Search Results
Results 201 - 250 of 1244
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Bell Katy J L - - 2010
Most clinicians monitor blood pressure to estimate a patient's response to blood pressure-lowering therapy. However, the apparent change may not actually reflect the effect of the treatment, because a person's blood pressure varies considerably even without the administration of drug therapy. We estimated random background within-person variation, apparent between-person variation, ...
McManus Richard J RJ Primary Care Clinical Sciences, University of Birmingham and National Institute for Health Research (NIHR) National School for Primary Care Research, Birmingham, UK. - - 2010
Control of blood pressure is a key component of cardiovascular disease prevention, but is difficult to achieve and until recently has been the sole preserve of health professionals. This study assessed whether self-management by people with poorly controlled hypertension resulted in better blood pressure control compared with usual care. This ...
Franklin Stanley S - - 2010
This post hoc analysis of a 7-week, randomized, double-blind trial evaluated the efficacy and safety of initial irbesartan/hydrochlorothiazide treatment in 468 patients with severe, uncontrolled, hypertension (diastolic blood pressure [DBP] > or =100 mm Hg) at high cardiovascular risk. Systolic blood pressure (SBP)/DBP reductions ranged from 28.0 to 42.9/22.9 to ...
Afsar Baris - - 2010
The relationship between 24-hour urinary albumin excretion (UAE) rate and the pattern of nondipping (isolated systolic nondipping, isolated diastolic nondipping, and both systolic and diastolic nondipping) is not known. Medical history, physical examination, laboratory analysis, and office and ambulatory blood pressure measurements were performed. Twenty-four hour urine specimens were collected ...
Earle Kenneth A - - 2010
BACKGROUND: Hypertension is a major risk factor for the long-term complications of diabetes. Mobile, self-measurement of blood pressure is emerging as a method to manage blood pressure in general, but its impact in patients with diabetes is unclear. METHODS: We randomized 137 patients with diabetes and hypertension to either mobile ...
Ogihara Toshio - - 2010
In this prospective, randomized, open-label, blinded end point study, we aimed to establish whether strict blood pressure control (<140 mm Hg) is superior to moderate blood pressure control (> or =140 mm Hg to <150 mm Hg) in reducing cardiovascular mortality and morbidity in elderly patients with isolated systolic hypertension. ...
Edelman David - - 2010
Group medical clinics (GMCs) are widely used in the management of diabetes and hypertension, but data on their effectiveness are limited. To test the effectiveness of GMCs in the management of comorbid diabetes and hypertension. Randomized, controlled trial. (ClinicalTrials.gov registration number: NCT00286741) 2 Veterans Affairs Medical Centers in North Carolina ...
Egan Brent M - - 2010
CONTEXT: Hypertension is a major risk factor for cardiovascular disease and treatment and control of hypertension reduces risk. The Healthy People 2010 goal was to achieve blood pressure (BP) control in 50% of the US population. OBJECTIVE: To assess progress in treating and controlling hypertension in the United States from ...
Turchin Alexander - - 2010
The relationship between encounter frequency (average number of provider-patient encounters over a period of time) and blood pressure for hypertensive patients is unknown. We tested the hypothesis that shorter encounter intervals are associated with faster blood pressure normalization. We performed a retrospective cohort study of 5042 hypertensive patients with diabetes ...
Ko-Ko-Zaw - - 2011
A study was performed among 4616 people aged 20 years and above in Yangon Division in 2003 to determine the prevalence of hypertension and its associated factors. The prevalence of hypertension (systolic blood pressure ≥140 mm Hg, diastolic blood pressure ≥90 mm Hg, or use of antihypertensive drugs) was 33.8% ...
Kaholokula Joseph Keawe'aimoku - - 2010
To examine the effects of perceived racism and acculturation on the hypertension status of Native Hawaiians. Cross-sectional data from 94 Native Hawaiian adults were obtained which included the following: 1) socio-demographic variables and self-reported hypertension status; 2) a 5-item Hawaiian cultural identity subscale (HCSS) and a 5-item American cultural identity ...
Ng Tze-Pin - - 2010
BACKGROUND: The relationships between blood pressure and depression are unclear. There are inconsistent reports of an association between low blood pressure and depressive symptoms. METHODS: In a population-based sample of 2611 Chinese older adults aged 55 years and above, including participants with treated (n=1088), untreated (n=545), or no hypertension (n=978), ...
Minns Alicia B - - 2011
Background: Salicylate poisoning is a common problem with appreciable morbidity and mortality. We present a case of a patient with a large aspirin ingestion who expired despite aggressive hemodialysis (HD). Case Report: A 35-year-old man arrived at the Emergency Department 7.5 h after ingesting 400 tablets of 325-mg aspirin. He ...
Baig Arshiya A - - 2010
To measure the effect of faith community nurse referrals versus telephone-assisted physician appointments on blood pressure control among persons with elevated blood pressure at health fairs. Randomized community-based intervention trial conducted from October 2006 to October 2007 of 100 adults who had an average blood pressure reading equal to or ...
Crews Deidra C - - 2010
Hypertension is both a cause and a consequence of chronic kidney disease, but the prevalence of chronic kidney disease throughout the diagnostic spectrum of blood pressure has not been established. We determined the prevalence of chronic kidney disease within blood pressure categories in 17 794 adults surveyed by the National ...
Vogt Liffert - - 2010
The urotensin system has been hypothesized to play an important role in the pathophysiology of diabetic nephropathy. In this multicenter, randomized, double-blind, placebo-controlled, 2-period crossover study, the effects of the urotensin receptor antagonist palosuran on urinary albumin excretion and blood pressure in hypertensive patients with type 2 diabetic nephropathy treated ...
- - 2010
There is no evidence from randomized trials to support a strategy of lowering systolic blood pressure below 135 to 140 mm Hg in persons with type 2 diabetes mellitus. We investigated whether therapy targeting normal systolic pressure (i.e., <120 mm Hg) reduces major cardiovascular events in participants with type 2 ...
Desch Steffen - - 2010
Dark chocolate may have blood pressure-lowering properties. We conducted a prospective randomized open-label blinded end-point design trial to study a potential dose dependency of the presumed antihypertensive effect of dark chocolate by directly comparing low vs. higher doses of dark chocolate over the course of 3 months. We enrolled a ...
Wallaert Matthew - - 2010
Research has begun to reveal the malleability of implicit prejudice. One measure of this construct, the race Implicit Association Test (IAT), represents a widely-used tool to assess individuals' positive and negative associations with different racial groups. In two studies, we demonstrate the capacity of salient pressures to alter implicit racial ...
Carter Barry L - - 2010
To assess blood pressure control after discontinuation of a physician-pharmacist collaborative intervention. Comparative analysis of data of the patients who received the intervention versus a control group from a prospective, cluster-randomized, 9-month efficacy trial and the same patients' data 18 and 27 months after completion of the trial, abstracted from ...
Ritzema Jay - - 2010
BACKGROUND: Previous studies suggest that management of ambulatory hemodynamics may improve outcomes in chronic heart failure. We conducted a prospective, observational, first-in-human study of a physician-directed patient self-management system targeting left atrial pressure. METHODS AND RESULTS: Forty patients with reduced or preserved left ventricular ejection fraction and a history of ...
Hartog Jasper W L - - 2010
To investigate the relationship between advanced glycation end-products (AGEs) and diastolic function and the response to blood pressure treatment in patients with hypertension and diastolic dysfunction. Data were analysed from 97 patients (aged 65 +/- 10 years, 36% male) who were randomly assigned to 6 months open-label treatment with either ...
- - 2010
OBJECTIVE: To determine the feasibility and acute (i.e., within 72 hrs) safety of three levels of systolic blood pressure reduction in subjects with supratentorial intracerebral hemorrhage treated within 6 hrs after symptom onset. DESIGN: A traditional phase I, dose-escalation, multicenter prospective study. SETTINGS: Emergency departments and intensive care units. PATIENTS: ...
Hollenberg Norman K - - 2010
The beneficial effects of flavonoid consumption on cardiovascular risk are supported by mechanistic and epidemiologic evidence. We aimed to systematically review the effectiveness of different flavonoid subclasses and flavonoid-rich food sources on cardiovascular disease (CVD) and risk factors-ie, lipoproteins, blood pressure, and flow-mediated dilatation (FMD). Methods included a structured search ...
Dahlberg Suzanne E - - 2010
PURPOSE Bevacizumab is a monoclonal antibody that targets vascular endothelial growth factor (VEGF) with demonstrated efficacy in combination with carboplatin and paclitaxel (PCB) for the treatment of advanced non-small-cell lung cancer (NSCLC). Administration of bevacizumab is postulated to decrease nitric oxide synthesis and lead to hypertension, which may be a ...
Durán-Cantolla Joaquín - - 2010
To assess the effect of continuous positive airway pressure (CPAP) on 24 hour ambulatory blood pressure monitoring values in a large number of patients with untreated systemic hypertension of new onset and obstructive sleep apnoea. Multicentre, double blind, randomised, placebo controlled trial. Eleven general hospitals in Spain between 2004 and ...
Gasowski Jerzy - - 2010
BACKGROUND: Perindopril, a long-acting angiotensin converting enzyme-inhibitor, reduces incidence of cardiovascular end points in a wide range of patients. This effect depends on both the antihypertensive and blood pressure lowering unrelated effects. The aim of the study was to check the possible influence of patients' clinical profile on the antihypertensive ...
Carlsen Karen - - 2010
A 79-year-old Caucasian woman with rheumatoid arthritis (RA) for 27 years presented with a swelling on her left wrist. Both pain and a tingling sensation in the radial four fingers could be elicited by applying light pressure on the swelling. The patient was uncertain as to the actual onset of ...
Jafar Tazeen H - - 2010
To assess the effectiveness of a community based lifestyle intervention on blood pressure in children and young adults in a developing country setting. Cluster randomised controlled trial. 12 randomly selected geographical census based clusters in Karachi, Pakistan. 4023 people aged 5-39 years. Three monthly family based home health education delivered ...
Christiansen Buris - - 2010
Ingestion of glucosinolates has previously been reported to improve endothelial function in spontaneously hypertensive rats, possibly because of an increase in NO availability in the endothelium due to an attenuation of oxidative stress; in our study we tried to see if this also would be the case in humans suffering ...
Kramer C K - - 2010
Type 2 diabetes mellitus (T2DM) and hypertension frequently occur together. We examined whether blood pressure (BP) levels predict 8-year incident diabetes. Participants were community-dwelling older adults who had BP measured twice and an oral glucose tolerance test at baseline and again 8.3 years later. At baseline, participants were classified as ...
Solomon Scott D - - 2010
Diastolic dysfunction may precede development of heart failure in hypertensive patients. We randomized 228 patients with uncontrolled hypertension, preserved ejection fraction, and diastolic dysfunction to 2 targeted treatment strategies: intensive, with a systolic blood pressure target of <130 mm Hg, or standard, with a systolic blood pressure target of <140 ...
Bavry Anthony A - - 2010
Hypertension is a common risk factor for peripheral arterial disease (PAD). Guidelines suggest treating PAD patients to a blood pressure <130/80 mm Hg; therefore, our objective was to explore whether attainment of this target blood pressure is associated with improved outcomes. We performed a post hoc analysis of the INternational ...
Muntner Paul - - 2010
A low rate of blood pressure control has been reported in patients with chronic kidney disease (CKD). These data were derived from population-based samples with a low rate of CKD awareness. Cross-sectional. Data from the baseline visit of the Chronic Renal Insufficiency Cohort (CRIC) Study (n = 3,612) were analyzed. ...
Bergman Suzanne M - - 2009
BACKGROUND: Dialysis in patients with severe congestive heart failure and low blood pressure is difficult even in a hospital setting. We retrospectively recorded the effects and usefulness of an alpha (1) agonist in an outpatient dialysis unit in 5 patients with end-stage renal disease with symptomatic heart failure and low ...
Nakamura Teppei - - 2009
Pharmaceutical angiotensin-converting enzyme (ACE) inhibitors have been shown to reduce arterial stiffness; the possible effect of food-derived putative ACE inhibitory peptides on this degenerative process, however, has not been reported. In the present study, casein hydrolysate containing the lactotripeptides, Val-Pro-Pro (VPP) and Ile-Pro-Pro (IPP), which has been found to have ...
Svetkey Laura P - - 2009
Despite widely publicized hypertension treatment guidelines for physicians and lifestyle recommendations for patients, blood pressure control rates remain low. In community-based primary care clinics, we performed a nested, 2 x 2 randomized, controlled trial of physician intervention versus control and/or patient intervention versus control. Physician intervention included internet-based training, self-monitoring, ...
Beck Adam W - - 2010
Although technical success of renal artery stenting (RAS) is high and adverse events are infrequent, clinical success (improved blood pressure and renal function) and durability have been less predictable. Identifying those patients who will respond to RAS could improve overall outcomes of the procedure. This was a retrospective analysis of ...
Ito Sadayoshi - - 2010
This 12-week, multicenter, open-label study assessed the efficacy, pharmacokinetics and safety of a once-daily aliskiren in Japanese hypertensive patients with renal dysfunction. Patients (n=40, aged 20-80 years) with mean sitting diastolic blood pressure (msDBP) >or=95 and <110 mm Hg and serum creatinine between >or=1.3 and <3.0 mg per 100 ml ...
Haldar Arabinda - - 2009
Effects of Al, Mn and Sb dopings in CeFe(2) and the effect of applied pressure have been investigated. Al doping gives rise to the FM-AFM transition and a reduction in the magnetic moment and T(C) values, clearly indicating the growth of the AFM component. Mn and Sb dopings only cause ...
Jafar Tazeen H - - 2009
Despite convincing evidence that lowering blood pressure decreases cardiovascular morbidity and mortality, the hypertension burden remains high and control rates are poor in developing countries. To assess the effectiveness of 2 community-based interventions on blood pressure in hypertensive adults. Cluster randomized, 2 x 2 factorial, controlled trial. (ClinicalTrials.gov registration number: ...
Burney Basil O - - 2009
Many trials focused on cardiovascular outcomes demonstrate that reduction in blood pressure to levels below 140/90 mm Hg reduce cardiovascular events including stroke and myocardial infarction. There are very few such trials, however, in the elderly cohort, especially among those aged 70 and older. In the few outcome trials that ...
Witham Miles D - - 2009
OBJECTIVES: Vitamin D insufficiency has been linked to hypertension and cardiovascular events in observational studies. It is unclear whether vitamin D supplementation can reduce blood pressure, and, if so, by how much. METHODS: We performed a systematic review and meta-analysis to examine whether vitamin D reduces blood pressure. Databases including ...
Momo Kenji - - 2010
The aim of this study was to determine whether mexiletine, a CYP1A2 inhibitor, altered the pharmacokinetics and pharmacodynamics of tizanidine. The pharmacokinetics of tizanidine were examined in an open-label study in 12 healthy participants after a single dose of tizanidine (2 mg) with and without mexiletine coadministration (50 mg, 3 ...
Weber Michael A - - 2009
Hypertension cannot always be adequately controlled with available drugs. We investigated the blood-pressure-lowering effects of the new vasodilatory, selective endothelin type A antagonist, darusentan, in patients with treatment-resistant hypertension. This randomised, double-blind study was undertaken in 117 sites in North and South America, Europe, New Zealand, and Australia. 379 patients ...
Garland Emily M - - 2009
Supine hypertension is difficult to manage in patients with pure autonomic failure (PAF), because treatment can worsen orthostatic hypotension. Supine hypertension in PAF has been associated with left ventricular hypertrophy, but end organ damage in the kidney has not been assessed. We reviewed hemodynamic and laboratory data of 64 male ...
Zhang John - - 2009
This study was designed to evaluate the effects of a fruit and vegetable powder mix on cardiovascular health as determined by blood pressure and heart rate variability (HRV) in a chiropractic college faculty and student population. Forty subjects were recruited in the study via a schoolwide e-mail notification and through ...
Yang Y - - 2009
We have reported a Raman scattering investigation of bismuth ferrite (BiFeO(3)) under high pressure up to 50 GPa. Distinct changes in the Raman spectra show evidence for three pressure-induced structural transitions. The abrupt frequency redshifts of the Raman modes near 300 cm(-1) at around 3 GPa are attributed to the modulation of the ...
Higgins S - - 2010
BACKGROUND: A full consensus has not been reached about the hemodynamic efficacy of hydrocortisone administration in hypotensive and vasopressor-dependent preterm neonates. OBJECTIVE: To examine the efficacy of hydrocortisone for treatment of hypotension and reduction of vasopressor requirements in preterm infants. METHOD: Standard meta-analytic techniques, including random and fixed effects models, ...
Goldstein David S - - 2009
6-(18)F-fluorodopa PET depicts the striatal dopaminergic lesion characterizing Parkinson disease (PD); however, striatal uptake of 6-(18)F-fluorodopa-derived radioactivity can be normal. Supine hypertension (SH) might increase 6-(18)F-fluorodopa uptake. METHODS: We measured putamen, caudate, and occipital cortex 6-(18)F-fluorodopa-derived radioactivity and supine blood pressure in patients with PD + SH (systolic pressure >/= ...
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