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Winokur Eric S - - 2012
A continuous, wearable and wireless vital signs monitor at the ear is demonstrated. The device has the form factor of a hearing aid and is wirelessly connected to a PC for data recording and analysis. The device monitors the electrocardiogram (ECG) in a single lead configuration, the ballistocardiogram (BCG) with ...
Loniewska Beata - - 2012
Objective. The 1936G AKAP10 allele is associated with increased adult basal heart rate (HR) and decreased variability, markers of low cholinergic/vagus sensitivity associated with hypertension. Blood pressure (BP) values in newborns are important measurable markers of cardiovascular risk later in life. The question was whether decreased vagal function-related 1936A > ...
Gemignani Tiago - - 2012
BackgroundChanging from a supine to an orthostatic posture is associated with substantial increments in leg blood pressure (BP) levels, which could ultimately influence the hemodynamic burden imposed on the heart. This study investigated the relationship between brachial and leg BP measurements and the left cardiac chamber's structure and assessed the ...
Kong Hong - - 2012
C-reactive protein (CRP), an acute phase reactant and marker of inflammation, has been shown to be associated with CRP genetic variants and incident hypertension, but it is unclear whether this link is causal. We therefore conducted a prospective, nested case-control study to examine the relationship between single-nucleotide polymorphisms (SNPs) within ...
Shimbo Daichi - - 2012
Accumulating evidence suggests that increased visit-to-visit variability (VVV) of blood pressure is associated with stroke. No study has examined the association between VVV of blood pressure and stroke in postmenopausal women, and scarce data exist as to whether this relation is independent of the temporal trend of blood pressure. We ...
Haussen Diogo C - - 2012
Several variables are associated with poor outcome and mortality after intracerebral hemorrhage (ICH).(1) Among modifiable factors, hematoma expansion may have a predominant role, and has been the target of recent therapeutic trials in ICH. The Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT) and Antihypertensive Treatment of Acute ...
Takahara Mitsuyoshi - - 2012
To investigate whether diabetes and regular hemodialysis are associated with false elevation of ankle systolic blood pressure and ankle-brachial systolic pressure index (ABI) because of their arterial calcification in patients with critical limb ischemia (CLI). We recruited 269 Japanese patients who underwent endovascular therapy for CLI. Ankle systolic blood pressure ...
Forman John P - - 2012
A high-sodium diet has little short-term effect on blood pressure in nonhypertensive individuals but, for unclear reasons, is associated with hypertension if consumed long term. We hypothesized that a chronically high sodium intake would be associated with increases in biomarkers of endothelial dysfunction, specifically serum uric acid (SUA) and urine ...
Andreadis Emmanuel A - - 2012
We aimed to investigate the association between automated office blood pressure (AOBP) readings and urine albumin excretion (UAE), and to assess if this association is as close as that between 24-h ambulatory blood pressure (ABP) and UAE. A strong association would suggest that AOBP may serve as an indicator of ...
Virtanen Jyrki K - - 2012
Fish or fish oil consumption has been associated with lower blood pressure. Fish may also contain methylmercury, which has been associated with cardiovascular diseases and higher blood pressure. Our aim was to study the associations of serum long-chain n-3 polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and ...
Kalra Sundeep S SS BHF Centre of Research Excellence, Cardiovascular Division, King's College London, - - 2012
Vascular calcification is an active and regulated process which is integral to cardiovascular disease and intimately linked to hypertension. Dysfunctional vascular smooth muscle cells, microvesicles, and dysregulated mineralization inhibitors play key roles in the calcification process, which occurs in the vessel intima in association with atherosclerosis as well as in ...
Rao A D - - 2013
Serum- and glucocorticoid-inducible kinase 1 (SGK1) has a central role in epithelial sodium channel (ENaC)-dependent Na(+) transport in the distal nephron. We hypothesized that SGK1 gene variants may contribute to the effect of dietary salt intake on blood pressure (BP) in humans with hypertension, and consequentially influence renin-angiotensin-aldosterone (RAA) system ...
Padmanabhan Sandosh - - 2012
Blood pressure (BP) is a complex trait regulated by an intricate network of physiological pathways involving extracellular fluid volume homeostasis, cardiac contractility and vascular tone through renal, neural or endocrine systems. Untreated high BP, or hypertension (HTN), is associated with increased mortality, and thus a better understanding of the pathophysiological ...
Han Jia - - 2012
Hypertension is an important risk factor for chronic kidney disease. The kidney, in turn, has an important role in the regulation of blood pressure (BP). On the basis of a genome-wide association study, single-nucleotide polymorphisms in the uromodulin (UMOD) promoter region had been considered to influence both renal sodium reabsorption ...
Li Xiao-Mu - - 2012
Proprotein convertase subtilisin/kexin-type 1 (PCSK1) is a prohormone convertase that has an important role in prohormone maturation including the process of prorenin to renin. We studied the association of the PCSK1 single-nucleotide polymorphism (SNP) rs6235 (encoding an S690T substitution) with essential hypertension (EH), obesity and related traits in the Han ...
Kaikkonen Jari E - - 2012
BACKGROUND: In adults, dietary fatty acids (FAs) modify blood pressure (BP), but it is not known whether childhood FA quality is associated with adulthood BP. OBJECTIVE: The purpose of the study was to investigate links between childhood serum cholesterol ester fatty acid (CEFA) proportions and adulthood systolic blood pressure (SBP) ...
Ishikura Kazuki - - 2012
We identified the factors associated with home blood pressure (BP) variability in 1933 patients treated with hypertensive drugs (mean age, 67 years; women, 55%). Multivariate regression analysis showed that female gender, advanced age, home BP value, and home heart rate variability were positively associated with home BP variability, whereas home ...
Rich David Q - - 2012
Background: Mechanisms underlying previously reported air pollution and cardiovascular (CV) morbidity associations remain poorly understood. Objectives: We examined associations between markers of pathways thought to underlie these air pollution/CV associations and ambient particle concentrations in post-infarction patients. Methods: We studied 76 patients, from June 2006 to November 2009, participating in ...
Hamrefors Viktor - - 2012
OBJECTIVE:: We aimed to test whether eight common recently identified single-nucleotide polymorphisms (SNPs), strongly associated with blood pressure (BP) in the population, also have impact on the degree of BP reduction by antihypertensive agents with different mechanisms. METHODS:: In 3863 Swedish hypertensive patients, we related number of unfavorable alleles of ...
Ruiz-Fuertes J - - 2012
High-pressure optical-absorption measurements performed in CuWO_{4} up to 20 GPa provide experimental evidence of the persistence of the Jahn-Teller (JT) distortion in the whole pressure range both in the low-pressure triclinic and in the high-pressure monoclinic phase. The electron-lattice couplings associated with the e_{g}(E⊗e) and t_{2g}(T⊗e) orbitals of Cu^{2+} in CuWO_{4} ...
Hall Jennifer L - - 2012
The prevalence of hypertension in African Americans in the USA is among the highest in the world and increasing. The identification of genes and pathways regulating blood pressure in African Americans has been challenging. An early predictor of hypertension is arterial stiffness. The prevalence of arterial stiffness is significantly higher ...
Griffiths Paula L PL School of Sport, Exercise and Health Sciences, Loughborough University, - - 2012
Factors resulting in high risk for cardiovascular disease have been well studied in high income countries, but have been less well researched in low/middle income countries. This is despite robust theoretical evidence of environmental transitions in such countries which could result in biological adaptations that lead to increased hypertension and ...
Guessous Idris - - 2012
The 15q24.1 locus, including CYP1A2, is associated with blood pressure. The CYP1A2 rs762551 C allele is associated with lower CYP1A2 enzyme activity. CYP1A2 metabolizes caffeine and is induced by smoking. The association of caffeine consumption with hypertension remains controversial. We explored the effects of CYP1A2 variants and CYP1A2 enzyme activity ...
Hong Kyung-Won - - 2012
Increased pulse pressure (PP) and decreased mean arterial pressure (MAP) are strong prognostic predictors of adverse cardiovascular events. Recently, the International Consortium for Blood Pressure Genome-Wide Association Studies (ICBP-GWAS) reported eight loci that influenced PP and MAP. The ICBP-GWAS examined 51 cohorts--comprising 122 671 individuals of European ancestry--and identified eight SNPs: ...
Skilton Michael R - - 2012
OBJECTIVE: Structural modification of the arterial adventitia may be an early event in atherosclerosis. Carotid extra-medial thickness is a new measure of arterial adventitial thickness. We examined the association of cardiovascular risk factors with extra-medial thickness, in childhood. METHODS: Carotid extra-medial thickness was assessed by high-resolution ultrasound in 389 non-diabetic ...
Stevens Gerin R - - 2012
This study investigated whether right ventricular (RV) adaptation to chronic pressure overload is associated with pulmonary artery (PA) stiffness beyond the degree of severity of pulmonary hypertension (PH). Increased PA stiffness has been associated with reduced survival in PH. The mechanisms for this association remain unclear. Right heart catheterization and ...
Weber Joel R - - 2012
The term `crossover second toe' has been used to describe a deformity of the second metatarsophalangeal joint (MTPJ) that includes a progressive migration of the second toe in a dorsal and medial direction. The long onset and complex anatomy of the deformity has led to uncertainty about its etiology and ...
Malinowska Barbara - - 2012
The cannabinoids comprise three major classes of substances, including compounds derived from the cannabis plant (e.g. Δ(9) -tetrahydrocannabinol and the chemically related substances CP55940 and HU210), endogenously formed (e.g. anandamide) and synthetic compounds (e.g. WIN55212-2). Beyond their psychotropic effects, cannabinoids have complex effects on blood pressure, including biphasic changes of ...
Wayne Erik J - - 2012
Problematic dialysis vascular access is a major health issue. The purpose of this study was to evaluate for potentially modifiable factors associated with access patency, particularly, the association of early postoperative, or maturation period, blood pressure with patency. A retrospective review was performed of patients who had undergone placement of ...
Olsén Lena - - 2012
Studies have pointed out associations between various chemicals with estrogenic activity and cardiovascular disease. Being ubiquitous, the plastic additive substances bisphenol A (BPA), and phthalates have been detected in almost all types of analyzed human samples. The aim of this study was to investigate whether circulating levels of BPA and/or ...
Fahim Mohammad - - 2012
Neurohumoral disturbances characterize chronic heart failure (CHF) and are reflected, in part, as impairment of baroreflex sensitivity (BRS) and sympathetic function. However, the mechanisms that trigger these neurohumoral abnormalities in CHF are not clear. We hypothesized that the BRS is blunted early in CHF and that the humoral effects occur ...
Schwartz Joel J Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02215, - - 2012
Particulate air pollution is associated with cardiovascular events, but the mechanisms are not fully understood. The main objective was to assess the relationship between long-term exposure to traffic-related air pollution and blood pressure (BP). The authors used longitudinal data from 853 elderly men participating in the Veterans Administration Normative Aging ...
Shatriah Ismail - - 2012
  High intraocular pressure is a rare ophthalmic condition associated with infantile hemangiomas that involves the orbit, eyelid, or both. Here, we describe a patient with extensive facial and orbital infantile hemangiomas associated with high intraocular pressure in the affected eye. The prompt management of this challenging condition is essential.
Cukrowicz Kelly C - - 2012
Rural-dwelling adults face different health concerns and risks than do adults living in urban areas, with reduced assess to care. Studies examining the associations between anxiety and/or depression and blood pressure have yielded mixed results. This study addressed this by examining the association of these symptoms to blood pressure in ...
Gugleta Konstantin - - 2012
PURPOSE:: To analyze an association between the presumed risk factors for glaucoma and the actual extent of glaucomatous damage in untreated primary open-angle glaucoma. PATIENTS AND METHODS:: In 50 untreated open-angle glaucoma patients, we analyzed an association between the level of glaucomatous damage and presumed glaucoma risk factors: mean untreated ...
Krebs Christian - - 2012
BackgroundCCR5 is expressed on infiltrating T cells in hypertensive mice and CCR5 antagonists reduce hypertension making CCR5 an interesting target in treatment of hypertension.MethodsTo evaluate the role of CCR5 in hypertensive renal and cardiac end-organ damage, we induced hypertension with desoxycorticosterone acetate (DOCA) and angiotensin II (Ang II) in wild-type ...
Iwata Shinichi - - 2012
Atherosclerotic plaque in the aortic arch is an independent risk factor for ischemic stroke. Although high blood pressure (BP) measured at the doctor's office is known to be associated with aortic atherosclerosis, little is known on the association between 24-h ambulatory BP and aortic arch plaque presence and severity. Our ...
Gavras Irene - - 2012
It is widely believed that salt-dependent hypertension is induced and maintained by expansion of intravascular fluid volume resulting from excessive retention of sodium. The purpose of this brief article is to present a series of arguments in support of the thesis that volume overload per se does not raise the ...
Paulis Ludovit - - 2012
Pulse wave velocity (PWV), a direct marker of arterial stiffness, is an independent cardiovascular risk factor. Although the angiotensin II type 1 receptor blockade belongs to major antihypertensive and cardioprotective therapies, less is known about the effects of long-term stimulation of the angiotensin II type 2 receptor. Previously, compound 21, ...
Al-Nimer Marwan S - - 2012
Hypertension is the most important controllable and modifiable risk factor for stroke. The relationship between blood pressure and stroke mortality is strong and linear. Angiotensin receptor blockers (sartans) are competitive pharmacological antagonists of angiotensin II receptors, and some of them are approved for use in the treatment of hypertension. These ...
Clark Vernessa R - - 2012
The purpose of our study was to determine which measure of obesity is better at predicting cardiovascular risk in African Americans. We hypothesized that BMI alone would be significantly associated with cardiovascular reactivity. We also hypothesized that waist circumference alone would be significantly associated with cardiovascular reactivity. Lastly, we hypothesized ...
Kim In Byung - - 2012
Intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are significantly associated with morbidity and mortality. We performed a prospective observational study and applied recently published consensus criteria to measure and describe the incidence of IAH and ACS, identify risk factors for their development and define their association with outcomes. We ...
Masugata H - - 2012
This study examined the association between cardiac function and pulmonary function in hypertensive patients. Hypertensive patients without overt cardiovascular disease were enrolled (n = 43; mean ± SD age 71 ± 9 years). Pulmonary function was measured by the percentage of predicted forced vital capacity (%FVC) and the ratio of ...
Kidambi Srividya - - 2012
A recent genome wide association study in 1017 African Americans identified several single nucleotide polymorphisms that reached genome-wide significance for systolic blood pressure. We attempted to replicate these findings in an independent sample of 2474 unrelated African Americans in the Milwaukee metropolitan area; 53% were women and 47% were hypertensives. ...
Guo Youling - - 2012
Hypertension is caused by the interaction of environmental and genetic factors. The condition which is very common, with about 18% of the adult Hong Kong Chinese population and over 50% of older individuals affected, is responsible for considerable morbidity and mortality. To identify genes influencing hypertension and blood pressure, we ...
Gaál Emília Ilona - - 2012
Although genome-wide association studies (GWAS) have identified hundreds of complex trait loci, the pathomechanisms of most remain elusive. Studying the genetics of risk factors predisposing to disease is an attractive approach to identify targets for functional studies. Intracranial aneurysms (IA) are rupture-prone pouches at cerebral artery branching sites. IA is ...
Duarte Julio D - - 2012
Nearly one-third of the United States adult population suffers from hypertension. Hydrochlorothiazide (HCTZ), one of the most commonly used medications to treat hypertension, has variable efficacy. The renal epithelial sodium channel (ENaC) provides a mechanism for fine-tuning sodium excretion, and is a major regulator of blood pressure homeostasis. DOT1L, MLLT3, ...
Liang Jun - - 2012
The American Diabetes Association (ADA) recently published new clinical guidelines in which hemoglobin A1c (HbA1c) was recommended as a diagnostic test for diabetes. The present study was to investigate the association between HbA1c and cardiovascular risk, and compare the associations with fasting glucose and 2-hour oral glucose tolerance test (2 ...
Gan Wei - - 2012
Dysregulation of the complement system has been linked to pathogenesis of hypertension. However, whether genetic changes of complement factor H (CFH) and its related genes are associated with hypertension is unknown. We genotyped three SNPs in the CFH gene cluster that are closely linked to age-related macular degeneration, namely rs1061170 ...
Kumar Pradeep - - 2012
Due to their self-catalytic properties, small RNAs with bulge bases are hypothesized to be primordial molecules which could form elementary translation systems. Using molecular dynamics simulations, we study the binding propensity of small RNAs by calculating the free energy barrier corresponding to the looped out conformations of bulge bases, which ...
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