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Frishman William H WH Department of Medicine, New York Medical College, Valhalla, NY, 10595, USA, - - 2014
Resistant systemic hypertension in patients is defined as the inability to control blood pressure despite taking at least three antihypertensive drugs, one of which is a diuretic. Two nonpharmacologic approaches are being evaluated in resistant hypertensive patients. First, the Rheos® Baroreflex Hypertension Therapy system is an implantable device that activates ...
Yang Diya D Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing, - - 2014
Purpose. To examine the influence of experimentally reduced cerebrospinal fluid pressure (CSFP) on retinal nerve fiber layer (RNFL) thickness and neuroretinal rim area of the optic nerve head. Methods. The experimental study included 9 monkeys which underwent an implantation of a lumbar-peritoneal CSF shunt. In the study group (n= 4 ...
Kim Joong-Seok JS Department of Neurology, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, 505, Banpo-dong, Seocho-gu, Seoul, 137-701, South Korea, - - 2014
Cognitive dysfunction constitutes a major non-motor manifestation of Parkinson disease (PD), but the mechanisms remain incompletely understood. Neurocirculatory abnormalities such as supine hypertension (SH) and orthostatic hypotension (OH), white matter hyperintensities upon magnetic resonance imaging, and dementia are inter-related in PD, even in patients with early, levodopa-untreated disease. These abnormalities ...
Mathis Keisa W KW Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216-4505, - - 2014
One in every three adults in the United States has hypertension, and the underlying cause of most of these cases is unknown. Therefore, it is imperative to continue the study of mechanisms involved in the pathogenesis of hypertension. Decades ago, studies speculated that elements of an autoimmune response were associated ...
Godfrey G E P GE Department of Anaesthesia, Hillingdon Hospital, London, - - 2014
Current guidelines for intra-operative fluid management recommend the use of increments in stroke volume following intravenous fluid bolus administration as a guide to subsequent fluid therapy. To study the physiological premise of this paradigm, we tested the hypothesis that healthy, non-starved volunteers would develop an increment in their stroke volume ...
Prabhakaran Shyam - - 2014
This review focuses on the recommendations for management of hypertension, dyslipidemia, diabetes mellitus, diet, physical activity, and lifestyle choices commonly encountered in neurologic practice. Specific studies, including those relevant to lipid targets, blood pressure targets, and adherence to medications after stroke, are reviewed. In addition to traditional risk factors such ...
Sui Binbin B Radiology Department, Beijing Neurosurgical Institute, Affiliated Beijing Tiantan Hospital, Capital Medical University, Beijing, PR - - 2014
Histopathological studies have shown significant differences in plaque components and surface conditions between upstream and downstream of the stenosis. It can be deduced that the flow status near the plaques is different from the flow status at the upstream side, stenosis center, or downstream side of the plaque. To study ...
Swallow D M A DM University of Aberdeen, Aberdeen, - - 2014
Infusion tests are important tools to assess cerebrospinal fluid (CSF)dynamics used in the preoperative selection of patients for shunt surgery, or to predict the scope of improvement from shunt revision. The aim of this study was to assess the repeatability of the key quantitative parameters describing CSF dynamics that are ...
Niemuth Jennifer N JN College of Veterinary Medicine, North Carolina State University, Raleigh, NC, - - 2014
A 34-year-old western lowland gorilla presented with peracute blindness. Clinical evaluation, diagnostic imaging, laboratory analyses, blood pressure measurements, and necropsy were performed. The clinical and postmortem findings supported malignant hypertension. We describe a case of naturally occurring hypertensive encephalopathy and retinopathy in a gorilla.
Wang Ji-Hung JH Division of Cardiology, School of Medicine, Tzu Chi University, Hualien, Taiwan; Buddhist Tzu Chi General Hospital, School of Medicine, Tzu Chi University, Hualien, - - 2014
Osteoprotegerin (OPG) has been implicated in the process of vascular stiffness. The aim of this study was to evaluate the relationship between fasting serum OPG concentration and carotid-femoral pulse wave velocity (c-f PWV) in hypertensive patients. Fasting blood samples were obtained from 184 participants with or without hypertension. c-f PWV ...
Williams Michael A MA From The Sandra and Malcolm Berman Brain & Spine Institute, Adult Hydrocephalus Center, and Center for Gait and Mobility, Sinai Hospital of Baltimore, - - 2014
Idiopathic normal-pressure hydrocephalus (iNPH) is a reversible syndrome of gait impairment, dementia, and incontinence that affects persons over 65 years of age.(1) Currently, the only effective treatment is surgical implantation of a shunt(2); however, the need for pharmacologic adjunctive treatments was noted at the 2005 NIH workshop on hydrocephalus.(3.)
Yun Lin L Department of Cardiology, Qianfoshan Hospital of Shandong Province, Shandong - - 2014
The aim of this study was to evaluate the correlations between microalbuminuria (MAU) and endothelial function in hypertensive patients with carotid plaques (CP). A total of 71 hypertensive patients with CP (CP group) and 20 healthy people as normal controls (NC group) were enrolled in this study. The CP group ...
McClain Jonathon L JL Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, - - 2014
Hypertension causes cerebral artery remodeling and increases the risk of stroke. Renin angiotensin system blockade during the development of hypertension has therapeutic effects even after treatment withdrawal. Mineralocorticoid receptor (MR) activation has been implicated in artery remodeling and impaired endothelial function. The possibility that there is a critical therapeutic window ...
Pergola Pablo E PE Department of Medicine, University of Texas Health Sciences Center at San Antonio and Renal Associates PA, San Antonio, - - 2014
Lowering blood pressure (BP) after stroke remains a challenge, even in the context of clinical trials. The Secondary Prevention of Small Subcortical Strokes (SPS3) BP protocol, BP management during the study, and achieved BPs are described here. Patients with recent symptomatic lacunar stroke were randomized to 1 of 2 levels ...
Bath Philip M W PM Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham, - - 2014
High blood pressure is common during the acute phase of stroke and is associated with a poor outcome. However, the management of high blood pressure remains unclear. The 'Efficacy of Nitric Oxide in Stroke' trial tested whether transdermal glyceryl trinitrate, a nitric oxide donor that lowers blood pressure, is safe ...
Byrd James Brian JB Division of Cardiovascular Medicine, Department of Medicine, University of Michigan, 20-209W, North Campus Research Complex 2800 Plymouth Road, Ann Arbor, MI, 48109-2800, USA, - - 2014
The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) recommended a thiazide-like diuretic, alone or in combination with other antihypertensive drug classes, as initial therapy for hypertension. JNC 7, however, did not specify preferred combinations. The Avoiding Cardiovascular Events ...
Salma Asem A Department of Neurosurgery, Illinois Neurological Institute, University of Illinois College of Medicine at Peoria, 530 NE Glen Oak, Peoria, IL, 61637, USA, - - 2014
The theme of this paper is to outline that the genesis of normal pressure hydrocephalus (NPH) is governed by the intracranial pressure (ICP) homeostatic principle. The development of this new concept is based mainly on rethinking the well-known Monro-Kellie doctrine in the way that ICP homeostasis mechanism is not only ...
Fischer Urs U Stroke Prevention Research Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, - - 2014
It is often assumed that blood pressure increases acutely after major stroke, resulting in so-called post-stroke hypertension. In view of evidence that the risks and benefits of blood pressure-lowering treatment in acute stroke might differ between patients with major ischaemic stroke and those with primary intracerebral haemorrhage, we compared acute-phase ...
Tang Lingyan L aDepartment of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou bDepartment of Cardiology, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China *L.T. and T.X. contributed equally to this - - 2014
The purpose of this study was to evaluate the effect of hypertension and alcohol drinking on stroke incidence and whether alcohol drinking would increase the risk of stroke in hypertension participants among Inner Mongolians. A prospective cohort study from June 2003 to July 2012 was conducted among 2535 people aged ...
Wohlfahrt Peter P aCenter for Cardiovascular Prevention of the First Faculty of Medicine, Charles University and Thomayer Hospital, Prague bInternational Clinical Research Center, St Ann's University Hospital, Brno cDepartment of Preventive Cardiology, Institute for Clinical and Experimental Medicine, Prague d2nd Department of Internal Medicine, Charles University, Center for Hypertension, Pilsen, Czech Republic eDepartment of Pharmacology, Georges Pompidou European Hospital, INSERM U970 and Paris University Descartes, Paris, France fDepartment of Cardiology and Angiology, First Faculty of Medicine, Charles University, Prague, Czech - - 2014
Aortic stiffness is increased in lacunar stroke. The precise mechanism linking aortic stiffness to symptomatic lacunar stroke is not well understood. The aim of this study was to compare the effects of aortic stiffness, carotid stiffness, central blood pressure, and cerebrovascular resistance on carotid flow pulsatility according to stroke subtype. ...
Johnson Rebecca C RC University of California, San - - 2014
Patients with pulmonary hypertension associated with congenital heart disease survive longer with preserved right ventricular (RV) function compared to those with primary pulmonary hypertension. The purpose of this study was to test the hypothesis that superior RV performance can be demonstrated, at baseline and when challenged with increased RV afterload, ...
Mandraffino G G Department of Clinical and Experimental Medicine, University of Messina, Messina, - - 2014
We investigated whether different degrees of hypertension-related cardiovascular involvement are associated with changes in circulating proangiogenic hematopoietic cell (PHC) numbers and/or phenotypes and/or in the PHC redox system in hypertensive individuals with isolated arterial stiffening (AS) hypertensives or with both carotid intima-media thickening and left ventricular hypertrophy (LVH) hypertensives. We ...
Buratti Laura L Neurological Clinic, Marche Polytechnic University, Ancona, - - 2014
The aim of this study was to evaluate the relationship between arterial blood pressure (BP) variability during the acute phase and the 3-month outcome in ischemic stroke patients with internal carotid artery (ICA) occlusion. At least 10 BP measurements during the first 48h after stroke onset were obtained in 89 ...
Powers William J WJ From the Department of Neurology (W.J.P.), University of North Carolina School of Medicine, Chapel Hill; Clinical Trials Statistics and Data Management Center (W.R.C.), University of Iowa College of Public Health, Iowa City; Departments of Neurological Surgery (R.L.G., C.P.D.), Radiology (R.L.G., T.O.V., C.P.D.), and Neurology (T.O.V., C.P.D.), Washington University School of Medicine, St. Louis, MO; and the Department of Neurology (H.P.A.), University of Iowa Carver School of Medicine, Iowa - - 2014
To determine whether strict blood pressure (BP) control is the best medical management for patients with symptomatic carotid artery occlusion and hemodynamic cerebral ischemia. In this prospective observational cohort study, we analyzed data from 91 participants in the nonsurgical group of the Carotid Occlusion Surgery Study (COSS) who had recent ...
Gottesman Rebecca F RF From the Department of Neurology (R.F.G.), Johns Hopkins University School of Medicine, Baltimore, MD; and The George Institute for Global Health (J.C.), Sydney, - - 2014
Classical neurologic teaching suggests that a higher cerebral systemic blood pressure (BP) be targeted for individuals with occlusive carotid disease, in order to improve cerebral perfusion through collaterals. This conflicts, however, with observational, population-based studies and clinical trials supporting better outcomes associated with lower BPs. In this issue of Neurology®, ...
Hart Michael Gavin MG Academic Division of Neurosurgery, Departments of Clinical Neurosciences and Neurosurgery, Addenbrooke's Hospital, Cambridge, - - 2014
Introduction: Slit ventricle syndrome remains a complex entity presenting a considerable challenge to treat successfully. This study aims to demonstrate the application of dual intracranial pressure (ICP) and infusion studies together with the novel shunt occlusion test in both a diagnostic and therapeutic role. Case Report: An 8-year-old child had ...
Rosa J J 1] 3rd Department of Medicine, Centre for Hypertension, General University Hospital, First Faculty of Medicine, Charles University, Prague, Czech Republic [2] Cardiocentre, Third Faculty of Medicine, Charles University, Prague, Czech - - 2014
Catheter-based renal denervation (RD) has been introduced recently as a potentially effective invasive treatment of refractory hypertension. The proportion of patients with severe hypertension suitable for RD is not clear. The aim of this study was to identify what percentage of patients has truly resistant essential hypertension and are thus ...
Kim Joosup J aStroke and Ageing Research Unit 2, Department of Medicine, Southern Clinical School, Monash University, Melbourne bMenzies Research Institute Tasmania, University of Tasmania, Hobart cFlorey Neuroscience Institutes, Heidelberg, Victoria, - - 2014
Lowering blood pressure after stroke reduces the risk of recurrent stroke and other vascular events. However, there is recent evidence that low blood pressure may also result in poor outcome. For the first time, this study aimed to investigate the relationship between blood pressure and outcome in long-term survivors of ...
Stea Francesco F aInternal Medicine Department, Pisa University bIstituto di Fisiologia Clinica Consiglio Nazionale delle Ricerche, Pisa, Italy cInserm U970, Université Paris Descartes, Assistance Publique hôpitaux de Paris, Paris dPulse Wave Consulting, Saint Leu la Foret, - - 2014
The Complior device (Alam Medical, France) was used in epidemiological studies which established pulse wave velocity (PWV) as a cardiovascular risk marker. Central pressure is related, but complementary to PWV and also associated to cardiovascular outcomes. The new Complior Analyse measures both PWV and central blood pressure during the same ...
Faul John J Asthma Research Center, BCF Diagnostics, Connolly Hospital Blanchardstown, Dublin, Ireland. Electronic address: - - 2014
Vasodilators are used with caution in patients with chronic obstructive pulmonary disease (COPD). We have developed a device for percutaneous arteriovenous shunt creation in the iliac region to increase cardiac output and oxygen delivery for patients with COPD. Although this device does not cause significant blood pressure changes in normotensive ...
Judd E E Vascular Biology and Hypertension Program, University of Alabama at Birmingham, Birmingham, AL, - - 2014
Resistant hypertension, defined as blood pressure (BP) remaining above goal despite the use of 3 antihypertensive medications at maximally tolerated doses (one ideally being a diuretic) or BP that requires 4 agents to achieve control, has received more attention with increased efforts to improve BP control rates and the emergence ...
Chen Yequn Y aThe First Affiliated Hospital bCardiovascular Research Center, Shantou University Medical College, Shantou, Guangdong, - - 2014
End-stage renal disease (ESRD) is complicated by high blood pressure (BP) and severe atherosclerosis, which may lead to different values of BP measured by invasive and noninvasive methods. However, the differences in BP values between these two methods and their possible mechanisms in ESRD have not been investigated. Forty-one ESRD ...
Kwon Hyung-Min - - 2014
Abnormalities in nocturnal blood pressure dipping are well known for its relationship to cardiovascular diseases. Cerebral microbleeds are frequently observed in patients with hypertension and are known to be potent risk factors for stroke. However, there are scanty reports about the relationship between nocturnal dipping and cerebral microbleeds. We recruited ...
Limberg Jacqueline K JK 1 Mayo Clinic, United - - 2014
Activation of the carotid body chemoreceptors with hypoxia alters baroreceptor mediated responses. We aimed to examine whether this relationship can be translated to other chemoreceptor stimuli (i.e. hypoglycaemia) and hypothesized: 1) activation of the carotid body chemoreceptors with hypoglycaemia would reduce spontaneous cardiac baroreflex sensitivity (sCBRS) in healthy humans and, ...
Chari Aswin A Department of Neurosurgery, Cambridge University Hospital National Health Service Trust, Cambridge, United - - 2014
Object The Cambridge Shunt Evaluation Laboratory was established 20 years ago. This paper summarizes the findings of that laboratory for the clinician. Methods Twenty-six models of valves have been tested long-term in the shunt laboratory according to the expanded International Organization for Standardization 7197 standard protocol. Results The majority of ...
Cherpanath Thomas Gv TG Department of Intensive Care Medicine, Academic Medical Centre, Amsterdam, The - - 2014
The present study examined the relationship between centrally measured stroke volume variation (SVV) and peripherally derived pulse pressure variation (PPV) in the setting of increased total arterial compliance (CA rt ). Ten male Wistar rats were anaesthetized, paralysed and mechanically ventilated before being randomized to receive intrapulmonary lipopolysaccharide (LPS) or ...
Chen Jer-Ming JM School of Physics, The University of New South Wales, Sydney New South Wales 2052, - - 2014
Horn players have observed that timpani strokes can interfere disruptively with their playing, especially when they are seated close to the timpani. Measuring the horn's transfer function in the bell-to-mouthpiece direction reveals that the horn behaves as an acoustic impedance matching device, capable of transmitting waves with pressure gains of ...
Prabhakar Puttachandra P Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, - - 2014
Background. Hypertension is an established risk factor for small-vessel cerebral stroke and the renin-angiotensin system plays an important role in the maintenance of blood pressure. We aimed at evaluating the contribution of the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism to the risk of small-vessel stroke in south Indian population. ...
David Melissa M Clinical Research Branch, National Institute of - - 2014
Carotid-femoral pulse wave velocity is considered the gold standard for measurements of central arterial stiffness obtained through noninvasive methods(1). Subjects are placed in the supine position and allowed to rest quietly for at least 10 min prior to the start of the exam. The proper cuff size is selected and a ...
Sakima Hirokuni H Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus Graduate School of - - 2014
An 82-year-old man had a transient ischemic attack (TIA) with symptoms of consciousness disturbance and right hemiparesis while resting in a sitting position after breakfast. His symptoms improved around 1 h after onset when he lied in a supine position and received intravenous hydration. Duplex carotid ultrasonography revealed severe stenosis ...
Xiong Huahua H Department of Ultrasound, The Second Peoples' Hospital of Shenzhen, Shenzhen 518029, - - 2014
Large blood pressure variability (BPV) will not only harm the target organ but also increase the possibility of the cardiovascular events. Since the damage of vascular system always leads to the alteration of the carotid wall, the structure and function of the carotid artery have been extensively examined in previous ...
Zoellner Jamie J Virginia Tech, Department of Human Nutrition, Foods and Exercise, Integrated Life Sciences Building 23, Room 1034 (0913), 1981 Kraft Dr, Blacksburg, VA 24061. E-mail: - - 2014
Effective strategies are needed to reach and treat people who lack awareness of or have uncontrolled hypertension. We used data from a community-based participatory research initiative, Hub City Steps, to quantify the prevalence of undiagnosed hypertension and determine the relationship between hypertension status at baseline and postintervention improvements in blood ...
Pachatouridis Dimitrios D Department of Neurosurgery, University Hospital of Ioannina, P.O. Box 103, Neohoropoulo, 45500 Ioannina, - - 2013
Background. The aim of the present study was to assess the value of electromagnetic programmable shunt valves for the treatment of subdural collections. Methods. Adult patients with hydrocephalus of various causes that were treated with programmable shunt valves during the last ten years were retrospectively studied. In 127 patients, 139 ...
Lin Wenhua W Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing Street, Sha Tin, Hong Kong Special Administrative - - 2013
External counterpulsation (ECP) is a noninvasive method used to augment cerebral perfusion but the optimal use of ECP in ischemic stroke has not been well documented. We aimed to investigate the effects of ECP treatment pressure on cerebral blood flow and blood pressure (BP). We recruited 38 ischemic stroke patients ...
Kwater A - - 2013
The current study aims to check the relationship between parameters derived from brachial blood pressure, the carotid artery intima-media thickness (IMT), pulse wave velocity (PWV) and mean cerebral blood flow velocity (mCBFV) in the middle cerebral artery (MCA). In consecutive adult outpatients we recorded the brachial systolic blood pressure (SBP), ...
Hoshide Satoshi - - 2013
Early morning hypertension has attracted more attention because of the close relationship between blood pressure levels in the early morning and cardiovascular risk. However, there are some unsolved issues on early morning hypertension. First, is early morning hypertension more special than other hypertension evaluated by other blood pressure indices? Second, ...
Liu Zhendong - - 2013
To investigate variability in self-measured home blood pressure (HBP) and its effects on carotid artery atherosclerosis and endothelial function in normotensive and mild-moderate hypertensive individuals. This is a cross-sectional study. HBP monitoring over 7 consecutive days, carotid artery ultrasound, and brachial artery flow-mediated dilation (FMD) were performed in 314 normotensive, ...
Arora Alok - - 2013
Idiopathic intracranial hypertension is a disorder of increased intracranial pressure of unknown cause. Idiopathic intracranial hypertension can present with a wide spectrum of neurological signs, especially cranial nerve palsies, which are mostly thought to be caused by a pressure-dependent stretching mechanism. Treatment is guided by aetiology whenever possible; otherwise drainage ...
Kwon Hyung-Min - - 2013
Lowering blood pressure (BP) and reducing diurnal variation are important for the prevention of stroke in patients with hypertension. This study was conducted to compare the BP-lowering and diurnal BP variation effects of amlodipine and losartan on acute stroke patients. Seventy-seven hypertensive patients with acute stroke were enrolled in this ...
Blackburn Daniel J - - 2013
Stroke is a common cause of cognitive impairment and dementia. However, effective strategies for reducing the risk of post-stroke dementia remain undefined. Potential strategies include intensive lowering of blood pressure and/or lipids. Design: multi-centre prospective randomised open-label blinded-endpoint controlled partial-factorial phase IV trial in secondary and primary care.Participants: 100 participants ...
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