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Shajari Hamideh - - 2011
Despite an increasing prevalence of obesity and hypertension in young age, there is limited information on the contribution of body mass index (BMI) to blood pressure (BP) in these populations, especially in developing countries. This study examines the association between BMI and BP in four populations of school age children ...
Friebe D - - 2011
Studies in adults identified the -803 G>A promoter polymorphism (rs3758539) in the RBP4 gene (RBP4) as a functional variant conferring an increased risk for obesity and type 2 diabetes.We genotyped this polymorphism in a cohort of 304 lean and 283 obese children to assess a potential association with early onset obesity ...
Engi Sheila A - - 2011
ABSTRACT: Cocaine and androgenic-anabolic steroids (AAS) abuse have become a serious public health problem. Despite reports of an increase in the incidence of simultaneous illicit use of these substances, potential toxic interactions between cocaine and AAS on the cardiovascular system are unknown. In the present study, we investigated the effect ...
Oikonen Mervi - - 2011
Clinical relevance of a genetic predisposition to elevated blood pressure was quantified during the transition from childhood to adulthood in a population-based Finnish cohort (N=2357). Blood pressure was measured at baseline in 1980 (age 3-18 years) and in follow-ups in 1983, 1986, 2001, and 2007. Thirteen single nucleotide polymorphisms associated ...
Büsst Cara J CJ Department of Physiology, University of Melbourne, Melbourne, Victoria, Australia. - - 2011
Variants in the gene encoding the γ-subunit of the epithelial sodium channel (SCNN1G) are associated with both Mendelian and quantitative effects on blood pressure. Here, in 4 cohorts of 1611 white European families composed of a total of 8199 individuals, we undertook staged testing of candidate single-nucleotide polymorphisms for SCNN1G ...
Ned Renée M - - 2011
BackgroundThe insertion/deletion (I/D) variant (rs4646994) of the angiotensin I-converting enzyme (ACE) gene is one of the most studied polymorphisms in relation to blood pressure and essential hypertension in humans. The evidence to date, however, on an association of this variant with blood pressure-related outcomes has been inconclusive.MethodsWe examined 5,561 participants ...
Konoshita Tadashi - - 2011
The concept of "pharmacogenomics" or "pharmacogenetics" promises to offer the ultimate in personalized medicine, and the renin-angiotensin system (RAS) is one of the most plausible candidates for the application of this approach in the area of hypertension. For the past two decades, genetic variants of the RAS have been tested ...
Faruque Mezbah U MU National Human Genome Center, Howard University College of Medicine, Washington, District of Columbia, - - 2011
Although an increasing number of hypertension-associated genetic variants is being reported, replication of these findings in independent studies has been challenging. Several genes in a human chromosome 1q linkage region have been reported to be associated with hypertension. We examined polymorphisms in three of these genes (ATP1B1, RGS5 and SELE) ...
Harari Raúl - - 2011
Traditional gold mining, using metallic mercury (Hg(0)) to form gold amalgam, followed by burning to remove the Hg(0), is widely used in South America, Africa and Asia. The gold is sold to merchants who burn it again to eliminate remaining Hg(0). In Ecuador, 200 gold miners, 37 gold merchants and ...
Wain Louise V LV Department of Health Sciences, University of Leicester, Leicester, - - 2011
Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P ...
Gu Wei - - 2011
No consensus has been reached on the association between the angiotensinogen gene polymorphism T174M and hypertension risk in the Chinese population. We conducted a meta-analysis to systematically pursue their possible association. Case-control studies in the Chinese and English publications were identified by searching the MEDLINE, EMBASE, CBM, CNKI, Wanfang and ...
Kim Jenny J JJ Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, - - 2012
Biomarkers that predict response or toxicity to antiangiogenic therapy are sought to favorably inform the risk/benefit ratio. This study evaluated the association of vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR2) genetic polymorphisms with the development of hypertension (HTN) and clinical outcome in metastatic clear cell renal cell ...
Goncharov Alexander F - - 2011
The phase diagram and polymorphism of oxygen at high pressures and temperatures are of great interest to condensed matter and earth science. X-ray diffraction and Raman spectroscopy of oxygen using laser and resistively heated diamond anvil cells reveal that the molecular high-pressure phase ɛ-O(2), which consists of (O(2))(4) clusters, reversibly ...
Chakraborty Raja - - 2011
Background: Waist circumference (WC) has been previously shown to be the most efficient measure to explain variability in body mass index (BMI) and percentage body fat (PBF) in Bengalee males, including those under study. Aim: The objective was to evaluate the relative usefulness of WC and its single suitable value, ...
Cheung Bernard M Y - - 2011
BackgroundInterleukin-6 (IL6) plays a central role in inflammation, insulin resistance, and atherogenesis. We investigated the associations of plasma IL6 and its genetic variants with hypertension in both cross-sectional and prospective study designs.MethodsPlasma IL6 was measured in 648 normotensive and 294 hypertensive subjects from the Hong Kong Cardiovascular Risk Factor Prevalence ...
Hirose Takuo - - 2011
Adrenomedullin 2/intermedin (AM2/IMD) is a novel vasodilator peptide with various effects on the renal function and cardiovascular system. An exonic insertion (I)/deletion (D) polymorphism (rs3840963) may influence generation of AM2/IMD-53, due to its location within the N-terminal sequence. We investigated the association of this polymorphism with blood pressure, renal function ...
Xi Bo - - 2011
The cytochrome P450 family 3 subfamily A polypeptide 5 (CYP3A5) gene has been implicated in the regulation of blood pressure (BP) and thus, may serve as a potential risk factor for the development of hypertension. However, current results regarding the association between CYP3A5 single nucleotide polymorphisms and BP/hypertension have been ...
Lupton Samantha J - - 2011
Cardiovascular diseases are the leading cause of death worldwide. Essential hypertension is a major risk factor for the development of other cardiovascular diseases and is caused by a combination of environmental and genetic factors, with up to 50% of blood pressure variance currently attributed to an individual's genetic makeup. By ...
Orun Oya - - 2011
Dopamine has been shown to influence blood pressure by regulating renal sodium excretion through direct interaction with the dopamine receptors, especially with the Dopamine D1 receptor (DRD1). To better understand the role of polymorphisms in those effects, we investigated the association between two polymorphic sites in the DRD1 promoter region ...
Firouzabadi Negar - - 2011
Most of renin-angiotensin system (RAS) gene polymorphisms have not yet been studied in the Iranian population. In the present study, the frequencies of common polymorphisms in the RAS genes, including angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and three single-nucleotide polymorphisms (SNPs), i.e., A-240T, T-93C and A2350G, angiotensinogen M235T, angiotensin II receptor ...
Shin Sung Joon - - 2011
Sodium sensitivity (SS) is a variable response of blood pressure (BP) to changes in sodium intake. The present study evaluated the existence and the characteristics of subjects with SS in Koreans. One hundred one subjects with (n = 31, 57.7 ± 9.8 yr) or without hypertension (n = 70, 40.8 ...
Borah Prasanta K - - 2011
Aims: Polymorphisms of genes encoding phase II metabolic enzymes, for example, glutathione S-transferase, have been linked with hypertension. The present study aimed at finding out the association between GSTM1 and GSTT1 polymorphism and hypertension in a population from North-East India. Materials and Methods: We carried out a case-control study in ...
Patel Y R - - 2011
Endothelium-dependent vasodilation is impaired in obese versus lean humans. We set out to evaluate whether agonist-mediated endothelium-dependent vasodilation varies by season in a cross-sectional dataset of lean and obese humans, and whether this effect differed by obesity status. All vascular studies performed in our laboratory over a 12year period from ...
Ward Mary - - 2011
Hypertension is a leading risk factor for cardiovascular disease (CVD) and stroke. A common polymorphism in the gene encoding the enzyme methylenetetrahydrofolate reductase (MTHFR), previously identified as the main genetic determinant of elevated homocysteine concentration and also recognized as a risk factor for CVD, appears to be independently associated with ...
Lin Rong - - 2011
Biliverdin reductase A (BLVRA) is a powerful intracellular antioxidant enzyme and an antagonist to insulin-mediated glucose uptake by the cells. Increased oxidative stress and insulin-resistance (IR) are associated with increased risk for hypertension. Therefore, we hypothesized that BLVRA might be attributable to the variation of susceptibility to essential hypertension, and ...
Inamo Jocelyn - - 2011
BACKGROUND AND PURPOSE: The epidemiological characteristics of hypertension and obesity in French Overseas Territories (FOTs) have never been compared. METHODS: This cross-sectional survey included representative population-based samples of 602, 601, 620 and 605 men and women aged more than 15 years, respectively, from four FOTs of Guadeloupe, Martinique, French Guiana, ...
Wang H - - 2011
Previous research has demonstrated that adipokines influence blood pressure (BP). Limited data exist in healthy adolescents, who are in a critical period for preventing the development of high BP. This study investigated the association of leptin, adiponectin and the leptin-to-adiponectin ratio (LAR) with BP in rural Chinese adolescents. This report ...
Han Yunfeng - - 2011
OBJECTIVES: Our purpose was to investigate whether with-no-K[Lys] kinase (WNK) 1 and WNK4 genetic polymorphisms are associated with both hypertension and diuretics response. DESIGN AND METHODS: Two WNK1 and one WNK4 polymorphisms were detected in two independent populations (n=1592 and 602) for association with hypertension, and in two clinical trials ...
Yaël Nossent A - - 2011
BackgroundWe hypothesized that single nucleotide polymorphisms (SNPs) located in microRNA (miR) binding sites in genes of the renin angiotensin aldosterone system (RAAS) can influence blood pressure and risk of myocardial infarction.MethodsUsing online databases dbSNP and TargetScan, we identified 10 SNPs in potential miR binding sites in eight RAAS-related genes, common ...
Goumidi Louisa - - 2011
BackgroundThyroid hormones (THs) exert multiple biological roles including effects on the cardiovascular system (lipid profile, blood pressure (BP) and cardiac output). The lipid-lowering actions of TH are mediated by the TH receptor-β whereas the mechanisms explaining the BP variations concomitant with the thyroid disorders are less understood. As the TH ...
Weil Brian R - - 2011
BackgroundEndothelial vasodilator dysfunction contributes to the development of hypertension (blood pressure (BP) ≥140/90 mm Hg) and cardiovascular disease (CVD). Prehypertension (BP 120-139/80-89 mm Hg) has recently been identified as an independent risk factor for hypertension and CVD. It is currently unclear whether BP in the prehypertensive range is associated with endothelial vasodilator ...
Miyaki K - - 2011
Genome-wide association studies have identified several polymorphisms that appear to be on hypertension-susceptible regions. We performed the current replication study in order to evaluate the association of these loci with hypertension in healthy Japanese males and then examined the combined effect of 12 independent variants. Overall, 735 Japanese men from ...
Ridderstråle Wilhelm - - 2011
The endogenous fibrinolytic system and the ability of the endothelium to release tissue-plasminogen activator (t-PA) play a pivotal role to protect humans from atherothrombotic events. We have recently reported that the decreased capacity for t-PA release in hypertension is restored with chronic blood pressure lowering. Thus, we explored if acute ...
Bujak Maciej - - 2011
Directional ClCl type I and II interactions govern the low-density aggregation of 1,1,2,2-tetrachloroethane molecules in synclinal conformation in the crystalline state at low temperature, whereas the dense molecular packing in high-pressure is achieved for the antiperiplanar conformers and electrostatically less favored ClCl contacts. The mechanism of transformation between loose and ...
Colzato Lorenza S - - 2011
BACKGROUND: The brain-derived neurotrophic factor (BDNF) is a key protein in maintaining neuronal integrity. The BDNF gene is thought to play an important role in the pathophysiology of mood and anxiety disorders. The aim of this study was to investigate, for the first time in a single study, the association ...
Zhao Qi Q Department of Epidemiology, Tulane University School of Medicine, New Orleans, LA, - - 2011
Rare mutations of the epithelial sodium channel (ENaC) lead to mendelian forms of salt-sensitive hypertension or salt-wasting hypotension. We aimed to examine the association between common variants in the ENaC genes and salt sensitivity of blood pressure (BP). A total of 1906 Han Chinese participated in the Genetic Epidemiology Network ...
Saedon Habiba - - 2011
We report the rare complication of anterior dislocation of a capsular tension ring (CTR) and a simple management option, with excellent results and no inflammatory or pressure-related sequelae. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.
Samir Arnaout M - - 2011
Abstract Background: The prevalence and clinical consequences of hypertension in countries in Africa and the Middle East have not been studied as well as in other regions. Scope: We have reviewed the literature on the epidemiology and management of hypertension and related cardiovascular complications in countries within Africa and the ...
Tobe Sheldon W - - 2011
An interaction between the endothelin-1 gene (EDN1), blood pressure (BP) and social determinants has been previously found. Using a well-characterized cohort of participants, the impact of associations between genetic factors and job strain on BP was evaluated. A cross-sectional analysis of five polymorphisms covering the EDN1, of which 2 were ...
Boonprasert Kanyarat - - 2011
The aims of the study were to investigate (i) the effects of environmental cadmium (Cd) on hypertension, biological markers of renal dysfunction and renal cytochrome P450-mediated arachidonate metabolism; and (ii) the association between genetic polymorphism of heme oxygenase-1 (HO-1) and hypertension and Cd-induced renal injury in the exposed Thai population. ...
Koh Hideo - - 2011
It is unclear which blood pressure (BP) components (that is, systolic BP (SBP), diastolic BP (DBP), pulse pressure (PP) and mean arterial pressure (MAP)) are superior predictors of chronic kidney disease (CKD). Furthermore it is unclear whether the combination of SBP+DBP or PP+MAP is superior to any of these four ...
Krum Henry - - 2011
Despite the considerable advances in the treatment of hypertension that have been made over the past few decades, adequate management and control of this condition remains poor, and efforts are ongoing to develop new strategies to improve related outcomes. Novel therapeutic approaches to the management of systemic hypertension fall into ...
Soto-Ruiz Karina M - - 2011
The delivery of supplemental oxygen is a critical part in the management of patients presenting with acute hypoxemia. While a number of delivery options are available, one of easiest and least invasive is the simple facemask or "Venturi" mask. Worldwide, these types of masks have been used for over 50 ...
Steiner John - - 2011
The author elaborates on Bion's (9961) description of "the numbing feeling of reality", to which the analyst may become susceptible in certain clinical situations; that is, the analyst may become preoccupied with the patient's reality and, under pressure of his morality, can become numbed to an awareness of the psychic ...
de Marco Kátia Cristina - - 2011
Nitric oxide (NO) is a potent vasodilator with multiple protective effects involved in the regulation of cardiovascular functions. Endothelial NO synthase (eNOS) gene polymorphisms and environmental factors, such as mercury (Hg) exposure, may influence NO levels and increase the risk of cardiovascular damage. The aim of this study was to ...
Townsend Raymond R - - 2011
Several noninvasive devices are now available to assess blood vessel structure and function and have been shown in longitudinal cohort studies to provide additional cardiovascular event prediction over that obtained by conventional brachial blood pressure (BP) measurements. Among these newer measurements are estimates of vascular stiffness (as determined by the ...
Thomas Christopher A - - 2011
To determine the efficacy and safety of labetalol for hypertensive crisis in children ≤ 24 months of age. Retrospective chart review. Statistical analysis utilized analysis of variance for continuous data, chi-square tests for nominal data, and linear regression. A 737-bed pediatric teaching institution. Twenty-seven patients ≤ 24 months of age ...
Ong Kwok-Leung - - 2011
Lipocalin-2 is recently recognized as a biomarker of obesity and inflammation, which are both risk factors for hypertension. We therefore investigated the association of common single nucleotide polymorphisms (SNPs) in the gene encoding lipocalin-2 (LCN2) with elevated blood pressure (BP) in Hong Kong Chinese. Five tagging SNPs were genotyped in ...
Gragnoli Claudia - - 2011
Chromosome 12q24 was recently associated with hypertension. Proteasome Modulator 9 (PSMD9) lies in the 12q24 locus and is in linkage with MODY3, type 2 diabetes (T2D), microvascular and macrovascular pathology, carpal tunnel syndrome, and hypercholesterolemia in Italian families. Our goal was to determine whether PSMD9 is linked to elevated blood ...
Citterio Lorena - - 2011
The importance of excess salt intake in the pathogenesis of hypertension is widely recognized. Blood pressure is controlled primarily by salt and water balance because of the infinite gain property of the kidney to rapidly eliminate excess fluid and salt. Up to fifty percent of patients with essential hypertension are ...
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