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Amigoni Angela - - 2011
In this study we monitored renal, hepatic and muscular oxygen saturations by near-infrared spectroscopy and we evaluated the correlation with variables that could affect tissue oxygenation in 16 paediatric patients during surgical heart procedure. We considered the following phases: 1) basal time (after induction of anaesthesia and before median sternotomy), ...
Fogari Roberto R Department of Internal Medicine and Therapeutics, Centro per l'ipertensione e la fisiopatologia cardiovascolare, University of Pavia, Pavia, Italy. - - 2012
This study evaluated the effect of telmisartan, ramipril, and amlodipine on atrial fibrillation (AF) recurrence and severity in hypertensive patients with metabolic syndrome. A total of 391 hypertensive outpatients with metabolic syndrome, in sinus rhythm but with at least 2 episodes of AF in the previous 6 months were randomized ...
Santhanakrishnan Arvind - - 2011
The morphology, muscle mechanics, fluid dynamics, conduction properties, and molecular biology of the developing embryonic heart have received much attention in recent years due to the importance of both fluid and elastic forces in shaping the heart as well as the striking relationship between the heart's evolution and development. Although ...
Monnet Xavier - - 2011
OBJECTIVE:: To evaluate to which extent the systemic arterial pulse pressure could be used as a surrogate of cardiac output for assessing the effects of a fluid challenge and of norepinephrine. DESIGN:: Observational study. SETTING:: Medical intensive care unit. PATIENTS:: Patients with an acute circulatory failure who received a fluid ...
Howard Siobhán - - 2011
The Type D personality (identified by high levels of both negative affectivity and social inhibition) has been associated with negative health consequences in cardiac patients. However, few studies have explored whether the Type D personality is associated with particular patterns of cardiovascular responses to stress. In the present study, cardiovascular ...
Koeken Yvette - - 2011
Clinical observations suggest that the assumption of a linear relationship between chest compression pressure and cardiac output may be oversimplified. More complex behaviour may occur when the transmural pressure is large, changing the compliances and resistances in the intra-thoracic vasculature. A fundamental understanding of these compression induced phenomena is required ...
Lancien Frédéric - - 2011
Although PACAP and VIP exert diverse actions on heart and blood vessels along the vertebrate phylum, no information is currently available concerning the potential role of these peptides on the regulation of the baroreflex response, a major mechanism for blood pressure homeostasis. Consequently, the goal of this study was to ...
Okutucu Sercan - - 2011
Arterial blood pressure fluctuates with a pattern that follows a circadian rhythm, with a peak in the early morning hours and a trough during nighttime. Nocturnal dipping of arterial blood pressure is part of this normal circadian pattern, and its absence, which is called non-dipping is associated with more severe ...
Hamid Tahir - - 2011
The pressure wire has emerged as a useful tool to assess the clinical severity of moderate coronary artery lesions. We report a novel use of the pressure wire in adult patients with complex congenital cardiac disease in whom it was used in assessing pressures beyond the stenosis in the distal ...
Neira Victor M - - 2011
PURPOSE: The prone position is required for posterior spinal fusion surgery and may be associated with cardiovascular changes, including a decrease in venous return and cardiac index. We report a case of a patient who developed cardiovascular collapse, increased central venous pressure (CVP), and massive bleeding during posterior spinal fusion ...
Kittnar Otomar - - 2011
Operations in pleural cavity have circulatory effects both in pulmonary and systemic circulations. Nevertheless studies of these effects have yielded conflicting results. The importance of good understanding of hemodynamic changes during the operation in pleural cavity consists in fact that they are one of the factors influencing postoperative course of ...
Cuspidi Cesare - - 2011
The association between a blunted decrease in day–night heart rate and subclinical organ damage has not been investigated earlier in human hypertension. Therefore, we assessed such an association in a cohort of 658 untreated essential hypertensive patients. All patients underwent procedures including cardiac and carotid ultrasonography, 24-h urine collection for ...
Oka H - - 2011
Background:  Clinical symptoms of Parkinson's disease (PD) include not only motor distress, but also autonomic dysfunction. Objective:  To study the characteristics of subclinical autonomic nervous dysfunction in de novo PD without orthostatic hypotension (OH). Methods:  Autonomic nervous function including cardiac sympathetic gain was evaluated on the basis of cardiac radioiodinated ...
Guglin Maya - - 2011
Renal dysfunction in heart failure is thought to be due to poor perfusion of the kidney. We tested the hypothesis that passive congestion is more important than poor perfusion. We retrospectively studied the data on 178 patients who underwent right heart catheterization for evaluation of heart failure and had serum ...
Etter Karen E - - 2011
Eur J Clin Invest 2011 ABSTRACT: Background  Of the many possible factors that may contribute to orthostatic intolerance, the loss of circulating blood because of capillary filtration is one of the few that can explain the gradual decline of arterial pressure during stand tests. This study used a computer model ...
Amin Ahmad - - 2011
The authors studied the relationship between liver function tests and serum uric acid level with clinical and hemodynamic profiles in heart failure. Fifty patients (aged 44±15 years; 74.5% men) with an ejection fraction (EF) <35% were enrolled and clinical assessment was performed. Hemodynamic indices (including pulmonary arterial pressure [PAP], pulmonary ...
Cividjian Andrei - - 2011
The delay t between rising systolic blood pressure (SBP) and baroreflex bradycardia has been found to increase when vagal tone is low. The alpha-2 agonist, clonidine increases cardiac vagal tone, and this study tested how it affects t. In 8 conscious supine human volunteers clonidine (6 µg/kg p.o.) re-duced t, ...
Cao Jie J - - 2011
Left atrial (LA) size and function reflect left ventricular (LV) hemodynamics. In the present study, we developed a novel method to determine LA circulation transit time (LATT) by MRI and demonstrated its close association with LV filling pressure. All subjects were prospectively recruited and underwent contrast-enhanced MR dynamic imaging. Mean ...
Proulx François - - 2011
OBJECTIVES:: To summarize the physiologic principles underlying the hemodynamic monitoring using the PiCCO device (Pulsion, Munich, Germany) incorporating the transpulmonary thermodilution technique, the pulse contour cardiac output, and estimation of the arterial pressure variation method. Analysis and review of the current literature. DESIGN:: A MEDLINE-based literature search using the key ...
Kim S H - - 2011
BACKGROUND: /st> Peripheral venous pressure (PVP) is strongly correlated with central venous pressure (CVP) during various surgeries. Laparoscopic surgery in the Trendelenburg position with pneumoperitoneum typically increases CVP. To determine whether PVP convincingly reflects changes in CVP, we evaluated the correlation between PVP and CVP in patients undergoing laparoscopic colorectal ...
Baumert Mathias - - 2011
Elevated QT interval variability is a predictor of malignant ventricular arrhythmia, but the underlying mechanisms are incompletely understood. A recent study in dogs with pacing-induced heart failure suggests that QT variability is linked to cardiac sympathetic nerve activity. The aim of this study was to determine whether increased cardiac sympathetic ...
Ando Masahiko - - 2011
Recent developments in adjunct therapeutic options for end-stage heart failure have enabled us to remove implanted left ventricular assist devices (LVADs) from more patients than before. However, a safe and proper protocol for pump-off trials is yet to be established, because diastolic backward flow in a pump circuit turns up ...
Dalen Havard - - 2011
BACKGROUND: The aim of this study was to determine whether blood pressure, body mass index (BMI), serum lipids, glucose, and renal function are associated with left ventricular (LV) and right ventricular function in a low-risk population. METHODS: The associations of common risk factors with cardiac function were assessed, using multiple ...
Lestar Melinda - - 2011
Background: Robot-assisted laparoscopic radical prostatectomy has gained widespread use. However, circulatory effects in patients subjected to an extreme Trendelenburg position (45°) are not well characterized. Methods: We studied 16 patients (ASA physical status I-II) with a mean age of 59 years scheduled for robot-assisted laparoscopic radical prostatectomy (45° head-down tilt, ...
Cordaillat Magali - - 2011
Rats fed an early and long-term high-salt diet (HS, NaCl 8%) developed significant cardiovascular hypertrophy without major changes in blood pressure. The mechanism of this cardiac hypertrophy has not been yet elucidated. In the present work, we assessed the influence of volume overload and arterial stiffness on the structural and ...
Mitchell Jamie R - - 2011
During mechanical ventilation, increased pulmonary vascular resistance (PVR) may decrease RV performance. We hypothesized that volume loading, by reducing PVR, and therefore RV afterload, can limit this effect. Deep anesthesia was induced in 16 mongrel dogs (8 oleic acid-induced acute lung injury and 8 controls). We measured ventricular pressures, dimensions ...
Nagai Toshiyuki - - 2011
Serum C-reactive protein (CRP) elevation predicts the development of heart failure in patients with hypertension. CRP activates macrophages and enhances oxidative stress. We hypothesize that CRP itself has a pathogenic role in the development of pressure overload-induced cardiac remodeling. Transgenic mice with human CRP overexpression (CRPtg) and nontransgenic littermates (CON) ...
Geersing Pieter G K B - - 2011
OBJECTIVES:: Rapid parasympathetic and sympathetic hemodynamic effects during electroconvulsive therapy (ECT) may pose vulnerable patients to significant risk for cardiovascular complications. Here, we evaluated the clinical feasibility of noninvasive beat-to-beat arterial blood pressure (BP) measurements in patients undergoing ECT. METHODS:: Beat-to-beat hemodynamic effects were measured with a noninvasive BP monitor ...
Fiorelli A I - - 2011
Advantages of the bicaval versus the biatrial technique have been reported, emphasizing atrial electrical stability and less tricuspid regurgitation. To analyze the impact of the surgical technique on long-term pulmonary pressures, contractility, and graft valvular behavior after heart transplantation. Among 400 orthotopic heart transplantation recipients from 1985 to 2010, we ...
Muradbegovic Mirza - - 2011
Ventricular assist devices (VADs) are used in treatment for terminal heart failure or as a bridge to transplantation. We created biVAD using the artificial muscles (AMs) that supports both ventricles at the same time. We developed the test bench (TB) as the in vitro evaluating system to enable the measurement ...
McMahon C Geraldine - - 2011
The integrity of the arterial baroreflex is central to cardiovascular homeostasis. There is evidence of altered cardiovascular regulation after acute traumatic brain injury (TBI). We hypothesized that arterial baroreflex is modified by acute TBI. An experimental study using 18 terminally anesthetized male Wistar rats weighing 240 to 260 g was ...
Eide Per K - - 2011
In patients with idiopathic normal pressure hydrocephalus (iNPH) responding to shunt surgery, we have consistently found elevated intracranial pressure (ICP) wave amplitudes during diagnostic ICP monitoring prior to surgery. It remains unknown why ICP wave amplitudes are increased in these patients. Since iNPH is accompanied by a high incidence of ...
Raval Deena - - 2011
Sleep disordered breathing (SDB) is frequently present in heart failure (HF), and it may take the form of obstructive (OSA) and central (CSA) sleep apnea. The use of continuous positive airway pressure (CPAP) in patients with OSA and HF is associated with an improved neuroendocrine profile and cardiac function. The ...
Lee Jong-Hwan - - 2011
Pulse pressure variation (PPV) is increasingly advocated as a predictor of fluid responsiveness in patients receiving mechanical ventilation. However, the ability of PPV has never been studied during one-lung ventilation (OLV). Therefore, we evaluated the value of PPV to predict fluid responsiveness in patients receiving conventional and protective OLV using ...
Bulte Carolien S E - - 2011
According to international standards, autonomic function is assessed by heart rate variability (HRV) calculated from R-R intervals obtained with an electrocardiogram (ECG). However, intra-operative movement artefacts and electrical interference may complicate R-wave detection. Pulse rate variability (PRV) derived from continuous blood pressure measurements may provide a feasible alternative for HRV. ...
Misumi Ikuo - - 2011
An 85-year-old woman with hypertension was referred to our hospital for the management of chest pain. Echocardiography showed left ventricular (LV) hypertrophy with impaired systolic function (ejection fraction, 40%) and mitral regurgitation. Pulsed Doppler echocardiography for checking mitral inflow showed triphasic mitral inflow velocity. Simultaneous recording of the LV and ...
Mizutani Tomohiro - - 2011
Human atrial natriuretic peptides and nitrite compounds (NC) are infused for the initial management of acute heart failure (HF). However, there have been few studies comparing their hemodynamic effects.Fifty-two patients in acute decompensated HF (ADHF) who received carperitide (0.07 ± 0.05 µg/kg/minute, n = 23, group C) or NC (0.39 ...
Iwamoto Yoichi - - 2011
The purpose of the present study was to determine the relationship of inferior vena cava diameter (IVCD) and its respirophasic variation (IVC collapsibility index: IVCCI) with central venous pressure (CVP), and thereby to provide reference cut-offs for such IVC parameters to estimate elevation in CVP in pediatric patients with cardiovascular ...
Trof Ronald J - - 2011
Static cardiac filling volumes have been suggested to better predict fluid responsiveness than filling pressures, but this may not apply to hearts with systolic dysfunction and dilatation. We evaluated the relative value of cardiac filling volume and pressures for predicting and monitoring fluid responsiveness, according to systolic cardiac function, estimated ...
Baldo Marcelo Perim - - 2011
To evaluate the effect of spironolactone on ventricular stiffness in spontaneously hypertensive adult rats subjected to high salt intake. High salt intake leads to cardiac hypertrophy, collagen accumulation and diastolic dysfunction. These effects are partially mediated by cardiac activation of the renin-angiotensin-aldosterone system. Male spontaneously hypertensive rats (SHRs, 32 weeks) ...
Gruenewald Matthias - - 2011
Continuous cardiac output monitoring is used for early detection of hemodynamic instability and guidance of therapy in critically ill patients. Recently, the accuracy of pulse contour-derived cardiac output (PCCO) has been questioned in different clinical situations. In this study, we examined agreement between PCCO and transcardiopulmonary thermodilution cardiac output (COTCP) ...
Tahvanainen Anna - - 2011
Nitrates may facilitate syncope through various pathways, but the precise mechanism of nitrate-induced syncope is still under debate. The purpose of the present study was to compare the underlying haemodynamic mechanisms in subjects without and with presyncopal symptoms during a nitroglycerin-stimulated tilt-table test. A major decrease in systemic vascular resistance ...
Mondritzki Thomas - - 2011
Arginine vasopressin (AVP) is increased in patients with heart failure (HF). Its actions are linked to free water reabsorption (V2-) and arteriolar vasoconstriction (V1a receptor). AVP can exacerbate the cardiorenal syndrome with excess fluid retention and afterload increase. Tolvaptan (TOL; selective V2 antagonist) and Conivaptan (CON; dual V1a/V2 antagonist) are ...
Champion Tatiana T Department of Animal Surgery and Clinical Sciences, Faculty of Agricultural and Veterinary Sciences (FCAV), São Paulo State University (UNESP), Via de Acesso Professor Paulo Donato Castellane, km 5, 14884-900 Jaboticabal, SP, - - 2011
The aim of this study was to evaluate the hemodynamic and acid-base status of dogs subjected to acute normovolemic anemia. The dogs (n = 10) were evaluated 15 minutes and 24 hours after induction of anemia (hematocrit below 18%) with blood withdrawal and simultaneously replacement of same volume of Ringer's ...
Wilson Thad E TE Institute for Neuromusculoskeletal Research, Ohio University, Athens, OH 45701, USA. - - 2011
Whole-body heating decreases pulmonary capillary wedge pressure and cerebral vascular conductance and causes an inotropic shift in the Frank-Starling curve. Whole-body cooling increases pulmonary capillary wedge pressure and cerebral vascular conductance without changing systolic function. These and other data indicate that factors affecting cardiac function may mechanistically contribute to syncope ...
Sugano Yasuo Y Department of Medicine, UC San Diego, VA San Diego Healthcare System, San Diego, CA 92161, - - 2011
Cardiac-directed adenylyl cyclase 6 (AC6) expression attenuates left ventricular (LV) hypertrophy and dysfunction in cardiomyopathy, but its effects in the pressure-overloaded heart are unknown. Mice with cardiac-directed and regulated expression of AC6 underwent transaortic constriction (TAC) to induce LV pressure overload. Ten days prior to TAC, and for the duration ...
Schulz André - - 2010
Stress may affect cardio-afferent neural traffic. We investigated whether acute autonomic stress has an impact on cardiac modulation of startle (CMS), a 'background' methodology for assessing baro-afferent signal transmission. Therefore, 38 healthy volunteers received acoustic startle stimuli (105dB) at 6 different latencies relative to the R-wave (R +0, 100, 200, ...
Bhuiyan Taslima - - 2011
ATTR cardiac amyloidosis can result from a mutated variant of transthyretin (eg, V122I) or wild-type variant (ATTRwt). We evaluated pressure-volume (PV) indices at baseline and over time to further characterize abnormal pump function in these subjects. Twenty-nine subjects (18 with ATTRwt and 11 with ATTRm (V122I) had 2-dimensional echocardiograms with ...
Kelly Rf - - 2010
Aims:  The purpose of this investigation was to determine the effects of flow mediated dilatation on arterial incremental elasticity (E(inc) ). Methods:  In 4 female anaesthetized pigs the iliac artery and vein were connected by a shunt with a variable resistance which allowed blood flow and therefore shear stress to ...
Namasivayam Mayooran - - 2011
Myocardial oxygen consumption is increased by arterial stiffening. It is not known precisely how. This study aimed to evaluate the role of the incident and reflected pressure wave in raising myocardial oxygen demand. Central (aortic) pressure waveforms were generated from radial waveforms using a generalized transfer function in 1628 cardiology ...
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