguinal herniotomy under general anesthesia. After extubation, airway obstruction followed by pulmonary edema appeared for which the baby was reintubated and ventilated. The baby made a complete recovery and extubated after about 2 h. A post-operative computed tomography scan revealed a posterior mediastinal cystic ...
Carlson Jestin N - - 2014
ABSTRACTObjective:Pulmonary aspiration of gastric contents occurs 20 to 30% of the time during cardiopulmonary resuscitation (CPR) of cardiac arrest due to loss of protective airway reflexes, pressure changes generated during CPR, and positive pressure ventilation (PPV). Although the American Heart Association has recommended the laryngeal mask airway (LMA) as an ...
Saran Sai S Departments of Anaesthesiology & Critical Care, Jawaharlal Institute of Post-Graduate Medical Education and Research, Gorimedu, Puducherry, - - 2014
i-gel™ and the ProSeal™ laryngeal mask airway (PLMA) are two supraglottic airway devices with gastric channel used for airway maintenance in anesthesia. This study was designed to evaluate the efficacy of i-gel compared with PLMA for airway maintenance in pediatric patients under general anesthesia with controlled ventilation. A total of ...
Meftahuzzaman S M SM Professor ASM Meftahuzzaman, Professor, Department of Anaesthesiology, Mymensingh Medical College (MMC), Mymensingh, - - 2014
Stress response due to laryngoscopy and intubation has been universally recognized phenomenon resulting in increase in heart rate, arterial, intracranial, and intraocular pressure. Various pharmacological approaches have been used to blunt or attenuate such pressure responses. This prospective, randomized, placebo controlled, double blinded study was designed to compare the efficacy ...
Muñoz Vilma V Escuela de Rehabilitación Humana, Facultad de Salud, Universidad del Valle, Cali, - - 2014
Objective: Early weaning from mechanical ventilation is one of the primary goals in managing critically ill patients. There are various techniques and measurement parameters for such weaning. The objective of this study was to describe the practices of ventilatory weaning in adult intensive care units in the city of Cali. ...
Szyld Edgardo E Research Department, FUNDASAMIN, Fundación para la Salud Materno Infantil, Buenos Aires, Argentina. Electronic address: - - 2014
To evaluate the effectiveness and safety of a T-piece resuscitator compared with a self-inflating bag for providing mask ventilation to newborns at birth. Newborns at ≥26 weeks gestational age receiving positive-pressure ventilation at birth were included in this multicenter cluster-randomized 2-period crossover trial. Positive-pressure ventilation was provided with either a self-inflating ...
Mansukhani Meghna P MP Sleep Medicine, Affiliated Communities Medical Center, 101 Willmar Avenue SW, Willmar, MN, - - 2014
For most patients with obstructive sleep apnea syndrome (OSA), continuous positive airway pressure (CPAP) is an effective therapy. However, for a subset of individuals, CPAP is either not effective or is poorly tolerated. Bilevel positive airway pressure (BPAP) is potentially capable of treating OSA at a lower mean pressure than ...
Luo Haiyan H Department of Mechanical Engineering, The Cooper Union for the Advancement of Science and Art, 41 Cooper Square, New York, NY, - - 2014
Improvements in obstructive sleep apnea syndrome (OSAS) severity may be associated with improved pharyngeal fluid mechanics following adenotonsillectomy (AT). The study objective is to use image-based computational fluid dynamics (CFD) to model changes in pharyngeal pressures after AT, in obese children with OSAS and adenotonsillar hypertrophy. Three-dimensional models of the ...
Nguyen Binh B Pulmonary/Critical Care Medicine, Fletcher Allen Health Care, Burlington, - - 2014
The current ventilatory care goal for acute respiratory distress syndrome (ARDS) and the only evidence-based approach for managing ARDS is to ventilate with a tidal volume (VT) of 6 mL/kg predicted body weight (PBW). However, it is not uncommon for some caregivers to feel inclined to deviate from this strategy ...
Vasanth Karthik R R Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Parel, Mumbai, 400012, - - 2014
The incidence of postoperative pharyngolaryngeal complications after laryngeal mask airway (LMA) insertion can be as high as 50 %. Over-inflation of the LMA cuff may be a causal factor. We conducted a single-centre parallel group randomised trial to determine whether maintaining LMA-ProSeal intra-cuff pressures below 60 cm H2O decreases postoperative pharyngolaryngeal complications. ...
Kus Alparslan A From the Medical Faculty of Kocaeli University, Department of Anesthesiology and Reanimation, Umuttepe/Kocaeli, - - 2014
Supraglottic airway devices such as the LMA-Supreme (LMA-S) and I-gel, which have an additional lumen for the insertion of a gastric tube, can be useful in the management of the difficult airway. To test the performance of these two devices in the difficult paediatric airway, we compared the size 2 ...
Linz Dominik D Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg/Saar, - - 2014
Obstructive sleep apnea (OSA) is associated with hypertension and the progression of chronic kidney disease (CKD). Renal sympathetic innervation contributes to either condition. We investigated the effect of renal sympathetic denervation (RDN) on blood pressure (BP), renal perfusion, and neurohumoral responses during and after repetitive obstructive apneas in a pig ...
Lopez-Navas Kristel - - 2014
Abstract The proper setting of support ventilation aims to follow the patients' demands, ensuring adequate assistance to their respiratory effort. Effort assessment is thus necessary. But invasive procedures like measuring transdiaphragmatic pressure (Pdi) are impractical in long-term ventilation. Our purpose was therefore the development of the Occlusion+Delta (O+D) method for ...
Thomas Peter P Department of Physiotherapy, Royal Brisbane and Women's Hospital, Brisbane, Australia. Electronic address: - - 2014
To compare the effect of semi-recumbent and sitting positions on gas exchange, respiratory mechanics and hemodynamics in patients weaning from mechanical ventilation. Upright positions are encouraged during rehabilitation of the critically ill but there effects have not been well described. A prospective, randomized, cross-over trial was conducted. Subjects were passively ...
Erdemir Aydin A Tepecik Education and Research Hospital, Department of Pediatrics, Neonatology Clinic, Yenisehir, Izmir, - - 2014
To compare the effects and short-term outcomes of pressure support ventilation with volume guarantee versus synchronized intermittent mandatory ventilation in the weaning phase of very low-birth weight infants with respiratory distress syndrome. Randomized controlled prospective study. Tertiary care neonatal unit. A total of 60 premature infants who were less than ...
Shrivastava Deepak D University of California, Davis, CA, USA; Division of Sleep Medicine, Pulmonary and Critical Care, SJGH Sleep Center, 500, West Hospital Road, French Camp, CA 95231, USA. Electronic address: - - 2014
Sleep-disordered breathing (SDB) is a major public health problem. Various anatomic, pathophysiologic, and environmental changes contribute to SDB. The successful treatment of SDB reverses many of these abnormal processes. The present article discusses the current clinical evidence that supports the reversibility and its potential application in the management of SDB. ...
Macrae Phoebe P a Department of Physical Medicine and Rehabilitation, School of Medicine , Johns Hopkins University , Baltimore , - - 2014
ABSTRACT Volitional control of autonomic responses, such as heart rate and blood pressure, can be facilitated with the use of augmented feedback. Oropharyngeal swallowing typically includes both volitional and reflexive components, offering a unique opportunity for observing how performance is affected by feedback. Sixteen healthy participants (M age = 29 years, ...
Pickerd Nicole N Department of Child Health, Cardiff University, Cardiff, United - - 2014
To compare tidal breathing on different continuous positive airway pressure (CPAP) devices and pressures and to serially measure tidal breathing during weaning off CPAP using electromagnetic inductive plethysmography. Using electromagnetic inductive plethysmography, tidal breathing was measured in 29 preterm infants receiving CPAP, gestational age 28 ± 2 weeks. Variable-flow nasal CPAP (nCPAP), bubble ...
Adelborg K K Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark; Research Center for Emergency Medicine, Aarhus University Hospital, Aarhus, - - 2014
Forty surf lifeguards attempted to ventilate a manikin through one out of three supraglottic airways inserted in random order: the Portex® Soft Seal®; the Intersurgical® i-gel™; and the Ambu® AuraOnce™. We recorded the time to ventilate and the proportion of inflations that were successful, without and then with concurrent chest ...
White David E - - 2014
Continuous positive air pressure (CPAP) users frequently report troublesome symptoms of airway dryness and nasal congestion. Clinical investigations have demonstrated that supplementary humidification reduces these symptoms but the reason for their occurrence remains unexplained. Investigations using human computational air-conditioning models are unable to reproduce or quantify the apparent airway drying ...
Visaya Jiovani M JM Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medical College, New York, New - - 2014
IMPORTANCE Endoscopic balloon dilation is commonly performed in children with airway stenosis, but guidelines are needed for selecting safe and effective balloon inflation parameters. OBJECTIVE To determine the feasibility and safety of airway balloon dilation in live rabbits using a range of balloon diameters and pressures. DESIGN AND SETTING Prospective ...
Hoff Fabrícia C FC Intensive Care Unit, Hospital Mãe de Deus, Porto Alegre, Brazil; Graduate Program in Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, - - 2014
Expiratory asynchrony during pressure support ventilation (PSV) has been recognized as a cause of patient discomfort, increased workload, and impaired weaning process. We evaluated breathing pattern, patient comfort, and patient effort during PSV comparing 2 flow termination criteria: fixed at 5% of peak inspiratory flow vs automatic, real-time, breath-by-breath adjustment ...
Pouraghaei Mahboob M Anesthesiology Research Team, Department of Anesthesiology, Tabriz University of Medical Sciences, Tabriz, - - 2014
Laryngoscopy and tracheal intubation lead to the alteration of hemodynamic parameters, including blood pressure and heart rate, in traumatic patients who sustain rapid sequence intubation (RSI). Various drugs such as fentanyl, alfentanil and sufentanil have been used to modify these hemodynamic responses. The aim of the present study is to ...
Tracy Mark B MB Neonatal Intensive Care Unit, Westmead Hospital, Westmead, Sydney, Australia; Sydney Medical School, University of Sydney, Sydney, - - 2014
To determine changes in respiratory mechanics when chest compressions are added to mask ventilation, as recommended by the International Liaison Committee On Resuscitation (ILCOR) guidelines for newborn infants. Using a Laerdal Advanced Life Support leak-free baby manikin and a 240 mL self-inflating bag, 58 neonatal staff members were randomly paired ...
Owens Robert Llewellyn RL 1Brigham & Women's Hospital and Harvard Medical - - 2014
The upper airway is often modeled as a classical Starling resistor, featuring a constant inspiratory airflow, or plateau, over a range of downstream pressures. However, airflow tracings from clinical sleep studies often show an initial peak before the plateau. To conform to the Starling model, the initial peak must be ...
Wasserthal Lutz T LT University of Erlangen-Nuremberg, - - 2014
Respiration in insects is thought to be independent of the circulatory system because insects typically lack respiratory pigments and because oxygen transport occurs in the gaseous phase via a ramified tracheal system by diffusion and convection directly to the tissues. In the blowfly, as in other insects with periodic heartbeat ...
Ntoumenopoulos George G School of Physiotherapy, Australian Catholic University , North Sydney, New South Wales , Australia - - 2014
Abstract Background: Chest physiotherapy may aid sputum clearance during conventional ventilation. However, the role of chest physiotherapy during high-frequency oscillatory ventilation (HFOV) is unclear. This study aimed to determine the effects manually-assisted cough (MAC), postural drainage, saline instillation and airway suction during HFOV. Methods: This was an observational study of ...
Liu Rui R State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, - - 2014
This study evaluated the effect of high selective bilateral vagotomy of hilus pulmonis with video-assisted thoracoscopy on asthma. Eight dogs with skin sensitive to Ascaris suum antigens were randomly divided into groups A and B. Asthma was induced by aerosol inhalation of A suum antigens. Respiratory rate and peak airway ...
Yehya Nadir N 1Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA. 2Division of Pediatric Critical Care Medicine, Department of Pediatrics and Public Health Science, Penn State Hershey Children's Hospital, Hershey, PA. 3Division of Critical Care Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, - - 2014
Children with an immunocompromised condition and requiring invasive mechanical ventilation have high risk of death. Such patients are commonly transitioned to rescue modes of nonconventional ventilation, including airway pressure release ventilation and high-frequency oscillatory ventilation, for acute respiratory distress syndrome refractory to conventional ventilation. Our aim was to describe our ...
Vaschetto Rosanna - - 2014
Interface choice is crucial for non-invasive ventilation (NIV) success. We compared a new interface, the helmet next (HN), with the facial mask (FM) and the standard helmet (HS) in twelve healthy volunteers. In this study, five NIV trials were randomly applied, preceded and followed by a trial of unassisted spontaneous ...
Bernad Elena S - - 2014
In this study, effects of serial stenosis on coronary hemodynamics were investigated in the human right coronary artery (RCA) using blood flow analysis. A 3-D model of a serial stenosed RCA was reconstructed based on multislice computerized tomography images. Numerical analysis examined the effect of multiple serial stenoses on the ...
Türköz Ayda A Department of Anesthesiology, Baskent University Istanbul Teaching and Medical Research Center, ─░stanbul, - - 2014
Aims and Objectives: We used near-infrared spectroscopy to document changes in cerebral tissue oxygen saturation (SctO 2 ) in response to ventilation mode alterations after bidirectional Glenn (BDG; superior cavopulmonary connection) procedure. We also determined whether spontaneous ventilation have a beneficial effect on hemodynamic status, lactate and SctO 2 when ...
Bergmann Ingo I Department of Anaesthesiology, Emergency and Intensive Care Medicine, University of Göttingen Medical School, Robert-Koch Str, 40, 37075 Göttingen, Germany. - - 2014
The conventional sequence when using supraglottic airway devices is insertion, cuff inflation and fixation. Our hypothesis was that a tighter fit of the cuff and tip could be achieved with a consequently lower incidence of air leak, better separation of gastrointestinal and respiratory tracts and less airway morbidity if the ...
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