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Premaratna R - - 2013
BACKGROUND: Fluid leakage remains the hallmark of dengue hemorrhagic fever (DHF). The applicability of currently recommended predictors of DHF for adults with dengue is questionable as these are based on studies conducted in children. METHODS: One hundred and two adults with dengue were prospectively followed up to investigate whether home-based ...
González-Marrero Ibrahim - - 2013
The aim of the present work is to analyze the cerebrospinal fluid proteomic profile, trying to find possible biomarkers of the effects of hypertension of the blood to CSF barrier disruption in the brain and their participation in the cholesterol and β-amyloid metabolism and inflammatory processes. Cerebrospinal fluid (CSF) is ...
Tan Xing-Lin - - 2013
A 40-year-old woman presented with worsening headache accompanied by vomiting, anorexia, and tinnitus. The headaches were initially orthostatic. MRI showed chronic progressive subdural hematomas (SDH) with significant mass effect, diffuse pachymeningeal enhancement, and pituitary enhancement/enlargement (figure, A and B), indicating intracranial hypotension due to spontaneous spinal CSF leak, which was ...
Saitoh Youichi - - 2013
A method to enhance the withstanding pressure of fibrin sealant in gasket-seal closure to prevent cerebrospinal fluid (CSF) leakage after extended transsphenoidal surgery (ETSS) was investigated by adjusting the mixing ratio of the components. A plastic chamber (200 ml) was constructed with a lid made of hydroxyapatite with a hole ...
Kim Jung B - - 2013
Headache is the most common symptom of cerebral venous thrombosis (CVT); however, the detailed underlying mechanisms and characteristics of headache in CVT have not been well described. Here, we report two cases of CVT whose primary and lasting presentation was orthostatic headache, suggestive of decreased intracranial pressure. Contrary to our ...
Chaudhry Hans - - 2013
In this paper, we computed fluid pressure and force on fascia sheets during manual therapy treatments using Squeeze Film Lubrication theory for non-Newtonian fluids. For this purpose, we developed a model valid for three dimensional fluid flow of a non-Newtonian liquid. Previous models considered only one-dimensional flows in two dimensions. ...
Martin Bryn A - - 2013
Elevated or reduced velocity of cerebrospinal fluid (CSF) at the craniovertebral junction (CVJ) has been associated with type I Chiari malformation (CMI). Thus, quantification of hydrodynamic parameters that describe the CSF dynamics could help assess disease severity and surgical outcome. In this study, we describe the methodology to quantify CSF ...
Vardakis John C JC Institute of Biomedical Engineering and Department of Engineering Science, University of Oxford, Oxford, United - - 2013
This study proposes the implementation of a Multiple-Network Poroelastic Theory (MPET) model coupled with finite-volume computational fluid dynamics for the purpose of studying, in detail, the effects of obstructing CSF transport within an anatomically accurate cerebral environment. The MPET representation allows the investigation of fluid transport between CSF, brain parenchyma ...
Kataoka Hiroshi H Department of Neurology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522 - - 2013
Intracranial hypertension, which often occurs in patients with tuberculous meningitis, is associated with high morbidity and mortality. We describe a patient with tuberculous meningitis who had intracranial hypertension -induced fulminant headache that responded to intravenous butorphanol-midazolam combination therapy. A 50-year-old woman with a fever and headache for 24 days was ...
Ishii Kazunari K Department of Radiology, Kinki University Faculty of Medicine, Osakasayama, Tokyo, Japan ; Department of Radiology, Hyogo Brain and Heart Center, Himeji, Tokyo, - - 2013
To measure the cerebrospinal fluid (CSF) space volume in idiopathic normal pressure hydrocephalus (INPH), we developed a software that allows us to automatically measure the regional CSF space and compared the volumes of the ventricle systems (VS), Sylvian fissures (SF) and sulci at high convexity and midline (SHM) among INPH ...
Hickman Stephen H - - 2012
As part of the government response to the Deepwater Horizon blowout, a Well Integrity Team evaluated the geologic hazards of shutting in the Macondo Well at the seafloor and determined the conditions under which it could safely be undertaken. Of particular concern was the possibility that, under the anticipated high ...
Brainard Laura - - 2012
OBJECTIVE: To determine the incidence of intracranial hypertension in patients with spontaneous encephalocele with cerebrospinal fluid (CSF) leak. STUDY DESIGN: Retrospective case review. SETTING: Tertiary care neurotology practice. PATIENTS: Patients presenting between 2008 and 2011 with spontaneous encephalocele and CSF leak in the temporal bone. INTERVENTION(S): Lumbar puncture with opening ...
Dannevig Ingrid - - 2012
Background:We compared current guidelines for neonatal resuscitation to alternative measures and aimed to find if this modulated brain inflammation.Methods:Progressive asphyxia was induced in 94 newborn pigs until asystole. With the reference being resuscitation guidelines, 30s of initial positive pressure ventilation before compressions and ventilations (C:V) 3:1 in 21% oxygen, pigs ...
Weis P - - 2012
Porphyry-type ore deposits are major resources of copper and gold, precipitated from fluids expelled by crustal magma chambers. The metals are typically concentrated in confined ore shells within vertically extensive vein networks, formed through hydraulic fracturing of rock by ascending fluids. Numerical modeling shows that dynamic permeability responses to magmatic ...
Horsburgh Avril - - 2012
Background:Idiopathic intracranial hypertension (IIH) is a condition of raised cerebrospinal fluid (CSF) pressure with normal ventricular size. Although the pathogenesis of IIH remains controversial, increased CSF formation may be important. We hypothesised that if increased CSF formation was an aetiologic factor, it might result in a macroscopic increase in size ...
Yu Bing - - 2012
Distraction osteogenesis has been used to treat diminished skull space caused by craniosynostosis. Our report investigated the relationship between space volume change by computer technology and the intracranial pressure change. Cerebrospinal fluid (CSF) regular test and CSF biochemistry test were also performed to ensure the safety of distraction process. Seven ...
Piazza Ornella - - 2012
Metabolic management of brain-death organ donors includes correction of the hormonal perturbations that occur after cerebral death and impair circulatory function. Vasopressin is a hormone secreted by the posterior pituitary gland, which contributes to maintain systemic blood pressure by regulating urine secretion and small arteriole tonus. During brain death, the ...
Huang Lily L Department of Physiology, Tulane Hypertension and Renal Center of Excellence, Tulane University School of Medicine, New Orleans, - - 2012
This study was performed to determine whether chronic direct renin inhibition can prevent the development of slowly progressive angiotensin (ANG) II-dependent hypertension and the associated derangements in renal function in Cyplal-Ren2 transgenic rats with inducible expression of the Ren2 gene. Male Cyplal-Ren2 rats (n = 6) were fed a normal ...
Altinkaya Ayca - - 2012
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an acquired immune-mediated demyelinating neuropathy. In this report, we detail the course of a 58-year-old male patient who had headache and double vision followed by progressive paresthesia and difficulty in walking. The patient had bilateral papilledema and mild leg weakness, absent ankle jerks and ...
Hamilton Robert B - - 2012
The objective of this study is to investigate the relationship between intracranial pressure (ICP) pulse waveform morphology and selected hydrodynamic metrics of cerebrospinal fluid (CSF) movement using a novel method for ICP pulse pressure regional analysis based on the Morphological Clustering and Analysis of Continuous Intracranial Pulse (MOCAIP) algorithm.
Tyagi Alok - - 2012
New daily persistent headache (NDPH) is a chronic headache developing in a person who does not have a past history of headaches. The headache begins acutely and reaches its peak within 3 days. It is important to exclude secondary causes, particularly headaches due to alterations in cerebrospinal fluid (CSF) pressure ...
Spijkers Léon J A - - 2012
FTY720 (Fingolimod) is a recently approved orally administered drug for the treatment of multiple sclerosis. Phase II and III clinical trials have demonstrated that this drug modestly increases BP. We previously showed that inhibition of sphingosine kinase increases vascular tone and BP in hypertensive, but not normotensive rats. Since FTY720 ...
Hernanz Raquel - - 2012
PPARγ agonists, glitazones, have cardioprotective and anti-inflammatory actions associated with gene transcription interference. In this study, we determined whether chronic treatment of adult spontaneously hypertensive rats (SHR) with pioglitazone alters BP and vascular structure and function, and the possible mechanisms involved. Mesenteric resistance arteries from untreated or pioglitazone-treated (2.5 mg·kg⁻¹ ...
Zogovic B - - 2012
The neuromodulatory effects of the gut-neuropeptide neurotensin on sympathetic vasomotor tone, central respiratory drive and adaptive reflexes in the spinal cord, are not known. Neurotensin (0.5 µM-3 mM) was administered into the intrathecal (i.t.) space at the sixth thoracic spinal cord segment in urethane-anaesthetized, paralysed, vagotomized male Sprague-Dawley rats. Pulsatile ...
Murli Chitra - - 2012
Our high pressure Raman scattering experiments on carnosine, a dipeptide of L-histidine and -alanine show. pressure induced ring opening polymerization involving the imidazole ring. While the onset of polymeric transformation is found to be at ~ 2.8 GPa, a substantial fraction of the monomeric solid becomes polymerized by 12 GPa. ...
Saaby Marie-Louise - - 2012
AIM: Urethral pressure reflectometry (UPR) is a new method for measuring pressure and cross-sectional area in the urethra. Our aim was to investigate if the UPR parameters at rest and during squeeze were unchanged after TVT. METHODS: The technique enables measurement along the entire length of the urethra simultaneously and ...
Rahman Ahmed A - - 2012
The rostral ventrolateral medulla (RVLM) regulates sympathetic vasomotor outflow and reflexes. Intracerebroventricular neuromedin U (NMU) increases sympathetic nerve activity (SNA), mean arterial pressure (MAP) and heart rate (HR), but the central nuclei that mediate these effects are unknown. In urethane-anaesthetized, vagotomized and artificially ventilated male Sprague-Dawley rats (n = 36) ...
Yoshinaga Mariko - - 2012
OBJECTIVE: We investigated the effects of long-term miso soup drinking on salt-induced hypertension in Dahl salt-sensitive (Dahl S) rats. METHODS: Dahl S rats were divided into four groups that consumed 1) water, 2) a 0.9% NaCl solution, 3) a 1.3% sodium NaCl solution, or 4) miso soup containing 1.3% NaCl. ...
Praman Siwaporn - - 2012
ETHNOPHARMACOLOGICAL RELEVANCE: Tinospora crispa has been used in folkloric medicine for the control of blood pressure. We previously found that an extract of Tinospora crispa stems decreased the mean arterial blood pressure (MAP) with a transient decrease, followed by an increase in the heart rate (HR) in rats. AIM OF ...
Veeramani Chinnadurai - - 2012
This study was designed to investigate the protective effect of ethyl acetate fraction of Melothria maderaspatana (EAFM) leaf on electrolytes, catecholamines, endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1) peptide in uninephrectomized deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Administration of DOCA-salt significantly increased the systolic and diastolic blood pressure and treatment ...
Shirpoor Alireza - - 2012
Objective:  Hypertension is one of the important clinical problems of the diabetic cardiovascular disease. The aim of this study was to determine the effect of vitamin E on blood pressure parameters and adhesive molecule amounts in diabetic rat. Methods:  Twenty-four male Wistar rats were divided into three groups (n=8) Control(C), ...
Santos Cíntia L - - 2012
PURPOSE: We hypothesized that: (1) intraabdominal hypertension increases pulmonary inflammatory and fibrogenic responses in acute lung injury (ALI); (2) in the presence of intraabdominal hypertension, higher tidal volume reduces lung damage in extrapulmonary ALI, but not in pulmonary ALI. METHODS: Wistar rats were randomly allocated to receive Escherichia coli lipopolysaccharide ...
Ufnal Marcin - - 2012
1. Brain angiotensin II and vasopressin play important roles in the neurogenic regulation of the circulatory system, for example in cardiovascular responses to stress. Recently, it has become evident that the positive effects of statins are not limited to their lipid lowering properties, for example it has been found that statins ...
Ahmad Fiaz Ud Din - - 2012
Abstract The coexistence of hypertension and diabetes results in the rapid development of nephropathy. Hydrogen sulfide (H(2)S) is claimed to control the vascular and renal functions. This study tested the hypothesis that exogenous H(2)S lowers the blood pressure and decreases the progression of nephropathy in spontaneously hypertensive rats (SHR) that ...
Ikemura Miyako - - 2012
The effects of hesperidin, glucosyl hesperidin (G-hesperidin), a water-soluble derivative of hesperidin, and naringin on blood pressure and cerebral thrombosis were investigated using stroke-prone spontaneously hypertensive rats (SHRSP). Hesperidin, G-hesperidin and naringin were mixed with diet and fed to the animals for 4 weeks. No effect was evident on body weight, ...
Ardiansyah - - 2012
Supplementation with lupeol (0.67 g·kg(-1)) of the AIN-93M-based diet fed for 7 weeks to stroke-prone spontaneously hypertensive rats caused significantly decreased blood pressure as compared with a control group. Urinary 8-hydroxy-2'-deoxyguanosine was significantly lower in the lupeol group. Finally, lupeol suppressed the hepatic mRNA expression levels of the genes involved ...
Vargas Félix - - 2012
Oxidative stress contributes to the development of several cardiovascular diseases, including diabetes, renal insufficiency, and arterial hypertension. Animal studies have evidenced the association between higher blood pressure (BP) and increased oxidative stress, and treatment with antioxidants has been shown to reduce BP, while BP reduction due to antihypertensive drugs is ...
Moniwa Norihito - - 2012
Alterations in the circadian arterial pressure rhythm predict cardiovascular mortality. We examined the circadian arterial pressure rhythm and the effect of renin-angiotensin system blockade in congenic mRen2.Lewis hypertensive rats, a renin-dependent model of hypertension derived from the backcross of transgenic hypertensive [mRen-2]27 rats with Lewis normotensive ones. Twenty-nine mRen2.Lewis hypertensive ...
Eklund Anders - - 2012
The new Certas™ shunt for the treatment of hydrocephalus has seven standard pressure settings that according to the manufacturer range from 36 to 238 mmH2O, and an additional "Virtual Off" setting with an opening pressure >400 mmH2O. Information on actual pressure response and reliability of shunt performance is important in ...
Lindstedt Sandra - - 2012
Negative pressure wound therapy (NPWT) has gained acceptance among surgeons, for the treatment of open abdomen, since very high closure rates have been reported with this method, compared to other kinds of wound management for the open abdomen. However, the method has occasionally been associated with increased development of fistulae. ...
Schmidt Martin Jürgen - - 2012
Understanding the pathogenesis of the chiari-like malformation in the Cavalier King Charles Spaniel (CKCS) is incomplete, and current hypotheses do not fully explain the development of syringomyelia (SM) in the spinal cords of affected dogs. This study investigates an unconventional pathogenetic theory for the development of cerebrospinal fluid (CSF) pressure ...
Nishi Kouichirou - - 2012
To examine the hypothesis that resuscitative hypothermia would (1) reduce fluid requirements and reactive oxygen species production during a period of resuscitation and (2) improve survival after hemorrhagic shock (HS) in rats. Sixteen rats underwent an HS phase (phase I: 0-75 minutes), with pressure-controlled HS at a mean arterial pressure ...
Yosten Gina L C - - 2012
We recently reported that neuronostatin, a novel neuropeptide, biphasically increased mean arterial pressure, first through the activation of the sympathetic nervous system followed by the release of vasopressin. In those experiments, we found that centrally administered neuronostatin increased plasma vasopressin levels only 2-3 times greater than levels observed in saline-treated ...
Devadasu Venkat Ratnam - - 2011
The present study is an attempt to leverage therapeutic benefits of curcumin in pulmonary hypertension by encapsulating it in biodegradable poly(lactide-co-glycolic) acid nanoparticles. Pulmonary hypertension is induced in experimental animals by subjecting them to chronic hypoxic conditions. The ability of curcumin encapsulated nanoparticles to manage pulmonary hypertension is measured by ...
El-Mas Mahmoud M - - 2011
Although the intermediary role of central neurons in the hypertensive and sympathoexcitatory actions of cyclosporine (CSA) has been recognized in previous studies including our own, the underlying mechanism remains obscure. In this study, we tested the hypothesis that central pathways of nitric oxide (NO) and carbon monoxide (CO) modulate the ...
Raji Ismaila A - - 2011
ETHNOPHARMACOLOGICAL RELEVANCE: Tulbaghia violacea Harv. (Alliaceae) is a small bulbous herb which belongs to the family Alliaceae, most commonly associated with onions and garlic. In South Africa, this herb has been traditionally used in the treatment of various ailments, including fever, colds, asthma, paralysis, hypertension and stomach problems. The aim ...
Kenji Ninomiya - - 2011
Although some previous studies have reported patients who developed compartment syndrome or died because of locally applied negative pressure, no detailed investigation of pathologic changes caused by negative pressure-induced injury has been reported in the literature. The main purpose of this study was to examine the morphologic characteristics of injury ...
Bockx Ilse - - 2011
ObjectiveThe liver is innervated by the vagus nerve. Its efferent neurotransmitters acetylcholine (ACh) and vasoactive intestinal peptide (VIP) are both well-known vasodilators. A study was undertaken to determine whether electrical vagus nerve stimulation (STIM) influences portal vein pressure.MethodsThe left vagus nerve upstream of the hepatic branch was stimulated at 5 ...
Khoury Wisam - - 2011
INTRODUCTION: Pneumoperitoneum-associated ischemia-reperfusion (IR) may initiate renal dysfunction. Whether oxidants are responsible for renal structural damage, such as cell apoptosis, has not yet been evaluated. We investigated such eventuality in an isolated rat kidney model. METHODS: Thirty-five rat kidneys with their vessels and ureter were harvested and perfused within a ...
Tytgat Stefaan H A J - - 2012
The CO(2) pneumoperitoneum, which is used for laparoscopic surgery, causes local and systemic effects in patients. Concern arises about what the pressurized anoxic environment of the CO(2) pneumoperitoneum has on intestinal healing. Earlier experimental work showed a negative correlation between intestinal healing and the applied intra-abdominal pressure. To further elucidate ...
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