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Busk Troels M TM Department of Clinical Physiology and Nuclear Medicine, Centre of Functional Imaging and Research, Copenhagen University Hospital Hvidovre , Copenhagen , - - 2014
Abstract Objective. Cirrhotic portal hypertensive patients often develop hemodynamic complications and the diagnosis is often based on liver biopsy and measurements of the hepatic venous pressure gradient (HVPG). Potential noninvasive biomarkers for the severity of cirrhosis are the matrix metalloproteinase and their specific inhibitors such as tissue inhibitor of metalloproteinases-1 ...
Choi Seo-Youn SY From the Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul 135-710, Korea (S.Y.C., W.K.J.); and Departments of Radiology (Y.K., J.K.) and Internal Medicine (T.Y.K., J.H.S.), Hanyang University College of Medicine, Hanyang University Guri Hospital, Gyeonggi-do, - - 2014
Purpose To investigate whether liver stiffness (LS) and change in LS measurements (ΔLS) at shear-wave elastography (SWE) correlates with the hepatic venous pressure gradient (HVPG) and to assess the feasibility of using SWE to estimate the change in HVPG (ΔHVPG) in patients with portal hypertension. Materials and Methods Institutional review ...
Bolognesi Massimo M Massimo Bolognesi, Alberto Verardo, Marco Di Pascoli, Department of Medicine, University of Padua, Azienda Ospedaliera Università di Padova, 35128 Padova, - - 2014
Alcohol-related cirrhosis is a consequence of heavy and prolonged drinking. Similarly to patients with cirrhosis of other etiologies, patients with alcoholic cirrhosis develop portal hypertension and the hepatic, splanchnic and systemic hemodynamic alterations that follow. However, in alcoholic cirrhosis, some specific features can be observed. Compared to viral cirrhosis, in ...
Schwabl P P Div. of Gastroenterology and Hepatology, Dept. of Internal Medicine III, Medical University of Vienna; Vienna Hepatic Hemodynamic Lab, Medical University of - - 2014
Transient elastography (TE) can non-invasively diagnose cirrhosis and portal hypertension (PHT). New TE reliability criteria suggest classifying measurements as very reliable (IQR/M<0.1), reliable (IQR<0.3 or >0.3,if TE<7.1kPa), and poorly reliable (IQR/M>0.3,if TE>7.1kPa). Compare traditional (reliable: success rate>60%+IQR/M≤0.30) and new TE quality criteria (accurate: very reliable+reliable) regarding their diagnostic accuracy for ...
Sand L L Department of Anaesthesiology and Intensive Care Medicine, Institutes of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, - - 2014
To reduce blood loss during liver surgery, a low central venous pressure (CVP) is recommended. Nitroglycerine (NG) with its rapid onset and offset can be used to reduce CVP. In this study, the effect of NG on portal and hepatic venous pressures (PVP and HVP) in different body positions was ...
Bizzi Cezar A CA Departamento de Química, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul 97105-900, - - 2014
The present work evaluates the influence of vessel cooling simultaneously to microwave-assisted digestion performed in a closed system with diluted HNO3 under O2 pressure. The effect of outside air flow-rates (60-190m(3)h(-1)) used for cooling of digestion vessels was evaluated. An improvement in digestion efficiency caused by the reduction of HNO3 ...
Mehta Gautam G UCL Institute for Liver and Digestive Health, UCL Medical School, Division of Medicine, Royal Free Hospital, Rowland Hill Street, London, NW3 - - 2014
The main protagonist of the Emmy award-winning television series 'Breaking Bad', chemistry teacher Walter White, is famously noted for his ambiguous nature as both 'hero' and 'anti-hero'. In a similar vein, the ambiguous influence of microbiota on liver disease has been an active area of discussion in hepatology circles. Various ...
Sarin Shiv K SK Department of Hepatology, Institute of Liver and Biliary Sciences, D-1 Vasant Kunj, New Delhi 110070, India. Electronic address: - - 2014
Non-cirrhotic portal hypertension (NCPH) encompasses a wide range of disorders, primarily vascular in origin, presenting with portal hypertension (PHT), but with preserved liver synthetic functions and near normal hepatic venous pressure gradient (HVPG). Non-cirrhotic portal fibrosis/Idiopathic PHT (NCPF/IPH) and extrahepatic portal venous obstruction (EHPVO) are two prototype disorders in the ...
Skou Anne-Sofie AS Department of Paediatrics, Aarhus University Hospital Skejby, Aarhus, - - 2014
We investigated the spectrum, frequency, and risk factors for renal, gastrointestinal, and hepatic late adverse effects in survivors of childhood acute myeloid leukemia (AML) without relapse treated with chemotherapy alone according to three consecutive AML trials by the Nordic Society of Pediatric Hematology and Oncology (NOPHO). A population-based cohort of ...
Polverino Francesca F Department of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; The Lovelace Respiratory Research Institute, Albuquerque, NM, USA; Pulmonary Department, University of Parma, Parma, Italy. Electronic address: - - 2014
While the effects of postural change on arterial oxygenation have been well documented in normal subjects, and attributed to the relationship of closing volume (CV) to the tidal volume, in liver cirrhosis such postural changes have been evaluated mainly in a rare, peculiar clinical end-stage condition which is characterized by ...
Fors D D Department of Surgical Sciences, Anaesthesiology and Intensive Care, Uppsala University, Uppsala SE-75185, - - 2014
/st>Positive pressure mechanical ventilation causes rhythmic changes in thoracic pressure and central blood flow. If entrainment occurs, it could be easier for carbon dioxide to enter through a wounded vein during laparoscopic liver lobe resection (LLR). High-frequency jet ventilation (HFJV) is a ventilating method that does not cause pronounced pressure ...
Chang C-D CD Liver Transplantation Program and Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, - - 2014
The relationship between portal pressure and small-for-size syndrome (SFSS) is unsettled. The purpose of this study was to evaluate the role of portal pressure in predicting SFSS. Thirty-four patients with end-stage liver disease who received adult-to-adult living-donor liver transplantation (ALDLT) were included. Recipients were grouped based on whether they received ...
Komori Yoko Y Department of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita, 879-5593, Japan, - - 2014
A recent study demonstrated that high pressure of carbon dioxide (CO2) pneumoperitoneum before liver resection impairs postoperative liver regeneration. This study was aimed to investigate effects of varying insufflation pressures of CO2 pneumoperitoneum on liver regeneration using a rat model. 180 male Wistar rats were randomly divided into three groups: ...
Fahrner René R 1 Division of Visceral Surgery and Medicine, Inselspital, University Hospital Bern, Bern, Switzerland. 2 Department of Clinical Research, Inselspital, University Hospital Bern, Bern, Switzerland. 3 Department of Pathology, Inselspital, University Hospital Bern, Bern, Switzerland. 4 Address correspondence to: Guido Beldi, M.D., Division of Visceral Surgery and Medicine, University Hospital Bern, CH-3010 Bern, - - 2014
Liver regeneration is of crucial importance for patients undergoing living liver transplantations or extended liver resections and can be associated with elevated portal venous pressure, impaired hepatic regeneration, and postoperative morbidity. The aim of this study was to assess whether reduction of portal venous pressure by terlipressin improves postoperative liver ...
Suk Ki Tae KT Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, - - 2014
Portal hypertension is a severe consequence of chronic liver diseases and is responsible for the main clinical complications of liver cirrhosis. Hepatic venous pressure gradient (HVPG) measurement is the best available method to evaluate the presence and severity of portal hypertension. Clinically significant portal hypertension is defined as an increase ...
Rathke Hendrik H Department of Radiology, Charité-University Medicine, Berlin, - - 2014
We aimed to validate actually achieved macroscopic ablation volumes in relation to calculated target volumes using four different radiofrequency ablation (RFA) systems operated with default settings and protocols for 3 and 5 cm target volumes in ex vivo bovine liver. Sixty-four cuboid liver specimens were ablated with four commercially available ...
Kimer Nina N Department of Clinical Physiology and Nuclear Medicine; Gastro Unit, Copenhagen University Hospital - - 2014
Patients with cirrhosis have substantial circulatory imbalance between vasoconstrictive and vasodilating forces. The study of circulatory vasoactive peptides may provide important pathophysiological information. This study aimed to assess concentrations, organ extraction and relations to haemodynamic changes of the pro-peptides copeptin, proadrenomedullin and proANP in patients with cirrhosis. Fifty-four cirrhotic patients ...
Rodríguez Sarai S Liver Diseases Laboratory, Liver Unit, Department of Internal Medicine, Hospital Universitari Vall d'Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, - - 2014
Droxidopa improves hemodynamic and renal alterations of cirrhotic rats without changing portal pressure. We aimed to evaluate the effects of a combined treatment with droxidopa and non-selective beta-blockers or statins in order to decrease portal pressure, while maintaining droxidopa beneficial effects. Acute studies combining droxidopa with carvedilol, propranolol or atorvastatin ...
Coch Laura L Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), CIBERehd, Hospital Clinic, University of Barcelona, 08036, Barcelona, - - 2014
Pathological angiogenesis represents a critical hallmark for chronic liver diseases. Understanding the mechanisms regulating angiogenesis is essential to develop new therapeutic strategies that specifically target pathological angiogenesis without affecting physiological angiogenesis. Here, we investigated the contribution and therapeutic impact of the endogenous angioinhibitor vasohibin-1 in portal hypertension and cirrhosis. The ...
Vilar Gomez Eduardo E Department of Research and Clinical Experimentation, National Institute of Gastroenterology, Havana, - - 2014
Arterial blood pressure (BP) is a reliable marker of circulatory dysfunction in cirrhotic patients. There are no prospective studies evaluating the association between different levels of arterial BP and ascites development in compensated cirrhotic patients. Therefore, we evaluated the relationship between arterial BP and ascites development in compensated cirrhotic patients. ...
Guo Can-Jie CJ Division of Gastroenterology and Hepatology, School of Medicine, Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Jiaotong University, 145 Shandong Middle Road, Shanghai, 200001, - - 2014
Intrahepatic portal hypertension accounts for most of the morbidity and mortality encountered in patients with liver cirrhosis, due to increased portal inflow and intrahepatic vascular resistance. Most treatments have focused only on portal inflow or vascular resistance. However, miRNA multitarget regulation therapy may potentially intervene in these two processes for ...
Shimizu Kazunori - - 2014
We previously developed an in vivo tissue suction-mediated transfection method (denoted as the tissue suction method) for naked nucleic acids, such as plasmid DNA (pDNA) and small interfering RNA (siRNA), in mice. However, it remains unclear whether the suction pressure conditions affect the results of this method. Therefore, in the ...
Jansen Christian C Department of Internal Medicine I, University of Bonn, Bonn, - - 2014
Circulating miRNA-34a is increased in blood of patients with different liver diseases when compared to healthy controls. However, the origin of miRNA-34a and its possible relationship with hemodynamics and outcome in cirrhotic patients with portal hypertension is unknown. We analyzed the levels of miRNA-34a in cirrhotic patients with severe portal ...
Scott Teresa R TR Teresa R Scott, Victoria T Kronsten, Robin D Hughes, Debbie L Shawcross, Institute of Liver Studies, King's College London School of Medicine at King's College Hospital, King's College Hospital, London SE5 9RS, United - - 2013
Cerebral oedema is a devastating consequence of acute liver failure (ALF) and may be associated with the development of intracranial hypertension and death. In ALF, some patients may develop cerebral oedema and increased intracranial pressure but progression to life-threatening intracranial hypertension is less frequent than previously described, complicating less than ...
Gracia-Sancho Jordi - - 2013
Portal hypertension is the main complication of cirrhosis and represents a leading cause of death in patients with chronic liver disease. Therapeutic agents to improve portal hypertension should ameliorate the underlying mechanisms of portal hypertension: the elevated hepatic resistance and the hyperdynamic circulation. In the current issue of Clinical Science, ...
Karvellas Constantine J CJ 1Divisions of Hepatology and Critical Care Medicine, University of Alberta, Edmonton, AB, Canada. 2Division of Gastroenterology, University of California, San Francisco, CA. 3Faculty of Medicine, Medical University of South Carolina, Charleston, SC. 4Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, - - 2013
To determine if intracranial pressure monitor placement in patients with acute liver failure is associated with significant clinical outcomes. Retrospective multicenter cohort study. Academic liver transplant centers comprising the U.S. Acute Liver Failure Study Group. Adult critically ill patients with acute liver failure presenting with grade III/IV hepatic encephalopathy (n ...
Hong Won Ki WK Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, - - 2013
Liver stiffness measurement (LSM) has been proposed as a non-invasive method for estimating the severity of fibrosis and the complications of cirrhosis. Measurement of the hepatic venous pressure gradient (HVPG) is the gold standard for assessing the presence of portal hypertension, but its invasiveness limits its clinical application. In this ...
Huang Steven Y SY Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, - - 2014
To assess the correlation among MR elastography (MRE) measured liver stiffness (LS), liver fibrosis, and hepatic venous pressure gradient (HVPG) in a swine model of cirrhosis. Three swine served as controls, and liver fibrosis was induced in eight swine by transarterial embolization. LS and HVPG were obtained at baseline and ...
Leeming D J - - 2013
The hepatic venous pressure gradient (HVPG) is an invasive, but important diagnostic and prognostic marker in cirrhosis with portal hypertension (PHT). During cirrhosis, remodelling of fibrotic tissue by matrix metalloproteinases (MMPs) is a permanent process generating small fragments of degraded extracellular matrix (ECM) proteins known as neoepitopes, which are then ...
Mendes R H - - 2013
Hyperhomocysteinemia (HHcy) is associated with cardiovascular disease, atherosclerosis and reactive oxygen species generation. Thus, our aim was to investigate whether there was an association between HHcy, blood pressure, autonomic control and liver oxidative stress. Male Wistar rats were divided into 2 groups and treated for 8weeks: one group (control, CO) ...
Karamercan Mehmet Akif - - 2013
Although mitochondrial dysfunction is thought to contribute to the development of post-traumatic organ failure, current techniques to assess mitochondrial function in tissues are invasive and clinically impractical. We hypothesized that mitochondrial function in peripheral blood mononuclear cells (PBMCs) would reflect cellular respiration in other organs during hemorrhagic shock and resuscitation ...
Lin Cheng-Xin - - 2013
Low central venous pressure (CVP) affects hemodynamic stability and tissue perfusion. This prospective study aimed to evaluate the optimal CVP during partial hepatectomy for hepatocellular carcinoma (HCC). Ninety-seven patients who underwent partial hepatectomy for HCC had their CVP controlled at a level of 0 to 5 mmHg during hepatic parenchymal ...
Huesler Carina C Department of Nephrology, Hypertension and Clinical Pharmacology, University Hospital Berne Berne, - - 2013
Recently, evidence was presented that uninephrectomy induces salt-sensitive hypertension in rats. The increase in blood pressure was abrogated by a mineralocorticoid receptor antagonist but not by an aldosterone synthase inhibitor. Here, we hypothesize that mineralocorticoid receptor activation occurred by an 11beta-hydroxy-glucocorticosteroid, as a consequence of dysregulated 11beta-hydroxysteroid dehydrogenase enzymes. Therefore, ...
El Sharkawy Osama A OA Department of Anesthesia, Faculty of Medicine, Liver Institute, Menoufiya University, - - 2013
Major hepatic resections may result in hemodynamic changes. Aim is to study transesophageal Doppler (TED) monitoring and fluid management in comparison to central venous pressure (CVP) monitoring. A follow-up comparative hospital based study. 59 consecutive cirrhotic patients (CHILD A) undergoing major hepatotomy. CVP monitoring only (CVP group), (n=30) and TED ...
Steib Christian J - - 2013
In liver cirrhosis, inflammation triggers portal hypertension. Kupffer cells (KC) produce vasoconstrictors upon activation by bacterial constituents. Here, we hypothesize that the anti-inflammatory action of the cannabinoid receptor 2 (CB2) agonists JWH-133 and GP 1a attenuate portal hypertension. In vivo measurements of portal pressures and non-recirculating liver perfusions were performed ...
Karmaniolou Iosifina - - 2013
ABSTRACT Introduction: The aim of the present study was to evaluate the effect of triiodothyronine (T3) administration in a porcine model of hemorrhagic shock due to liver surgery, in terms of hemodynamic stability, acid-base status, and hepatic injury markers. Materials and Methods: Hemorrhagic shock was induced in swine by left ...
Wang Mofei - - 2013
Anaphylactic shock is sometimes life-threatening, and is accompanied by hepatic venoconstriction in animals, which in part accounts for anaphylactic hypotension. Roles of norepinephrine and α-adrenoceptor in anaphylaxis-induced hypotension and portal hypertension were investigated in anesthetized ovalbumin-sensitized Sprague-Dawley rats. The sensitized rats were randomly allocated to the following pretreatment groups (n=6/group): ...
Kutty Shaija S - - 2013
Hepatic dysfunction is a recognized complication after Fontan palliation of congenital heart disease. We sought to quantitatively measure hepatic stiffness and vascular Doppler indices using ultrasound (US) and shear wave elastography (SWE) in a Fontan cohort. Subjects were prospectively recruited for echocardiography and real-time hepatic duplex US with SWE for ...
Delgado Maria Gabriela - - 2013
Increased hepatic vascular resistance mainly due to elevated vascular tone and to fibrosis is the primary factor in the development of portal hypertension in cirrhosis. Leptin, a hormone associated with reduction in nitric oxide bioavailability, vascular dysfunction and liver fibrosis, is increased in patients with cirrhosis. We aimed at evaluating ...
Karamercan Mehmet Akif - - 2013
Although mitochondrial dysfunction is thought to contribute to the development of post-traumatic organ failure, current techniques to assess mitochondrial function in tissues are invasive and clinically impractical. We hypothesized that mitochondrial function in peripheral blood mononuclear cells (PBMCs) would reflect cellular respiration in other organs during hemorrhagic shock and resuscitation ...
Zhang Wei - - 2013
Hemodynamics during anaphylactic shock remain unclear. We determined hepatic and splanchnic responses to anaphylactic hypotension, compared with hemorrhage or sodium nitroprusside (SNP)-induced hypotension, in anesthetized rats. Portal pressure, systemic arterial pressure (SAP), central venous pressure, portal and hepatic arterial blood flow were measured. Splanchnic (Rspl), portal venous (Rpv), and hepatic ...
Woolfson Jessica - - 2013
Hepatic venous pressure gradient (HVPG) is an indirect measure of portal venous pressure in cirrhosis, which is valid in cirrhotic adults for evaluating the severity of portal hypertension, predicting outcomes, and guiding therapeutic decisions. Published data on the measurement of HVPG in children is sparse. To determine the feasibility and ...
Heebøll Sara - - 2013
Abstract Objective. To assess the effect of propranolol treatment on the hepatic venous pressure gradient (HVPG) and the relationship between native HVPG and the effect of propranolol in patients with cirrhosis and portal hypertension in a prospective, observational, single-center study. Material and methods. The HVPG was registered prospectively in 124 ...
Shin Y H - - 2013
Orthotopic liver transplantation (OLT) is frequently associated with dramatic hemodynamic changes; thus, it is critical to accurately monitor blood pressure. Although comparisons between femoral arterial blood pressure (FABP) and radial arterial blood pressure (RABP) have been reported in adult liver recipients, we compared FABP with RABP in pediatric recipients. Thirty-five ...
Jomaa A - - 2013
Hypothermic machine perfusion (HMP) is better than conventional cold storage in kidney transplantation. Large animal models suggest that HMP may be beneficial for the liver as well, but questions remain about perfusion mode (dual portal/arterial flow versus single flow) and hepatic vascular injury including endothelial dysfunction or potential microbial infectivity ...
Foltys D - - 2013
The Achilles heel of liver transplantation remains the biliary system. The crucial step for liver preservation is effective rinsing and perfusion of the peribiliary plexus (PBP). Due to the physiology of the vascular tree, it seems almost impossible to achieve the necessary physiologic ranges of pressure and flow by the ...
Rotemberg Veronica V Department of Biomedical Engineering, Duke University, Room 136 Hudson Hall, Box 90281, Durham, NC 27708, USA. - - 2013
Elevated hepatic venous pressure is the primary source of complications in advancing liver disease. Ultrasound imaging is ideal for potential noninvasive hepatic pressure measurements as it is widely used for liver imaging. Specifically, ultrasound based stiffness measures may be useful for clinically monitoring pressure, but the mechanism by which liver ...
Post Ivo C J H - - 2013
INTRODUCTION: Donor graft washout can be impaired by colloids in organ preservation solutions that increase the viscosity and agglutinative propensity of red blood cells (RBC), potentially decreasing organ function. METHODS: The colloid-induced agglutinative effect on RBC and RBC retention after liver washout with Ringer's lactate (RL), histidine-tryptophan-ketoglutarate solution (HTK), University ...
Al-Chalabi Ahmed - - 2013
BACKGROUND: Mortality of patients with acute liver failure (ALF) is still unacceptably high. Available liver support systems are still of limited success at improving survival. A new type of albumin dialysis, the Hepa Wash(R) system, was newly introduced. We evaluated the new liver support system as well as the Molecular ...
Kaulitz R - - 2013
Moderate persistent elevation of the γ-glutamyltransferase (γGT) level is a frequent finding during long-term follow-up of patients with total cavopulmonary connection (TCPC) for palliation of functionally univentricular hearts. Serial intraindividual data revealed a significant increase in the γGT level within a minimum 4-year interval in more than 80 % of cases. ...
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