Search Results
Results 251 - 300 of 1233
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Nakagaki Toshiaki - - 2011
Abstract Angiotensin (Ang)-(1-7) Ang-(1-7) is formed from angiotensin II by angiotensin-converting enzyme 2 (ACE2) and modulates the renin-angiotensin system. We evaluated whether the Ang-(1-7)-Mas axis in the rostral ventrolateral medulla (RVLM) contributes to neural mechanisms of blood pressure (BP) regulation. We microinjected Ang-(1-7), Ang-(1-7)-Mas receptor antagonist A-779, and ACE2 inhibitor ...
Xiong Xuan - - 2011
This study was designed to investigate the effect of pulse width modulation electro-acupuncture (PWM-EA) on cardiovascular remodeling and nitric oxide (NO) in spontaneously hypertensive rats (SHR). Thirty-four male SHR were randomly divided into control, captopril, and two PWM-EA groups, which were treated with 350 Hz (SHR-350 Hz) and whole audio bandwith electro-acupuncture ...
Liu Bei - - 2011
Estrogen (E) and testosterone (T) are important in the sexually dimorphic pattern of blood pressure (BP) development. The goal was to examine the effects of endogenous E and exogenous T in the development of hypertension in female spontaneously hypertensive rats (SHR) on a high sodium diet. Female SHR (N = ...
Mohanan Anookh - - 2011
In hypertensive subjects, angiotensin II and endothelin participate in a manner involving closely interwoven pathways in increasing blood pressure (BP) and inducing end organ damage. The primary objective of this study was to determine the effect of TRC120038, a novel dual AT(1)/ET(A) receptor blocker on BP, in obese Zucker spontaneously ...
Jing Li - - 2011
The aim of this study is to investigate the effect of the extracellular signal-regulated kinases 1/2 (ERK1/2) inhibitor, PD98059, on high blood pressure and related vascular changes. Blood pressure was recorded, thicknesses of renal small artery walls were measured and ERK1/2 immunoreactivity and erk2 mRNA in renal vascular smooth muscle ...
Tveita Torkjel - - 2011
The purpose of our study was to determine whether hypothermia has any effects on physiological hemodynamic responses to epinephrine (Epi), and whether rewarming reverses these effects. Sprague-Dawley rats were instrumented to measure mean arterial pressure (MAP), and left ventricular (LV) pressure-volume changes were recorded by using a Millar pressure-volume conductance ...
Jaarin Kamsiah - - 2011
The goal of this study was to determine the possible mechanism that is involved in the blood pressure-raising effect of heated vegetable oils. Adult male Sprague-Dawley rats were divided into 11 groups; the control group was fed with rat chow, and the other groups were fed with chow that was ...
Spijkers Léon J A - - 2011
Hypertension is, amongst others, characterized by endothelial dysfunction and vascular remodeling. As sphingolipids have been implicated in both the regulation of vascular contractility and growth, we investigated whether sphingolipid biology is altered in hypertension and whether this is reflected in altered vascular function. In isolated carotid arteries from spontaneously hypertensive ...
Spijkers Léon J A - - 2011
We have previously shown that essential hypertension in humans and spontaneously hypertensive rats (SHR), is associated with increased levels of ceramide and marked alterations in sphingolipid biology. Pharmacological elevation of ceramide in isolated carotid arteries of SHR leads to vasoconstriction via a calcium-independent phospholipase A(2), cyclooxygenase-1 and thromboxane synthase-dependent release ...
Reddy Madhuri - - 2011
Unrelieved pressure or friction of the skin, particularly over bony prominences, can lead to pressure ulcers in up to one third of people in hospitals or community care, and one fifth of nursing home residents. Pressure ulcers are more likely in people with reduced mobility and poor skin condition, such ...
Aguilar N N Universidad Autónoma Metropolitana, México City. ab.nade@ - - 2011
The aim of this work was to build up a new monitoring technique for the lung preservation. The medical aside problem is to measure the integrity and functionality of the lung tissue, specifically at cellular preservation level in order to improve the survival time until it is grafted. The Impedance ...
McCubbin James A - - 2010
Shift work with sleep disruption is a systemic stressor that may possibly be associated with blood pressure dysregulation and hypertension. We hypothesize that rotation to a simulated night shift with sleep deprivation will produce blood pressure elevations in persons at risk for development of hypertension. We examined the effects of ...
Menon Vandana - - 2011
Most deaths in autosomal dominant polycystic kidney disease (ADPKD) are attributable to cardiovascular disease (CVD). We examined novel CVD biomarkers in different stages of ADPKD. We recruited 50 hypertensive subjects with ADPKD with estimated GFR (eGFR) of >60 ml/min per 1.73 m(2); 52 hypertensive subjects with ADPKD with eGFR of ...
Korner Paul I - - 2010
Structural changes in the large resistance vessels in hypertension amplify resistance responses in vitro, but their role in vivo has been controversial. To resolve this matter, we re-examined earlier data in Page hypertension. Total peripheral resistance (TPR) and total peripheral conductance (TPC) responsiveness were compared in hypertensive and normotensive rabbits, ...
Koroboki Eleni - - 2010
Clinical practice and research provide evidence indicating the involvement of psychological factors in essential hypertension. Little is known about interoception (i.e. the ability of perceiving bodily signals) in essential hypertension. The present study focused on the assessment of interoceptive awareness in newly diagnosed-untreated hypertensives by means of ambulatory blood pressure ...
Badaruddoza - - 2012
Familial aggregation of blood pressure with respect to anthropometric characteristics was investigated among the Lobana (a tribal origin) population in Punjab, a North Indian state. A total of 505 individuals comprised the study sample, constituting 116 families of 3 generations. The study represents a multivariate model analysis, which includes family ...
Kumagae Shun-ichi - - 2010
Endothelin-1 (ET-1) is a potent vasoconstrictor derived from the endothelium. However, most large scale cross-sectional studies in humans have indicated no relationship between plasma ET-1 levels and hypertension. The present study was designed to determine whether high plasma ET-1 levels predict the development of hypertension. A total of 1,492 subjects ...
Okutucu Sercan - - 2010
The aim of the present cross-sectional study was to evaluate heart rate recovery (HRR) in normotensive and hypertensive individuals with either nondipper or dipper type circadian rhythm of blood pressure. Eighty-five patients were divided into 4 groups according to the presence of hypertension and pattern of circadian blood pressure as ...
Xu Tao - - 2010
BACKGROUND: Few studies have been done on the effects that awareness, treatment, and control have on hypertension among governmental and institutional employees. HYPOTHESIS: The aim of this study was to explore prevalence, awareness, treatment and control of hypertension among governmental and institutional employees. METHODS: A total of 80 governmental organizations ...
Yang Ping - - 2010
BACKGROUND: Thrombotic, rather than hemorrhagic, events represent a major complication of hypertension. This study aims to explore the mechanism of the hypercoagulative state in hypertension and to assess its clinical significance. HYPOTHESIS: The hypercoagulative state and even the prothrombotic state exists in patients with hypertension. This may be attributed to ...
Feldstein Carlos A - - 2010
Our aims were to evaluate the prevalence and outcome of hypertension in patients with primary hyperparathyroidism (PHPT), previously and after follow-up of parathyroidectomy. A group of 46 consecutive patients with sporadic PHPT due to adenoma undergoing surgery were followed an average of 3.5 years (range 36 to 53 months). In ...
Contreras Freddy - - 2010
The objective is to determine cardiovascular and insulin release effects under metoclopramide (MTC) and dopamine (DA) infusion by using an acute comparative design with the intravenous infusion of both drugs. We evaluated 15 normal (normotensive and normoglycemic) subjects, 13 hypertensive, and 15 type 2 diabetic subjects. Subjects were submitted to ...
Wasilewska Anna - - 2010
The purpose of the study was to investigate serum uric acid (SUA), high-sensitivity C-reactive protein (hs-CRP) and mean platelet volume (MPV) in pre-hypertensive (PH) and hypertensive (HT) children and adolescents. The study group consisted of 80 patients aged 10-19 years subdivided into PH and HT groups according to mean daytime ...
Juhász Mária - - 2010
To assess whether a gender difference exists in adolescent hypertension and its target organ damage and to compare potential confounding factors and target organ damage in hypertensive and normotensive adolescent girls. From the Debrecen Hypertension Study, the anthropometric, blood pressure, and laboratory data as well as intima-media thickness (IMT) and ...
Obinata Kaoru - - 2010
We experienced a case of a Japanese boy who developed intractable idiopathic intracranial hypertension (IIH) during growth hormone (GH) treatment. At the age of 4 yr, the boy was diagnosed with idiopathic growth hormone deficiency, and recombinant human GH replacement was initiated. Nine months after initiation of the GH therapy, ...
Sharma P - - 2010
Cirrhosis with arterial hypertension is not uncommon. Haemodynamic alterations in these patients and the effects of beta-blocker on hepatic venous pressure gradient (HVPG) and systemic haemodynamics have not been evaluated. To compare the systemic haemodynamic alterations in hypertensive and normotensive cirrhotics, and to investigate the effects of propranolol on these ...
Lande Marc B MB Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. - - 2010
To determine the change in parental ratings of executive function and behavior in children with primary hypertension after anti-hypertensive therapy. Parents of subjects with untreated hypertension and control subjects completed the Behavior Rating Inventory of Executive Function (BRIEF) to assess behavioral correlates of executive function and the Child Behavior Checklist ...
Liu Yi - - 2010
Chronic hypoxia results in pulmonary hypertension. To investigate the role of Na+/H+ exchange in this process, we determined the effect of amiloride, a Na+/H+ exchange inhibitor, on hypoxic pulmonary hypertension and pulmonary arterial smooth muscle cell proliferation, both in vivo and in vitro. Sprague-Dawley rats were placed either in a ...
Tetri S - - 2010
Hypertension is the most important modifiable risk factor for primary intracerebral hemorrhage (ICH), but little is known of the effect of preceding hypertension on outcome. Because high mean arterial blood pressure (MABP) at admission is an independent predictor of early death in patients with ICH, we explored its role on ...
Chen Yi-Liang - - 2010
Exercise is recommended as a lifestyle intervention in preventing hypertension based on epidemiological findings. However, previous intervention studies have presented mixed results. This discrepancy could be associated with shortcomings related to sample sizes or the inclusion of normotensive participants. The aim of this prospective cohort study (N = 463) was ...
Jonas Jost B - - 2010
Because relatively little has been known about the actual prevalence of hypertension in India, particularly for its rural population, we investigated the prevalence of arterial hypertension in a rural Indian population. The Central India Eye and Medical Study is a population-based study in a rural Central Indian region. It included ...
Gonz?lez-Mu?oz Mar?a Jos? - - 2010
This study was performed on scalp hair samples from postmenopausal women (n=26; 12 normotensives and 14 hypertensives) to determine the relationship between blood pressure and metal and metalloids in hair samples. Hair concentrations of Al, Ba, Cd, Co, Cr, Mn, Mo, Ni, Pb, Sb, Se, Sr and V were measured ...
Sowmya R - - 2010
The objective of this study was to assess blood pressure and autonomic activity during rest and recovery in young adult normotensives offsprings of hypertensives. A total of 49 healthy normotensive males with BMI of 18.5-24.9 kg/m2 chosen for the study and classified into two groups based on their parental history ...
Shehata Marlene F - - 2010
The goal of the present correlational study is to test the hypothesis that anger initiates essential hypertension in Canadian Caucasian adults with a family history of hypertension. The study population will include a cohort of 100 men and women aged 25 to 45 years at enrollment recruited from the University ...
Song Shu-Wei - - 2010
Blood pressure reduction is an important and effective strategy in stroke prevention in hypertensives. Recently, we found that baroreflex restoration was also crucial in stroke prevention. The present work was designed to test the hypothesis that a combination of blood pressure reduction and baroreflex restoration may be a new strategy ...
Rodrigues Ticiana C - - 2010
AIM: To analyze the prevalence of masked hypertension and its possible association with microvascular complications in patients with type 1 diabetes (T1D). METHODS: A cross-sectional study was conducted in 188 consecutive normotensive patients at the office with T1D without renal replacement therapy or previous renal transplant. All patients were assessed ...
Mayas María D - - 2009
Fatty acid (FA) synthesis enzymes (FA synthase (FASN) and acetyl-CoA carboxylase (ACC)) are related to metabolic alterations such as obesity, insulin resistance, or dyslipidemia. Due to the fact that there is no literature that relates FASN and ACC expression with hypertension, we investigate how FASN and ACC expression in adipose ...
Myredal Anna - - 2010
BACKGROUND: We have used a novel ultra high-frequency (55MHz) ultrasound technique to non-invasively measure the radial arterial vessel wall and separate the intima-media (IMT) complex into measurements of intima and media thickness (IT and MT). Since no previous study has measured IT and MT separately in individuals with prehypertension and ...
Fromy B?reng?re - - 2010
Healthy skin is protected from pressure-induced ischemic damage because of the presence of pressure-induced vasodilation (PIV). PIV relies on small sensory nerve fibers and endothelial function. Since aging alters both nervous and vascular functions, we hypothesized that PIV is altered with aging. We compared PIV in non-neuropathic and neuropathic older ...
Friedman Oded - - 2009
Nocturnal blood pressure abnormalities are independently associated with an increased risk of death and cardiovascular disease. It is unclear, however, whether they are related to the presence or severity of hypertension. To determine and compare the prevalence of sleep pattern disturbances in normotensive (NT) and hypertensive patients. The present cross-sectional ...
Wandeler G - - 2010
OBJECTIVE: Limited information is available on the quantitative relationship between family history and the corresponding underlying traits. We analyzed these associations for blood pressure, fasting blood glucose, and cholesterol levels. METHODS: Data were obtained from 6,102 Caucasian participants (2,903 men and 3,199 women) aged 35-75 years using a population-based cross-sectional ...
Salako Babatunde L - - 2009
BACKGROUND: Hypertension is a disease characterized by end-organ complications, leading to high morbidity and mortality in many cases. People with untreated or uncontrolled hypertension often run the risk of developing complications directly associated with the disease. Left ventricular hypertrophy (LVH) has been shown to be a significant risk factor for ...
Shimada Morio - - 2009
The anti-hypertensive effect of GABA-rich Chlorella was studied after oral administration for 12 weeks in the subjects with high-normal blood pressure and borderline hypertension in the placebo-controlled, double-blind manner in order to investigate if GABA-rich Chlorella, a dietary supplement, is useful in control of blood pressure. Eighty subjects with Systolic ...
Harada Naoaki - - 2009
Insulin-like growth factor-I (IGF-I) reduces arterial blood pressure. Since administration of capsaicin and isoflavone increases serum levels of IGF-I by sensory neuron stimulation in subjects with alopecia, it is possible that administration of capsaicin and isoflavone reduces arterial blood pressure in patients with hypertension. Systolic and diastolic blood pressure (BP) ...
Pasqualini L - - 2010
Obesity and hypoadiponectinemia are often associated with high blood pressure. Moreover, microvascular dysfunction is reported to be an early event in patients with hypertension and may be involved in the pathogenesis of organ damage. We investigated the impact of 8-week moderate-intensity aerobic training on adiponectin plasma levels and skin microvascular ...
Stabouli Stella - - 2009
The purpose of this study was to investigate differences in left ventricular mass index (LVMI) and the prevalence of left ventricular hypertrophy (LVH) in children and adolescents classified as normotensives, prehypertensives and hypertensives by ambulatory blood pressure (BP) levels. A total of 124 consecutive children and adolescents aged 5 to ...
Cugini Pietro - - 2009
Because of recent papers on "Cugini's syndrome", as a new nosographic cardiovascular entity, the writer of this article has seen of medical interest to interview Prof. Cugini in person for a better elucidation of this syndrome. It must be stressed that the syndrome we are dealing with has been identified ...
Thomopoulos Costas - - 2009
The aim of the study was to investigate whether diverse clinical blood pressure phenotypes are associated with free leptin surrogates, as reflected by plasma leptin, human soluble leptin receptor, and their ratio (ie, free leptin index) in nonobese normoglycemic subjects. Three separate clinic blood pressure measurements and ambulatory blood pressure ...
Solini A - - 2009
The predisposition to thrombogenesis is increased in essential hypertension, and hypertensive patients are prone to develop more vulnerable atherosclerotic plaques. To evaluate the possible influence of family history of hypertension on some indicators of early atherosclerosis, we studied eighty-five healthy normotensive individuals with (FH+) or without (FH-) family history of ...
Dauphinot Virginie - - 2009
BACKGROUND: Because inflammation is known to be related with several cardiovascular diseases, we sought to determine whether C-reactive protein (CRP) might precede the onset of hypertension. METHODS: The study population was selected from the Proof study cohort including 1011 individuals initially aged 65 years at baseline and followed for 7 ...
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