Search Results
Results 251 - 300 of 1270
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Dahlberg Suzanne E - - 2010
PURPOSE Bevacizumab is a monoclonal antibody that targets vascular endothelial growth factor (VEGF) with demonstrated efficacy in combination with carboplatin and paclitaxel (PCB) for the treatment of advanced non-small-cell lung cancer (NSCLC). Administration of bevacizumab is postulated to decrease nitric oxide synthesis and lead to hypertension, which may be a ...
Durán-Cantolla Joaquín - - 2010
To assess the effect of continuous positive airway pressure (CPAP) on 24 hour ambulatory blood pressure monitoring values in a large number of patients with untreated systemic hypertension of new onset and obstructive sleep apnoea. Multicentre, double blind, randomised, placebo controlled trial. Eleven general hospitals in Spain between 2004 and ...
Gasowski Jerzy - - 2010
BACKGROUND: Perindopril, a long-acting angiotensin converting enzyme-inhibitor, reduces incidence of cardiovascular end points in a wide range of patients. This effect depends on both the antihypertensive and blood pressure lowering unrelated effects. The aim of the study was to check the possible influence of patients' clinical profile on the antihypertensive ...
Carlsen Karen - - 2010
A 79-year-old Caucasian woman with rheumatoid arthritis (RA) for 27 years presented with a swelling on her left wrist. Both pain and a tingling sensation in the radial four fingers could be elicited by applying light pressure on the swelling. The patient was uncertain as to the actual onset of ...
Jafar Tazeen H - - 2010
To assess the effectiveness of a community based lifestyle intervention on blood pressure in children and young adults in a developing country setting. Cluster randomised controlled trial. 12 randomly selected geographical census based clusters in Karachi, Pakistan. 4023 people aged 5-39 years. Three monthly family based home health education delivered ...
Christiansen Buris - - 2010
Ingestion of glucosinolates has previously been reported to improve endothelial function in spontaneously hypertensive rats, possibly because of an increase in NO availability in the endothelium due to an attenuation of oxidative stress; in our study we tried to see if this also would be the case in humans suffering ...
Kramer C K - - 2010
Type 2 diabetes mellitus (T2DM) and hypertension frequently occur together. We examined whether blood pressure (BP) levels predict 8-year incident diabetes. Participants were community-dwelling older adults who had BP measured twice and an oral glucose tolerance test at baseline and again 8.3 years later. At baseline, participants were classified as ...
Solomon Scott D - - 2010
Diastolic dysfunction may precede development of heart failure in hypertensive patients. We randomized 228 patients with uncontrolled hypertension, preserved ejection fraction, and diastolic dysfunction to 2 targeted treatment strategies: intensive, with a systolic blood pressure target of <130 mm Hg, or standard, with a systolic blood pressure target of <140 ...
Bavry Anthony A - - 2010
Hypertension is a common risk factor for peripheral arterial disease (PAD). Guidelines suggest treating PAD patients to a blood pressure <130/80 mm Hg; therefore, our objective was to explore whether attainment of this target blood pressure is associated with improved outcomes. We performed a post hoc analysis of the INternational ...
Muntner Paul - - 2010
A low rate of blood pressure control has been reported in patients with chronic kidney disease (CKD). These data were derived from population-based samples with a low rate of CKD awareness. Cross-sectional. Data from the baseline visit of the Chronic Renal Insufficiency Cohort (CRIC) Study (n = 3,612) were analyzed. ...
Bergman Suzanne M - - 2009
BACKGROUND: Dialysis in patients with severe congestive heart failure and low blood pressure is difficult even in a hospital setting. We retrospectively recorded the effects and usefulness of an alpha (1) agonist in an outpatient dialysis unit in 5 patients with end-stage renal disease with symptomatic heart failure and low ...
Nakamura Teppei - - 2009
Pharmaceutical angiotensin-converting enzyme (ACE) inhibitors have been shown to reduce arterial stiffness; the possible effect of food-derived putative ACE inhibitory peptides on this degenerative process, however, has not been reported. In the present study, casein hydrolysate containing the lactotripeptides, Val-Pro-Pro (VPP) and Ile-Pro-Pro (IPP), which has been found to have ...
Svetkey Laura P - - 2009
Despite widely publicized hypertension treatment guidelines for physicians and lifestyle recommendations for patients, blood pressure control rates remain low. In community-based primary care clinics, we performed a nested, 2 x 2 randomized, controlled trial of physician intervention versus control and/or patient intervention versus control. Physician intervention included internet-based training, self-monitoring, ...
Beck Adam W - - 2010
Although technical success of renal artery stenting (RAS) is high and adverse events are infrequent, clinical success (improved blood pressure and renal function) and durability have been less predictable. Identifying those patients who will respond to RAS could improve overall outcomes of the procedure. This was a retrospective analysis of ...
Ito Sadayoshi - - 2010
This 12-week, multicenter, open-label study assessed the efficacy, pharmacokinetics and safety of a once-daily aliskiren in Japanese hypertensive patients with renal dysfunction. Patients (n=40, aged 20-80 years) with mean sitting diastolic blood pressure (msDBP) >or=95 and <110 mm Hg and serum creatinine between >or=1.3 and <3.0 mg per 100 ml ...
Haldar Arabinda - - 2009
Effects of Al, Mn and Sb dopings in CeFe(2) and the effect of applied pressure have been investigated. Al doping gives rise to the FM-AFM transition and a reduction in the magnetic moment and T(C) values, clearly indicating the growth of the AFM component. Mn and Sb dopings only cause ...
Jafar Tazeen H - - 2009
Despite convincing evidence that lowering blood pressure decreases cardiovascular morbidity and mortality, the hypertension burden remains high and control rates are poor in developing countries. To assess the effectiveness of 2 community-based interventions on blood pressure in hypertensive adults. Cluster randomized, 2 x 2 factorial, controlled trial. (ClinicalTrials.gov registration number: ...
Burney Basil O - - 2009
Many trials focused on cardiovascular outcomes demonstrate that reduction in blood pressure to levels below 140/90 mm Hg reduce cardiovascular events including stroke and myocardial infarction. There are very few such trials, however, in the elderly cohort, especially among those aged 70 and older. In the few outcome trials that ...
Witham Miles D - - 2009
OBJECTIVES: Vitamin D insufficiency has been linked to hypertension and cardiovascular events in observational studies. It is unclear whether vitamin D supplementation can reduce blood pressure, and, if so, by how much. METHODS: We performed a systematic review and meta-analysis to examine whether vitamin D reduces blood pressure. Databases including ...
Momo Kenji - - 2010
The aim of this study was to determine whether mexiletine, a CYP1A2 inhibitor, altered the pharmacokinetics and pharmacodynamics of tizanidine. The pharmacokinetics of tizanidine were examined in an open-label study in 12 healthy participants after a single dose of tizanidine (2 mg) with and without mexiletine coadministration (50 mg, 3 ...
Weber Michael A - - 2009
Hypertension cannot always be adequately controlled with available drugs. We investigated the blood-pressure-lowering effects of the new vasodilatory, selective endothelin type A antagonist, darusentan, in patients with treatment-resistant hypertension. This randomised, double-blind study was undertaken in 117 sites in North and South America, Europe, New Zealand, and Australia. 379 patients ...
Garland Emily M - - 2009
Supine hypertension is difficult to manage in patients with pure autonomic failure (PAF), because treatment can worsen orthostatic hypotension. Supine hypertension in PAF has been associated with left ventricular hypertrophy, but end organ damage in the kidney has not been assessed. We reviewed hemodynamic and laboratory data of 64 male ...
Zhang John - - 2009
This study was designed to evaluate the effects of a fruit and vegetable powder mix on cardiovascular health as determined by blood pressure and heart rate variability (HRV) in a chiropractic college faculty and student population. Forty subjects were recruited in the study via a schoolwide e-mail notification and through ...
Yang Y - - 2009
We have reported a Raman scattering investigation of bismuth ferrite (BiFeO(3)) under high pressure up to 50 GPa. Distinct changes in the Raman spectra show evidence for three pressure-induced structural transitions. The abrupt frequency redshifts of the Raman modes near 300 cm(-1) at around 3 GPa are attributed to the modulation of the ...
Higgins S - - 2010
BACKGROUND: A full consensus has not been reached about the hemodynamic efficacy of hydrocortisone administration in hypotensive and vasopressor-dependent preterm neonates. OBJECTIVE: To examine the efficacy of hydrocortisone for treatment of hypotension and reduction of vasopressor requirements in preterm infants. METHOD: Standard meta-analytic techniques, including random and fixed effects models, ...
Goldstein David S - - 2009
6-(18)F-fluorodopa PET depicts the striatal dopaminergic lesion characterizing Parkinson disease (PD); however, striatal uptake of 6-(18)F-fluorodopa-derived radioactivity can be normal. Supine hypertension (SH) might increase 6-(18)F-fluorodopa uptake. METHODS: We measured putamen, caudate, and occipital cortex 6-(18)F-fluorodopa-derived radioactivity and supine blood pressure in patients with PD + SH (systolic pressure >/= ...
Verdecchia Paolo - - 2009
BACKGROUND: The level to which systolic blood pressure should be controlled in hypertensive patients without diabetes remains unknown. We tested the hypothesis that tight control compared with usual control of systolic blood pressure would be beneficial in such patients. METHODS: In this randomised open-label trial undertaken in 44 centres in ...
Pereira Erlick A C - - 2010
Deep brain stimulators were implanted in the left periaqueductal gray matter (PAG) and sensory thalamus for right sided neuropathic facial pain refractory to other treatments in a man aged 58 years. PAG stimulation 8 months later acutely reduced systolic blood pressure by 25 mm Hg during revision surgery. One year ...
Lakhal Karim - - 2009
BACKGROUND: Arterial cannulation is strongly recommended during shock. Nevertheless, this procedure is associated with significant risks and may delay other emergent procedures. We assessed the discriminative power of brachial cuff oscillometric noninvasive blood pressure (NIBP) for identifying patients with an invasive mean arterial blood pressure (MAP) below 65 mm Hg ...
Agarwal Rajiv - - 2009
Patients with chronic kidney disease have less than expected decline in blood pressure during sleep (nondipping) and commonly experience the vexing symptom of nocturia. To better understand the relationship among nocturia, nighttime physical activity, and nondipping, we studied 98 patients with chronic kidney disease on 2 occasions, 1 month apart, ...
Tang Hsin-Yi Jean - - 2009
BACKGROUND: Stress management is one element of the lifestyle modification that is recommended for blood pressure control. Reduction in sympathetic arousal may be achieved through a series of audio relaxation training. AIMS: The purpose of this study was to evaluate the short-term and long-term effects of two audio relaxation programs ...
Yeh Lan Lan Liang - - 2009
OBJECTIVES: We previously reported pain intensity as the primary outcome of Four-Agents-Decoction (Si Wu Tang) for treating primary dysmenorrhea. We further explored other effects of this formula in accordance with the theory of Traditional Chinese Medicine on anemia-related hemogram parameters for "nourishing blood" and uterine artery pulsatility index (PI) for ...
Kim Sang-Hyun - - 2009
OBJECTIVE: This study was designed to compare the efficacy and tolerability of a new generic formulation of ramipril (test) and the branded formulation of ramipril (reference) to satisfy regulatory requirements for marketing of the generic product for use in Korean patients with mild to moderate hypertension. METHODS: This was an ...
Deinzer Anja - - 2009
The authors assessed whether patient empowerment in the management of hypertension improved more with the practice of shared decision making (SDM) than by education programs. In a prospective controlled clinical study, 15 general practitioners in Nuremberg, Germany who were specially trained to conduct SDM consultations participated in a 12-month study. ...
Lopez-Garcia Esther - - 2009
OBJECTIVES: To examine the association between self-reported sleep duration, prevalent and incident hypertension, and control of high blood pressure in older adults. DESIGN: Logistic regression models were used to investigate the associations of interest in a prospective cohort study conducted from 2001 to 2003. SETTING: Cohort representative of the noninstitutionalized ...
Chrysant Steven G - - 2009
This post hoc analysis of the Irbesartan/Hydrochlorothiazide (HCTZ) Blood Pressure Reductions in Diverse Patient Populations (INCLUSIVE) trial evaluated the efficacy and safety of fixed-dose irbesartan/HCTZ in patients with isolated systolic hypertension. Adults with uncontrolled systolic blood pressure (SBP) (140-179 mm Hg; 130-179 mm Hg in type 2 diabetes) after 4 ...
Kadonaga Yumi - - 2009
OBJECTIVE: To evaluate the effect of smoking initiation on annual changes in body weight, blood pressure, and blood biochemistry. METHODS: This study analyzed the results of annual health examinations from 1991 to 2005 in male Japanese workers. Subjects who started smoking (n=214) initially responded as non-smokers in a self-administered questionnaire ...
McRae Marc P - - 2009
Folic acid supplementation has been shown to be an effective agent for improving endothelial function, a prognostic factor for cardiovascular disease; but its effects on systolic and diastolic blood pressure in hypertensive individuals has been met with mixed results. Therefore, the purpose of this study was to provide a comprehensive ...
Zhang John - - 2009
Arterial hypertension is considered a major contributor to coronary arterial disease. The purpose of the study was to investigate the effects of Hans electrical stimulation of acupuncture points on blood pressure. Subjects with normal and elevated blood pressure were recruited and randomly assigned into control and experimental groups. Only the ...
Saladini Francesca - - 2009
The evolution of hypertension (HT) subtypes in young-to-middle-age subjects is unclear. We did a prospective study in 1,141 participants aged 18-45 years from the HARVEST study screened for stage 1 HT, and 101 nonhypertensive subjects of control during a median follow-up of 72.9 months. At baseline, 13.8% of the subjects ...
Dempsey E M - - 2009
INTRODUCTION: Many practitioners routinely treat infants whose mean arterial blood pressure in mm Hg is less than their gestational age in weeks (GA). OBJECTIVE: To assess the effectiveness of utilising a combined approach of clinical signs, metabolic acidosis and absolute blood pressure (BP) values when deciding to treat hypotension in ...
Adair C D - - 2009
OBJECTIVE: An endogenous digitalis-like factor (EDLF) has been implicated in the pathophysiology of preeclampsia (PE). This hypothesis is supported by two cases of preeclampsia in which administration of digoxin immune Fab (DIF) reduced mean arterial pressure (MAP). STUDY DESIGN: To study this observation further, we performed a double-blind, placebo-controlled, randomized ...
Chalmers J D - - 2009
BACKGROUND: The aim of this study was to identify key factors on admission predicting the development of complicated parapneumonic effusion or empyema in patients admitted with community-acquired pneumonia. METHODS: A prospective observational study of patients admitted with community-acquired pneumonia in NHS Lothian, UK, was conducted. Multivariate regression analyses were used ...
Wang Shu-Ming - - 2009
BACKGROUND/AIMS: Low mean arterial pressure (MAP) is associated with poor outcome in patients with cardiovascular disease; however, the prognostic role of MAP for chronic hemodialysis (HD) patients is unknown. This study was conducted to determine the association between MAP and mortality in chronic HD patients. METHODS: We prospectively analyzed all ...
Aguado Alba - - 2009
BACKGROUND: Information on hypertension in the very elderly is sparse. Until recently evidence of benefits from pharmacological treatment was inconclusive. We estimated the prevalence of hypertension in subjects aged 80 or more, the proportion of awareness, treatment and control. Explanatory variables associated with good control were also studied. METHODS: Cross ...
Musini Vijaya M - - 2009
Systematic reviews can often reveal much more than the original objective of the work. The objectives of this retrospective analysis were to answer three basic questions about blood pressure variability: 1) Does blood pressure entry criterion have an effect on baseline blood pressure variability? 2) Do thiazide diuretics have a ...
Nilsson Mats - - 2009
We evaluated the feasibility and quality of uncomplicated hypertension care based on telemedicine in a rural area of northern Sweden. The intervention subjects were 91 consecutive patients with primary hypertension. For comparison, 182 age- and sex-matched patients with hypertension were randomly selected from a similar health centre. The telemedicine equipment ...
Murphy A W - - 2009
To test the effectiveness of a complex intervention designed, within a theoretical framework, to improve outcomes for patients with coronary heart disease. Cluster randomised controlled multicentre trial. General practices in Northern Ireland and the Republic of Ireland, regions with different healthcare systems. 903 patients with established coronary heart disease registered ...
Gusmão Josiane Lima de - - 2009
The goal of antihypertensive treatment is to reduce blood pressure without interfering in health-related quality of life (HRQL) OBJECTIVE: This study aimed to assess the influence of hypertension control upon HRQL in hypertensive patients with and without complications. Seventy-seven hypertensive outpatients (71% women, 58% white, 60% with elementary school level ...
Keenan Katherine - - 2009
To determine the value of monitoring blood pressure by quantifying the probability that observed changes in blood pressure reflect true changes. Analysis of blood pressure measurements of patients in the perindopril protection against recurrent stroke study (PROGRESS). Randomised placebo controlled trial carried out in 172 centres in Asia, Australasia, and ...
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