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Mizutani Tomohiro - - 2011
Human atrial natriuretic peptides and nitrite compounds (NC) are infused for the initial management of acute heart failure (HF). However, there have been few studies comparing their hemodynamic effects.Fifty-two patients in acute decompensated HF (ADHF) who received carperitide (0.07 ± 0.05 µg/kg/minute, n = 23, group C) or NC (0.39 ...
Iwamoto Yoichi - - 2011
The purpose of the present study was to determine the relationship of inferior vena cava diameter (IVCD) and its respirophasic variation (IVC collapsibility index: IVCCI) with central venous pressure (CVP), and thereby to provide reference cut-offs for such IVC parameters to estimate elevation in CVP in pediatric patients with cardiovascular ...
Trof Ronald J - - 2011
Static cardiac filling volumes have been suggested to better predict fluid responsiveness than filling pressures, but this may not apply to hearts with systolic dysfunction and dilatation. We evaluated the relative value of cardiac filling volume and pressures for predicting and monitoring fluid responsiveness, according to systolic cardiac function, estimated ...
Baldo Marcelo Perim - - 2011
To evaluate the effect of spironolactone on ventricular stiffness in spontaneously hypertensive adult rats subjected to high salt intake. High salt intake leads to cardiac hypertrophy, collagen accumulation and diastolic dysfunction. These effects are partially mediated by cardiac activation of the renin-angiotensin-aldosterone system. Male spontaneously hypertensive rats (SHRs, 32 weeks) ...
Gruenewald Matthias - - 2011
Continuous cardiac output monitoring is used for early detection of hemodynamic instability and guidance of therapy in critically ill patients. Recently, the accuracy of pulse contour-derived cardiac output (PCCO) has been questioned in different clinical situations. In this study, we examined agreement between PCCO and transcardiopulmonary thermodilution cardiac output (COTCP) ...
Tahvanainen Anna - - 2011
Nitrates may facilitate syncope through various pathways, but the precise mechanism of nitrate-induced syncope is still under debate. The purpose of the present study was to compare the underlying haemodynamic mechanisms in subjects without and with presyncopal symptoms during a nitroglycerin-stimulated tilt-table test. A major decrease in systemic vascular resistance ...
Mondritzki Thomas - - 2011
Arginine vasopressin (AVP) is increased in patients with heart failure (HF). Its actions are linked to free water reabsorption (V2-) and arteriolar vasoconstriction (V1a receptor). AVP can exacerbate the cardiorenal syndrome with excess fluid retention and afterload increase. Tolvaptan (TOL; selective V2 antagonist) and Conivaptan (CON; dual V1a/V2 antagonist) are ...
Champion Tatiana T Department of Animal Surgery and Clinical Sciences, Faculty of Agricultural and Veterinary Sciences (FCAV), São Paulo State University (UNESP), Via de Acesso Professor Paulo Donato Castellane, km 5, 14884-900 Jaboticabal, SP, - - 2011
The aim of this study was to evaluate the hemodynamic and acid-base status of dogs subjected to acute normovolemic anemia. The dogs (n = 10) were evaluated 15 minutes and 24 hours after induction of anemia (hematocrit below 18%) with blood withdrawal and simultaneously replacement of same volume of Ringer's ...
Wilson Thad E TE Institute for Neuromusculoskeletal Research, Ohio University, Athens, OH 45701, USA. - - 2011
Whole-body heating decreases pulmonary capillary wedge pressure and cerebral vascular conductance and causes an inotropic shift in the Frank-Starling curve. Whole-body cooling increases pulmonary capillary wedge pressure and cerebral vascular conductance without changing systolic function. These and other data indicate that factors affecting cardiac function may mechanistically contribute to syncope ...
Sugano Yasuo Y Department of Medicine, UC San Diego, VA San Diego Healthcare System, San Diego, CA 92161, - - 2011
Cardiac-directed adenylyl cyclase 6 (AC6) expression attenuates left ventricular (LV) hypertrophy and dysfunction in cardiomyopathy, but its effects in the pressure-overloaded heart are unknown. Mice with cardiac-directed and regulated expression of AC6 underwent transaortic constriction (TAC) to induce LV pressure overload. Ten days prior to TAC, and for the duration ...
Schulz André - - 2010
Stress may affect cardio-afferent neural traffic. We investigated whether acute autonomic stress has an impact on cardiac modulation of startle (CMS), a 'background' methodology for assessing baro-afferent signal transmission. Therefore, 38 healthy volunteers received acoustic startle stimuli (105dB) at 6 different latencies relative to the R-wave (R +0, 100, 200, ...
Bhuiyan Taslima - - 2011
ATTR cardiac amyloidosis can result from a mutated variant of transthyretin (eg, V122I) or wild-type variant (ATTRwt). We evaluated pressure-volume (PV) indices at baseline and over time to further characterize abnormal pump function in these subjects. Twenty-nine subjects (18 with ATTRwt and 11 with ATTRm (V122I) had 2-dimensional echocardiograms with ...
Kelly Rf - - 2010
Aims:  The purpose of this investigation was to determine the effects of flow mediated dilatation on arterial incremental elasticity (E(inc) ). Methods:  In 4 female anaesthetized pigs the iliac artery and vein were connected by a shunt with a variable resistance which allowed blood flow and therefore shear stress to ...
Namasivayam Mayooran - - 2011
Myocardial oxygen consumption is increased by arterial stiffening. It is not known precisely how. This study aimed to evaluate the role of the incident and reflected pressure wave in raising myocardial oxygen demand. Central (aortic) pressure waveforms were generated from radial waveforms using a generalized transfer function in 1628 cardiology ...
Kapur Navin K NK Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA. - - 2010
Progressive left ventricular (LV) dysfunction induces expression of the cytokine transforming growth factor-β1. Endoglin (CD105) is a transforming growth factor-β1 co-receptor that is released into the circulation as soluble endoglin (sEng). The objective of the present study was to assess the serum levels of sEng in patients with heart failure ...
Shi Yubing - - 2010
This paper investigates ventricular assist device (VAD)-assisted cardiovascular dynamics under proportion-integration-differentiation (PID) feedback control. Previously, we have studied the cardiovascular responses under the support of an in-series connected reciprocating-valve VAD through numerical simulation, and no feedback control was applied in the VAD. In this research, we explore the contribution of ...
de Leeuw Marcel A - - 2010
Background: Hemodynamic variables can theoretically be influenced by a combined psoas compartment-sciatic nerve block (CPCSNB) owing to a relatively high systemic absorption of local anesthetics and extended vasodilatation in the anesthetized limb (hemisympatectomy). In this study we assessed and documented hemodynamic changes during CPCSNB for elective orthopedic surgery. Methods: Twenty ...
Buckley Thomas - - 2011
Bereavement is associated with increased cardiovascular risk, particularly in surviving spouses and parents, however the mechanism is not well understood due to limited studies. The purpose of this study was to evaluate haemodynamic changes (blood pressure (BP) and heart rate (HR)), that may contribute to increased cardiac risk in early ...
Geelhoed J J Miranda - - 2011
Glucocorticoid receptor-9β polymorphism (rs6198) is associated with the susceptibility for cardiovascular disease. To examine whether the GR-9β variant is also associated with blood pressure and heart growth in early childhood. This study was embedded in a population-based prospective cohort study from fetal life onwards. Analyses were based on 857 children. ...
Iversen Nina K - - 2010
The Asian swamp eel (Monopterus albus) is an air-breathing teleost with very reduced gills that uses the buccal cavity for air-breathing. Here we characterise the cardiovascular changes associated with the intermittent breathing pattern in M. albus and we study the autonomic control of the heart during water- and air-breathing. The ...
Frithiof Robert - - 2011
Small volume hypertonic saline resuscitation can be beneficial for treating hemorrhagic shock, but the mechanism remains poorly defined. We investigated the effects of hemorrhagic resuscitation with hypertonic saline on cardiac (CSNA) and renal sympathetic nerve activity (RSNA) and the resulting cardiovascular consequences. Studies were performed on conscious sheep instrumented with ...
De Backer Daniel - - 2011
Second-generation FloTrac software has been shown to reliably measure cardiac output (CO) in cardiac surgical patients. However, concerns have been raised regarding its accuracy in vasoplegic states. The aim of the present multicenter study was to investigate the accuracy of the third-generation software in patients with sepsis, particularly when total ...
Kivikko Matti - - 2011
Abstract Objective. Levosimendan is indicated for acute heart failure. The formation of levosimendan's active metabolite OR-1896 is dependent on the acetylator status. We evaluated whether acetylator status affects the hemodynamic responses after levosimendan infusion. Methods. Forty-one NYHA III to IV heart failure patients were divided into rapid and slow acetylators ...
Hm Delnoy Peter Paul - - 2011
Pressure-Volume Loop Analyses during CRT Implants. Introduction: cardiac resynchronization therapy (CRT) may improve prognosis in patients with chronic right ventricular (RV) pacing, and optimal lead position can decrease nonresponders. We evaluated the clinical and echocardiographic response to CRT in patients with previous chronic RV pacing, using pressure-volume loop analyses to ...
Pereira de Souza Neto Edmundo - - 2011
A research area of increasing interest consists of studying the benefits of using spectral analysis to screen neurogenic erectile dysfunctions. Our hypothesis is that spectral analysis consists of a non-invasive and simple procedure to investigate such patients. Subjects were allocated into two groups: control, no erectile dysfunction (n = 17), ...
Takayama Narimasa - - 2011
Pronounced variability in blood pressure (BP) is an aggravating factor of hypertensive end-organ damage. However, its pathogenesis remains unknown. Statins have various protective effects on the cardiovascular system. Thus, we determined whether simvastatin would attenuate the aggravation of hypertensive cardiac remodeling in a rat model of hypertension with large BP ...
Pine J K - - 2010
Donation after cardiac death donation allows donor pool expansion. The period between withdrawal of treatment and donor a systole is extremely variable; its prolongation often results in unsuccessful organ procurement. We sought to assess a variety of donor variables to determine whether they predicted successful organ retrieval. We included all ...
Hattori T - - 2010
The role of histamine in the pathophysiology of irritable bowel syndrome (IBS) is largely unknown. Dysfunction of the autonomic nervous system (ANS) in IBS patients is also not fully confirmed. We hypothesized that blockade of histamine H₁ receptors affects ANS responses differently between IBS subjects and controls. Subjects were 12 ...
Sethi Sameer - - 2010
Blood pressure is a basic hemodynamic index often utilized to guide therapeutic interventions, especially in critically ill patients, patients with major vascular surgery or cardiac disorders. Ringing or resonance creates a potential for misdiagnosis and mismanagement. We have a simple solution to the ringing phenomenon.
Alan Nima - - 2010
Individuals with high spinal cord injury (SCI) are prone to significant fluctuation in blood pressure with episodes of very high and low blood pressure during autonomic dysreflexia (AD) and orthostatic hypotension, respectively. We do not know how such blood pressure lability affects the vasculature. We used a well-characterized animal model ...
Lang Irene M - - 2010
Pulmonary hypertension is defined as an increase in mean pulmonary arterial pressure ≥25 mm Hg at rest and occurs in a majority of patients with heart failure. Diagnostic imaging targets the right ventricle and the pulmonary vasculature. Although echocardiography is cost-effective for screening and follow-up, right heart catheterization is still ...
Chai Norin - - 2010
A 3-yr-old intact female snow leopard (Uncia uncia) was evaluated for progressive apathy, lethargy, and decreased appetite. Cardiac auscultation revealed a left basal grade IV/VI systolic ejection murmur, and an echocardiogram confirmed a severe pulmonic valvular stenosis (pressure gradient of 98 mm Hg). The lesion was managed by balloon valvuloplasty, ...
Suezawa Takanori - - 2010
We developed a new cardiopulmonary bypass (CPB) method to minimize myocardial damage during aortic arch reconstruction. In this method, coronary flow and heartbeat were stabilized by maintaining the aortic root pressure with an adjusted preload of the ventricle during aortic cross-clamping. This study was performed to determine the appropriate root ...
Heiss John D JD Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1414, USA. - - 2010
Craniocervical decompression for Chiari malformation Type I (CM-I) and syringomyelia has been reported to fail in 10%-40% of patients. The present prospective clinical study was designed to test the hypothesis that in cases in which syringomyelia persists after surgery, craniocervical decompression relieves neither the physiological block at the foramen magnum ...
Al-Hiti H - - 2011
In some patients, heart failure (HF) is associated with increased pulmonary vascular resistance (PVR). The magnitude and the reversibility of PVR elevation affect the HF management. Sildenafil has been recently recognized as potent PVR-lowering drug in HF. The aim of the study was to compare hemodynamic effects and pulmonary selectivity ...
Jain Samay S University of Pittsburgh School of Medicine, PA, USA. - - 2011
In Parkinson's disease (PD), neurodegenerative changes have been observed in autonomic pathways involving multiple organ systems. We explore pupillary and cardiac autonomic measures as physiological manifestations of PD neurodegeneration. Pupil measures (pupillary unrest (spontaneous changes of pupil diameter in darkness), constriction velocity and redilation velocity) were assessed in 35 participants ...
Kumar Gideon P - - 2011
Vascular support structures are important devices for treating valve stenosis. Large populations of patients are treated for valvular disease and the principal mode of treatment is the use of percutaneous valvuloplasty. Stent devices are proving to be imperative in minimally invasive cardiac surgery. This new technology provides highly effective results ...
Fernandes Rômulo Araújo - - 2011
To analyze the association between resting heart rate and blood pressure in male children and adolescents and to identify if this association is mediated by important confounders. Cross-sectional study carried out with 356 male children and adolescents from 8 to 18 years old. Resting heart rate was measured by a ...
Huaringa Armando J - - 2011
We performed this study to determine the pulmonary capillary permeability (PCP) measuring radiolabeled human serum albumin leakage into the lung. The objective was to use PCP to differentiate between cardiogenic and non-cardiogenic pulmonary edema etiologies. We conducted this study in 10 patients admitted to the intensive care unit who had ...
Kramer-Johansen Jo - - 2011
During manual chest compressions for cardiac arrest the waveforms of chest compressions are generally sinusoidal, whereas mechanical chest compression devices can have different waveforms, including trapezoidal. We studied the haemodynamic differences of such waveforms in a porcine model of cardiac arrest. Eight domestic pigs (weight 31±3kg) were anaesthetised and instrumented ...
Shibasaki Manabu - - 2011
An estimation of cardiac output can be obtained from arterial pressure waveforms using the Modelflow method. However, whether the assumptions associated with Modelflow calculations are accurate during whole body heating is unknown. This project tested the hypothesis that cardiac output obtained via Modelflow accurately tracks thermodilution-derived cardiac outputs during whole ...
Jagomägi Kersti - - 2011
Non-invasive beat-to-beat mean arterial pressure (MAP) in finger arteries recorded by the differential oscillometric device was compared with MAP recorded invasively from A. radialis in 22 patients after cardiac surgery. Based on all 132 paired measurements, the MAP values measured at the radial artery were 2.7 ± 4.9 mmHg higher than those measured ...
Odenbach Jeffrey J Department of Biochemistry, School of Molecular and Systems Medicine, University of Alberta, Edmonton, Alberta, - - 2011
Development of cardiovascular disease induced by excessive Gq protein-coupled receptor agonist stimulation depends on signaling networks involving multiple matrix metalloproteinases (MMPs) and metalloproteinase disintegrins (ADAMs). Here, we hypothesized that MMP-2, being a major gelatinase in cardiac and vascular tissue, was likely to play a key role in cardiovascular homeostasis. We ...
Gole Yoann - - 2011
Hyperoxia causes hemodynamic alterations. We hypothesized that cardiovascular and autonomic control changes last beyond the end of hyperoxic period into normoxia. Ten healthy volunteers were randomized to breathe either medical air or 100% oxygen for 45 min in a double-blind study design. Measurements were performed before (baseline) and during gas exposure, ...
del Paso Gustavo A Reyes - - 2010
Baroreceptor reflex sensitivity (BRS) is frequently evaluated using the spontaneous sequence method. Many of these studies use the inter-systolic interval (ISI) derived from a blood pressure monitor (e.g., Finapres) as interbeat interval measure instead of the traditionally recommended R-R series derived from the ECG. In this study, we examine possible ...
Kauling Ana Laura Colle AL Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil. - - 2010
Conscious sedation in the ambulatory setting albeit common is not risk-free. The present study aimed at evaluating the blood pressure, heart rate and peripheral oxygen saturation in patients submitted to conscious sedation for upper digestive endoscopy performed by endoscopists. A total of 105 patients of both sexes were selected, aged ...
Ohashi Yayoi Y Department of Anesthesia and Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Toronto, - - 2010
We compared hemodynamic profiles of healthy and mildly preeclamptic pregnant women at term, as well as those of non-pregnant controls, using a new non-invasive cardiac output monitor (NICOM) based on bio-reactance. We studied healthy term pregnant women at term (Preg, n = 10), mildly preeclamptic pregnant women at term (PregPE, ...
Li Zengyong - - 2011
The objective of this study is to assess the blood oxygenation oscillations in the tissue over the sacrum, a high risk area for pressure ulcer, using spectral analysis of near-infrared spectroscopy (NIRS) signals based on wavelet transform. A total of twenty subjects were recruited for this study, of which ten ...
Wyller Vegard Bruun VB Department of Pediatrics, Rikshospitalet University Hospital, 0027, Oslo, Norway. - - 2011
Hemodynamic abnormalities have been documented in the chronic fatigue syndrome (CFS), indicating functional disturbances of the autonomic nervous system responsible for cardiovascular regulation. The aim of this study was to explore blood pressure variability and closed-loop baroreflex function at rest and during mild orthostatic stress in adolescents with CFS. We ...
Sziegoleit W - - 2010
The influences of both being in a supine position for a prolonged period and food intake on cardiovascular variables were studied under clinical-pharmacological test conditions. In a randomized crossover design study without drug or placebo administration, 6 healthy male volunteers received a light standard meal before and during test A ...
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