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Gebhard Simon - - 2011
OBJECTIVE: Hypertension is a risk factor for arterial thrombosis. We investigated the effects of angiotensin II (ANG II)-dependent hypertension on the platelet proteome. METHODS AND RESULTS: Hypertension was induced in cyp1a1ren-2 transgenic rats by feeding indole-3-carbinol (n = 10) and in Fischer 344 rats by subcutaneously infusing ANG II (n = 7). After 14 ...
Tang Xiaorui - - 2011
The baroreflexes stabilize moment-to-moment arterial pressure. Sinoaortic denervation (SAD) of the baroreflexes results in a large increase in arterial pressure variability (APV) across various species. Due to an incomplete understanding of the nonlinear interactions between central and peripheral systems, the major source of APV remains controversial. While some studies suggested ...
Agarwal Deepmala D Department of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, - - 2012
Exercise training (ExT) is a recommended adjunct to many pharmaceutical antihypertensive therapies. The effects of chronic ExT on the development of hypertension-induced renal injury remain unknown. We examined whether ExT would preserve renal hemodynamics and structure in the spontaneously hypertensive rat (SHR), and whether these effects were mediated by improved ...
Saravana Kumar Murugesan - - 2011
The present study was undertaken to assess the antihypertensive and antioxidant effects of veratric acid on N(ω)-nitro-L arginine methyl ester (l-NAME) induced hypertensive rats. Hypertension was induced in adult male albino rats of the Wistar strain, weighing 180-220g, by oral administration of the l-NAME (40mg/kg body weight/day) in drinking water ...
Abe Chikara - - 2011
To examine a cooperative role for the baroreflex and the vestibular system in controlling arterial pressure (AP) during voluntary postural change, AP was measured in freely moving conscious rats, with or without sinoaortic baroreceptor denervation (SAD) and/or peripheral vestibular lesion (VL). Voluntary rear-up induced a slight decrease in AP (-5.6 ...
Rizzi Elen - - 2011
BACKGROUND: Increased oxidative stress upregulates matrix metalloproteinases (MMPs) and transforming grow factor (TGF-β), which are involved in hypertensive cardiac remodeling. We tested the hypothesis that tempol (an antioxidant) could prevent these alterations in two-kidney, one-clip (2K1C) hypertension. METHODS: Sham-operated or hypertensive rats were treated with tempol (18mg.kg(-1)day(-1) or vehicle) for ...
Mori Asami - - 2011
The aim of this study was to determine the role of β(3)-adrenoceptors in the action of endogenous catecholamines (adrenaline and noradrenaline) on rat retinal arterioles in vivo. Using an original high-resolution digital fundus camera, the rat ocular fundus images were captured. The diameter of retinal arterioles contained in the images ...
Wang Xin-Bao - - 2011
Sulfur dioxide is considered a toxic gas in air pollution and detrimental to many organs, however, it can be generated endogenously in the cardiovascular system in vivo. Gaseous sulfur dioxide has an endothelium-dependent vasorelaxing effect at low concentrations, but is endothelium-independent at high concentrations and has a negative inotropic effect ...
Jaenisch Rodrigo B - - 2011
Respiratory muscle training (RMT) improves functional capacity in chronic heart-failure (HF) patients, but the basis for this improvement remains unclear. We evaluate the effects of RMT on the hemodynamic and autonomic function, arterial baroreflex sensitivity (BRS), and respiratory mechanics in rats with HF. Rats were assigned to one of four ...
Vasudevan Harish - - 2011
Endothelial dysfunction and increased blood pressure following insulin resistance play an important role in the development of secondary cardiovascular complications. The presence of testosterone is essential for the development of endothelial dysfunction and increased blood pressure. Testosterone regulates the synthesis of vasoconstrictor eicosanoids such as 20-hydroxyeicosatetranoic acid (20-HETE). In a ...
Smith David W - - 2011
BACKGROUND: Traumatic brain injury (TBI) remains a devastating condition for which traditionally extra-cranial protection has been utilized in the form of helmets, which largely fail to protect against intracranial injury. OBJECTIVE: To determine if the pathologic outcome after TBI can be improved via slosh mitigation by internal jugular vein (IJV) ...
Blaudszun Grégoire - - 2011
The end-systolic pressure-volume relationship (ESPVR) is proposed and used as a reliable index of left ventricle (LV) contractility despite the fact that its afterload-independency has been challenged. Furthermore, the physiological relevance of its volume-axis intercept, V0, remains unclear. Systemic haemodynamics and pressure-volume loops obtained by inferior vena cava occlusion were ...
Shimizu Hideo - - 2011
Both osteoporosis and high blood pressure are major diseases in aging populations. Recent studies demonstrated that some antihypertensive drugs reduced the risk of bone fracture in elderly patients. Although calcium channel blockers (CCB) are widely used as first-line antihypertensive agents, there is no evidence that they prevent osteoporosis. In this ...
- - 2011
[This corrects the article on p. 54 in vol. 14, PMID: 21120177.].
Chen Tao - - 2011
To probe into the intervening action of polysaccharides of Zhu Zi Shen (Rhizoma Panacis Majoris) (PZZS) on oxidative stress and hemodynamics in rats with adriamycin-induced chronic congestive heart failure (CHF). After SD rats were successfully modeled with adriamycin, they were randomly divided into a normal control group, a model group, ...
Penn Alexander H AH Department of Bioengineering, The Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA. - - 2011
Hemorrhagic shock and splanchnic arterial occlusion (SAO) followed by reperfusion are associated with high mortality. However, rapid cardiovascular failure and death may also occur before reperfusion in hemorrhagic shock and SAO. We show in a rat SAO model that, upon gut ischemia, mean arterial blood pressure transiently elevates and then ...
Zhou Zhang-Yan - - 2011
This study aimed to investigate the role of insulin-like growth factor-binding protein-3 (IGFBP-3) in erectile dysfunction (ED) in two-kidney one-clip (2K-1C) hypertensive rats treated with the β-blocking agent propranolol. Adult male Wistar rats were randomly divided into three groups: a normal control group, a hypertensive control group and a propranolol ...
Li Huan - - 2011
The blood pressure lowering effect of a pea protein hydrolysate (PPH) that contained <3 kDa peptides, isolated by membrane ultrafiltration from the thermolysin digest of pea protein isolate (PPI), was examined using different rat models of hypertension as well as hypertensive human subjects. The PPH showed weak in vitro activities ...
Ferreira Halina C - - 2011
Lung mechanics, histology, oxygenation and type-III procollagen (PCIII) mRNA were studied aiming to evaluate the need to readjust ventilatory pattern when going from two- to one-lung ventilation (OLV). Wistar rats were assigned to three groups: the left lung was not ventilated while the right lung received: (1) tidal volume (V(T))=5ml/kg ...
Kitta Takeya - - 2011
PURPOSE: Stress urinary incontinence is often seen in postmenopausal women but limited information is available on hormone dependent changes of urethral function. Thus, we examined how ovariectomy and estrogen replacement affect urethral continence mechanisms. MATERIALS AND METHODS: In female nulliparous Sprague-Dawley® rats under urethane anesthesia after ovariectomy with or without ...
Zogovic Branimir - - 2011
Bombesin, a 14 amino-acid peptide, is pressor when administered intravenously in rat, and pressor and sympathoexcitatory when applied intracerebroventricularly. To determine the spinal effects of bombesin, the peptide was administered acutely into the intrathecal space at around thoracic spinal cord level six of urethane anaesthetised, paralysed and bilaterally vagotomised rats. ...
Vida Vladimiro L - - 2011
INTRODUCTION: Pulmonary artery root does not adapt properly when exposed to increased pressure stress, with progressive dilatation. The aim of this study was to evaluate, in an animal model, the histologic changes of the pulmonary root wall under increased pressure load. METHODS AND RESULTS: To increase the systolic pressure in ...
Lindsey Sarah H SH Hypertension and Vascular Research Center, Wake Forest University Health Sciences, Winston-Salem, NC 27157-1032, USA. - - 2011
The current study assessed whether activation of the novel estrogen receptor GPR30 ameliorates salt-dependent renal damage in intact mRen2.Lewis (mRen2) females. Hemizygous mRen2 rats were maintained on either a normal salt (0.5% Na) or high-salt (HS; 4.0% Na) diet for 10 weeks (5 to 15 weeks of age), and HS ...
Ng C F - - 2011
ETHNOPHARMACOLOGICAL RELEVANCE: Radix Salviae miltiorrhizae (Danshen) and Radix Puerariae lobatae (Gegen) have long been used in traditional Chinese Medicine and serve as the principal herbs in treating cardiovascular disease. AIMS OF THE STUDY: In the present study, an aqueous extract comprising Danshen and Gegen in the ratio of 7:3 (DG) ...
Safar Michel E - - 2011
Aldosterone influences independently the vascular environment in humans, acting through structural and functional modifications of the arterial wall as derived from mineralocorticoid receptors. In rats, aldosterone infusion increases arterial stiffness in the presence of high-sodium intake, together with development of extracellular matrix and inflammatory factors. A selective increase in systolic ...
Johnson Megan S - - 2011
The aim of this investigation was to evaluate sex differences in baroreflex and heart rate variability (HRV) dysfunction and indexes of end-organ damage in the TG(mRen2)27 (Ren2) rat, a model of renin overexpression and tissue renin-angiotensin-aldosterone system overactivation. Blood pressure (via telemetric monitoring), blood pressure variability [BPV; SD of systolic ...
Takahashi Hakuo - - 2011
The central nervous system has a key role in regulating the circulatory system by modulating the sympathetic and parasympathetic nervous systems, pituitary hormone release, and the baroreceptor reflex. Digoxin- and ouabain-like immunoreactive materials were found >20 years ago in the hypothalamic nuclei. These factors appeared to localize to the paraventricular ...
Banes-Berceli Amy K L - - 2011
Janus kinase (JAK) 2 is activated by ANG II in vitro and in vivo, and chronic blockade of JAK2 by the JAK2 inhibitor AG-490 has been shown recently to attenuate ANG II hypertension in mice. In this study, AG-490 was infused intravenously in chronically instrumented rats to determine if the ...
Kung Ling-Hsuan LH Neuroscience Institute and Department of Molecular Pharmacology and Therapeutics, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, - - 2011
Serotonin neurons of the caudal raphe facilitate ventilatory and sympathetic responses that develop following blood loss in conscious rats. Here, we tested whether serotonin projections to the caudal portion of the dorsomedial brain stem (including regions of the nucleus tractus solitarius that receive cardiovascular and chemosensory afferents) contribute to cardiorespiratory ...
Ishikawa Makoto - - 2011
PURPOSE. High levels of glutamate can be toxic to retinal GCs. Thus, effective buffering of extracellular glutamate is important in preserving retinal structure and function. GLAST, a major glutamate transporter in the retina, and glutamine synthetase (GS) regulate extracellular glutamate accumulation and prevent excitotoxicity. This study was an examination of ...
Tare Marianne - - 2011
Increasing evidence links vitamin D deficiency and cardiovascular dysfunction in human adults. There is a worldwide increase in the prevalence of vitamin D deficiency in women of reproductive age, particularly dark-skinned and/or veiled women and their infants. We used a rat model to determine the functional impact of vitamin D ...
Honetschlägerová Zuzana - - 2011
In the present study, we compared the effects of treatment with the novel soluble epoxide hydrolase (sEH) inhibitor (c-AUCB) with those of the AT1 receptor antagonist losartan on blood pressure (BP), autoregulation of renal blood flow (RBF) and on glomerular filtration rate (GFR) and the pressure-natriuresis relationship in response to ...
Waki Hidefumi H Department of Physiology, Wakayama Medical University School of Medicine, Wakayama, Japan. - - 2011
The brainstem nucleus of the solitary tract (nucleus tractus solitarii, NTS) is a pivotal region for regulating the set-point of arterial pressure, the mechanisms of which are not fully understood. Based on evidence that the NTS exhibits O2-sensing mechanisms, we examined whether a localized disturbance of blood supply, resulting in ...
Ren Zuhai - - 2011
Background/Aims: The aim of this study was to investigate the effect of terlipressin on hepatic hemodynamics in small-for-size livers at early phase after major hepatectomy. Methodology: Thirty-six rats were divided into treatment group (Group Th) and control group (Group Ch) for hemodynamic study. Hepatic hemodynamic parameters were detected before hepatectomy ...
Fujisawa Yoshihide - - 2011
Afferent renal nerves (ARNs) convey signals generated by physiological changes in the kidney to the central nervous system. The aim of this study was to determine whether ARNs contribute to cardiovascular regulation through central renin-angiotensin system (RAS)-dependent pathways. Blood pressure and renal sympathetic nerve activity (RSNA) were monitored during elevations ...
Mohan Mahalaxmi - - 2012
Fructose feeding induces a rise in blood pressure in normal rats that is associated with insulin resistance, hyperinsulinemia, hyperglycaemia, hypercholesterolaemia and hypertriglyceridaemia. We have examined the effect of chronic administration of A-HRS (100 and 300 mg kg⁻¹; p.o.) isolated from Hibiscus rosa sinensis (Malvaceae) on systolic blood pressure (SBP), vascular reactivity, serum ...
Engholm M - - 2011
Background: Tissue transglutaminase (t-TG) has been implicated in small artery remodelling. The aim of this study was to determine if cystamine, an inhibitor of t-TG, could reduce blood pressure in spontaneously hypertensive rats (SHR) and if so to what extent this is mediated through small arteries. Methods: In vitro inhibition ...
Matsukawa Ryuichi - - 2011
OBJECTIVES: Neuregulin-1 (NRG-1), located in the central nervous system (CNS), plays an important role in synaptic function, neurite outgrowth, and survival of neurons and glia acting on the ErbB receptor family. However, the functional role of NRG-1/ErbB signaling in the CNS and blood pressure regulation is unknown, particularly in the ...
Kamkaew Natakorn - - 2011
ETHNOPHARMACOLOGICAL RELEVANCE: Bacopa monnieri (Brahmi) provides traditional cognitive treatments possibly reflecting improved cerebral hemodynamics. Little is known about the cardiovascular actions of Brahmi. We sought to assess its effects on blood pressure and on isolated arteries, thus providing insights to clinical applications. MATERIALS AND METHODS: Intravenous Brahmi (20-60mg/kg) was tested ...
Endlich Patrick W - - 2011
The aim of this study was to compare, under resting conditions, the influence of chronic training in swimming or running on mean arterial pressure (MAP) and the involvement of the natriuretic peptide system in this response. Two-month-old male spontaneously hypertensive rats (SHR) were divided into three groups-sedentary (SD), swimming (SW) ...
Baldo Marcelo P - - 2011
The aim of the present study was to evaluate the effect of low-dose spironolactone initiated during the early stages of hypertension development and to assess the effects of chronic pressure overload on ventricular remodeling in rats. Male spontaneously hypertensive rats (SHRs) (4 weeks) were randomized to receive daily spironolactone (20 ...
Groban Leanne - - 2012
No proven pharmacological therapies to delay or reverse age-related diastolic dysfunction exist. We hypothesized that late-life low-dose (non-blood-pressure-lowering) angiotensin-converting enzyme inhibition vs. angiotensin II receptor blockade would be equally efficacious at mitigating diastolic dysfunction in the senescent Fischer 344 × Brown Norway rat. Enalapril (10 mg/kg/day; n = 9) initiated at 24 months of age and ...
Radziszewski P - - 2011
BACKGROUND: Bombesin (BOM) and gastrin releasing peptide (GRP) have been located to the lower urinary tract (LUT). However, there is a paucity of data demonstrating the impact of these endogenous peptides. OBJECTIVES: The aim of the present study was to investigate the contractile actions of BOM and GRP on the ...
Radziszewski P - - 2011
BACKGROUND: Bombesin (BOM) and gastrin releasing peptide (GRP) have been located to the lower urinary tract. However, there is a paucity of data demonstrating the impact of these neuropeptides. OBJECTIVES: The present study investigates the impact of BOM and GRP in the female Sprague-Dawley rats 225 g b.w. n = 37 urethras in ...
Mackenzie Lindsay D - - 2011
Introduction.  Mean arterial pressure (MAP) and specific regulation of penile blood flow are the primary determinants of an erection. While this concept is well recognized, the differential relationship between systemically acting vasoactive factors on arterial pressure and erectile responses is not well described. Aim.  The aim of this study was ...
Chan Vincent - - 2011
Selective β1-adrenoceptor antagonists are part of standard therapy to prolong survival in human heart failure. This study has measured structural, functional, and electrical changes in the cardiovascular system of ageing male Spontaneously Hypertensive Rats to determine whether β1-adrenoceptor antagonist treatment can prevent or reverse the development of cardiovascular remodeling and ...
Aikawa Priscila - - 2011
BACKGROUND: The combination of high positive end expiratory pressure (PEEP) and low-tidal volume (LTV) avoids negative effects mechanical ventilation (MV)-induced, including pulmonary overdistension, damage due to cyclic opening and closing of the alveoli and inadequate inflammatory responses that may lead to distal organ dysfunction. We hypothesized that mesenteric microcirculatory disturbances ...
Grandič Marjana - - 2011
APS12-2 is one in a series of synthetic analogs of the polymeric alkylpyridinium salts isolated from the marine sponge Reniera sarai. As it is a potential candidate for treating non small cell lung cancer (NSCLC), we have studied its possible toxic and lethal effects in vivo. The median lethal dose ...
Declercq Vanessa - - 2011
Conjugated linoleic acid (CLA) has been reported to reduce blood pressure in obese insulin-resistant rats, but its mechanism of action has not been identified. The objective of this study was to determine whether CLA isomers can reduce obesity-related hypertension in the fa/fa Zucker rat in relation to adiponectin production and ...
Delbeck Martina - - 2011
Aims Anticoagulation with warfarin is recommended for the treatment of patients with pulmonary arterial hypertension. However, the therapeutic benefit of anticoagulation has not yet been demonstrated experimentally or clinically. Here, rivaroxaban, an oral, direct factor Xa inhibitor, was compared with warfarin and enoxaparin in the prevention of right ventricular dysfunction ...
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