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Morrison Jonathan J JJ The Academic Department of Military Surgery & Trauma, Royal Centre for Defence Medicine, Birmingham, United Kingdom; The United States Army Institute of Surgical Research, Fort Sam Houston, Texas; Academic Unit of Surgery, Glasgow Royal Infirmary, Glasgow, United - - 2014
Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a hemorrhage control and resuscitative adjunct that has been demonstrated to improve central perfusion during hemorrhagic shock. The aim of this study was to characterize the systemic inflammatory response associated and cardiopulmonary sequelae with 30, 60, and 90 min of balloon occlusion ...
Rengier Fabian F 1 University Hospital Heidelberg, Department of Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany ; 2 German Cancer Research Center (dkfz) Heidelberg, Department of Radiology, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany ; 3 Karlsruhe Institute of Technology (KIT), Department of Informatics, Institute for Anthropomatics and Robotics, Adenauerring 2, 76131 Karlsruhe, Germany ; 4 University Hospital Heidelberg, Department of Paediatric Cardiology, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany ; 5 Inselspital, University Hospital Bern, Institute for Diagnostic, Interventional and Pediatric Radiology (DIPR), Freiburgstr. 10, 3010 Bern, - - 2014
To develop a method for computing and visualizing pressure differences derived from time-resolved velocity-encoded three-dimensional phase-contrast magnetic resonance imaging (4D flow MRI) and to compare pressure difference maps of patients with unrepaired and repaired aortic coarctation to young healthy volunteers. 4D flow MRI data of four patients with aortic coarctation ...
Ripley Toni L TL University of Oklahoma College of Pharmacy, Oklahoma City, OK, - - 2014
To review the pharmacology, pharmacokinetics, and pharmacodynamic properties of commonly used β-blockers (atenolol, carvedilol, metoprolol succinate, metoprolol tartrate, and nebivolol). A MEDLINE literature search (1966-May 2013) was performed using the following key terms: hypertension, β-blockers, atenolol, carvedilol, metoprolol tartrate, metoprolol succinate, nebivolol, pharmacology, pharmacodynamics, pharmacokinetics, blood pressure, metabolic, lipid, central ...
Ikeda Shohei S From the Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan (S.I., K.S., N.K., S.M., K.S., J.O., T.S., Y.F., Y.S., H.S.); and Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima, Japan (Ke. Kobayashi, Ka. - - 2014
Right ventricular (RV) failure is the leading cause of death in various cardiopulmonary diseases, including pulmonary hypertension. It is generally considered that the RV is vulnerable to pressure overload as compared with the left ventricle (LV). However, as compared with LV failure, the molecular mechanisms of RV failure are poorly ...
Thio M M Neonatal Services, The Royal Women's Hospital, , Melbourne, - - 2014
In neonatal resuscitation, the use of a sustained inflation (SI) may facilitate lung aeration. Previous studies comparing different resuscitation devices have shown that one model of self-inflating bag (SIB) could not deliver an SI. We aimed to compare the delivery of an SI using four SIBs with that of a ...
Juraszek Andrzej A Center for Medical Physics and Biomedical Engineering, Vienna, - - 2014
The aim of the study was to simulate the effect of different bicuspid aortic valve configurations on the dynamic pressure distribution in the ascending aorta. Aortic specimens were harvested from adult domestic pigs. In Group 1, bicuspidalization was created by a running suture between the left and the right coronary ...
Everett T R TR Fetal Medicine Department, Rosie Hospital, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 2QQ, - - 2014
To determine the effects of in vivo S-nitrosoglutathione infusion on cardiovascular, platelet function, proteinuria and biomarker parameters in early-onset pre-eclampsia. We performed an open-label dose-ranging study of S-nitrosoglutathione in early-onset pre-eclampsia. Six women with underwent S-nitrosoglutathione infusion whilst receiving standard therapy. S-nitrosoglutathione dose was incrementally increased to 100μg/min whilst maintaining ...
Theilade Simone S Diabetes Complication Research Department, Steno Diabetes Center, Gentofte, - - 2014
We sought to investigate associations between central hemodynamic parameters (estimated from radial pulse wave analyses (PWAs)), cardiovascular disease (CVD), and albuminuria in type 1 diabetes. We conducted an observational study of 636 type 1 diabetes patients. Central hemodynamics were measured by PWA as central aortic systolic pressure (CASP), central aortic ...
Corazza Ivan I Experimental, Diagnostic and Specialty Medicine Department, University of Bologna, Via Massarenti, 9, 40138 Bologna, Italy. Electronic address: - - 2014
Aortic counterpulsation (IABP) consists in an ECG-controlled forced deflation and inflation of a balloon positioned in the aorta. The device is designed to decrease the ventricular afterload during systole and to increase the coronary driving pressure during diastole. In biomechanical terms, the IABP improves the mechanical matching between the pump ...
Bargiotas Ioannis I Sorbonne Universités, UPMC Univ Paris 06, UMR 7371, UMR_S 1146, Laboratoire d'Imagerie Biomédicale, Paris, France; INSERM, UMR_S 1146, Laboratoire d'Imagerie Biomédicale, Paris, France; CNRS, UMR 7371, Laboratoire d'Imagerie Biomédicale, Paris, - - 2014
We sought to noninvasively estimate aortic impedance indices from MR and tonometric data. MR aortic velocity-encoded and carotid applanation tonometry pressure data of 70 healthy subjects (19-79 years) were used to calculate the following indices from impedance spectrum: (i) characteristic impedance (Zc) reflecting pulsatile component of left ventricular (LV) afterload, ...
Huang Feng F * The State Key Laboratory of Fluid Power Transmission and Control, Zhejiang University, Hangzhou, - - 2014
Sufficient pulsation is important for physiological perfusion if adequate flow is to be guaranteed. A fuzzy control method for rotary blood pumps using active speed modulation is proposed in this paper. It maintains the mean aortic pressure to provide sufficient perfusion while it simultaneously enhances the pulse pressure. The controller ...
Pabittei Dara R DR Department of Cardiothoracic Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The - - 2014
The low welding strength of laser-assisted vascular anastomosis (LAVA) has hampered the clinical application of LAVA as an alternative to suture anastomosis. To improve welding strength, LAVA in combination with solder and polymeric scaffolds (ssLAVA) has been optimized in vitro. Currently, ssLAVA requires proof-of-concept in a physiologically representative ex vivo model before ...
Bailly L L Aix Marseille Université, CNRS, Centrale Marseille, IRPHE UMR 7342, 13384 Marseille, France. Electronic address: - - 2014
This work proposes an in vitro tensile testing protocol that is able to characterize abdominal aortic (AA) analogues under physiologically inspired mechanical loadings. Kinematic parameters are defined in agreement with in vivo measurements of aortic dynamics. A specific focus is given to the choice of the applied loading rates, deriving ...
Divchev Dimitar D Department of Cardiology, University Heart Center Rostock, Rostock, - - 2014
We report on feasibility, safety, and mid-term outcomes of renal sympathetic denervation (RSD) in hypertensive patients after endovascular treatment for aortic dissection. Six patients were subjected to RSD after receiving endovascular treatment for complicated aortic dissection. Between April 2011 and May 2012, RSD procedure was applied for persistent hypertension despite ...
Ochodnicky Peter P Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University Bratislava, Slovak Republic. Electronic address: - - 2014
Peroxisome proliferator-activated receptor γ (PPARγ) agonists have been shown to ameliorate diabetic nephropathy, but much less is known about their effects in non-diabetic nephropathies. In the present study, metabolic parameters, blood pressure, aortic endothelial function along with molecular and structural markers of glomerular and tubulointerstitial renal damage, were studied in ...
Figueroa Arturo A Department of Nutrition, Food and Exercise Sciences, The Florida State University, Tallahassee, - - 2014
Cold-induced increases in aortic blood pressure (BP) may cause adverse cardiac events in hypertensives by increasing ventricular afterload. L-citrulline supplementation reduces BP at baseline and during the cold pressor test (CPT), but the effect on wave reflection (augmentation pressure (AP) and index (AIx)) is controversial. Our aim was to assess ...
Beck Darren T DT Department of Kinesiology, University of Rhode Island, Kingston, Rhode - - 2014
Central hemodynamic and augmentation indices are independent predictors of cardiovascular events and all-cause mortality that can be estimated noninvasively by pulse wave analysis. The purpose of this study was to assess the reliability and validity of a newly engineered wristband tonometer for acquiring radial artery pressure waveforms. Radial artery pulse ...
Eleid Mackram F MF Division of Cardiovascular Diseases, Mayo - - 2014
The non-invasive evaluation of prosthetic valve function is challenging. The effects of flow rate, valvular geometry, leaflet motion and pressure recovery all impact the Doppler assessment of prosthetic performance. Differentiating prosthesis obstruction from pressure recovery in patients who are found to have high Doppler velocities across an aortic valve prosthesis ...
Niccoli Giampaolo G Department of Cardiovascular Medicine, Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy. Electronic address: - - 2014
Our study aimed to elucidate mechanisms underlying discordance between fractional flow reserve (FFR) and hyperemic stenosis resistance (hSR) in some patient subsets. To do this, we enrolled 30 consecutive patients with stable angina or non-ST elevation myocardial infarction (non-STEMI) and with a nonculprit intermediate coronary lesion (40% to 70%) by ...
Libhaber Carlos D CD Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South - - 2014
To determine whether SBP or DBP is best associated with different components of left ventricular diastolic dysfunction. In 241 randomly selected participants, echocardiographic left ventricular diastolic function was assessed from early-to-atrial (E/A) transmitral velocity and E/e' where e' represents myocardial tissue lengthening velocity in early diastole as measured at the ...
Jansen-Park So-Hyun SH Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Aachen, - - 2014
Real-time monitoring of the aortic valve function and the loading state of the left ventricle (LV) during mechanical circulatory support is essential. Therefore, we developed a system that determines accurately the aortic valve closing moment based on integrals derived from the pump inlet pressure and the pump power [pressure-power area ...
Rogers Chad I CI Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT - - 2014
Pneumatically actuated, non-elastomeric membrane valves fabricated from polymerized polyethylene glycol diacrylate (poly-PEGDA) have been characterized for temporal response, valve closure, and long-term durability. A ~100 ms valve opening time and a ~20 ms closure time offer valve operation as fast as 8 Hz with potential for further improvement. Comparison of ...
Rinaudo Antonino A a Dipartimento di Ingegneria Chimica , Gestionale, Informatica e Meccanica, Universita' di Palermo , Viale delle Scienze Ed. 8, 90128 , Palermo , - - 2014
Coarctation of aorta (CoA) is a narrowing of the aorta leading to a pressure gradient (ΔP) across the coarctation, increased afterload and reduced peripheral perfusion pressures. Indication to invasive treatment is based on values of maximal (systolic) trans-coarctation ΔP. A computational fluid dynamic (CFD) approach is herein presented for the ...
Abdi-Ali A A 1Department of Medicine, University of Calgary, Calgary, - - 2014
IgA nephropathy is associated with increased cardiovascular risk, though whether this is due to loss of kidney function or proteinuria is unclear. For this study 10 normotensive IgA nephropathy subjects with early kidney disease (41±5 yrs, glomerular filtration rate (GFR) 87±9 ml/min, proteinuria 720±300 mg/d) and 10 gender- and blood ...
Kaneko Kazuyoshi K Department of Cardiology, Kitamurayama Municipal Hospital, Yamagata, - - 2014
Elevated aortic stiffness determined by transesophageal echocardiography (TEE), and presence of complicated aortic plaque provide prognostic information about cerebrovascular disease risk. Recently, pulse-wave tissue Doppler imaging (PW-TDI) has offered a new technique for assessing aortic wall stiffness. The following aortic long-axis view TEE measurements were carried out in 103 consecutive ...
McEniery Carmel M CM Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Box 110, Cambridge CB2 2QQ, - - 2014
Pressure measured with a cuff and sphygmomanometer in the brachial artery is accepted as an important predictor of future cardiovascular risk. However, systolic pressure varies throughout the arterial tree, such that aortic (central) systolic pressure is actually lower than corresponding brachial values, although this difference is highly variable between individuals. ...
Kuetting Maximilian M Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen, University, Aachen, Germany. Electronic address: - - 2014
Although CT-studies as well as intraoperative analyses have described broad anatomic variations of the aortic annulus, which is predominantly found non-circular, commercially available transcatheter aortic heart valve prostheses are circular. In this study, we hypothesize that the in vitro hydrodynamic function of a self-expanding transcatheter heart valve (Medtronic CoreValve(®)) assessed ...
Courand Pierre-Yves PY Cardiology Department, European Society of Hypertension Excellence center, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, F-69004 Lyon, France; Génomique Fonctionnelle de l'Hypertension artérielle, EA 4173, Université Claude Bernard Lyon1, F-69100 Villeurbanne, France; Hôpital Nord-Ouest, F-69400 Villefranche sur Saône, France. Electronic address: - - 2014
Our study aimed at determining the interaction between the prognostic value of diastolic blood pressure (DBP) and aortic atherosclerosis (ATS). With aging, equal systolic blood pressures (SBPs) become associated with low DBPs; i.e., high pulse pressures (PPs) become associated with a high risk of cardiovascular death. This association is usually ...
Vlachopoulos Charalambos C Peripheral Vessels and Hypertension Unit, 1st Department of Cardiology, Hippokration Hospital, Athens Medical School, Greece. Electronic address: - - 2014
Low testosterone levels and increased aortic stiffness are predictors of cardiovascular events. The influence of androgen level on the age- and blood pressure-related increase in aortic stiffness is unknown. From January 2007 to June 2011 we enrolled 455 consecutive men with no evidence of cardiovascular disease from a large cohort ...
Edwards Maria-Benedicta MB Department of BioMedical Engineering, University Strathclyde, Glasgow, - - 2014
Increasing numbers of patients with cardiac valve prostheses are being referred for magnetic resonance imaging (MRI) despite concerns about the potential for functional valve impedance due to Lenz forces. This study aims to determine, in vitro, the occurrence of Lenz forces on 9 heart valve prostheses at 1.5 T and ...
Shih Yuan-Ta YT Molecular Imaging Center, National Taiwan University, Taipei, - - 2014
The N-point moving average (NPMA) is a mathematical low-pass filter that can smooth peaked noninvasively acquired radial pressure waveforms to estimate central aortic systolic pressure using a common denominator of N/4 (where N=the acquisition sampling frequency). The present study investigated whether the NPMA method can be applied to brachial pressure ...
Wens Stephan C A SC Department of Neurology, Erasmus University Medical Center, Mailbox 2040, 3000 CA, Rotterdam, The - - 2014
Vascular abnormalities and glycogen accumulation in vascular smooth muscle fibres have been described in Pompe disease. Using carotid-femoral pulse wave velocity (cfPWV), the gold standard methodology for determining aortic stiffness, we studied whether aortic stiffness is increased in patients with Pompe disease. Eighty-four adult Pompe patients and 179 age- and ...
Gupta-Malhotra Monesha M Division of Pediatric Cardiology, Department of Pediatrics, Children's Memorial Hermann Hospital, The University of Texas Medical School at Houston, Houston, TX, USA. Electronic address: - - 2014
The aim of the study was to determine the presence of aortic dilatation in hypertensive children, the prevalence of which is 4% to 10% in hypertensive adults. Prospectively enrolled multiethnic children, untreated for their hypertension, underwent an echocardiogram to exclude congenital heart disease and evaluate for end-organ damage and aortic ...
Webb Alastair John Stewart AJ From the Stroke Prevention Research Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United - - 2014
Visit-to-visit and day-to-day variability in systolic blood pressure (SBP) are associated with an increased risk of stroke, more strongly than variability on 24-hour ambulatory BP monitoring, but underlying physiological mechanisms are unclear. We related potentially relevant physiological characteristics to beat-to-beat, ambulatory, and day-to-day BP variability to identify underlying mechanisms and ...
Cakici Musa M Departments of aCardiology bBiostatistics, School of Medicine, Adiyaman University, Adiyaman cDepartment of Cardiology, School of Medicine, Dumlupinar University, Kutahya dDepartment of Cardiology, School of Medicine, Gaziantep University, Gaziantep, - - 2014
The aim of the present cross-sectional study was to evaluate either non-dipper-type or dipper-type circadian rhythm of blood pressure (BP) in normotensive rheumatic mitral stenosis (MS) patients. Eighty-eight normotensive rheumatic mitral valve disease (RMVD) patients and 41 normal participants were enrolled in the study. All participants underwent ambulatory blood pressure ...
Liang Fuyou - - 2014
Central aortic pressures are better predictors of cardiovascular events than peripheral pressures. However, central aortic blood pressures cannot be measured noninvasively; for this reason, estimating aortic pressures from noninvasive measurements of peripheral pressures has been the subject of numerous studies. In the present study, a novel method was proposed to ...
Hahn Jin-Oh - - 2014
This paper presents a comparative study on the relative performance of alternative strategies for estimating an individualized central aortic blood pressure (BP) waveform. Based on the transmission line representation of the central aortic-radial arterial line, a fully individualized (ITF 1), two partially individualized (ITF 2 and ITF 3 ), and ...
Fatima Nishat N Department of Clinical Pharmacology and Therapeutics, Nizam's Institute of Medical Sciences, Panjagutta, Hyderabad, - - 2014
Acute and chronic stress is a risk factor for the development and progression of coronary artery disease. Increased arterial stiffness is an independent marker for cardiovascular disease. Cold pressor test (CPT) is known to be associated with substantial activation of the autonomic nervous system. The aim of this study was ...
Williams Bryan B Department of Cardiovascular Sciences and National Institute for Health Research (NIHR) University College London (UCL) Hospitals Biomedical Research Centre, University College London, London, - - 2014
Hypertension in elderly people is characterised by elevated systolic blood pressure (SBP) and increased pulse pressure (PP), which indicate large artery ageing and stiffness. LCZ696, a first-in-class angiotensin receptor neprilysin inhibitor (ARNI), is being developed to treat hypertension and heart failure. The Prospective comparison of Angiotensin Receptor neprilysin inhibitor with ...
Kozor Rebecca R North Shore Heart Research Group, Kolling Institute of Medical Research, University of Sydney, Sydney, Australia; Department of Cardiology, Royal North Shore Hospital, Sydney, - - 2014
The cardiovascular impact of cocaine use in otherwise healthy individuals who consider themselves 'social' users is not well established. Twenty regular cocaine users and 20 control subjects were recruited by word-of-mouth. Cardiovascular magnetic resonance was performed to assess cardiac and vascular structure and function. Cocaine users had higher systolic blood ...
Freercks R J RJ 1.Renal Unit, Groote Schuur Hospital, University of Cape Town, South - - 2014
Central aortic systolic pressure (CASP) strongly predicts cardiovascular outcomes. We undertook to measure ambulatory CASP in 74 prevalent dialysis patients using the BPro (HealthStats, Singapore) device. We also determined whether coronary or abdominal aortic calcification was associated with changes in CASP and whether interdialytic CASP predicted ambulatory measurement. All patients ...
Peotta Veronica A VA Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of - - 2014
The F508del mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) is the most common cause of cystic fibrosis (CF). Both CF patients and F508del carriers have decreased blood pressure. While this has been attributed to salt depletion, recent studies have shown F508del expression interferes with smooth muscle cell calcium ...
Kuznetsova Tatyana Y TY Faculty of Medicine, Petrozavodsk State University, Petrozavodsk, - - 2014
The purpose of this study was to examine the pulse wave velocity, aortic augmentation index corrected for heart rate 75 (AIx@75), and central systolic and diastolic blood pressure during 24-hour monitoring in normotensive volunteers. Overall, 467 subjects (206 men and 261 women) were recruited in this study. Participants were excluded ...
Saiyed Anjum A Department of Anaesthesiology, SMS Medical College and Associated Group of Hospitals, Jaipur, Rajasthan, - - 2014
Complete obstruction of the abdominal aorta at the renal artery level is a difficult surgical problem. Aortic clamping and declamping can lead to profound haemodynamic changes, myocardial infarction, ventricular failure or even death may result. These complications are important challenges in anesthetic management of these patients. Between August, 2010 and ...
Kotovskaya Yulia V YV Propedeutics Department, Peoples' Friendship University of Russia, Moscow, - - 2014
The objective of this study was to validate the novel integration of oscillometric (Vasotens(®)) technology into a BPLab(®) ambulatory blood pressure (BP) monitoring system to measure central BP, the aortic augmentation index, and pulse wave velocity (PWV) compared with the recommended and widely accepted tonometric method. The ARTERY Society guidelines ...
Salum Erik E Department of Cardiology, University of Tartu, 8 Puusepa Street, Tartu 51014, Estonia ; Endothelial Centre, University of Tartu, 8 Puusepa Street, Tartu 51014, Estonia ; Department of Biochemistry, Centre of Excellence for Translational Medicine, University of Tartu, 19 Ravila Street, Tartu 50411, - - 2014
Prevention or attenuation of diabetic vascular complications includes anti-hypertensive treatment with renin-angiotensin system inhibitors on account of their protective effects beyond blood pressure reduction. The present study aimed to investigate the effects of telmisartan, an angiotensin II type 1 receptor blocker (ARB), on blood pressure, aortic stiffening, and aortic remodelling ...
Gs Ajith Kumar AK Cardio Vascular Disease Biology, Rajiv Gandhi Centre for - - 2014
Ascending aortic constriction is the most common and successful surgical model for creating pressure overload induced cardiac hypertrophy and heart failure. Here, we describe a detailed surgical procedure for creating pressure overload and cardiac hypertrophy in rats by constriction of the ascending aorta using a small metallic clip. After anesthesia, ...
Kamoi Shun S Department of Mechanical Engineering, University of Canterbury, Christchurch, New - - 2014
Accurate, continuous, left ventricular stroke volume (SV) measurements can convey large amounts of information about patient hemodynamic status and response to therapy. However, direct measurements are highly invasive in clinical practice, and current procedures for estimating SV require specialized devices and significant approximation. This study investigates the accuracy of a ...
Baschiera Fabio F Novartis Pharma AG, Basel, - - 2014
Systolic hypertension is the most common form of hypertension in elderly patients. There is increasing evidence that measurement of central aortic pressure (CAP) better accounts for cardiovascular risk than brachial blood pressure (BP). The Aliskiren for GEriatric LowEring of SyStolic hypertension (AGELESS) study in elderly patients with systolic hypertension showed ...
Borlaug Barry A BA Division of Cardiovascular Diseases, Mayo Clinic, Rochester, - - 2014
Medication treatment decisions in heart failure (HF) are currently informed by measurements of brachial artery pressure, but ventricular afterload is more accurately represented by central aortic pressure, which differs from brachial pressure. We sought to determine whether aggressive titration of vasoactive medicines beyond goal-directed heart failure medical therapy (GDMT) based ...
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