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Ishikawa Makoto M Ophthalmology, Akita Graduate University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Akita, 010-8543, Japan - - 2014
Purpose. Allopregnanolone is a neurosteroid and powerful modulator of neuronal excitability. The neuroprotective effects of allopregnanolone involve potentiation of γ-aminobutyric acid (GABA) inhibitory responses. Although glutamate excitotoxicity contributes to ganglion cell death in glaucoma, the role of GABA in glaucoma remains uncertain. The aim of this study was to determine ...
Paciga Andrea - - 2014
The effect of ammonia on the partitioning of two dicarboxylic acids, oxalic (C2) and adipic (C6) is determined. Measurements by a Tandem Differential Mobility Analysis system and a thermodenuder (TD-TDMA) system are used to estimate the saturation vapor pressure and enthalpy of vaporization of ammonium oxalate and adipate. Ammonia dramatically ...
Ciccone Marco Matteo MM Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, piazza G. Cesare, 11, 70124, Bari, Italy, - - 2014
Several studies examined the possibility that idiopathic pulmonary hypertension is related to thyroid autoimmune diseases. The aim of our study was to highlight the possible correlations between the pulmonary hypertension and Hashimoto's thyroiditis (HT). A total of 93 patients were enrolled, 70 suffering from HT in euthyroidism state and 23 ...
Levendoski Elizabeth Erickson EE Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, Indiana, - - 2014
Environmental humidification is a simple, cost-effective method believed to reduce superficial laryngeal drying. This study sought to validate this belief by investigating whether humidification treatment would reduce the negative effects of superficial laryngeal dehydration on phonation threshold pressure (PTP). Phonation threshold pressure data analysis may be vulnerable to bias because ...
Rosenthal Allison L AL Department of Communication Sciences and Disorders, Syracuse University, Syracuse, New - - 2014
The purpose of this study was to determine the aerodynamic and acoustic features of speech produced at comfortable, maximal and minimal levels of vocal effort. Prospective, quasi-experimental research design. Eighteen healthy participants with normal voice were included in this study. After task training, participants produced repeated syllable combinations at comfortable, ...
- - 2013
Members of safe staffing pressure group 4:1 protested last week against the government's decision not to introduce minimum staffing levels.
Farahani Mehrdad H - - 2013
The false vocal folds are hypothesized to affect the laryngeal flow during phonation. This hypothesis is tested both computationally and experimentally using rigid models of the human larynges. The computations are performed using an incompressible Navier-Stokes solver with a second order, sharp, immersed-boundary formulation, while the experiments are carried out ...
Khosla Sid S Department of Otolaryngology/Head & Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, - - 2013
Current theories regarding the mechanisms of phonation are based on assumptions about the aerodynamics between the vocal folds during the closing phase of vocal fold vibration. However, many of these fundamental assumptions have never been validated in a tissue model. In this study, the main objective was to determine the ...
Sjögren Karin - - 2013
This study examined the control of voice intensity using acoustic and aerodynamic recordings. A total of 34 subjects participated half of them with and half without song training, 21 females and 13 males. The subjects produced the syllable sequence /papapa/ while the acoustic signal, the oral air flow, and the ...
Ittermann Till T Institute for Community Medicine, University of Greifswald, Germany. - - 2013
Recent data from a population-based study in children and adolescents suggest that serum thyrotropin (TSH) levels are associated with arterial blood pressure and hypertension. These results are in agreement with some but not all population-based studies in adults. Discrepancies in results might be explained by drug intake, different iodine supplies, ...
Enflo Laura - - 2013
The phonation threshold pressure (PTP) is defined as the lowest subglottal pressure needed for obtaining and sustaining vocal fold oscillation. It has been found to increase during vocal fatigue. In the present study, PTP is measured together with the threshold pressure needed for vocal fold collision; henceforth, the collision threshold ...
Amador Ana A Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois 60637, USA. - - 2013
In most animals that vocalize, control of fundamental frequency is a key element for effective communication. In humans, subglottal pressure controls vocal intensity but also influences fundamental frequency during phonation. Given the underlying similarities in the biomechanical mechanisms of vocalization in humans and songbirds, songbirds offer an attractive opportunity to ...
Asvold Bjorn O - - 2013
Objective In cross-sectional studies, TSH levels within the reference range have been positively associated with blood pressure and adverse serum lipid levels. In a prospective study, we aimed to find out if differences in TSH within the reference range are associated with future levels of blood pressure and lipids.Design Prospective ...
Weiss Sandra - - 2013
Since voice production is the precondition for speech and, therefore, verbal communication, people suffering from voice disorders are limited in their everyday life. Physiological voice disorders, like vocal fold nodules are understood to result from increased contact pressure of the vocal folds during vibration. Thus, measurement of arising contact pressure ...
Mihaescu Mihai - - 2013
During the closing phase of the phonation cycle the true vocal-folds (TVF) have a convergent-divergent shape. The negative pressures generated by the flow through the glottal passage are producing closing forces acting on the TVFs towards the center of the larynx. Intra-glottal pressures can affect both vocal-fold vibration and voice ...
Alipour Fariborz F Department of Communication Sciences and Disorders, The University of Iowa, 334E WJSHC, Iowa City, Iowa 52242-1012, USA. - - 2013
The acoustic effects of the supraglottic laryngeal structures (SGSs), including the false vocal folds (FVFs) laryngeal ventricle, and the epiglottis were investigated in an excised canine larynx model with and without these anatomical structures. The purpose of this study was to better understand the acoustic contributions of these structures to ...
Li Zhe - - 2013
Mechanical stresses on the vocal folds surface during high pitch or amplitude phonation have been postulated to cause vocal fold damage. Models for the quantitative estimate of the contact pressure may be valuable for prevention and treatment. The objective of this study was to non-invasively estimate the contact pressure for ...
Ryu Jung-Hee - - 2013
BACKGROUND: Postoperative sore throat (POST) is a common complaint after general anesthesia, especially following thyroidectomy. MATERIALS AND METHODS: We examined the effect of adjusting the endotracheal tube cuff pressure during thyroidectomy on the incidence of airway complications. Ninety patients scheduled for elective thyroidectomy were randomized into two groups: control (group ...
Kalezic Nevena - - 2013
We studied the influence of demographic characteristics, comorbidity, and type and duration of surgery and anesthesia on the occurrence of intraoperative hypertension (IOHTA). Logistic regression analyses were used in order to determine the predictors of occurrence of IOHTA. More than 60% of our patients had IOHTA. Multivariate analysis showed that ...
Akasaka Kazuyuki - - 2012
The unique role of pressure in protein folding studies is emphasized. The variable-pressure NMR experiments carried out under equilibrium conditions gives unique opportunities to explore the energy landscape for protein folding. Intermediate conformers that may appear transiently in the kinetic folding experiments may be stably trapped under pressure, allowing examination ...
Segar Jeffrey L JL Department of Pediatrics, University of Iowa Carver College of Medicine, University of Iowa Children's Hospital, 200 Hawkins Drive, Iowa City, IA 52242, USA. - - 2013
Thyroid hormone exerts broad effects on the adult heart, but little is known regarding the role of thyroid hormone in the regulation of cardiac growth early in development and in response to pathophysiological conditions. To address this issue, we determined the effects of fetal thyroidectomy on cardiac growth and growth-related ...
Kim Jie-Ae - - 2012
BACKGROUND: Increased intraocular pressure (IOP) during surgery can result in serious ophthalmic complications. We hypothesized that carbon dioxide (CO(2)) insufflation of the neck during endoscopic thyroidectomy would constrict the jugular veins mechanically, causing elevated venous pressure and thus elevated IOP. We compared IOP changes at each step of open thyroidectomy ...
Oren Liran - - 2012
A major assumption of previously published PIV measurements in excised larynges, is that the vortices seen directly above the glottal exit during closing are due to the flow separation vortices (FSV) that formed in the glottis. This assumption needed experimental validation. In addition, the pressures associated with the vortices above ...
Daher M - - 2012
We investigated whether genetic variations of the beta-2 adrenergic receptor (ADRB2) modulate the haemodynamic response following spinal anaesthesia for caesarean delivery. We focused on the effects of haplotypes formed by combinations of the Arg16Gly and Gln27Glu polymorphisms. Clinical data from 143 healthy parturients were collected. Only the ArgGln haplotype appeared ...
Grubb Tamara - - 2012
Objective  To assess oxygenation, ventilation-perfusion (V/Q) matching and plasma endothelin (ET-1) concentrations in healthy horses recovering from isoflurane anaesthesia administered with or without pulse-delivered inhaled nitric oxide (iNO). Study Design  Prospective experimental trial. Animals  Healthy adult Standardbred horses. Methods  Horses were anaesthetized with isoflurane in oxygen and placed in lateral ...
Theiler L - - 2012
BACKGROUND: While surveys about anaesthesia practice appear regularly in the anaesthesia literature, they are usually bound to one country. We compared the approach to specific airway management issues among anaesthesiologists from three different European countries. METHODS A questionnaire was distributed during the main session of three anaesthesia meetings in Austria(A), ...
Cooper D - - 2012
BACKGROUND: Hypotension and nausea occur frequently during spinal anaesthesia for caesarean section. The aim of this evaluation was to assess systolic arterial pressure control with our routine prophylactic intravenous phenylephrine infusion regimen. We audited a local standard for an incidence of hypotension of ⩽25% during the first 15min of anaesthesia. ...
Vettorato Enzo E Royal (Dick) School of Veterinary Studies, Division of Veterinary Clinical Sciences, The University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, UK. - - 2012
To compare isoflurane and sevoflurane in lambs undergoing prolonged anaesthesia for spinal surgery. Prospective randomised clinical study. Eighteen Scottish blackface lambs 3-6 weeks of age and weighing 10-17 kg. After intramuscular medetomidine, anaesthesia was induced and maintained with either isoflurane (group I) or sevoflurane (group S) delivered in oxygen. Meloxicam, ...
O'Neill Daniel K - - 2012
A treatment challenge for patients with sacral pressure ulcers is balancing the need for adequate surgical debridement with appropriate anaesthesia management. We are functioning under the hypothesis that regional anaesthesia has advantages over general anaesthesia. We describe our regional anaesthesia protocol for perioperative and postoperative management.
McCarthy T - - 2012
We compared the ability of automated non-invasive intermittent oscillometric blood pressure monitoring with a new device, CNAP(TM) (continuous non-invasive arterial pressure) to provide a new blood pressure reading in each 1-min interval between spinal anaesthesia and delivery during caesarean section. We also compared the accuracy of continuous non-invasive arterial pressure ...
Segura Julian - - 2011
Lowering blood pressure by pharmacologic intervention reduces the incidence of cardiovascular events. Nevertheless, despite the widespread availability of effective antihypertensive medications, the vast majority of hypertensive patients worldwide continue to have inadequate blood pressure control. The development of new antihypertensive drugs could contribute to improving the hypertension control rate, and ...
Watts Stephanie W SW Department of Pharmacology & Toxicology, Michigan State University, East Lansing, MI 48824-1317, USA. - - 2011
Serotonin (5-hydroxytryptamine [5-HT]) was named for its isolation from blood serum (sero-) and ability to contract smooth muscle (-tonin). Thus, its relationship with the cardiovascular system began with its discovery. This review will focus on the effects of 5-HT and its receptors in the vasculature, with a focus on their ...
Meyer Rachel - - 2011
Medical management of cerebral vasospasm following aneurysmal subarachnoid hemorrhage (SAH) includes hypertensive, hypervolemic, and hemodilution ("triple-H") therapy. However, there is little information regarding the indications and guidance used to initiate and adjust triple-H therapy. A 43-item questionnaire was e-mailed to 375 members of the Neurocritical Care Society. Questions were designed ...
Oudejans Raoul R D - - 2011
Choking under pressure in sport has been explained by either explicit attention to skill execution (self-focus theories), or attention to performance worries (distraction theories). The aim of the present study was to find out which focus of attention occurs most often when expert athletes perform under pressure. Two retrospective methods ...
Wong J - - 2010
Following the recent Ongoing Telmistartan Alone and in Combination With Ramipril Global Endpoint Trial (ONTARGET) finding of adverse renal outcomes, dual renin-angiotensin blockade has fallen out of favour, despite antihypertensive and antiproteinuric efficacy. However, in high-risk severe hypertension, not studied in ONTARGET, whether combination treatment should be withheld or withdrawn ...
Vadera Raj - - 2011
Methods DATA SOURCES: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and references in review articles were searched. The authors also attempted to identify the grey literature by contacting trialists. STUDY SELECTION: Randomized controlled trials that enrolled patients with hypertensive emergencies in which a selected antihypertensive agent was compared with ...
Sciarretta Sebastiano - - 2011
It is still debated whether there are differences among the various antihypertensive strategies in heart failure prevention. We performed a network meta-analysis of recent trials in hypertension aimed at investigating this issue. Randomized, controlled trials published from 1997 through 2009 in peer-reviewed journals indexed in the PubMed and EMBASE databases ...
Zhenfeng Zheng - - 2011
Aliskiren is a novel antihypertensive agent and the first direct renin inhibitor (DRI) in clinical use. Several clinical trials have compared DRI with angiotensin receptor blockers (ARBs) in the management of essential hypertension. However, systematic comparison of efficacy and safety between DRIs and ARBs is still lacking. We reviewed randomized ...
Mensah George A - - 2010
Hypertension and prehypertension are major public health challenges. Prevention and control of prehypertension through lifestyle changes and the treatment of hypertension to goal blood pressure (BP) are important objectives. In most patients, 2 or more medications with complementary mechanisms of action should be used in combination. Referral for evaluation of ...
Mancia Giuseppe - - 2010
In 2009 the European Society of Hypertension (ESH) has developed a document updating the recommendations for the diagnosis and treatment of hypertension issued in 2007. The main elements of novelty refer to the assessment of organ damage, the blood pressure thresholds for treatment initiation as well as the blood pressure ...
Verdecchia Paolo - - 2010
The combined use of angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) poses a dilemma to clinicians. On the one hand, indirect evidence from compelling, but still surrogate outcome measures such as blood pressure and proteinuria suggest some merits of this combination. On the other hand, the outcome ...
Banach Maciej - - 2010
The aim of this issue of Expert Opinion on Pharmacotherapy is to present the most important and controversial problems in hypertension and nephrology. To this end, the most important points of the current (2009) recommendations of the European Society of Hypertension (ESH) are discussed, including aspects related to the treatment ...
Shantsila Alena - - 2010
Malignant hypertension (MHT) is the most severe form of hypertension which is clinically defined as the presence of high blood pressure in association with bilateral retinal haemorrhages and/or exudates, with or without papilloedema. The aim of this review article is to discuss whether MHT is a problem which is truly ...
Oigman Wille W State University of Rio de Janeiro, Av. 28 de Setembro 77 sala 329, Rio de Janeiro, RJ 20551-030, Brazil. - - 2010
The rate of control of hypertension remains suboptimal despite widespread educational programs and an increasing number of novel medications. The combination of drugs with different mechanisms of action has become an alternative to improve blood pressure reduction and control, enhance adherence to the treatment and reduce adverse events. Telmisartan and ...
Barrios Vivencio - - 2010
A significant proportion of patients with hypertension will need three or more antihypertensive agents to achieve blood pressure goals, particularly those at higher risk. On the other hand, fixed combinations provide an extra beneficial effect, as they improve medication adherence and, secondarily, the attainment of blood pressure goals during follow-up. ...
Aguilar Maria I - - 2010
Spontaneous intracerebral hemorrhage (sICH) is defined as bleeding within the brain parenchyma, and occurs twice as commonly as subarachnoid hemorrhage, but is equally as deadly. Risk factors for sICH include hypertension, advanced age, leukoaraiosis, prior ICH, renal failure, use of anticoagulant drugs, and cerebral amyloid angiopathy. When a patient is ...
Stepień Mariusz - - 2010
Central arterial systolic blood pressure is a very important factor in the pathophysiology of cardiovascular diseases. Central arterial pressure is a better predictor of cardiovascular risk than peripheral brachial blood pressure. Measurement of central blood pressure is useful for a diagnosis of spurious systolic hypertension in young people. Antihypertensive drugs ...
Grassi Guido - - 2010
Resistant hypertension, namely the hypertensive state characterized by the inability of multiple antihypertensive drug interventions to lower blood pressure to goal levels, represents a condition frequently detected in clinical practice. Its main features are represented by its heterogeneous etiology as well as its very high cardiovascular risk. This latter peculiarity ...
Acelajado Maria Czarina - - 2010
Hypertension is a very common modifiable risk factor for cardiovascular morbidity and mortality. Patients with hypertension represent a diverse group. In addition to those with primary hypertension, there are patients whose hypertension is attributable to secondary causes, those with resistant hypertension, and patients who present with a hypertensive crisis. Secondary ...
Chrostowska Marzena - - 2010
Hypertension, the leading cause of mortality and the third largest cause of disability, is poorly controlled worldwide. The failure to control hypertension takes an unacceptable toll on patients and their families. In addition to the personal cost, to the individual patient, uncontrolled hypertension creates huge, avoidable economic burdens when viewed ...
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