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Kouda Katsuyasu - - 2012
Background: Body fat distribution is defined as the pattern of fat deposits in different regions of the body and usually expressed as a ratio. There are few studies on the relationship between blood pressure and the ratio of central fat measured on dual-energy X-ray absorptiometry (DXA) in childhood. Methods and Results: The ...
Basati Sukhraaj - - 2012
Object Experimental data about the evolution of intracranial volume and pressure in cases of hydrocephalus are limited due to the lack of available monitoring techniques. In this study, the authors validate intracranial CSF volume measurements within the lateral ventricle, while simultaneously using impedance sensors and pressure transducers in hydrocephalic animals. ...
Kim Seong-Man - - 2012
BACKGROUND: To evaluate the left atrial (LA) volume and function of obese patients with/without obstructive sleep apnea (OSA) and its association with left ventricular (LV) diastolic function independent of obesity. METHODS: LA volumetric and functional parameters were measured by 2-dimensional and strain echocardiography in 49 obese (body mass index≥25kg/m(2)) subjects ...
Fan Shih-Kang - - 2012
The manipulation of bubbles and the ignition of microplasma within a 200 nL bubble at atmospheric pressure and in an inert silicone oil environment were achieved. Driven by dielectrophoresis (DEP), bubble generation, transportation, mixing, splitting, and expelling were demonstrated. This process facilitated the preparation of various bubbles with tuneable gas ...
Hemerka Joseph N - - 2012
Hypotension after traumatic brain injury (TBI) worsens outcome. We published the first report of TBI plus hemorrhagic shock (HS) in mice using a volume-controlled approach and noted increased neuronal death. To rigorously control blood pressure during HS, a pressure-controlled HS model is required. Our hypothesis was that a brief, severe ...
Davis Michael J - - 2012
Collecting lymphatic vessels share functional and biochemical characteristics with cardiac muscle; thus, we hypothesized that the lymphatic vessel pump would exhibit behavior analogous to homeometric regulation of the cardiac pump in its adaptation to elevated afterload, i.e., an increase in contractility. Single lymphangions containing two valves were isolated from the ...
Sakai Eriko - - 2012
PURPOSE:: To assess a newly developed eyelid pressure measurement system called a blepharo-tensiometer that uses a tactile pressure sensor. METHODS:: The tactile sensor was 10 mm in diameter and approximately 0.4 mm thick. The sensor was covered with silicon rubber and was placed between a soft contact lens on the ...
Cheng Hao-Min - - 2012
BackgroundThe prognostic value of central aortic pulse pressure (PP-C) may have been underestimated due to its measurement inaccuracy. We aimed to investigate the accuracy of noninvasive brachial cuff-based estimation of PP-C by a generalized transfer function (GTF) or a novel pulse wave analysis (PWA) approach to directly estimate PP-C.MethodsInvasive high-fidelity ...
Zhang L-X - - 2012
The aim of this study was to evaluate the effects of an analogue of lacidipine, CZ454 in in vitro and in vivo. The isometric tension of Sprague-Dawley rat arterial ring segments was recorded by a myography system. Intracellular calcium of vascular smooth muscle was determined by the confocal laser microscopy. ...
Tomiyama Hirofumi - - 2012
We examined whether the central aortic systolic blood pressure, a marker of the function of the systemic arterial tree, might be a more powerful predictor of the development of hypertension than the brachial-ankle pulse wave velocity, a marker of the stiffness of the large- to middle-sized arteries, independent of the ...
Girerd Nicolas - - 2012
BackgroundThe impact of various methods of travel distance estimation on the prognostic value of pulse wave velocity (PWV) and on the adequacy of cut-offs has never been addressed within a single population of hypertensive patients.MethodsFour carotid-femoral PWVs were calculated from four different travel distances (Direct, Real, Subtracted, and Estimated) divided ...
Ciccone Marco Matteo - - 2012
Aim: The study aim was to evaluate the acute hemodynamic effects of intranasal 17-beta-estradiol on ophthalmic arterial circulation in postmenopausal women.Methods: Twenty-one healthy women in natural menopause for at least 6 months (mean age: 53.2± 2.9 years) were investigated. Each patient received 300 µg intranasal 17-beta-estradiol. We evaluated the heart ...
Kosar Altug - - 2012
BACKGROUND: In this experimental study, the effectiveness of N-butyl cyanoacrylate tissue adhesive on preventing air leakage after pulmonary wedge resection was observed. METHODS: Twenty pairs of sheep lungs were used. Before initiating the study, the sheep lungs were ventilated to identify any air leakage from the parenchyma. On positive results, ...
Doi Yohei - - 2012
BackgroundThe renal resistive index (RI) measured using Doppler ultrasonography has been used as a diagnostic tool in the daily work-up of kidney diseases. A better understanding of its relationship with preclinical organ damage may help in determining overall cardiovascular risk in hypertensive patients.MethodsWe evaluated the association between RI and the ...
May Ole - - 2012
BACKGROUND: Enhanced external counterpulsation (EECP) has been reported to reduce blood pressure (BP) using clinic BP readings. The aim of this study was to assess the effect of a course of EECP on BP using ambulatory BP (ABP) measurements. HYPOTHESIS: EECP has a lasting BP lowering effect. METHODS: Patients referred ...
Jünger Michael - - 2012
Objective: To investigate macro- and microperfusion during 14 days of treatment with a new 2-layer compression system (3M™ Coban™ 2 Lite), designed for patients with leg ulcer and concomitant peripheral arterial occlusive disease. Methods: A single-centre, open-label, prospective pilot study was performed with 15 subjects suffering from peripheral arterial occlusive ...
Han J-C - - 2012
Two very different sorts of experiments have characterized the field of cardiac energetics over the past three decades. In one of these, Gibbs and colleagues measured the heat production of isolated papillary muscles undergoing isometric contractions and afterloaded isotonic contractions. The former generated roughly linear heat vs. force relationships. The ...
Canpolat Dilek Gunay - - 2012
The aim of this study was to compare ketamine-propofol (KP) and ketamine-dexmedetomidine (KD) combinations for deep sedation and analgesia during pediatric burn wound dressing changes. After obtaining approval from the University Ethics Committee, burn wound care or wound dressing changes were performed on 60 ASA physical status I and II ...
Schnidrig Silvia - - 2012
Our understanding of regional filling of the lung and regional ventilation distribution is based on studies using stepwise inhalation of radiolabelled tracer gases, magnetic resonance imaging and positron emission tomography. We aimed to investigate whether these differences in ventilation distribution at different end-expiratory levels (EELs) and tidal volumes (V (T)s) ...
Vinten Martin - - 2012
Purpose. A small-scale pilot study of the pathophysiology of diabetic macular edema (DME) was made by assessing concomitant changes in macular volume (MV), mean arterial blood pressure (MABP), intraocular pressure (IOP), retinal artery diameter (RAD), and retinal vein diameter (RVD) in response to 120 minutes of pure oxygen breathing. Methods. ...
Güne Ahmet - - 2012
OBJECTIVE: Endothelial dysfunction is considered the first stage in the development of atherosclerosis and assessed by flow-mediated dilatation (FMD) and aortic flow velocity propagation (AVP). Ankle-brachial index (ABI) is used to assess peripheral arterial disease and is associated with FMD but the relationship between ABI and AVP is unknown. In ...
Liu Xiangju - - 2012
Recent studies indicate that chronic ouabain treatment leads to hypertension and hypertensive vascular remodeling. Grape seed proanthocyanidin extract (GSPE) has been reported to be effective in treating arteriosclerosis, while little is known about its effect on systolic blood pressure and vascular remodeling. In this study, the effects of GSPE on ...
Cittadini Antonio A Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Via Sergio Pansini 5, 80131 Naples, Italy. - - 2012
The suppressors of cytokine signalling (SOCS) are identified inhibitors of cytokine and growth factor signalling that act via the Janus kinase (JAK) signal transducers and activators of transcription (STAT) pathways. Aberrant JAK/STAT signalling promotes progression from hypertrophy to heart failure. Little information is available concerning the role of SOCS in ...
Lee Dexter L DL Department of Physiology and Biophysics, Howard University, Washington, DC, - - 2012
Adenosine, acting on A(1)-receptors (A(1)-AR) in the nephron, increases sodium reabsorption, and also increases renal vascular resistance (RVR), via A(1)-ARs in the afferent arteriole. ANG II increases blood pressure and RVR, and it stimulates adenosine release in the kidney. We tested the hypothesis that ANG II-infused hypertension is potentiated by ...
Mączka M - - 2012
A high-pressure Raman scattering study of wolframite-type Mn(0.97)Fe(0.03)WO(4) is presented up to 10.4 GPa. The phonon wavenumbers vary linearly with pressure. The mode Grüneisen parameters are larger for many bending and lattice modes when compared to the stretching modes due to the larger compressibility of Mn(Fe)O(6) octahedra when compared to WO(6) ...
Mongia Anil - - 2012
Background:The mineralocorticoid receptor is protected from excess of glucocorticoids by conversion of active cortisol to inactive cortisone by enzyme 11β-hydroxysteroid dehydrogenase type 2 present in the kidney. The metabolites of cortisol and cortisone are excreted in the urine as tetrahydrocortisol (5αTHF+5βTHF) and tetrahydrocortisone (THE), respectively.Hypothesis:Patients with chronic kidney disease (CKD) ...
Lucas Rebekah A I - - 2012
The contribution of sweating to heat stress-induced reductions in haemorrhagic tolerance is not known. This study tested the hypothesis that fluid loss due to sweating contributes to reductions in simulated haemorrhagic tolerance under heat stress conditions. Eight subjects (35±8 y; 77±5 kg) underwent a normothermic time control and two heat ...
Kara Necip - - 2012
Purpose: To investigate the effect of different positions on the intraocular pressure (IOP) and ocular perfusion pressure (OPP) in nonglaucomatous pregnant. Material and methods: Thirty-one women in their third trimester of pregnancy were enrolled in this prospective and observational study. IOP in both eyes was measured with a Tono-pen® in ...
Rafiq Muhammad K - - 2012
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition, respiratory failure being the commonest cause of death. Quality of life and survival can be improved by supporting respiratory function with non-invasive ventilation. Transcutaneous carbon dioxide monitoring is a non-invasive method of measuring arterial carbon dioxide levels enabling simple and efficient ...
Matsumoto Naoki - - 2012
Although landiolol is useful in the emergency management of atrial fibrillation, atrial flutter, and tachycardia, as well as in perioperative arrhythmia control, the influence of hemodynamic changes on the pharmacokinetics of landiolol is unknown. We investigated the influence of hemodynamic variation and the following hepatocirculatory changes after systemic heparinization on ...
Santos Sheyla Oliveira - - 2012
Gestational hypothyroidism is a prevalent disorder in pregnant women. We aimed to investigate the impact of experimental gestational hypothyroidism (EGH) on cardiovascular and autonomic nervous systems (ANS) in the offspring of rats. EGH was induced with methimazole (MMI) 0.02% in drinking water from day 9 of gestation until birth. Sixty ...
Vollebregt Karlijn Corien - - 2012
Objective: It is not known if automated devices for measuring blood pressure perform better than conventional sphygmomanometry in predicting preeclampsia. This study compares two different automated devices with conventional sphygmomanometry for their association with development of preeclampsia or gestational hypertension. Design: Prospective observational cohort study. Setting: University hospital, Amsterdam, the ...
Lacourcière Yves Y Hypertension Unit, Centre Hospitalier Universitaire de Québec, Québec, Canada. - - 2013
The aim of this review was to compare telmisartan and valsartan in the treatment of hypertension. PubMed searches were conducted to identify randomized trials (n = 14) comparing the two agents, alone or combined with hydrochlorothiazide. With one exception, all studies with blood pressure reduction as primary endpoint showed significantly ...
Luo Wenshu - - 2012
BACKGROUND: Few prospective studies on association between waist circumference and hypertension have taken account of the dynamic change of WC, which caused by lifestyle modification. METHODS: After a baseline investigation, we conducted the first and the second follow-up assessments for subjects after 2 and 5years, respectively. The difference value (D-value, ...
Pariaut R - - 2012
BACKGROUND: The impact of pulmonary hypertension (PH) on right ventricular systolic function is difficult to assess. Tricuspid annular plane systolic excursion (TAPSE) is an echocardiographic measurement of right ventricular systolic function and a strong predictor of outcome in human PH patients. HYPOTHESIS/OBJECTIVES: Determine a reference range for TAPSE in healthy ...
Terai Naim - - 2012
Purpose:  To investigate the effect of caffeine on retinal vessel diameter before and during flicker light stimulation in young healthy subjects. Methods:  Seventeen healthy subjects (mean age: 29.6 ± 3.73 years, range: 22-35 years) were included in this study. The diameter of retinal vessels was measured continuously with the retinal vessel analyzer (RVA) before ...
Scallan Joshua P - - 2012
We tested the responses of single, isolated lymphangions to selective changes in preload and the effects of changing preload on the response to an imposed afterload. The methods used were similar to those described in our companion paper. Step-wise increases in input pressure (P(in); preload) over a pressure range between ...
Lima Eric G EG Cooper Union, Department of Mechanical Engineering, 41 Cooper Square, New York, NY 10003, USA. - - 2012
In this study, we explored the application of lipid-shelled, gas-filled microbubbles as a method for creating on-demand microporous hydrogels for cartilage tissue engineering. The technique allowed for homogenous distribution of cells and micropores within the scaffold, increasing the absorption coefficient of large solutes (70kDa dextran) over controls in a concentration-dependent ...
Underwood Patricia C PC Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, RFB 386, Boston, Massachusetts 02115, USA. - - 2012
It is assumed that in individuals with type 2 diabetes mellitus (T2DM), blood pressure sensitivity to salt intake and the frequency of a low renin state are both increased compared with the nondiabetic population. However, studies supporting these assumptions may have been confounded by participant inclusion criteria, and study results ...
Gons Rob A R - - 2012
Vascular factors play a role in the etiology of Alzheimer's disease (AD), presumably due to emergence of white matter lesions. However, important white matter structures involved in the etiology of AD, including the corpus callosum (CC), remain invariably free from macroscopical white matter lesions, although loss of microstructural integrity assessed ...
Foltz Wibke U - - 2012
Pressure overload is associated with cardiac hypertrophy and electrical remodeling. Here, we investigate the effects of the antioxidant N-acetylcysteine (NAC) on the cellular cardiac electrophysiology of female Sprague-Dawley rats with ascending aortic stenosis (AS). Rats were treated with NAC (1 g/kg body weight) or control solution 1 week before the intervention and ...
Cong Li - - 2012
PURPOSE:: The purpose of this study was to determine whether a continuous quality improvement program would reduce pressure ulcer prevalence. SUBJECTS AND SETTING:: The study sample comprised 2913 patients who were used as a baseline comparison group and 3019 patients who acted as the intervention group. The research setting was ...
Berkenstadt Haim - - 2012
Cardiac arrest in the parturient is often fatal, but appropriate resuscitation in this special situation may save the lives of the mother and/or unborn baby. Concern has arisen as to application of recommended techniques for resuscitation in the obstetric patient. The Israel Board of Anesthesiology has incorporated simulation assessment into ...
Larsen Thomas - - 2012
Low 25-hydroxy-vitamin D (25(OH)D) levels are inversely related to blood pressure (BP) and have been associated with incident hypertension. In people living at northern latitudes diminished cholecalciferol synthesis in the winter increases the risk of vitamin D deficiency. We wanted to test the hypothesis that daily cholecalciferol supplementation in the ...
Mei Hao - - 2012
The authors conducted a genome-wide linkage scan and positional association analysis to identify the genetic determinants of salt sensitivity of blood pressure (BP) in a large family-based, dietary-feeding study. The dietary intervention was conducted among 1,906 participants in rural China (2003-2005). A 7-day low-sodium intervention was followed by a 7-day ...
Bhatnagar Vibha - - 2012
Blood pressure is a complex quantitative trait with a strong genetic component. In this study, we leveraged the Veterans Affairs electronic medical record system to explore the relationship between Paraoxonase 1 (PON1)-108 C/T (rs705379) and mean arterial blood pressure (MAP). Outpatient blood pressure data over an approximate 8-year period was ...
Koebnick Corinna - - 2012
Background/Aims Extreme obesity is an increasing concern in pediatric care but its association with pre-hypertension and hypertension are not clear. The objective of the present study is to assess the prevalence of different stages of pre-hypertension and hypertension in the pediatric population, to investigate potential disparities, and to evaluate the ...
Chalidis Byron E - - 2012
Tourniquet application is a widely accepted adjuvant technique in extremity surgery. The purpose of this prospective, randomized trial was to evaluate the effect of cuff width on skeletal muscle ischemia-reperfusion injury. A 2- or 4-cm wide curved tourniquet cuff was applied around the midthigh of 36 New Zealand White rabbits ...
Pal G K - - 2012
Prehypertension has recently been observed as a potent cardiovascular risk factor. Though prehypertension has a strong familial predisposition, the pathophysiological mechanisms that cause its progression to prehypertension in normotensive sibling of hypertensive parents have not yet been fully elucidated. Therefore, the present study was conducted in normotensive and prehypertensive sibling ...
Eriksson Marie - - 2012
The Hawksley random-zero sphygmomanometer (random-zero) has been used widely in epidemiological observation studies. This study compares blood pressure measurements using the random-zero with measurements using an automated oscillometric device and suggests a correction of the automated oscillometric measurements to enable comparisons of blood pressure levels over time. The northern Sweden ...
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