Search Results
Results 1 - 50 of 1142
1 2 3 4 5 6 7 8 9 10 >
Tsai Amy G AG Department of Bioengineering, University of California , San Diego, La Jolla, CA , - - 2014
Malemide polyethylene glycol-conjugated Hb (MP4OX, Sangart Inc.), a high-affinity low-concentration acellular hemoglobin (P50 = 5 mmHg, 4.3 g/dl) solution, has been shown to optimize microvascular perfusion and target oxygen delivery to anoxic tissue. Microvascular perfusion during an acute hypoxic challenge in a transgenic anemic sickle cell disease mouse model was ...
Ozturk Cemile Nurdan CN Head and Neck Surgery & Plastic Surgery, Roswell Park Cancer Institute, Buffalo, - - 2014
Postoperative flap monitoring is a key component for successful free tissue transfer. Tissue oxygen saturation measurement (TOx) with near-infrared spectrophotometry (NIRS) is a method used for this purpose. The aim of this study was to identify external variables that can affect TOx. Patients who had breast reconstruction with free flaps ...
Studer Daniel D 1] Institute of Anatomy, University of Bern, Bern, Switzerland. - - 2014
Electron microscopy (EM) allows for the simultaneous visualization of all tissue components at high resolution. However, the extent to which conventional aldehyde fixation and ethanol dehydration of the tissue alter the fine structure of cells and organelles, thereby preventing detection of subtle structural changes induced by an experiment, has remained ...
Choi Woo June - - 2014
ABSTRACT. Characterization of the relationship between external pressure and blood flow is important in the examination of pressure-induced disturbance in tissue microcirculation. Optical coherence tomography (OCT)-based microangiography is a promising imaging technique, capable of providing the noninvasive extraction of functional vessels within the skin tissue with capillary-scale resolution. Here, we ...
Vyas Krishna K From the *University of Kentucky College of Medicine; and †Division of Plastic Surgery, Department of Surgery, University of Kentucky, Lexington, - - 2014
Intraoperative management of hemodynamic instability during microvascular flap reconstruction is often based on anecdotal experience. Randomized controlled trials are difficult to perform when overall success rates are high. This study seeks to determine current practices for management of intraoperative hypotension during microsurgical free tissue transfer. An anonymous, 17-question, multiple choice, ...
Wee Hsiao-Yue HY Department of Neurosurgery, Chi-Mei Medical Center, Tainan, - - 2014
Herein, we report an unusual case of a patient who presented with a severe, sinking skin flap after a decompressive craniectomy and ventriculoperitoneal shunt surgery due to a traumatic brain injury. After cranioplasty, the patient's neurological deficiency improved and was confirmed by transcranial Doppler sonography. In addition to discussing the ...
Nisanci Mustafa - - 2013
Management of long-term bedridden patients experiencing pressure sores still represents a surgical challenge due to limited flap alternatives and high recurrence rates after the treatment. Fasciocutaneous, musculocutaneous, local perforator-based flaps, and free flaps have all been used for treatment of trochanteric pressure sores. This study presents a new use of ...
Bertheuil Nicolas - - 2013
The aim of our study was to analyze which of these 2 techniques (biceps femoris myocutaneous flap vs gluteus maximus myocutaneous flap) gave the best result for ischial pressure ulcers treatment. A retrospective comparative analysis of medical records for stage III and IV pressure ulcers was conducted between the 2 ...
Cheng Paul Ting-Yuan - - 2013
Massive bilateral pressure ulcers of dependent areas may complicate spinal cord injuries. These may be life threatening to patients and challenging for reconstructive surgeons. In massive recurrent ulcers, local tissue is either inadequate or previously exhausted. The total thigh musculocutaneous flap is an operation of last resort; we present a ...
Allen William N - - 2013
Microdialysis is one of several methods described for monitoring the anastomosis and blood flow to the donor tissue in microvascular-free tissue transfer for craniofacial reconstructive surgery. A case is presented where a microdialysis free flap monitoring system detected metabolic aberrations within the free flap secondary to a rise in intracranial ...
Cugmas Bla┼ż - - 2013
ABSTRACT. Acquiring near infrared spectra in vivo usually requires a fiber-optic probe to be pressed against the tissue. The applied pressure can significantly affect the optical properties of the underlying tissue, and thereby the acquired spectra. The existing studies consider these effects to be distortions. In contrast, we hypothesize that ...
Ganguly Arnab - - 2013
The study is aimed at quantifying the relative contribution of key heat transfer modes in lyophilization. Measurements of vial heat transfer rates in a laboratory-scale freeze-dryer were performed using pure water, which was partially sublimed under various conditions. The separation distance between the shelf and the vial was systematically varied, ...
Li Xiao C XC Laboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, - - 2013
The role of intracellular ANG II in proximal tubules of the kidney remains poorly understood. We tested the hypothesis that proximal tubule-dominant transfer of AT(1a) receptors in the cortex mediates intracellular ANG II-induced blood pressure responses in AT(1a) receptor-deficient (Agtr1a-/-) mice. A GFP-tagged AT(1a) receptor, AT(1a)R/GFP, and an enhanced cyan ...
Greco Manfredi - - 2013
Muscular flaps are considered by many surgeons as a treatment of choice for pressure sores. Nevertheless fasciocutaneous and adipofascial flaps are less sensitive to ischemia, more resistant to pressure and have higher mechanical resistance. The aim of this study is to evaluate the results of our integrated rehabilitative and surgical ...
Yan Yuan - - 2013
Intracellular free iron of Escherichia coli was determined by whole-cell electron paramagnetic resonance spectrometry. Ultrahigh pressure (UHP) increased both intracellular free iron and cell lethality in a pressure-dose-dependent manner. The iron chelator 2,2'-dipyridyl protected cells against UHP treatments. A mutation that produced iron overload conditions sensitized E. coli to UHP ...
Dolgos Michelle R - - 2012
Off the axis: A new lead-free bismuth based perovskite has been formed at ambient pressure in the polar Pmc2(1) structure. Measurements give evidence for ferroelectricity and piezoelectricity. The material is significant due to a rotation of the polarization direction off the [111](p) axis, making it important to the design of ...
Xu Haibo - - 2012
Establishing biochemical markers of pre-hypertension and early hypertension could help earlier diagnostics and therapeutic intervention. We assess dynamics of junctional adhesion molecule-A (JAM-A) expression in rat models of hypertension and test whether JAM-A expression could be driven by angiotensin (ANG) II and whether JAM-A contributes to the progression of hypertension. ...
Liu Bing - - 2012
BACKGROUND: Recently, alpha-lipoic acid (ALA) has been reported to afford protection against neurodegenerative disorders in humans and experimental animals, yet little study elucidates whether it works in glaucomatous optic neuropathy. OBJECTIVE: This study aims to investigate whether ALA possesses neuroprotection against hydrostatic pressure-induced damage and explore its possible protective mechanism ...
Grace Josephine A - - 2012
The RAS (renin-angiotensin system) is now recognized as an important regulator of liver fibrosis and portal pressure. Liver injury stimulates the hepatic expression of components of the RAS, such as ACE (angiotensin-converting enzyme) and the AT1 receptor [AngII (angiotensin II) type 1 receptor], which play an active role in promoting inflammation ...
Duseja Ajay - - 2012
See article in J. Gastroenterol. Hepatol. 2012; 27: 1336-1340.
Wang Ji-Guang - - 2012
In China, the prevalence of hypertension is currently 18.8 %, and a major risk factor for hypertension is unbalanced dietary sodium and potassium intakes. High dietary sodium intake may change the circadian rhythm of 24-h blood pressure, which is characterized by a higher nighttime blood pressure. The prevalence of isolated nighttime ...
Pfisterer Larissa - - 2012
AIMS: Hypertension evokes detrimental changes in the arterial vessel wall which facilitate stiffening and thus leads to a further rise in mean blood pressure eventually causing heart failure. The underlying pathophysiological remodeling process is elicited by an increase in wall stress (WS) and strictly dependent on the activation of vascular ...
Proctor Stephen A - - 2012
A paradigm of cytokinesis in animal cells is that the actomyosin contractile ring provides the primary force to divide the cell. In the fission yeast Schizosaccharomyces pombe, cytokinesis also involves a conserved cytokinetic ring, which has been generally assumed to provide the force for cleavage (see also [5]). However, in ...
Zicha J - - 2012
Fifty years ago, Lewis K. Dahl has presented a new model of salt hypertension - salt-sensitive and salt-resistant Dahl rats. Twenty years later, John P. Rapp has published the first and so far the only comprehensive review on this rat model covering numerous aspects of pathophysiology and genetics of salt ...
Litteri Gaia G Department of Biomedical Sciences, University of Padova, Viale G. Colombo, 3, 35131 Padova, - - 2012
Emilin-1 is a protein of elastic extracellular matrix involved in blood pressure (BP) control by negatively affecting transforming growth factor (TGF)-β processing. Emilin1 null mice are hypertensive. This study investigates how Emilin-1 deals with vascular mechanisms regulating BP. This study uses a phenotype rescue approach in which Emilin-1 is expressed ...
Campbell Norm R C - - 2012
Blood pressure surveillance, monitoring, and evaluation of programs to prevent and control hypertension are critical because increased blood pressure is a leading risk for premature death and disability. Since 2003, the Hypertension Outcomes Research Task Force has existed in Canada, with members who assist in the development and revision of ...
Tayebati Seyed Khosrow - - 2012
Arterial hypertension is the main risk factor for stroke and plays a role in the development of vascular cognitive impairment (VCI) and vascular dementia (VaD). An association between hypertension and reduced cerebral blood flow and VCI is documented and arterial hypertension in midlife is associated with a higher probability of ...
Sussman Norman - - 2012
Portopulmonary hypertension is a serious complication of cirrhosis that is associated with mortality in excess of the MELD score. Increased pulmonary vascular resistance may be initiated by pulmonary vasoconstriction, altered levels of circulating mediators, or shear stress, eventually leading to the classic vascular remodeling (plexiform lesion) that characterizes portopulmonary hypertension. ...
Ando Katsuyuki - - 2012
Abstract Dietary salt intake is the most important factor contributing to hypertension, but the salt susceptibility of blood pressure (BP) is different in individual subjects. Although the pathogenesis of salt-sensitive hypertension is heterogeneous, it is mainly attributable to an impaired renal capacity to excrete sodium (Na(+) ). We recently identified ...
Iwase F - - 2012
A high-frequency NMR apparatus for use in pressure cell is described. All components of the resonance circuit are set in the pressure cell. This method makes the resonance frequency much less influenced by large stray capacitance residing at the electrical feedthrough of the pressure cell. With the use of this ...
Cates Matthew J MJ Torbay Hospital, Lawes Bridge, Torquay, TQ2 7AA, UK. - - 2012
There is evidence of sympathetic overdrive in a significant proportion of patients with essential hypertension and an animal model of the condition, the spontaneously hypertensive rat (SHR). The reasons for this remain elusive. However, there is also evidence of narrowing of the arteries supplying the brainstem in the SHR and ...
Jafari Behrouz - - 2012
BackgroundObstructive sleep apnea (OSA) is a highly prevalent disorder that increases the risk of systemic hypertension and cardiovascular diseases. Heme oxygenase (HO) has been shown to be upregulated in patients with OSA and its overexpression in mice causes hypertension. End products of HO are carbon monoxide (CO) and bilirubin. CO ...
Roberie Dustin R - - 2012
PURPOSE OF REVIEW: Resistant hypertension, defined as blood pressure uncontrolled on three, or controlled with at least four, antihypertensive agents (including a diuretic), is associated with higher risk of secondary hypertension, cardiovascular and renal events, and increased healthcare expenditures. Until recently, however, the prevalence of resistant hypertension in the United ...
Shook Robin P - - 2012
Family history of hypertension increases the risk of an individual to develop hypertension, whereas moderate-to-high cardiorespiratory fitness has the opposite effect. However, the joint association of each on the development of hypertension is not well understood. We studied fitness and incident hypertension in 6278 participants who were given a preventative ...
Debbaut C - - 2012
Due to the growing shortage of donor livers, more patients are waiting for transplantation. Living donor liver transplantation may help expanding the donor pool, but is often confronted with the small-for-size syndrome. Since the hemodynamic effects of partial hepatectomy are not fully understood, we developed an electrical rat liver model ...
Buys Emmanuel S - - 2012
Nitric oxide (NO) plays an essential role in regulating hypertension and blood flow by inducing relaxation of vascular smooth muscle. Male mice deficient in a NO receptor component, the α1 subunit of soluble guanylate cyclase (sGCα1), are prone to hypertension in some, but not all, mouse strains, suggesting that additional ...
Nakashima Y - - 2012
This paper presents a micro cell compression stimulator for evaluating real-time cellular responses to compression stimuli. The device was produced by a micro three-dimensional structure fabrication process using multiple exposures to the photoresist. The device consists of a pressure inlet port, cell inlet ports, a gasket, microchannels, cell culture chambers, ...
Arima Hisatomi - - 2012
The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure defined blood pressure (BP) levels of 120 to 139/80 to 89 mm Hg as prehypertension and those of ≥140/90 mm Hg as hypertension. Hypertension can be divided into 3 categories, isolated diastolic ...
Sasaki Natsu - - 2012
Alternating-pressure air mattresses can reduce interface pressure and prevent pressure ulcer development. However, bottoming out sometimes occurs, resulting in an increase in interface pressure. Therefore, optimal settings should be determined based on interface pressures and inner air cell pressures. The purpose of this study was to investigate the most effective ...
Nishiyama Masayoshi - - 2012
The bacterial flagellar motor is a molecular machine that converts an ion flux to the rotation of a helical flagellar filament. Counterclockwise rotation of the filaments allows them to join in a bundle and propel the cell forward. Loss of motility can be caused by environmental factors such as temperature, ...
Carmichael Justin R - - 2012
A new high-pressure cell design for use in neutron reflectometry (NR) for pressures up to 50 MPa and a temperature range of 300-473 K is described. The cell design guides the neutron beam through the working crystal without passing through additional windows or the bulk fluid, which provides for a ...
Phillips Robert A - - 2012
In uncomplicated hypertension, <140/90 mmHg is the treatment goal for individuals aged 18-79 and between 140 mmHg and 150 mmHg in those 80 years of age. Inhibitors of the renin-angiotensin-aldosterone system, as well as calcium channel blockers, are universally accepted as first-line therapy in uncomplicated hypertension, but controversy exists over ...
Bower Julie K - - 2012
Diabetes and hypertension often co-occur and share risk factors. Hypertension is known to predict diabetes. However, hyperglycemia also may be independently associated with future development of hypertension. We investigated glycated hemoglobin (HbA(1c)) as a predictor of incident hypertension. We conducted a prospective analysis of 9,603 middle-aged participants in the Atherosclerosis ...
Scalzo Fabien - - 2012
Intracranial pressure (ICP) elevation (intracranial hypertension, IH) in neurocritical care is typically treated in a reactive fashion; it is only delivered after bedside clinicians notice prolonged ICP elevation. A proactive solution is desirable to improve the treatment of intracranial hypertension. Several studies have shown that the waveform morphology of the ...
Monin Joan K JK Chronic Disease Epidemiology, Social and Behavioral Sciences, Yale School of Public Health, New Haven, CT 06520, USA. - - 2012
This study examined linguistic markers of emotion regulation and cardiovascular stress reactivity in spousal caregivers. Fifty-three individuals were audiotaped while they privately disclosed an instance of partner suffering and a typical partner interaction (i.e., a meal together). Systolic blood pressure, diastolic blood pressure, and heart rate (HR) were measured. Linguistic ...
Machura Katharina - - 2012
The salt intake of an organism controls the number of renin-producing cells in the kidney by yet undefined mechanisms. This study aimed to assess a possible mediator role of preglomerular blood pressure in the control of renin expression by oral salt intake. We used wild-type (WT) mice and mice lacking ...
Marvar Paul J PJ Department of Psychiatry, Emory University School of Medicine, Atlanta, Georgia, USA. - - 2012
Psychological stress is a significant risk factor for hypertension and also directly affects the immune system. We have previously reported that T lymphocytes are essential for development of hypertension and that the central nervous system contributes to peripheral T-lymphocyte activation and vascular inflammation in this disease; however, the role of ...
Gamboa Alfredo - - 2012
The purpose of this study was to determine if tonic restrain of blood pressure by nitric oxide (NO) is impaired early in the development of hypertension. Impaired NO function is thought to contribute to hypertension, but it is not clear if this is explained by direct effects of NO on ...
Funder J W - - 2012
The prevalence of primary aldosteronism (PA) is around 10% of hypertensives, with markedly increased risk of cardiovascular damage compared with age-, sex- and BP-matched essential hypertension (EH). Currently, if hypertension is present in 20% of the population, PA will account for 2%; of these PA patients only 1% are ever ...
Ramírez Gonzalo - - 2012
Portal hypertension is a hemodynamic abnormality that involves a high risk of disability as well as a reduced life expectancy in patients with cirrhosis. Progress in the knowledge of pathophysiology of portal hypertension has opened a new perspective for different pharmacological approaches. In this context, the pleiotropic actions of statins ...
1 2 3 4 5 6 7 8 9 10 >