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Colzato Lorenza S - - 2011
BACKGROUND: The brain-derived neurotrophic factor (BDNF) is a key protein in maintaining neuronal integrity. The BDNF gene is thought to play an important role in the pathophysiology of mood and anxiety disorders. The aim of this study was to investigate, for the first time in a single study, the association ...
Zhao Qi - - 2011
Rare mutations of the epithelial sodium channel (ENaC) lead to mendelian forms of salt-sensitive hypertension or salt-wasting hypotension. We aimed to examine the association between common variants in the ENaC genes and salt sensitivity of blood pressure (BP). A total of 1906 Han Chinese participated in the Genetic Epidemiology Network ...
Saedon Habiba - - 2011
We report the rare complication of anterior dislocation of a capsular tension ring (CTR) and a simple management option, with excellent results and no inflammatory or pressure-related sequelae. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.
Samir Arnaout M - - 2011
Abstract Background: The prevalence and clinical consequences of hypertension in countries in Africa and the Middle East have not been studied as well as in other regions. Scope: We have reviewed the literature on the epidemiology and management of hypertension and related cardiovascular complications in countries within Africa and the ...
Tobe Sheldon W - - 2011
An interaction between the endothelin-1 gene (EDN1), blood pressure (BP) and social determinants has been previously found. Using a well-characterized cohort of participants, the impact of associations between genetic factors and job strain on BP was evaluated. A cross-sectional analysis of five polymorphisms covering the EDN1, of which 2 were ...
Boonprasert Kanyarat - - 2011
The aims of the study were to investigate (i) the effects of environmental cadmium (Cd) on hypertension, biological markers of renal dysfunction and renal cytochrome P450-mediated arachidonate metabolism; and (ii) the association between genetic polymorphism of heme oxygenase-1 (HO-1) and hypertension and Cd-induced renal injury in the exposed Thai population. ...
Koh Hideo - - 2011
It is unclear which blood pressure (BP) components (that is, systolic BP (SBP), diastolic BP (DBP), pulse pressure (PP) and mean arterial pressure (MAP)) are superior predictors of chronic kidney disease (CKD). Furthermore it is unclear whether the combination of SBP+DBP or PP+MAP is superior to any of these four ...
Krum Henry - - 2011
Despite the considerable advances in the treatment of hypertension that have been made over the past few decades, adequate management and control of this condition remains poor, and efforts are ongoing to develop new strategies to improve related outcomes. Novel therapeutic approaches to the management of systemic hypertension fall into ...
Soto-Ruiz Karina M - - 2011
The delivery of supplemental oxygen is a critical part in the management of patients presenting with acute hypoxemia. While a number of delivery options are available, one of easiest and least invasive is the simple facemask or "Venturi" mask. Worldwide, these types of masks have been used for over 50 ...
Steiner John - - 2011
The author elaborates on Bion's (9961) description of "the numbing feeling of reality", to which the analyst may become susceptible in certain clinical situations; that is, the analyst may become preoccupied with the patient's reality and, under pressure of his morality, can become numbed to an awareness of the psychic ...
de Marco Kátia Cristina - - 2011
Nitric oxide (NO) is a potent vasodilator with multiple protective effects involved in the regulation of cardiovascular functions. Endothelial NO synthase (eNOS) gene polymorphisms and environmental factors, such as mercury (Hg) exposure, may influence NO levels and increase the risk of cardiovascular damage. The aim of this study was to ...
Townsend Raymond R - - 2011
Several noninvasive devices are now available to assess blood vessel structure and function and have been shown in longitudinal cohort studies to provide additional cardiovascular event prediction over that obtained by conventional brachial blood pressure (BP) measurements. Among these newer measurements are estimates of vascular stiffness (as determined by the ...
Thomas Christopher A - - 2011
To determine the efficacy and safety of labetalol for hypertensive crisis in children ≤ 24 months of age. Retrospective chart review. Statistical analysis utilized analysis of variance for continuous data, chi-square tests for nominal data, and linear regression. A 737-bed pediatric teaching institution. Twenty-seven patients ≤ 24 months of age ...
Ong Kwok-Leung - - 2011
Lipocalin-2 is recently recognized as a biomarker of obesity and inflammation, which are both risk factors for hypertension. We therefore investigated the association of common single nucleotide polymorphisms (SNPs) in the gene encoding lipocalin-2 (LCN2) with elevated blood pressure (BP) in Hong Kong Chinese. Five tagging SNPs were genotyped in ...
Gragnoli Claudia - - 2011
Chromosome 12q24 was recently associated with hypertension. Proteasome Modulator 9 (PSMD9) lies in the 12q24 locus and is in linkage with MODY3, type 2 diabetes (T2D), microvascular and macrovascular pathology, carpal tunnel syndrome, and hypercholesterolemia in Italian families. Our goal was to determine whether PSMD9 is linked to elevated blood ...
Citterio Lorena - - 2011
The importance of excess salt intake in the pathogenesis of hypertension is widely recognized. Blood pressure is controlled primarily by salt and water balance because of the infinite gain property of the kidney to rapidly eliminate excess fluid and salt. Up to fifty percent of patients with essential hypertension are ...
Meetz Richard E - - 2011
In hypertensive crises, ocular findings are pivotal to making correct management decisions. Joint National Committee on Prevention, Detection, and Treatment of High Blood Pressure (JNC-7) guidelines define hypertensive crises as blood pressure greater than 180/120 mmHg associated with signs or symptoms of target organ damage. Urgent cases are those without ...
Shah Sachin A - - 2010
The effects of oral aloe vera on electrocardiographic and blood pressure measurements were evaluated. In this double-blind, placebo-controlled, crossover study, healthy volunteers over age 18 years received either 1200 mg of oral aloe vera powder or matching placebo on day 1 of the study and the treatment not received during ...
Parati Gianfranco G Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Italy. - - 2010
The aim of this meta-analysis was to compare the 24-h antihypertensive efficacy of different treatments using the smoothness index. Data were taken from the telmisartan ambulatory blood pressure monitoring (ABPM) clinical programme. Eleven clinical trials that randomized mild-to-moderate hypertensive patients to treatment with telmisartan 40/80 mg, losartan 50 mg, valsartan ...
Egert Sarah - - 2011
Our objective was to investigate the effect of quercetin supplementation on fasting resting energy expenditure (REE) and respiratory quotient (RQ) in humans. Six healthy, normal-weight women (mean age 25.5 ± 1.6 years, body mass index 21.4 ± 1.5 kg/m(2)) participated in a randomized, placebo-controlled, double-blinded crossover study. Treatments were administered as capsules of 150 mg quercetin (aglycone) ...
Kossaify Antoine - - 2010
We report on a 17-year-old female patient with anorexia nervosa (AN), who developed electrocardiographic abnormalities consisting of sinus arrest and junctional escape rhythm. She had complaints of general fatigue, lethargy, sweating, and nausea resulting from voluntary weight loss of more than 30 kg during the past six months. Her body ...
Drechsler A - - 2010
HISTORY AND ADMISSION FINDINGS: A 71-year-old patient with a superficial carcinoma of the urinary bladder and high risk of recurrence was treated with intravesical instillation of Bacillus Calmette-Guérin (BCG) after transurethral resection. As a complication of the catheterization during BCG-instillation therapy the patient suffered from tuberculosis. The patient received a ...
van den Bogaard Bas - - 2010
Flavanol-rich cocoa products have been reported to lower blood pressure. It has been suggested that theobromine is partially responsible for this effect. We tested whether consumption of flavanol-rich cocoa drinks with natural or added theobromine could lower peripheral and central blood pressure. In a double-blind, placebo-controlled 3-period crossover trial we ...
Jones-Burton Charlotte - - 2010
The renin inhibitor MK-8141 (ACT-077825) demonstrates substantial immunoreactive active renin (ir-AR) increase (sevenfold) without a persistent plasma renin activity (PRA) decrease. The present study assessed the antihypertensive efficacy of MK-8141 in hypertensive patients. In this double-blind, placebo- and active comparator-controlled study, 195 patients with hypertension (trough sitting diastolic blood pressure ...
Malekzadeh F - - 2010
Our objective was to investigate the effects and tolerability of fixed-dose combination therapy on blood pressure and LDL in adults without elevated blood pressure or lipid levels. This was a double-blind randomised placebo-controlled trial in residents of Kalaleh, Golestan, Iran. Following an 8-week placebo run-in period, 475 participants, aged 50 ...
Ried Karin - - 2010
To assess the effect, tolerability and acceptability of aged garlic extract as an adjunct treatment to existing antihypertensive medication in patients with treated, but uncontrolled, hypertension. A double-blind parallel randomised placebo-controlled trial involving 50 patients whose routine clinical records in general practice documented treated but uncontrolled hypertension. The active treatment ...
Kim Younmi - - 2010
This study evaluated how the Hypertension Disease Management Program (HDMP) affects patient's blood pressure, knowledge, health behaviors, and use of medical services. Evaluation was performed by 2 measures, which were before and after comparison within the management group (n = 210) and comparison between the management group and control group ...
Kario Kazuomi - - 2010
To study the impact of the dosing time of an angiotensin II receptor blocker (ARB) titrated by self-measured home blood pressure (HBP) on cardiorenal damage in hypertensives. We conducted an open-label multicenter trial, the J-TOP study, that enrolled 450 hypertensives with self-measured systolic HBP more than 135 mmHg. The study ...
Nakamura Tsukasa T Department of Medicine, Shinmatsudo Central General Hospital, Chiba, - - 2010
Blocking the renin-angiotensin system (RAS) with angiotensin receptor blockers or angiotensin-converting enzyme inhibitors protects against renal injury in patients with chronic kidney disease (CKD). The aim of this study was to compare the chronic effects of telmisartan and enalapril on proteinuria, urinary liver-type fatty acid-binding protein (L-FABP) and endothelin (ET)-1 ...
Ambrosioni Ettore - - 2010
INTRODUCTION: Systolic hypertension is very common in the elderly and is strongly associated with the risk of cardiovascular and cerebrovascular events. The control of systolic hypertension is difficult and most patients require combination antihypertensive therapy. Few data are available regarding the efficacy of angiotensin II receptor antagonists on systolic hypertension ...
Meng Yanyan - - 2010
OBJECTIVE: The objective of our study was to compare the effects of a combination therapy with amlodipine and fosinopril administered concomitantly or at different times on blood pressure and circadian blood pressure pattern in subjects with essential hypertension. METHODS: 40 subjects with grade 1-2 essential hypertension and uncontrolled blood pressure ...
Derosa Giuseppe - - 2010
Therapies that lower blood pressure or lipid levels slow the progression of atherosclerosis, and reduce morbidity and mortality in patients with hypertension or atherosclerotic disease. A combination tablet containing both amlodipine besylate and atorvastatin calcium has recently been approved for the treatment of hypertension and dyslipidemia in a growing number ...
Ahrens K - - 2010
Patients with moderate to severe hypertension frequently require>or=2 antihypertensives to achieve blood pressure (BP) control. The combination telmisartan/amlodipine is especially suitable for the treatment of severely hypertensive, high-risk patients, because it offers a substantial and sustained 24-h BP-lowering effect and is well tolerated in a range of patients with hypertension, ...
Judd Suzanne E - - 2010
Vitamin D has been reported to lower blood pressure in vivo by regulating the renin-angiotensin system; however, there are limited clinical studies to support this finding in humans. We investigated the effect of vitamin D treatment on hypertension in a three-arm randomized placebo controlled pilot and feasibility study. We tested ...
Boutouyrie Pierre - - 2010
The beta-blocker atenolol is less effective than angiotensin-receptor blockers and calcium-channel blockers for reducing central blood pressure (BP). The trial was designed to determine whether the advantages of angiotensin-receptor blockers over atenolol remained significant when both were combined with the calcium-channel blocker amlodipine. A prospective, randomized, blinded endpoint (PROBE design) ...
Hazan Lydie - - 2010
The current study investigated the efficacy and safety of olmesartan medoxomil in children with hypertension, defined as systolic blood pressure measured at or above the 95th percentile (90th percentile for patients with diabetes, glomerular kidney disease, or family history of hypertension) for age, gender, and height while off any antihypertensive ...
Lindauer A - - 2010
A pharmacokinetic/pharmacodynamic (PK/PD) study of the tyrosine kinase inhibitor sunitinib was conducted in 12 healthy volunteers using blood pressure and circulating biomarker levels as PD markers. Blood pressure was measured, and plasma concentration-time courses of sunitinib, its major metabolite SU12662, vascular endothelial growth factors VEGF-A and VEGF-C, and soluble VEGF ...
Kjeldsen Sverre E SE Department of Cardiology, Oslo University Hospital, Ullevaal, Oslo, Norway. - - 2010
Control of elevated blood pressure has been shown to reduce the risk of cardiovascular events. The angiotensin II receptor blocker (ARB), telmisartan, has been shown to provide effective 24-hour blood pressure control. Additional antihypertensive efficacy can be achieved by combining telmisartan with the thiazide diuretic hydrochlorothiazide (HCTZ). To review the ...
Komura Satoru - - 2010
The efficacy of antiarrhythmic drugs in terminating sustained monomorphic ventricular tachycardia (SMVT) was assessed in a retrospective manner to provide a basis for recommending their use. The 90 patients were included in this study to evaluate the efficacy to terminate SMVT using procainamide or lidocaine. All patients were alert and ...
Mehlsen Jesper - - 2011
Purpose:  Diabetic retinopathy is characterized by morphological changes in the retina secondary to disturbances in retinal blood flow. It has been shown that antihypertensive treatment has a protective effect on the development of diabetic retinopathy, and evidence suggests that inhibitors of the renin-angiotensin system have a protective effect beyond the ...
Yamada Hirotsugu - - 2010
BACKGROUND: Low-dose thiazide or thiazide-like diuretics have proven useful for the management of blood pressure in patients older than 65 years (elderly group). However, there are few reports about the antihypertensive effects of antihypertensive diuretic agents in patients younger than 65 years (middle-aged group). So, we evaluated the efficacy of ...
Abe M M Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan. - - 2010
We evaluated the changes in the blood pressure and urinary protein excretion in poorly controlled hypertensive and proteinuric patients with mild to moderate chronic kidney disease (CKD) after switching from the high-dose angiotensin receptor blockers (ARBs) to a combination of normal-dose telmisartan (40 mg) and low-dose hydrochlorothiazide (HCTZ; 12.5 mg). ...
Racine N - - 2010
The impact of an ARB, with or without hydrochlorothiazide (HCTZ), on glycaemic factors and the risk for developing diabetes in hypertensive patients with the metabolic syndrome have not been fully assessed. This was a 52-week multicentre, prospective, phase-IV, open-label, cohort study of losartan or losartan/HCTZ in hypertensive patients with metabolic ...
Jauhiainen T - - 2010
The milk casein-derived biologically active tripeptides, isoleucyl-prolyl-proline (Ile-Pro-Pro) and valyl-prolyl-proline (Val-Pro-Pro), have documented antihypertensive effect probably related to reduced angiotensin formation. It has been suggested that these tripeptides may reduce arterial stiffness and improve endothelial function. Our aim was to evaluate whether the milk-based drink containing Ile-Pro-Pro and Val-Pro-Pro influence ...
Nakamura Tsukasa - - 2010
INTRODUCTION: We examined the effects of 2 calcium channel blockers, benidipine (T-, L-, and N-type) and amlodipine (L- and N-type), on renal, inflammatory, oxidative, and atherosclerosis markers in hypertensive patients with mild chronic kidney disease (CKD). METHODS: Forty hypertensive patients with CKD were assigned randomly to either of the 2 ...
McFadden Kristina L - - 2010
Acupressure, a complementary and alternative medicine (CAM) treatment, uses fingertips, rather than needles, to stimulate acupoints on the skin and has been implicated as a successful treatment for a variety of medical disorders. However, acupressure's underlying mechanisms remain unclear. One theory is that acupoint stimulation modulates autonomic nervous system activity. ...
Modaghegh Mohammad-Hadi Saeed - - 2010
Using (Sequential) intermittent pneumatic compression (SIPC) is one of the most appropriate nonsurgical treatments for lymphoedema. In this study, we introduce a new mode for SIPC and evaluate its clinical results with higher pressures. Participants included 43 lower limb lymphoedema patients who underwent high pressure SIPC. Limb circumference pre- and ...
Zhao Xiuli - - 2010
The purpose of this study is to compare the effects and safety of azelnidipine and amlodipine in Chinese essential hypertensive patients. Patients were randomized to receive administration of azelnidipine 8-16 mg/day or amlodipine 2.5-5 mg/day for 8 weeks. The blood pressure and pulse rate were evaluated in an outpatient clinic ...
Miwa Yoshikazu - - 2010
Sustained proteinuria is an important risk factor for not only renal but also cardiovascular morbidity and mortality. Although inhibitors of the renin-angiotensin system (RAS) have been shown to reduce proteinuria. Monotherapy with those drugs is often insufficient for optimal blood pressure (BP)-lowering and therefore, combined therapy is needed. Recent reports ...
Fogari Roberto - - 2010
INTRODUCTION: The objective of this study was to compare the effect on ankle edema of adding valsartan (V) or olmesartan (O) to amlodipine (A) in the treatment of hypertension. METHODS: After a 4-week placebo period, 74 adult outpatients with essential hypertension (diastolic blood pressure [DBP] >90 and <110 mmHg, and ...
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