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Motoyama Hideki H Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, - - 2014
Although ex vivo lung perfusion (EVLP) has been clinically applied as a novel rig to evaluate marginal donor lungs, no parameters have been reported to objectively detect regional lung damage during EVLP. The aim of this study was to investigate whether regional donor lung malperfusion-related damage caused by a thrombus ...
Brassard Charles L CL Department of Anesthesiology and Critical Care, Université Laval, Quebec City, QC, - - 2014
The purpose of this Continuing Professional Development Module is to review the issues pertinent to one-lung ventilation (OLV) and to propose a management strategy for ventilation before, during, and after lung isolation. The need for optimal lung isolation has increased with the advent of video-assisted thoracoscopic surgery, as surgical exposure ...
Mortola Jacopo P - - 2014
Respiratory sinus arrhythmia (RSA) is an acceleration of heart rate during inspiration and deceleration with expiration. We asked whether or not in humans some of the volume-related information necessary for RSA originated from the chest wall. Men and women, 19-20 years old, were breathing supine. Rib cage and abdomen displacement ...
Teichert-Kuliszewska Krystyna K Division of Cardiology, Department of Medicine, University of Toronto, Toronto, - - 2014
S100A1, a 10-kDa, Ca(2+) -binding protein is expressed in endothelial cells (EC) and binds eNOS. Its absence is associated with impaired production of nitric oxide (NO) and mild systemic hypertension. As endothelial dysfunction contributes to clinical and experimental pulmonary hypertension (PH), we investigated the impact of deleting S100A1 in mice, ...
Cheifetz Ira M IM Department of Pediatrics, Children's Services, and Pediatric Critical Care Medicine, Duke University Medical Center, Duke Children's Hospital, Durham, North Carolina. - - 2014
The overall goal of the cardiorespiratory system is to provide the organs and tissues of the body with an adequate supply of oxygen in relation to oxygen consumption. An understanding of the complex physiologic interactions between the respiratory and cardiac systems is essential to optimal patient management. Alterations in intrathoracic ...
DiBlasi Robert M RM Seattle Children's Hospital, Seattle, Washington. Center for Developmental Therapeutics, Seattle Children's Hospital Research Institute, Seattle, Washington. - - 2014
Inhaled nitric oxide (INO) has been used with heated and humidified high-flow nasal cannula (HFNC), nasal CPAP and several forms of noninvasive ventilation (NIV). This study was designed to evaluate the delivered dose of INO, level of NO2 generation, and effect of net gas delivery (addition of INO to the ...
Cowie B B Department of Anaesthesia, St. Vincent's Hospital, Melbourne, Victoria, Australia; Department of Anesthesiology, University Hospitals Leuven, - - 2014
With the reduction in use of the pulmonary artery catheter, alternative methods of pulmonary pressure estimation are required. The use of echocardiographically-derived right ventricular systolic pressure has recently been questioned, but this technique has not been validated in anaesthetised surgical patients with transoesophageal echocardiography. One hundred measurements of right ventricular ...
Mellies Uwe U University of Essen, Pediatric Pulmonology and Sleep Medicine, Essen, Germany ; - - 2014
Background: For patients with neuromuscular disorders (NMD), lung insufflation with positive pressure is an accepted technique to increase inspiratory volume over Vital Capacity (VC) in order to improve Peak Cough Flow (PCF). However, the pressure or volume required to achieve the highest individual PCF is not known. Methods: In 40 ...
Soldati Gino G Emergency Medicine Unit, Castelnuovo Garfagnana General Hospital, Lucca, - - 2014
Background: Echographic vertical artifacts (B-lines) in chest ultrasonography have often been associated with pathological patterns. A scientifically sound explanation of these artifacts has not yet been proposed. Objectives: The 'spongy' nature of the lung in its liquid and solid components and the changes that take place in peripheral airspace (PAS) ...
Di Marco Fabiano F From the *Pneumologia, Ospedale San Paolo, Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, Italy; †Department of Experimental Medicine, University of Milano-Bicocca, Italy; ‡Centro Cardiologico Monzino IRCCS, Milano, Italy; §Centro Cardiologico Monzino IRCCS, Dipartimento di Scienze Cliniche e di Comunità, Sezione cardiovascolare, Università di Milano, Milan, Italy; ‖Division of Pulmonary and Critical Care and Medicine, Department of Medicine, University of Washington, Seattle, Washington; and ¶Anesthesia and Intensive Care, Ospedale Niguarda Ca' Granda, Milano, - - 2014
An increased alveolar-arterial oxygen tension difference is frequent in anesthetized patients. In this study, we evaluated the effect on the lung of anesthesia, muscle paralysis, and a brief course of mechanical ventilation. Lung diffusion for carbon monoxide (DLCO), including pulmonary capillary blood volume (Vc) and conductance of the alveolar-capillary membrane ...
Stahl C A CA Department of Anesthesiology and Intensive Care Medicine, University Medical Center Freiburg, Freiburg, - - 2014
It has been proposed that the analysis of positive end-expiratory pressure (PEEP)-induced volume changes can quantify alveolar recruitment. The potential of a lung to be recruited is expected to be high in acute respiratory distress syndrome (ARDS), where collapsed lung tissue is very common. The volume change that is beyond ...
Hess Dean R DR Respiratory Care Services, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts. - - 2014
Respiratory mechanics refers to the expression of lung function through measures of pressure and flow. From these measurements, a variety of derived indices can be determined, such as volume, compliance, resistance, and work of breathing. Plateau pressure is a measure of end-inspiratory distending pressure. It has become increasingly appreciated that ...
Hamedani Hooman H From the Department of Radiology (H.H., S.J.K., M.I., Y.X., K.E., B.H., H.S., D.G., W.G., R.R.R.), Department of Anesthesiology and Critical Care (M.C.), and Pulmonary, Allergy and Critical Care Division (M.D.R.), University of Pennsylvania, 308 Stemmler Hall, 3450 Hamilton Walk, Philadelphia, PA - - 2014
Purpose To assess the ability of helium 3 ((3)He) magnetic resonance (MR) imaging of regional alveolar partial pressure of oxygen ( Pao2 alveolar partial pressure of oxygen ) to depict smoking-induced functional alterations and to compare its efficacy to that of current diagnostic techniques. Materials and Methods This study was ...
Davis Daniel P - - 2014
Abstract Background: Inadvertent hyperventilation is associated with poor outcomes from traumatic brain injury (TBI). Hypocapnic cerebral vasoconstriction is well described and causes an immediate and profound decrease in cerebral perfusion. The hemodynamic effects of positive-pressure ventilation (PPV) remain incompletely understood but may be equally important, particularly in the hypovolemic patient ...
de Prost Nicolas N Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Medical Intensive Care Unit, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil, France - - 2014
PET with (18)F-FDG allows for noninvasive assessment of regional lung metabolism reflective of neutrophilic inflammation. This study aimed at determining during early acute lung injury whether local (18)F-FDG phosphorylation rate and volume of distribution were sensitive to the initial regional inflammatory response and whether they depended on the mechanism of ...
Marhong Jonathan J Interdepartmental Division of Critical Care Medicine, University of Toronto and the Department of Medicine, University Health Network and Mount Sinai Hospital, Toronto, Ontario, - - 2014
Hypercapnia and hypocapnia commonly complicate conditions that are present in critically ill patients. Both conditions have important physiologic effects that may impact the clinical management of these patients. For instance, hypercapnia results in bronchodilation and enhanced hypoxic vasoconstriction, leading to improved ventilation/perfusion matching. Hypocapnia reduces cerebral blood volume through arterial ...
Duyndam Anita A Erasmus MC - Sophia Children's Hospital, Rotterdam, The - - 2014
To evaluate to what extent physicians on a paediatric intensive care unit (PICU) adhered to a newly implemented ventilation algorithm. PICUs worldwide use different ventilators with a wide variety of ventilation modes. We developed an algorithm, as part of a larger protocol, for choice of ventilation mode at time of ...
Song Seok Young SY Department of Anesthesiology and Pain Medicine, Catholic University of Daegu School of Medicine, Daegu, - - 2014
The purpose of this study was to investigate the changes in airway pressure and arterial oxygenation between ventilation modes during one-lung ventilation (OLV) in patients undergoing thoracic surgery. We enrolled 27 patients for thoracic surgery with OLV in the lateral decubitus position. The subjects received various modes of ventilation in ...
Del Bo' Cristian C Università degli Studi di Milano, Department of Food, Environmental and Nutritional Sciences, Division of Human Nutrition, Milano, Italy. - - 2014
Cigarette smoking causes oxidative stress, hypertension and endothelial dysfunction. Polyphenol-rich foods may prevent these conditions. We investigated the effect of a single serving of fresh-frozen blueberry intake on peripheral arterial function and arterial stiffness in young smokers. Sixteen male smokers were recruited for a 3-armed randomized-controlled study with the following ...
Zhu Bing B Respiratory Technology, Woolcock Institute of Medical Research - - 2014
Abstract There are a multitude of formulation factors to consider when developing a solution-based pressurized metered dose inhaler (pMDI). Evaluation of these variables and their underpinning driving force has been performed over the years. Key components, including formulation composition and device design, play significant roles in determining the aerosol performance ...
Pouzou Jane G JG Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, - - 2014
Shipbuilding involves intensive welding activities within enclosed and confined spaces, and although ventilation is commonly used in the industry, its use and effectiveness has not been adequately documented. Workers engaged in welding in enclosed or confined spaces in two shipyards were observed for their use of ventilation and monitored for ...
Huynh Trang T Division of Newborn Medicine, Department of Pediatrics, New York Presbyterian Hospital, New York, - - 2014
Delivery room cardiopulmonary resuscitation is rare. Recent evidence suggests that effective ventilation may be compromised during chest compressions (CC). To determine whether trained neonatal personnel can assess effective ventilation during CC in the setting of changing lung compliance. Neonatal providers (n=30) provided CC using a 3:1 CC to ventilation ratio ...
Uzawa Yoshihiro Y Department of Rehabilitation, Kameda Medical Center. Electronic address: - - 2014
Lung volume changes involve the recruitment of collapsed alveoli and the expansion of already opened alveoli. This study aimed to determine the alveolar recruitment function by using a mathematical model from a Pressure-Volume curve (P-V curve). We assumed a lung model as VL=R(P)V0f(P), where R recruitment function is the fraction ...
Fischer Hendrik Stefan HS Department of Neonatology, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany, - - 2014
Nasal high-frequency oscillation ventilation (nHFOV) is a non-invasive ventilation mode that applies an oscillatory pressure waveform to the airways using a nasal interface. nHFOV has been shown to facilitate carbon dioxide expiration, but little is known about its use in neonates. In a questionnaire-based survey, we assessed nHFOV use in ...
Kollisch-Singule Michaela M Department of General Surgery, State University of New York Upstate Medical University, - - 2014
Improper mechanical ventilation settings can exacerbate acute lung injury by causing a secondary ventilator-induced lung injury. It is therefore important to establish the mechanism by which the ventilator induces lung injury to develop protective ventilation strategies. It has been postulated that the mechanism of ventilator-induced lung injury is the result ...
Mayhew Philipp D PD Departments of Surgical and Radiological Sciences, University of California-Davis, Davis, - - 2014
To document a technique for one-lung ventilation (OLV) in cats and evaluate the effect of low-pressure carbon dioxide insufflation and OLV (OLV-CDI) on cardiorespiratory variables in cats. Prospective randomized study. Cats (n = 6). General anesthesia was induced using a standardized anesthetic protocol. A thermodilution catheter was placed into the pulmonary artery ...
Suehiro Koichi K Department of Anesthesiology, Osaka City University Graduate School of Medicine, 1-5-7 Asahimachi, Abenoku, Osaka City, Osaka, 545-8586, Japan, - - 2014
This study was aimed at comparing the cardiac output (CO) measured by the Vigileo™-FloTrac™ system with that estimated by the thermodilution pulmonary artery catheter (PAC) during one-lung ventilation (OLV) and determining the reliability of this system in tracking phenylephrine-induced CO changes during OLV. Sixteen patients scheduled for descending aorta replacement ...
Strnad Matej M aCenter for Emergency Medicine, Community Health Center Maribor bMedical Faculty cFaculty of Health Sciences, University of Maribor, Maribor, - - 2014
The aim of this pilot study was to determine the usefulness of prehospital lung ultrasound in monitoring the effectiveness of treatment with continuous positive airway pressure (CPAP) versus standard therapy in patients with acute decompensated heart failure (ADHF). Twenty patients with ADHF were enrolled in this prospective, observational study. They ...
Berger David - - 2014
IntroductionAssist in unison to the patient¿s inspiratory neural effort and feedback- controlled limitation of lung distension with neurally adjusted ventilatory assist (NAVA) may reduce the negative effects of mechanical ventilation on right ventricular function.MethodsHeart-lung interaction was evaluated in 10 intubated patients with impaired cardiac function using esophageal balloons, pulmonary artery ...
Loring Stephen H SH http://orcid.org/0000-0002-6277-3979 Beth Israel Deaconess Medical Center - - 2014
Pneumoperitoneum for laparoscopic surgery is known to stiffen the chest wall and respiratory system, but its effects on resting pleural pressure in humans are unknown. We hypothesized that pneumoperitoneum would raise abdominal pressure, push the diaphragm into the thorax, raise pleural pressure and squeeze the lung, which would become stiffer ...
Fremuth Jiri J Pediatric intensive care unit (PICU), Department of Pediatrics, Faculty of Medicine, Charles University of Prague in Pilsen, Pilsen, Czech Republic - - 2014
Background: The aim of this comparative study was to assess the impact of two different settings of tidal volume (Vt) on the function and morphology of the mechanically ventilated lungs during a 12-h period. Materials and Methods: A total of 32 animals were randomly divided into two groups. Group A ...
Retamal Jaime - - 2014
IntroductionWhen alveoli collapse the traction forces exerted on their walls by adjacent expanded units may increase and concentrate. These forces may promote its re-expansion at the expense of potentially injurious stresses at the interface between the collapsed and the expanded units. We developed an experimental model to test the hypothesis ...
Potkay Joseph A JA VA Ann Arbor Healthcare System, Ann Arbor, MI 48105, USA. - - 2014
Microfluidic or microchannel artificial lungs promise to enable a new class of truly portable, therapeutic artificial lungs through feature sizes and blood channel designs that closely mimic those found in their natural counterpart. These new artificial lungs could potentially: 1) have surface areas and priming volumes that are a fraction ...
Guler Hasan H Department of Electrical-Electronics Engineering, Faculty of Engineering, Firat University, Elaziğ, Turkey - - 2014
The aim of this article is to develop a knowledge-based therapy for management of rats with respiratory distress. A mechanical ventilator was designed to achieve this aim. The designed ventilator is called an intelligent mechanical ventilator since fuzzy logic was used to control the pneumatic equipment according to the rat's ...
Ziebart Alexander - - 2014
BackgroundIn moderate acute respiratory distress syndrome (ARDS) several studies support the usage of assisted spontaneous breathing modes. Only limited data, however, focus on the application in systemic sepsis and developing lung injury. The present study examines the effects of immediate initiation of pressure support ventilation (PSV) in a model of ...
Blakeman Thomas T University of Cincinnati Department of Surgery, Division of Trauma and Critical Care , Cincinnati, OH , - - 2014
Abstract Purpose: Early ambulation in the ventilated patient is gaining wider acceptance. We evaluated a new portable (1 lb), gas powered, volume ventilator designed for NIV via a proprietary nasal pillows interface (Breathe Technologies, CA). We developed a model to approximate a patient's nose, upper airway and trachea. The model ...
Carlson Jestin N - - 2014
ABSTRACTObjective:Pulmonary aspiration of gastric contents occurs 20 to 30% of the time during cardiopulmonary resuscitation (CPR) of cardiac arrest due to loss of protective airway reflexes, pressure changes generated during CPR, and positive pressure ventilation (PPV). Although the American Heart Association has recommended the laryngeal mask airway (LMA) as an ...
Ruberto Franco F F Dipartimento di Anestesia e Rianimazione, UOD Anestesia e Terapia Intensiva Trapianti d'Organo, Policlinico Umberto I, "Sapienza", Rome, - - 2014
Independent lung ventilation (ILV) is a ventilation strategy used in patients with significant differences in respiratory mechanics between the 2 lungs owing to asymmetric or unilateral lung diseases. We report the case of a 66-year-old patient treated with ILV for a primary graft dysfunction occurred early after single lung transplantation. ...
Vargas Maria M Department of Neuroscience and Reproductive and Odontostomatological Sciences, University of Naples "Federico II," Naples, Italy; - - 2014
Percutaneous dilational tracheostomy is normally a bronchoscope-guided procedure. The insertion of a bronchoscope into an endotracheal tube (ETT) affects resistance, flow, and alveolar pressure. To improve airway management and ventilation during percutaneous tracheostomy, we developed a double lumen endotracheal tube (DLET). The aim of this in vitro study was to ...
Carvalho Nadja C NC 1Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany. 2Department of Electronic Engineering, Federal University of Minas Gerais, Belo Horizonte, Brazil. 3Institute for Medical Informatics and Biometry, Technische Universität Dresden, Dresden, Germany. 4Institute of Anatomy, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. 5Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.. 6Department of Surgical Sciences and Integrated Diagnostics, IRCCS San Martino Hospital, University of Genoa, Genoa, - - 2014
To assess the effects of different levels of spontaneous breathing during biphasic positive airway pressure/airway pressure release ventilation on lung function and injury in an experimental model of moderate acute respiratory distress syndrome. Multiple-arm randomized experimental study. University hospital research facility. Thirty-six juvenile pigs. Pigs were anesthetized, intubated, and mechanically ...
Hong Sung Ok SO From the Departments of *Oral Maxillofacial Surgery and †Anesthesiology and Pain Medicine, School of Medicine, Kyung Hee University Dental Hospital at Gangdong, Kyung Hee University, Seoul, Republic of - - 2014
Perioperative pulmonary edema is a rare complication of maxillofacial surgery. However, this potentially fatal complication may arise during any maxillofacial surgery. Negative pressure pulmonary edema can be caused by upper airway obstruction after operation. When this phenomenon arises, if not treated properly, it progresses rapidly causing fatal outcomes. Because orthognathic ...
Wirth Steffen S Division of Experimental Anesthesiology, Department of Anesthesiology and Intensive Care Medicine, University Medical Center, Hugstetter Straße 55, Freiburg, Germany. Electronic address: - - 2014
Recently, we presented Flow Controlled Expiration (FLEX) as a new option for lung-protective ventilation. FLEX delays the expiratory volume decrease in the lungs without prolonging the duration of expiration. Most ventilated patients nowadays receive spontaneous breathing support. We investigated whether FLEX is tolerated by awake subjects. In 24 healthy subjects ...
Stanzi Alessia A Laboratory for Experimental Thoracic Surgery, Department of Clinical and Experimental Medicine, KU Leuven University, Leuven, Belgium; Department of Thoracic Surgery, Ospedale Maggiore Policlinico, University of Milan, Milan, - - 2014
After normothermic ex vivo lung perfusion (EVLP), pulmonary grafts are usually flush-cooled and stored on ice until implantation although evidence for this practice lacks. We compared outcomes between 2 post-EVLP preservation strategies in a porcine left single-lung transplantation model. After cold flush and 2-h EVLP, donor lungs were prepared and split. ...
Bakhshesh Morteza M Department of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. - - 2014
Nasal mucosa has an extraordinary nerve supply with unique geometry that encompasses complex physiology. Among these, side-specific predilections to the respiratory and autonomic centers are the interesting issues that have been raised about the consequences of the nasal irritations. The aim of the study was an evaluation of how intranasal ...
Hartland Benjamin L - - 2014
Awake, spontaneously breathing humans sigh on average 9 to 10 times per hour. The sigh is a normal homeostatic reflex proposed to maintain pulmonary compliance and decrease the formation of atelectasis by recruiting collapsed alveoli. The induction and maintenance of anesthesia with muscle paralysis and a fixed tidal volume abolish ...
Hubmayr Rolf D RD Department of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota. - - 2014
In the following perspective, we will highlight seemingly remote, downstream consequences of common ventilator management decisions. For example, a change in PEEP may alter venous return, blood pressure, cardiac output, arterial and venous blood gas tensions, metabolic rate, respiratory sensations, breathing pattern, and the work of breathing. If providers consider ...
Lavoisier Pierre P P. Lavoisier, PT, MD, Centre d'Etudes des Dysfonctions Sexuelles (CEDS), 153 Rue Pierre Corneille 69003, Lyon, - - 2014
In men, involuntary or voluntary ischiocavernosus muscle contractions after erection lead to intracavernous blood pressures far higher than the systolic pressure, which builds and maintains penile rigidity. Thus, erectile dysfunction may be partly due to ischiocavernosus muscle atrophy and treated by rehabilitation interventions. Determine whether pelvic floor muscle strengthening interventions ...
Smith Andrea L AL Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, - - 2014
Lung lobectomy is necessary in neonatal patients for the treatment of a variety of congenital bronchopulmonary malformations. The working space required for traditional stapling devices limits their use in pediatric video-assisted thoracoscopic (VATS) lung lobectomy. The use of Hem-o-lok clips (Teleflex Medical Inc. Research Triangle Park, NC) has been described ...
Izumi Hideaki H Department of Urology, Tohoku University Graduate School of Medicine, 1-1 Seiryomachi, Aoba-ku, Sendai, 980-8574, - - 2014
Effects of tadalafil, a phosphodiesterase type 5 inhibitor, on the urethral continence reflex induced by sneezing were investigated. The amplitude of urethral pressure responses during sneezing (A-URS) and urethral baseline pressure (UBP) were measured in female rats using a microtransducer-tipped catheter. Sneeze leak-point pressure (S-LPP), defined as the lowest amount ...
Titze Ingo R IR National Center for Voice and Speech, 136 South Main Street, Suite 320, Salt Lake City, Utah - - 2014
The origin of vocal registers has generally been attributed to differential activation of cricothyroid and thyroarytenoid muscles in the larynx. Register shifts, however, have also been shown to be affected by glottal pressures exerted on vocal fold surfaces, which can change with loudness, pitch, and vowel. Here it is shown ...
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