Search Results
Results 301 - 350 of 1233
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Yan Li - - 2009
Recent studies have demonstrated the presence of autoantibodies against alpha(1)-adrenoceptor (alpha(1)-AAB) in the serum of patients with primary hypertension, and that these autoantibodies exert adrenergic-agonist-like effects. However, their role in the development of hypertension remains unclear. The current study determined whether alpha(1)-AAB can cause vascular contraction, and further investigated the ...
Yocum Gene T GT Department of Anesthesiology, Columbia University, New York, New York, - - 2009
Cognitive dysfunction is fairly common after noncardiac surgery and may be related to intraoperative blood pressure management. The authors present an analysis of risk factors for cognitive deterioration after spine surgery in older patients, with particular emphasis on intraoperative blood pressure in normotensive and hypertensive patients. This is a post ...
Tabak O - - 2009
BACKGROUND: Hypertension is one of the principal risk factors for cardiovascular disease. We aimed to evaluate the impact of hypertension on fibrinolytic balance and endothelial function by measuring plasma levels of plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator antigen (tPA), tPA/PAI-1 complex and fibrinogen. METHODS: Patients enrolled into the study ...
Takei Kazuo - - 2009
OBJECTIVES: It is known that the risk of cerebral stroke recurrence in post-stroke patients is comparatively higher than in normal subjects, and it is suggested that autonomic nervous system dysfunctions elevate this risk. We investigated the anti-hypertensive effects of cilnidipine, a Ca antagonist which suppresses sympathetic nerve activation, in hypertensives ...
Lee Jong Y - - 2009
Individuals genetically susceptible to hypertension may have preexisting membrane defects influencing cell sodium permeability. Fourteen Minnesotan families of Northern European descent were selected as having one or both progenitors with either high (HP) or low (LP) erythrocyte sodium permeability. We earlier found that over one-half of the (22)Na(+) influx into ...
Florczak Elzbieta - - 2009
The aim of our study was to evaluate renal resistive index (RI) value in never treated hypertensive patients in relation to ambulatory blood pressure measurement (ABPM) values and early target organ damage. The study included 318 subjects: 223 patients with never treated essential hypertension (mean age 37.1 years) and 95 ...
Tziolas Ioannis M - - 2009
We examined the effect of familial burden of hypertension on blood pressure (BP) levels, insulin resistance (IR), and intracellular ions in healthy offspring of Greek families with one, two, or no hypertensive parents. A total of 118 adolescents and young adults were recruited. Three groups were formed: Group A, both ...
Izzo Raffaele - - 2008
Increased levels of G protein coupled receptor kinase GRK2 appear to participate in hypertension presumably through the desensitization of beta adrenergic receptors (betaARs) that mediate vasodilatation. There are contrasting data on the occurrence of betaAR desensitization in the vasculature, we therefore investigated betaAR vasodilatation and desensitization in normotensives and in ...
Isezuo S A - - 2008
BACKGROUND: Both epistaxis and hypertension are common in the general population. OBJECTIVE: This study aimed at determining the prevalence of hypertension among epistaxics, and the relationship between epistaxis and hypertension. METHODS: Retrospective analysis of 62 adults comprising 31 each of males and females with a mean age of 41.4 +/- ...
Wilkinson Daniel Z - - 2009
We hypothesized that activation of endogenous baroreflexes would be associated with reduced responsivity to affective stimuli and that this effect would be enhanced in individuals at risk for hypertension. Images from the International Affective Picture System were presented during systolic and diastolic phases of the cardiac cycle. Affective responsivity was ...
Takase Hiroyuki - - 2008
Increased B-type natriuretic peptide (BNP) expression precedes the development of hypertension in spontaneously hypertensive rats. We therefore tested the hypothesis that elevated plasma BNP levels predict the onset of hypertension in normotensive subjects. Japanese normotensive participants who were at our hospital for a yearly physical check-up (mean age 52.7 years, ...
Adebayo Adedeji K AK Division of Cardiovascular Medicine, Department of Medicine, University College Hospital, Ibadan, Nigeria. - - 2008
Hypertension results in structural and functional changes in the heart. Early detection of abnormalities of cardiac structure and function is important in the assessment and treatment of hypertensive subjects. The aim of this study was to evaluate the utility of the tissue Doppler echocardiographic technique in characterising diastolic and systolic ...
Cadnapaphornchai Melissa A - - 2008
Autosomal dominant polycystic kidney disease (ADPKD) is a common hereditary condition that may be diagnosed in utero. Our goal was to evaluate symptoms of ADPKD in children, including left ventricular mass index (LVMI), renal volume, renal function and microalbuminuria in relation to systolic and diastolic blood pressure. Eighty-five children were ...
Falkner Bonita - - 2008
OBJECTIVE: There is little information in pediatrics on the persistence of the prehypertension and hypertension classifications or on the progression of prehypertension to hypertension. This study aimed to examine those issues. METHODS: An analysis of data from the National Childhood Blood Pressure database was conducted to examine the longitudinal blood ...
Xu Liang - - 2008
BACKGROUND: This study aimed to investigate the prevalence of arterial hypertension in China. METHODS: The Beijing Eye Study 2006 is a population-based investigation including 3,251 subjects aged 45+ years. Blood pressure measurements were performed for 3,222 (99.1%) subjects. Hypertension was defined as a systolic blood pressure > or =140 mm ...
Lieb Wolfgang W Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702-5803, - - 2008
Children of parents with hypertension are at increased risk of developing high blood pressure. We hypothesize that circulating concentrations of putative biomarkers (that may play a role in development of high blood pressure) are higher in nonhypertensive offspring of parents with hypertension. We compared concentrations of 4 different biomarkers (urinary ...
Zhou Lin - - 2008
Family history of hypertension is a primary predictor of high blood pressure (BP). This study attempted to determine whether there is a gradual increase in BP and an early change in arterial elasticity characteristics between young healthy individuals with or without a family history of hypertension and whether or not ...
Teixeira A M S - - 2008
We described angiotensin-I-converting enzyme (ACE) isoforms with molecular masses of 190, 90, and 65 kDa in the urine of normotensive offspring of hypertensive subjects. Since they did not appear in equal amounts, we suggested that 90 kDa ACE might be a marker for hypertension. We evaluated the endothelial response in ...
Davies Simon J C - - 2008
BACKGROUND: Autonomic nervous system dysfunction may be implicated in the association of hypertension with panic attacks and panic disorder. We hypothesised that panic symptoms of autonomic origin are more common in attacks experienced by hypertensive than normotensive patients, that autonomic panic symptoms cluster together as a distinct factor, and that ...
Coban Erkan - - 2008
The pathophysiological mechanism of hypertensive retinopathy (HR) is not fully established. Elevated blood pressure alone does not fully account for the extent of retinopathy so other pathogenic mechanisms may be involved, such as increased platelet activation. Mean platelet volume (MPV) is a marker of platelet activation. Therefore, this study was ...
Pramanik T - - 2008
Hypertension is a global burning health problem. Early detection of proneness to hypertension may help an individual to lead a healthy life by altering the life style (by diet restriction, exercise etc.). Subjects at high risk of future hypertension e.g. the persons of hypertensive family and/or having high resting heart ...
Kotsis Vasilios - - 2008
BACKGROUND: In this study we investigated (i) the prevalence of white coat hypertension (WCH) and masked hypertension (MH) in patients who had never been treated earlier with antihypertensive medication, and (ii) the association of these conditions with target organ damage. METHODS: A total of 1,535 consecutive patients underwent office blood ...
Kotchen Theodore A - - 2008
BACKGROUND: Blood pressure levels and the prevalence of hypertension are related to adiposity. We evaluated the relationship of adiposity to blood pressure in normotensive and untreated hypertensive African Americans-an ethnic group with a high prevalence of hypertension and obesity. METHODS: Outpatient measurements were obtained in 1,858 normotensive and 1,998 hypertensive ...
Goldstein Iris B - - 2008
BACKGROUND: Although family history is a major predictor of hypertension, other risk factors have been linked to elevated blood pressure (BP). This study explored the relationship of norepinephrine (NE), insulin resistance and lipids to family history of hypertension, and attempted to determine the combined effects of family history and these ...
Imatoh Takuya - - 2008
Adiponectin is a recently discovered protein that seems to be exclusively secreted by adipocytes and is the most abundant adipose tissue-derived protein. While some recent studies have demonstrated an association between adiponectin levels and hypertension, these studies were cross-sectional in design, and the results have been inconsistent. Therefore we performed ...
Papadopoulos D P - - 2008
Recent evidence demonstrate that masked hypertension (MH) is a significant predictor of cardiovascular disease, while, elevated levels of circulating antibodies against endothelial cell surface antigens (antiendothelial cell antibodies - AECA) seem to play an important role at the early stages of atherosclerosis process and of borderline hypertension as well. Aim ...
Saltiki Katerina - - 2008
Overt hypothyroidism has been associated with arterial hypertension and increased arterial stiffness. Results in euthyroid individuals have been conflicting. We investigated associations of thyroid function with systolic (SAP) and diastolic (DAP) arterial pressure in euthyroid subjects. 311 euthyroid individuals (185 women, mean age 43.9 +/- 9) without a history of ...
Gupta Ravi - - 2008
AIMS: The present study was conducted to assess the effects of duration of hypertension, systolic hypertension, diastolic hypertension, drug compliance and class-of-drug on cognitive functions. METHODS AND RESULTS: A cohort of young hypertensive subjects was recruited after obtaining informed consent. Subjects with confounding factors, e.g., substance use, neurological disorders, endocrinopathies, ...
Horváth Patrícia - - 2008
BACKGROUND: According to several reports, some cardiovascular signs of hypertension (left ventricular [LV] hypertrophy, impaired diastolic filling) can be found in the normotensive offspring of hypertensive parents. It is also well known that regular physical exercise decreases the risk of hypertension. AIM: The aim of the present study is to ...
Yanai Hidekatsu - - 2008
Astaxanthin is a biological antioxidant naturally found in a wide variety of aquatic living organisms, and has shown various pharmacological activities, such as anti-inflammatory and antidiabetic activities. A recent study reported that the administration of astaxanthin induced a significant reduction in blood pressure and delayed the incidence of stroke in ...
Matuszek Maria A - - 2008
1. Differences in blood lipids, glucose, insulin, amylin, adrenocorticotropic hormone (ACTH), cortisol, aldosterone, angiotensin II, metabolites of nitric oxide (nitrate, nitrite), asymmetric dimethyl arginine, endothelial leucocyte adhesion molecule-1, vascular cell adhesion molecule-1, C-reactive protein, homocysteine and oxidative status (urate, vitamin A, vitamin E, beta-carotene and total anti-oxidant capacity) were investigated ...
Sae-Sia Wipa - - 2007
OBJECTIVE: To test the effect of clinically relevant duration of pressure loading (2 h) on sacral skin blood flow (SBF) and skin temperature in subjects with spinal cord injury (SCI) within 24 to 96 hours after injury compared with subjects with acute orthopedic trauma and healthy subjects. DESIGN: Three-group, repeated-measures, ...
McIntyre David - - 2008
Modulation of simple reaction time over the cardiac cycle, which is likely to be mediated by activation of arterial baroreceptors, may be moderated by individual difference factors that affect baroreceptor activation, such as risk for hypertension. This study examined arterial baroreceptor effects on simple reaction times by presenting vibrotactile stimuli ...
Rampal L - - 2008
STUDY DESIGN: A cross-sectional study was conducted in all states of Malaysia to determine the prevalence, awareness, treatment and control of hypertension. A stratified two-stage cluster sampling design with proportional allocation was used. METHODS: Trained nurses obtained two blood pressure measurements from each subject. Hypertension was defined as mean systolic ...
Sossai P - - 2007
This study summarizes the results of an epidemiological investigation carried out on the occasion of the Second World Hypertension Day (May 13, 2006) in the city of Matelica in the Region of the Marches, Central Italy. In all, 518 subjects (298 males, average age 52.3 years; 220 females, average age ...
O'Donovan, D. G.
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Verberk Willem J - - 2007
Masked hypertension (blood pressure that is normal in the physicians' office but elevated elsewhere) is a common phenomenon as prevalence among studies varies from 8 to 45% and is seen at all ages. large discrepancies, however, exist between studies that have dealt with masked hypertension. It is of high clinical ...
Imatoh Takuya - - 2007
The object of this study is to assess whether elevated hsCRP levels are independently related to hypertension in non-obese Japanese males. This cross-sectional study comprised 86 hypertensive and 109 normotensive subjects. We defined hypertension as a systolic blood pressure >/=140 mmHg and/or a diastolic blood pressure >/=90 mmHg and/or taking ...
Grassi Guido - - 2007
Patients with hypertension exhibit an increased sympathetic activity. No information exists as to whether this is the case in normotensive individuals in whom there is an increased ambulatory blood pressure, a condition termed "masked" hypertension. We studied 18 middle-aged subjects with masked hypertension in whom we measured muscle sympathetic nerve ...
Ishikawa Shizukiyo - - 2007
Few studies have reported on risk factors by blood pressure categories based on antihypertensive treatment in the general population. We examined the associations between blood pressure categories and other risk factors in Japan. Cross-sectional study, multicenter population-based study was designed. A total of 11,302 men and women were eligible. Data ...
Esparza C M - - 2007
OBJECTIVE: To assess the association between inner ear dysfunction and retinal vascular changes related to systemic arterial hypertension. DESIGN: A comparative, cross-sectional and observational study. SETTING: Primary care. MAIN OUTCOMES MEASURES: Hearing and vestibular symptoms evaluated by a standardized questionnaire; cochlear function evaluated by audiometry and distortion product otoacoustic emissions; ...
SEKI, Yoshinobu
Background. Cyclosporin-induced hypertension is considered to be a result of elevated plasma endothelin-1 (ET-1) oo sodium retention. Methods. To evaluate the function and the degree of vascular damage of endothelial cells in cyclosporininduced hypertension after allogeneic bone marrow transplantation (BMT), we continuously measured blood pressure by ambulatory blood pressure monitoring ...
Skov Karin K Department of Pharmacology, University of Aarhus, Aarhus, Denmark. - - 2007
Offspring of hypertensive parents are at high risk of future hypertension and subsequent cardiovascular diseases. We investigated whether early treatment with an angiotensin-receptor blocker in young normotensive offspring of hypertensive parents persistently lowered blood pressure after treatment withdrawal, a possibility supported by animal studies. The study is an investigator-initiated, double-blind ...
Edwards Louisa - - 2007
Hypertension is characterized by cognitive deficits. As evidence for impaired psychomotor speed, including slower reaction times, is mixed, we aimed to provide a detailed investigation of simple reaction time in hypertension. Pre-motor and motor reaction times were measured across the cardiac cycle in 30 hypertensives and 29 normotensives to determine ...
Machado Adriana Caiado - - 2007
Mercury reduces cardiac contractility and arterial pressure at micromolar concentrations. We investigated the actions of 680ng/kg HgCl(2) on arterial pressure, heart rate (HR) and on the pressor reactivity to phenylephrine (PHE) in rats before and 1h after HgCl(2) administration and after hexametonium, verapamil and tempol treatments. HgCl(2) increased baseline systolic ...
Callegaro C C - - 2007
In patients with severe autonomic dysfunction, water ingestion elicits an acute pressor response. Hypertension may be associated with changes in cardiovascular autonomic modulation, but there is no information on the acute effects of water ingestion in patients with hypertension. In this study, we compared the effect of acute water ingestion ...
Armas-Padilla María Cristina - - 2007
Nitric oxide (NO), a multifunctional effector molecule that plays a central role in the maintenance of vascular homeostasis, regulates vascular tone and inhibits platelet and leukocyte adhesion to endothelial cells. NO status is related to the endothelial function. Patients with hypertension have lower levels of NO, increased free radical production, ...
Armas-Hernández María José - - 2007
The aim of this study was to evaluate the fibrinolytic system by measurement of fibrinogen, plasminogen, tissue-type plasminogen activator (t-PA), and plasminogen activator inhibitor-1 (PAI-1) in healthy normotensive subjects and in patients with essential hypertension. A group of 21 healthy normotensive subjects [age, 39.2 +/- 1.8 years; 8 males, 13 ...
Leenen Frans H H - - 2007
Cardiac beta-receptor responsiveness is diminished by both aging and hypertension. However, concomitant decreases in the activity of counterregulatory mechanisms, such as the arterial baroreflex and neuronal catecholamine uptake, influence the ultimate cardiac responses to adrenergic agents in vivo. In the present study, we evaluated by echocardiography cardiac responses to intravenous ...
Erdogan Dogan - - 2007
BACKGROUND: The assessment of coronary flow reserve (CFR) by transthoracic Doppler echocardiography has recently been introduced into clinical practice, and reduced CFR has been suggested to be a sensitive indicator of hypertensive end-organ damage; however, to date, this methodology has not been used to evaluate CFR in subjects with prehypertension. ...
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