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Davis Jason T - - 2012
The purpose of this study is to better understand the origins and progression of pre-hypertension. Pre-hypertension is a risk factor for progression to hypertension, cardiovascular disease, and increased mortality. We used a cross-sectional twin study design to examine the role of heredity in likely pathophysiological events (autonomic or hemodynamic) in ...
van der Spoel Anna G E - - 2012
To compare the Nexfin cardiac output (CO) with the CO obtained from transthoracic Doppler echocardiography (TTE) during routine cardiac function screening. Observational clinical study. Echocardiography laboratory. 40 ASA physical status 1 and 2 patients scheduled for routine TTE examination. None. In 40 patients scheduled for routine TTE examination, we obtained ...
Rong Chang - - 2012
Objective-To identify cardiac mechanisms that contribute to adaptation to high altitudes in Tibetan antelope (Pantholops hodgsonii). Animals-9 male Tibetan antelope and 10 male Tibetan sheep (Ovis aries). Procedures-Tibetan antelope and Tibetan sheep inhabiting a region with an altitude of 4,300 m were captured, and several cardiac variables were measured. Expression ...
Nolan Jerry P - - 2012
The first description of modern cardiopulmonary resuscitation (CPR) included the instruction to compress the chest 'about 60 times per minute';(1) however, the optimal compression rate was unknown. Franz Koenig is credited with describing the original technique for external cardiac massage, which included a compression rate of 30-40min(1,2) But in the ...
Cannesson Maxime - - 2012
phenylephrine is used daily during anesthesia for treating hypotension. However, the effects of phenylephrine on cardiac output (CO) are not clear. We hypothesized that the impact of phenylephrine on cardiac output is related to preload dependency. eight pigs were studied at a preload independent stage (after CO augmentation) and at ...
Morais Lúcio Kenny - - 2012
To describe technical aspects of a new experimental model that simulates a non heart beating organ donor. Landrace pigs were operated on and cardiac arrest was obtained by means of myocardial infarction and interruption of ventilator support. Mean cardiac frequency, systolic and diastolic blood pressure levels, central venous pressure, oxygen ...
Algalarrondo Vincent - - 2012
Cardiac amyloidosis due to familial amyloid polyneuropathy (FAP) includes restrictive cardiomyopathy, thickened cardiac walls, conduction disorders and cardiac denervation. Impaired blood pressure variability has been documented in FAP related to the Val30Met mutation. To document blood pressure variability in FAP patients with various mutation types and its relationship to the ...
Johnson Christopher K - - 2012
Biventricular pacing (BiVP) improves cardiac output (CO) and mean arterial pressure (MAP) after cardiopulmonary bypass (CPB) in selected patients at risk for acute left heart failure after cardiac surgery. Optimization of atrioventricular delay (AVD) and interventricular delay (VVD) to maximize the hemodynamic effect of pacing requires rapid and accurate data ...
von Lueder Thomas G - - 2012
GRK3ct transgenic mice with cardiac-specific expression of a peptide inhibitor of GRK3 display myocardial hypercontractility without hypertrophy, and enhanced α(1)-adrenergic receptor (α(1)AR) signaling. A role for GRK3 in the pathogenesis of heart failure (HF) has not been investigated, but inhibition of its isozyme GRK2 has been beneficial in several HF ...
Wu Rongxue - - 2012
Hexokinase-II (HKII) is highly expressed in the heart and can bind to the mitochondrial outer membrane. Since cardiac hypertrophy is associated with a substrate switch from fatty acid to glucose, we hypothesized that a reduction in HKII would decrease cardiac hypertrophy after pressure overload. Contrary to our hypothesis, heterozygous HKII-deficient ...
Park Chang Sik - - 2012
Evidence has shown that endoplasmic reticulum stress (ERS) is associated with the pathogenesis of cardiac hypertrophy. The aim of this study was to investigate whether direct alleviation of ER stress by 4-phenylbutyric acid (PBA), a known chemical chaperone drug, could attenuate pressure-overload cardiac hypertrophy in mice. The effects of orally ...
Pedersen Lars M - - 2012
Cerebral oximetry reflects circulatory stability during surgery. We evaluated whether frontal lobe oxygenation is influenced by a transient increase in intrathoracic pressure as induced by a lung recruitment manoeuvre. Intrathoracic pressure was increased to 40 cm H(2) O for 20 s immediately after cardiac surgery in ten patients (age 64 ± 10 year, mean ± SD) with ...
Kanellakis Peter - - 2012
AIMS: The mechanisms underlying cardiac fibrosis in hypertension are yet to be defined although inflammatory cells, fibroblasts and cytokines have been implicated. Here we investigated the role of interleukin-4 (IL-4) in cardiac fibrosis which is elevated in the hypertensive heart. IL-4 has been shown to be profibrotic in liver and ...
Jagadish Mittur N - - 2012
In view of the enormous challenge and pressure on farmers to feed 9 billion plus people and billions of animals who are going to be living in our planet in 2050, new technologies must be invented, assessed and adapted. Farmer welfare and provision of resources required for their work is ...
Valverde Alexander - - 2012
The objective of this study was to determine the effects of the administration of a high volume of isotonic crystalloid at a rapid rate on cardiovascular function in normovolemic, isoflurane-anesthetized dogs during induced hypotension.Using a prospective study, 6 adult dogs were induced to general anesthesia and cardiovascular and hematological values ...
Weng Yi-Chun - - 2012
Cardiac hypertrophy is an important compensatory mechanism in response to a pressure overload, but a sustained excessive cardiac workload may deteriorate to maladaptive hypertrophy and to increased risk of heart failure. In this study, we evaluated the effects of KS370G on left ventricular hypertrophy and function. Abdominal aortic banding was ...
Rossi Valentina A - - 2012
AimsThe preliminary evidence supports an association between obstructive sleep apnoea (OSA), disturbed cardiac repolarization, and consequent cardiac dysrhythmias. The aim of the current trial was to assess the effects of continuous positive airway pressure (CPAP) therapy withdrawal on the measures of cardiac repolarization in patients with OSA.Methods and resultsForty-one OSA ...
Martin Tamara P TP Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow, - - 2012
Left ventricular pressure overload in response to aortic banding is an invaluable model for studying progression of cardiac hypertrophy and transition to heart failure. Traditional aortic banding has recently been superceded by minimally invasive transverse aortic banding (MTAB), which does not require ventilation so is less technically challenging. Although the ...
Kim Yu Chang - - 2012
This paper analyzes the influence of feed channel spacers on the performance of pressure retarded osmosis (PRO). Unlike forward osmosis (FO), an important feature of PRO is the application of hydraulic pressure on the high salinity (draw solution) side to retard the permeating flow for energy conversion. We report the ...
Ehara Toru - - 2012
PURPOSE: The α(2)-adrenergic receptor agonist dexmedetomidine reportedly weakens heart rate (HR) responses to 'rapid' (during a few seconds) reduction in arterial pressure, but does not affect HR responses to 'gradual' (during 60 s) reduction in arterial pressure. As the speed of neurotransmission along the parasympathetic nerve is relatively rapid, alteration of ...
Kordić Kresimir - - 2012
The aim of this study was to analyze hemodynamic changes in hypertensive and normotensive patients undergoing total hip or knee replacement in spinal and general anesthesia. Eighty patients who underwent total hip or knee replacement surgery in the period between July 2010 and February 2011 at Sveti Duh University Hospital ...
Haller Steven T - - 2012
Cardiotonic steroids (CTS) are implicated in pathophysiology of uremic cardiomyopathy. In the present study, we tested whether a monoclonal antibody (mAb) against the bufadienolide CTS, marinobufagenin (MBG), alleviates cardiac hypertrophy and fibrosis in partially nephrectomized (PNx) rats. In PNx rats, we compared the effects of 3E9 anti-MBG mAb and of ...
Lee Jennifer K JK Department of Pediatric Anesthesiology and Critical Care Medicine, Johns Hopkins University, Blalock 904, 600 N. Wolfe Street, Baltimore, MD 21287, USA. - - 2012
Cerebrovascular autoregulation after resuscitation has not been well studied in an experimental model of pediatric cardiac arrest. Furthermore, developing noninvasive methods of monitoring autoregulation using near-infrared spectroscopy (NIRS) would be clinically useful in guiding neuroprotective hemodynamic management after pediatric cardiac arrest. We tested the hypotheses that the lower limit of ...
De La Mora-González Juan F - - 2012
Dexmedetomidine has demonstrated to be useful in several clinical fields due to its respiratory safety and cardiovascular stability. We undertook this study to determine its usefulness in plastic surgery. Sixty patients were divided into two parallel groups. A group received dexmedetomidine--fentanyl and the comparison group received nalbuphine--propofol, both with same ...
Liao Wen-Hsiang - - 2012
This paper describes a new low-temperature process underlying the synthesis of highly transparent ultrananocrystalline diamond [UNCD] films by low-pressure and unheated microwave plasma jet-enhanced chemical vapor deposition with Ar-1%CH4-10%H2 gas chemistry. The unique low-pressure/low-temperature [LPLT] plasma jet-enhanced growth even with added H2 and unheated substrates yields UNCD films similar to ...
Xiao Jinfeng - - 2012
Epidermal growth factor (EGF), latrophilin and seven transmembrane domain-containing protein 1 (ELTD1) is developmentally upregulated in the heart. Little is known about the relationship between ELTD1 and cardiac diseases. Therefore, we aimed to clarify the role of ELTD1 in pressure overload-induced cardiac hypertrophy. C57BL/6J wild-type (WT) mice and ELTD1-knockout (KO) ...
Nicolosi Liliana - - 2012
The aim of this study was to determine changes in arterial pressure (AP) and heart rate (HR) during dental treatment under local infiltration anesthesia (LIA) in patients with controlled arterial hypertension (AHT) versus normotensive patients. A longitudinal comparative study involving repeated measurements in well-controlled hypertensive (cases) and normotensive patients (controls) ...
Stevenson David - - 2012
Cardiac elastances are highly invasive to measure directly, but are clinically useful due to the amount of information embedded in them. Information about the cardiac elastance, which can be used to estimate it, can be found in the downstream pressure waveforms of the aortic pressure (P(ao)) and the pulmonary artery ...
Pournajafian Alireza - - 2012
Intravenous opioids are administered to prevent and control hemodynamic changes due to endotracheal intubation. Except for special cases such as preeclampsia, these drugs are not recommended for parturants candidate for cesarean section because of the respiratory depression caused in the newborn. According to rapid metabolism of remifentanil, the current study ...
Hosseinzadeh Hamzeh H Department of Anesthesiology, Tabriz University of Medical Sciences, Tabriz, - - 2012
Emergence from general anesthesia and especially post-extubation phase are the stages associated with cardiovascular hyperdynamic status in which patients with increased intracranial pressure (ICP) could be affected by severe cardiac and or cerebral complications. Administering remifentanil could be helpful in maintaining the hemodynamic stability at the end of the surgery ...
Ebrahimi Dehkordi Masih M Department of Anesthesiology, Shahid Beheshti University of Medical Sciences, Tehran, - - 2012
Considering the growing trend of laryngeal surgeries and the need to protect the airway during and after surgery, among several therapeutic regimens to induce sedation, two regimens of propofol-fentanyl and propofol-midazolam were compared in microlaryngeal surgeries. Forty ASA I-II class patients undergoing microlaryngeal surgeries and referring routinely for postoperative visits ...
Tanaka Ryou R Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, - - 2012
Enalapril maleate, the oldest and most widely distributed ACEI, and alacepril, the newest and antioxidant ACEI, were compared in the point of cardioprotective effect for Dahl salt-sensitive rat. In order to evaluate the correlation between the three factors, cardiac fibrosis and blood pressure/oxidative-stress marker (tissue TBARS), index of correlation was ...
Barnes Jill N JN Human Integrative Physiology Laboratory, Department of Anesthesiology, Mayo Clinic, Rochester MN, - - 2012
The magnitude of decrease in blood pressure (BP) during a vasoactive drug bolus may be associated with the calculated baroreflex sensitivity (BRS). The purpose of the present study was to evaluate whether sympathetic and/or cardiac BRS relates to the extent of change in BP and whether this was altered by ...
Dorantes-Mendez Guadalupe G Dipartimento di Bioingegneria, Politecnico di Milano, Piazza Leonardo da Vinci, 23, 20133 Milan, Italy. - - 2012
This paper presents the analysis of autonomic nervous system (ANS) control of heart rate (HR) and of cardiac baroreflex sensitivity (BRS) in patients undergoing general anesthesia for major surgery through spectral analysis techniques and with the Granger causality approach that take into account the causal relationships between HR and arterial ...
Perni Stefano - - 2011
Ultra-high molecular weight polyethylene (UHMWPE) is frequently employed in joint replacements because of its high biocompatibility; however, this material does not exhibit particularly strong wear performance, thus potentially reducing the longevity of such devices. Numerous techniques have been investigated to increase the resistance to wear of UHMWPE, but they are ...
McKie Paul M - - 2011
The natriuretic peptides, specifically atrial natriuretic peptide (ANP), are increasingly recognized to play a fundamental role in blood pressure (BP) regulation. This role in BP regulation reflects the pluripotent cardiorenal actions of ANP, which include diuresis, enhancement of renal blood flow and glomerular filtration rate, systemic vasodilatation, suppression of aldosterone, ...
Brown Russell D - - 2011
Awareness of sex differences in the pathology of cardiovascular disease is increasing. Previously, we have shown a role for the angiotensin type 2 receptor (AT(2)R) in the sex differences in the arterial pressure response to Ang II. Tubuloglomerular feedback (TGF) contributes in setting pressure-natriuresis properties, and its responsiveness is closely ...
Gao Yuejuan - - 2011
The purpose of this study was to investigate the vascular effects of microbubble-enhanced pulsed high-pressure ultrasound on liver blood perfusion. In the presence of circulating lipid-shell microbubbles, a focused ultrasound transducer was used to transcutaneously treat eight livers of healthy rabbits for perfusion analysis and to treat three livers with ...
Saheki Akira - - 2011
We examined the effect of 0-20% back pressure, which functions as a resistance to emulsification in a high-pressure homogenizer, on emulsification of lipid nanodispersions (emulsion and liposomes) less than 100nm in diameter. Back pressure in the range of 0.9-3.8% of the emulsification pressure enhanced the emulsification, and the particle diameter ...
Schulz Emilia - - 2011
The third harmonic generated during femtosecond filamentation in air is studied. By establishing a gradient from atmospheric pressure to vacuum conditions, we truncate the filament abruptly at defined positions. The introduction of the pressure gradient leads to an enhancement of the generated third harmonic radiation by 3 orders of magnitude. ...
Yiannikouris Frederique F Graduate Center for Nutritional Sciences, Univ. of Kentucky, Lexington, KY 40536-0200, - - 2012
Previous studies demonstrated that overexpression of angiotensinogen (AGT) in adipose tissue increased blood pressure. However, the contribution of endogenous AGT in adipocytes to the systemic renin-angiotensin system (RAS) and blood pressure control is undefined. To define a role of adipocyte-derived AGT, mice with loxP sites flanking exon 2 of the ...
Smith Phillip P PP Department of Surgery, University of Connecticut Health Center, Farmington, Connecticut 06030, USA. - - 2012
Bladder compliance is one expression of the pressure and volume relationship as the bladder fills. In addition to passive elements, autonomous micromotional detrusor activity contributes to this relationship. In the mouse cystometric model, compliance pressure contributes to voiding expulsive pressure. During attempts to isolate the detrusor contractile component of this ...
Eswaraiah Varrla - - 2011
Ultra-thin graphene (UG) has been prepared by exfoliation of graphite oxide by a novel technique based on focused solar radiation. Graphene based engine oil nanofluids have been prepared and their frictional characteristics (FC), anti-wear (AW) and extreme pressure (EP) properties have been evaluated. The improvement in FC, AW and EP ...
Bondonno Catherine P - - 2011
Flavonoids and nitrates in fruits and vegetables may protect against cardiovascular disease. Dietary flavonoids and nitrates can augment nitric oxide status via distinct pathways, which may improve endothelial function and lower blood pressure. Recent studies suggest that the combination of flavonoids and nitrates can enhance nitric oxide production in the ...
Abdel-Zaher Ahmed O - - 2011
In this study, the effects of simvastatin on the blood pressure and on the antihypertensive activity of ramipril in hypertensive hypercholesterolemic animals and patients were evaluated. In hypertensive hypercholesterolemic animals, repeated administration of simvastatin slightly but significantly decreased the systolic blood pressure, enhanced its progressive reductions induced by repeated administration ...
Grande María T - - 2011
Gender differences in the incidence and severity of hypertension have suggested the involvement of a sex-dependent mechanism. Transgenic (Tg) mice overexpressing kidney androgen-regulated protein (KAP) specifically in kidney showed hypertension associated with oxidative stress. Reactive oxygen species (ROS) are strongly implicated in the pathological signaling leading to hypertension in a ...
Kim Kee-Bum - - 2011
The increase in hydrogen back pressure unexpectedly enhances the overall dehydrogenation reaction rate of the 4LiBH(4) + YH(3) composite significantly. Also, argon back pressure has a similar influence on the composite. Gas back pressure seems to enhance the dehydrogenation reaction by kinetically suppressing the formation of the diborane by-product.
Salcido Richard - - 2011
PURPOSE:: To enhance the learner's competence with information about heel pressure ulcers. TARGET AUDIENCE:: This continuing education activity is intended for physicians and nurses with an interest in skin and wound care. OBJECTIVES:: After participating in this educational activity, the participant should be better able to: ABSTRACT: The heel is ...
Fedorchenko A V - - 2011
The magnetic susceptibility χ of FeTe(x) compounds ([Formula: see text]) was studied under hydrostatic pressure up to 2 kbar at fixed temperatures of 55, 78 and 300 K. Measurements were taken both for polycrystalline and single crystalline samples. At ambient pressure, with decreasing temperature a drastic drop in χ(T) was confirmed at ...
Meighan Michelle M - - 2011
Electrokinetic supercharging (EKS) combines field-amplified sample injection with transient isotachophoresis (tITP) to create a powerful on-line preconcentration technique for capillary electrophoresis. In this work, EKS is enhanced with a positive pressure (pressure-assisted EKS, or PA-EKS) during injection to improve stacking of non-steroidal anti-inflammatory drugs (NSAIDs). Several parameters, including buffer composition ...
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