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Results 301 - 350 of 1847
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Davis Robert Patrick RP Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, United - - 2013
A 7-day infusion of serotonin (5-hydroxytryptamine, 5-HT) causes a sustained fall in elevated blood pressure in the male deoxycorticosterone acetate (DOCA)-salt rat. As hypertension is a long-term disease, we presently test the hypothesis that a longer (30 day) 5-HT infusion could cause a sustained fall in blood pressure in the ...
Phillips Aaron A - - 2012
As sympathetic activity approximately doubles during intense lower body negative pressure (LBNP) of -60 mmHg or greater, we examined the relationship between surrogate markers of sympathetic activation and central arterial distensibility during severe LBNP. Eight participants were exposed to progressive 8-min stages of LBNP of increasing intensity (-20, -40, -60, and ...
Cui Xiaopei - - 2012
Grape seed proanthocyanidin extracts (GSPE) belonging to polyphenols, possess various biological effects including anti-inflammation, anti-oxidant, anti-aging, anti-atherosclerosis and et al. GSPE is potential in regulating endothelial function. However, the underlying mechanism is not clear yet. In this study, by siRNA knocking down, we proved that GSPE increase endothelial nitric oxide ...
Madueme Peace C - - 2012
BACKGROUND: In normotensive subjects, an exaggerated blood pressure response to exercise is associated with the development of resting hypertension. We sought to determine the prevalence of elevated blood pressures during exercise in post-operative coarctation patients with normal resting blood pressure, and investigate associations with exercise-induced hypertension in this population. METHODS: ...
Lee Melissa G Y - - 2012
OBJECTIVES: To determine by 24-hour blood pressure monitoring the risk of hypertension late after coarctation repair in patients with arch hypoplasia. METHODS: Sixty-two of 116 consecutive patients (age, ≥10 years) who had coarctation repair and were quoted subjectively by the surgeon or the cardiologist to have arch hypoplasia at the ...
Mortensen Kai - - 2012
J Clin Hypertens (Greenwich). 2012;14:861-870. ©2012 Wiley Periodicals, Inc. Renal sympathetic denervation (RDN) is a novel treatment strategy for patients with resistant arterial hypertension. Recently, the Symplicity trials demonstrated significant peripheral blood pressure (BP) reduction. The present study aimed at measuring central aortic pressures and arterial stiffness as better predictors ...
Hayashi Taro - - 2012
Cardiac tamponade is associated with fatal outcomes for patients with acute type A aortic dissection, and the presence of cardiac tamponade should prompt urgent aortic repair. However, treatment of the patient with critical cardiac tamponade who cannot survive until surgery remains unclear. We analyzed our experience of controlled pericardial drainage ...
Curran Sarah A - - 2012
Pressure distribution measurement offers an objective and quantifiable method of determining the loads applied to the human body during static and dynamic situations such as walking and the more demanding tasks associated with sporting activities. While there are various systems available on the market, the technology and developments offered by ...
Annavarajula S K - - 2012
Chronic kidney disease (CKD) is a growing problem worldwide. The disproportionate increase in the burden of cardiovascular disease in patients with CKD may be significantly contributed by nontraditional risk factors. Increased arterial stiffness has been recognized as an important player in contributing to this morbidity and mortality. The aim of ...
Mason R Preston - - 2012
ABSTRACT:: Most patients with diabetes also have hypertension, a risk factor associated with atherothrombotic disease and characterized by endothelial cell (EC) dysfunction and loss of nitric oxide (NO) bioavailability. Recent studies suggest a possible antihypertensive effect with dipeptidyl peptidase-4 (DPP4) inhibition; however, the underlying mechanism is not understood. In this ...
Okamura Homare - - 2012
PURPOSE: The effective orifice area index (EOAI) is used to define the prosthesis-patient mismatch (PPM) after aortic valve replacement (AVR). However, few studies have so far evaluated whether the cutoff value for PPM varies across prostheses. This study assessed the hemodynamics in patients given a mechanical valve and then re-evaluated ...
Fordyce P M - - 2012
Multilayer soft lithography (MSL) provides a convenient and low-cost method for fabricating poly(dimethyl siloxane) (PDMS) microfluidic devices with on-chip valves for automated and precise control of fluid flow. MSL casting molds for flow channels typically incorporate small patches of rounded positive photoresist at valve locations to achieve the rounded cross-sectional ...
Dang Yong-Qiang - - 2012
FRET has been used as a powerful tool in biological fields as biosensors, bioimaging, protein folding/unfolding monitoring, biomolecular interactions and so on. It is also important to applying FRET to high hydrostatic pressure studies on bio- or bio-related systems. Herein, we construct a FRET system by labeling Cy3 on C-phycocyanin ...
Webb Alastair J S AJ Stroke Prevention Research Unit, University of Oxford, Oxford, - - 2012
Arterial stiffening reduces damping of the arterial waveform and hence increases pulsatility of cerebral blood flow, potentially damaging small vessels. In the absence of previous studies in patients with recent transient ischemic attack or stroke, we determined the associations between leukoaraiosis and aortic and middle cerebral artery stiffness and pulsatility. ...
Reisman William M - - 2012
BACKGROUND: Near infrared spectroscopy (NIRS) has been suggested as a possible means for detecting perfusion deficits in patients with acute compartment syndrome (ACS). STUDY OBJECTIVES: To longitudinally examine NIRS in an ACS model to determine its responsiveness to decreasing perfusion pressure. METHODS: A NIRS sensor pad was placed under a ...
Gu Kaiyun - - 2012
The intraaorta pump is a novel left ventricular assist device (LVAD) whose hemodynamic effects on the circulatory system is unknown. This article aims to evaluate the different effects on the circulatory system supported by the intraaorta pump. In this article, the pump is controlled by three control strategies, including the ...
Reymond Philippe - - 2012
One-dimensional models of the systemic arterial tree are useful tools for studying wave propagation phenomena, however, their formulation for frictional losses is approximate and often based on solutions for developed flow in straight non-tapered arterial segments. Thus, losses due to bifurcations, tortuosity, non-planarity and complex geometry effects cannot be accounted ...
Cihan Abdullah - - 2012
Carbon dioxide injection into deep saline formations may induce large-scale pressure increases and migration of native fluid. Local high-conductivity features, such as improperly abandoned wells or conductive faults, could act as conduits for focused leakage of brine into shallow groundwater resources. Pressurized brine can also be pushed into overlying/underlying formations ...
Tamegai Hideyuki - - 2012
It is known that the facultative piezophile Shewanella violacea DSS12 alters its respiratory components under the influence of hydrostatic pressure during growth. This can be considered one of the mechanisms of bacterial adaptation to high pressure. In this study, we investigated the respiratory system of another well-studied piezophile, Photobacterium profundum ...
Parichatikanond Warisara - - 2012
Overactivation of the renin-angiotensin system is one of the most important risk factors for the development of hypertension. The use of the crude extracts and/or active compounds, such as anthocyanins and quercetin, of herbal plants that have antihypertensive effects is beneficial for decreasing of blood pressure level. However, the molecular ...
Nepple Kenneth G KG Division of Urology, Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA. - - 2013
Previous experimental research has reported minimal differences in pressure maintenance between different versions of standard insufflators (SI). However, a recent report identified potential clinical benefits with a valveless pressure barrier insufflator (PBI). We sought to perform a benchtop objective evaluation of SI and PBI systems. A rigid box system with ...
de Oliveira Fabricio Ferreira - - 2012
Normal pressure hydrocephalus is an unusual manifestation of systemic lupus erythematosus and its pathogenesis is still unclear. We report the case of a 39-year-old white woman with systemic lupus erythematosus who developed magnetic gait, speech difficulties, progressive memory impairment, urinary incontinence and episodes of involuntary closure of the eyelids. Signs ...
Ji Xiaoyan - - 2012
For CO2 geological storage, permitting impurities, such as H2S, in CO2 streams can lead to a great potential for capital and energy savings for CO2 capture and separation, but it also increases costs and risk management for transportation and storage. To evaluate the cost - benefits, using a recently developed ...
Melamed Roman - - 2012
OBJECTIVES: Invasive blood pressure monitoring is the most reliable method in critically ill patients. Noninvasive oscillometric pressure monitoring is also widely used in the ICU, and discrepancies between the methods are common. Inclusion of a blood-conserving device may influence the fidelity of the system and reliability of the invasive pressure ...
Etemadi M - - 2012
Congenital pulmonary hypoplasia is a devastating condition affecting fetal and newborn pulmonary physiology, resulting in great morbidity and mortality. The fetal lung develops in a fluid-filled environment. In this work, we describe a novel, implantable pressure sensing and recording device which we use to study the pressures present in the ...
Toal Corey B - - 2012
Calcium-channel blockers (CCBs) constitute a diverse group of compounds but are often referred to as a single homogeneous class of drug and the clinical responses indiscriminately summarized. Even within the dihydropyridine subgroup, there are significant differences in formulations, pharmacokinetics, durations of action and their effects on blood pressure, heart rate, ...
Groenewald Berlizé - - 2012
Gas exchange dynamics in insects is of fundamental importance to understanding evolved variation in breathing patterns, such as discontinuous gas exchange cycles (DGCs). Most insects do not rely solely on diffusion for the exchange of respiratory gases but may also make use of respiratory movements (active ventilation) to supplement gas ...
Kalupahana Nishan S - - 2012
The renin-angiotensin system (RAS) is classically known for its role in regulation of blood pressure, fluid and electrolyte balance. In this system, angiotensinogen (Agt), the obligate precursor of all bioactive angiotensin peptides, undergoes two enzymatic cleavages by renin and angiotensin converting enzyme (ACE) to produce angiotensin I (Ang I) and ...
Henderson Sarah - - 2012
Health professionals can fail to identify and treat serious illness or acute deterioration in children because of a lack of relevant training, experience or supervision. In Argyll and Bute in Scotland a standardised, monitoring system was initiated measuring six physiological parameters: temperature, pulse rate, respiratory rate, systolic blood pressure, oxygen ...
Antfolk Christian C Department of Measurement Technology and Industrial Electrical Engineering, Lund University, Lund, - - 2012
Lack of sensory feedback is a drawback in today's hand prostheses. We present here a non-invasive simple sensory feedback system, which provides the user of a prosthetic hand with sensory feedback on the arm stump. It is mediated by air in a closed loop system connecting silicone pads on the ...
Lion Thomas W - - 2012
Computer simulations of inhomogeneous soft matter systems often require accurate methods for computing the local pressure. We present a simple derivation, based on the virial relation, of two equivalent expressions for the local (atomistic) pressure in a molecular dynamics simulation. One of these expressions, previously derived by other authors via ...
Park Taehyun - - 2012
A novel thermoplastic fusion bonding method using a pressure-assisted boiling point (PABP) control system was developed to apply precise temperatures and pressures during bonding. Hot embossed polymethyl methacrylate (PMMA) components containing microchannels were sealed using the PABP system. Very low aspect ratio structures (AR = 1/100, 10 μm in depth ...
Marc Yannick - - 2012
Brain renin-angiotensin system hyperactivity has been implicated in the development and maintenance of hypertension. We reported previously in the brain that aminopeptidase A and aminopeptidase N are involved in the metabolism of angiotensin II and angiotensin III, respectively. By using in vivo specific and selective aminopeptidase A and aminopeptidase N ...
Hyam Jonathan A - - 2012
Deep brain stimulation (DBS) is an expanding field in neurosurgery and has already provided important insights into the fundamental mechanisms underlying brain function. One of the most exciting emerging applications of DBS is modulation of blood pressure, respiration and micturition through its effects on the autonomic nervous system. DBS stimulation ...
Hoppe Uta C - - 2012
BACKGROUND: Previous trials have demonstrated clinically significant and durable reductions in arterial pressure from baroreflex activation therapy (BAT), resulting from electrical stimulation of the carotid sinus using a novel implantable device. A second-generation system for delivering BAT, the Barostim neo™ system, has been designed to deliver BAT with a simpler ...
Kaczka David W - - 2012
The dynamic mechanical properties of the respiratory system reflect the ensemble behavior of its constituent structural elements. This study assessed the appropriateness of constant-phase descriptions of respiratory tissue viscoelasticity at various distending pressures. We measured the mechanical input impedance (Z) of the lungs, chest wall and total respiratory system in ...
Kimura Toshihiro - - 2012
No pressure: A simple monomeric tungstate, [WO(4) ](2-) , serves as a highly efficient homogeneous catalyst for various transformations of CO(2) at atmospheric pressure. The tungsten-oxo moiety activates CO(2) and the substrate simultaneously. The catalyst system is high yielding and applicable to a wide range of substrates such as amines, ...
Williams Bryan - - 2012
Arterial aging is associated with a progressive increase in aortic stiffening, which results in a rise in central aortic pressures. Traditionally, blood pressure (BP)-lowering therapy has been directed at brachial rather than central pressures. However, a key contemporary question is whether this strategy is optimal in reducing aortic pressure and ...
Szolnoky G - - 2012
Lipedema is a disproportional obesity due to unknown pathomechanism. Its major hallmark is frequent hematoma formation related to increased capillary fragility and reduced venoarterial reflex. Beyond microangiopathy, both venous and lymphatic dysfunction have also been documented. However, arterial circulation in lipedema has not been examined, and therefore we explored aortic ...
Sarazan R Dustan - - 2012
Increasing or decreasing cardiac contractility is an undesirable property of drugs being developed for noncardiovascular indications. The International Conference on Harmonization (ICH) Topic S7A and S7B guidelines only require the assessment of heart rate, blood pressure and the electrocardiogram in nonclinical in vivo safety pharmacology studies. Assessment of drug effects ...
Giridharan Guruprasad A - - 2012
Ventricular assist devices (VADs) have been used successfully as a bridge to transplant in heart failure patients by unloading ventricular volume and restoring the circulation. An artificial vasculature device (AVD) is being developed that may better facilitate myocardial recovery than VAD by controlling the afterload experienced by the native heart ...
Rubini Alessandro - - 2012
Context: Angiotensin stimulates smooth-muscle contraction. Accordingly, angiotensin-converting enzyme (ACE) inhibition is expected to decrease airway resistance. Objectives: To measure the effects of ACE inhibition on respiratory mechanics in healthy mammals. Materials and methods: We measured respiratory mechanics before and after i.p. ACE inhibitor captopril (100 mg/kg) in normal anaesthetised rats. The ...
Li Tao - - 2012
This paper describes a valve-regulated architecture for intrathecal, insulin and other drug delivery systems that offers high performance and volume efficiency through the use of micromachined components. Multi-drug protocols can be accommodated by using a valve manifold to modulate and mix drug flows from individual reservoirs. A piezoelectrically-actuated silicon microvalve ...
McCracken M J - - 2012
Reasons for performing study: Subjective evaluation of mild lameness has been shown to have poor interobserver reliability. Traditional methods of objective lameness evaluation require specialised conditions and equipment. Wireless inertial sensor systems have been developed to allow for simple, rapid, objective lameness detection in horses trotted over ground. Objective: The ...
Sternberg Zohara - - 2012
Multiple sclerosis (MS) is a disease with multiple etiologies. The most recent theory of the vascular etiology of MS, Chronic Cerebrospinal Venous Insufficiency (CCSVI), suggests that cerebral venous obstruction could lead to cerebral venous reflux, promoting local inflammatory processes. This review article offers strong evidence that the route of the ...
Parati Gianfranco - - 2012
Evidence assembled in this review indicates that sympathetic nervous system dysfunction is crucial in the development of heart failure and essential hypertension. This takes the form of persistent and adverse activation of sympathetic outflows to the heart and kidneys in both conditions. An important goal for clinical scientists is translation ...
Ward Gemma - - 2012
INTRODUCTION: The objective of this study was to evaluate the ability of a non-invasive telemetry monitoring system to detect and quantify changes in blood pressure and electrocardiogram (ECG) parameters in response to vehicle, l-NAME or minoxidil administration to freely moving beagle dogs. Data from a non-invasive telemetry monitoring system were ...
Chalmers E - - 2012
Bracing is a common non-surgical treatment for scoliosis, but its effectiveness has been debated. Some clinical studies have shown efficacy of brace treatment is correlated to how the brace has been worn. The more often the patients wear their braces to the prescribed tightness as well as the prescribed length ...
Ryska Ondrej - - 2012
Objectives: Extracorporeal liver support (ELS) may play a role in bridging therapy in patients with acute liver failure (ALF). The aim of this study was to compare the influence of nonbiological and biological methods on intracranial pressure (ICP) in an animal model of ALF. Methods: A surgical devascularization model of ...
Mitchell Greg W - - 2012
1. Determining how events interact across stages of the annual cycle is critical for understanding the factors that affect individual fitness. However, there is currently little information detailing how breeding events influence migratory behaviour. 2. Using an automated digital telemetry array and an isolated island-breeding population of Savannah sparrows Passerculus sandwichensis, we ...
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