Search Results
Results 351 - 400 of 2037
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Bolli Peter - - 2008
Treatment resistant hypertension is defined as a blood pressure not achieving a goal blood pressure (<140/90 mm Hg) with a combination of three or more antihypertensive drugs. There are several causes for patients not responding to antihypertensive medication. One of the major reasons is noncompliance to the treatment, often because ...
Lenfant Claude - - 2008
In this article, the clinical trials that have most effectively demonstrated the effectiveness of hypertension nonpharmacologic prevention interventions are presented and discussed. Thus, data from weight reduction, dietary interventions, and lifestyle modifications are shown and discussed. It is concluded that these interventions lead to control of hypertension either by themselves ...
Jelinek Herbert - - 2008
High blood pressure leads to greater risk of cardiovascular disease morbidity and mortality. Our aim was to determine the prevalence of hypertension in a cohort of people attending a rural university health screening program in response to community advertisements. In all, 674 individuals attended the screening program at our university ...
Campana C - - 2008
INTRODUCTION: Optimal pharmacologic management of heart transplant (HT) candidates is required prior to evaluation so as to obtain a reliable prognostic stratification and to address the donor shortage. The aim of this study was to determine whether a tailored medical approach was effectively achieved before HT waiting list enrollment. MATERIALS ...
Grossman Ehud - - 2008
A variety of therapeutic agents or chemical substances can induce either a transient or persistent increase in blood pressure or interfere with the blood pressure-lowering effects of antihypertensive drugs. Some agents either cause sodium retention and extracellular volume expansion or directly or indirectly activate the sympathetic nervous system. Other substances ...
Schmidt André C - - 2008
OBJECTIVE: Differences in quality of life (QoL) using antihypertensive drugs may account for differences in compliance, persistence and blood pressure control. As this is the prerequisite for cardiovascular risk reduction, QoL was investigated using highly tolerable drugs (such as olmesartan). RESEARCH DESIGN/METHODS: The non-interventional study was carried out in 4252 ...
Milchak Jessica L - - 2008
STUDY OBJECTIVE: To compare physician adherence to guidelines from the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure for patients younger than 65 years of age with those aged 65 years and older, and to analyze whether factor groupings (subsets of ...
Lenz Thomas L - - 2008
OBJECTIVES: To review the lifestyle modification components listed in the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) from the National Heart, Lung, and Blood Institute (NHLBI) and discuss how the guidelines can be used by pharmacists in the ...
Coly Gerard - - 2008
Hypertension control rates are low in inner-city African-Americans. This article describes the demographic and clinical characteristics of uncontrolled hypertension in this population. During a single outpatient visit, normotensive and hypertensive African-American volunteers (age 18 to 55) completed a questionnaire, and the following measurements were obtained: blood pressure (BP), anthropometric measures, ...
Calhoun David A - - 2008
Resistant hypertension is a common clinical problem faced by both primary care clinicians and specialists. While the exact prevalence of resistant hypertension is unknown, clinical trials suggest that it is not rare, involving perhaps 20% to 30% of study participants. As older age and obesity are 2 of the strongest ...
Odili, VU; ;
Purpose: The role of physicians in the overall management of hypertension and their adherence to the JNC VII, WHO/ISH and ESH guidelines were examined in this study. Method: Case notes of hypertensive patients diagnosed between 1 January 2004 and 30 September 2005, in the Cardiology Clinic of University of Benin ...
Delaney Joseph A C - - 2008
PURPOSE: Observational studies using clinical databases, such as the United Kingdom's General Practice Research Database (GPRD), may provide an alternative to clinical trial data for detecting longitudinal changes in blood pressure due to drug exposures that vary over time. Blood pressure data which are measured at variable intervals and are ...
Hemmelgarn Brenda R - - 2008
BACKGROUND: In 1999, the Canadian Hypertension Education Program (CHEP) was launched to develop and implement evidence-based hypertension guidelines. OBJECTIVES: To determine temporal trends in antihypertensive drug prescribing and physician visits for hypertension in Canada, and correlate these trends with CHEP recommendations. METHODS: Longitudinal drug data (Intercontinental Medical Statistics [IMS] CompuScript ...
Feldstein Carlos A - - 2008
The beneficial effects of statins in hypertension stem from their effects on endothelial function, their interactions with the renin-angiotensin system, and their influence on large artery compliance. Substantial evidence has recently accumulated showing that statins exert pleiotropic effects in vascular function. These include an increase in the synthesis of NO, ...
Khan Nadia A - - 2008
OBJECTIVE: To update the evidence-based recommendations for the prevention and management of hypertension in adults. OPTIONS AND OUTCOMES: For lifestyle and pharmacological interventions, evidence was preferentially reviewed from randomized controlled trials and systematic reviews of trials. Changes in cardiovascular morbidity and mortality were the primary outcomes of interest. However, for ...
Kolasinska-Malkowska Katarzyna - - 2008
The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in blood pressure regulation and hypertension-related complications. Angiotensin-converting enzyme inhibitors (ACEIs) were the first to be used to block the RAAS and now have many compelling indications in the treatment of hypertension and its cardiovascular and renal complications. Angiotensin II receptor blockers ...
- - 2008
The present paper summarizes and highlights key messages of the 2008 Canadian Hypertension Education Program recommendations for the diagnosis and management of hypertension. The 2008 recommendations emphasize proper self-measurement of blood pressure as a step toward greater patient involvement in hypertension management. Home measurement is a better predictor of cardiovascular ...
Aksnes Tonje A - - 2008
Hypertensive patients have an increased risk of developing atrial fibrillation (AF), which increases cardiovascular morbidity and mortality in this population. Primary prevention is a new strategy in treating AF; previously, it was more common to focus on preventing adverse outcomes and controlling the arrhythmia's rate and rhythm. In this review, ...
Susic Dinko - - 2008
Partial adherence to antihypertensive therapy remains a public health challenge and may be associated with increased cardiovascular risk. We quantitatively evaluated cardiovascular risk inherent in partial therapy adherence in spontaneously hypertensive rats with accelerated hypertension. Adult spontaneously hypertensive rats were divided into 5 groups; Group 1 (controls) did not receive ...
Frank Jennifer - - 2008
Combination therapy of hypertension with separate agents or a fixed-dose combination pill offers the potential to lower blood pressure more quickly, obtain target blood pressure, and decrease adverse effects. Antihypertensive agents from different classes may offset adverse reactions from each other, such as a diuretic decreasing edema occurring secondary to ...
Walsh Judith M E - - 2008
Many quality improvement strategies have focused on improving blood pressure control, and these strategies can target the patient, the provider, and/or the system. Strategies that seem to have the biggest effect on blood pressure outcomes are team change, patient education, facilitated relay of clinical information, and promotion of self-management. Barriers ...
Ferri Claudio - - 2008
Hypertension control is rare in clinical practice, particularly in high-risk patients. A large factor is therapeutic inertia deriving from poorly prescribed lifestyle changes, excess monotherapy use, and scarce on-treatment modifications. The use of drug combinations significantly improves blood pressure (BP) control; in particular, fixed combinations improve therapy without increasing daily ...
Kario Kazuomi - - 2008
Bedtime inhalation of a novel muscarinic M3 receptor antagonist markedly lowered ambulatory blood pressure (ABP), predominantly during sleep, in a chronic obstructive pulmonary disease (COPD) patient with masked nocturnal hypertension. This is the first case demonstrating that a bronchodilator significantly lowered ABP in a COPD patient with hypertension. This case ...
Kawano Yuhei - - 2008
Masked hypertension has been drawing attention recently because this condition is often seen in untreated and treated individuals and is associated with target organ damage and a poor cardiovascular prognosis. Although masked hypertension is defined as normal office blood pressure with elevated ambulatory or home blood pressure, there are several ...
Hicks Leroi S - - 2008
We conducted a cluster randomized controlled trial to examine the effectiveness of computerized decision support (CDS) designed to improve hypertension care and outcomes in a racially diverse sample of primary care patients. We randomized 2,027 adult patients receiving hypertension care in 14 primary care practices to either 18 months of ...
Rosario Barbara H BH Sheffield Teaching Hospitals NHS Foundation Trust, Department of Geriatric Medicine, Sir Robert Hadfield Wing, Northern General Hospital, Herries Road, Sheffield S5 7AU, - - 2008
Telmisartan is an orally active angiotensin II receptor antagonist prescribed once daily. To evaluate the efficacy of telmisartan on blood pressure control, and on other end points, when given as monotherapy or in combination. Review of published literature. Results: Telmisartan produces more effective control of blood pressure over 24 h, ...
Alderman Michael H - - 2008
New onset diabetes (NOD) is common among hypertensive patients, whether they are being treated for hypertension or not, and is associated with subsequently increased cardiovascular disease (CVD). Thiazide-like diuretics and beta-blockers are more likely to provoke hyperglycemia when compared with drugs that block the renin-angiotensin system, and calcium channel blockers. ...
Bakris G L - - 2008
Clinical practice guidelines recommend blockers of the renin-angiotensin system alone or in combination with other agents to reduce blood pressure and albuminuria in patients with type 2 diabetes. Dihydropyridine calcium channel blockers, however, may lower blood pressure but not albuminuria in these patients. Here we tested the hypothesis that combining ...
Bailey Kent R - - 2008
Despite 40 years of research demonstrating the efficacy of antihypertensive medications for lowering blood pressure and decreasing cardiovascular disease, hypertension control rates worldwide remain low. We explored here how both medication efficacy rates and patient/physician decision-making (discontinuation rates) affect overall hypertension control rates. To do this we introduced the use ...
Berend Kenrick - - 2008
BACKGROUND: Even after a century of hypertension management, several trivial issues have remained unsolved and still result in inadequate control of blood pressure in many patients. METHODS: We have performed a critical literature review on topics pertaining the assessment and management of hypertension, focusing on the gaps in knowledge and ...
Tardif Jean-Claude - - 2008
Elevated heart rate plays a major role in coronary artery disease, not only as a trigger of most ischemic episodes but also as a significant predictor of cardiovascular morbidity and mortality. Heart rate is an important target in the management of stable angina pectoris. Against this background, a new class ...
Wykretowicz Andrzej - - 2008
BACKGROUND: Evidence from various studies has shown that even a very small reduction in the blood pressure explains the majority of benefits in cardiovascular outcomes. Although doxazosin is a relatively old drug, it is a very effective add-on therapeutic agent. It has been used in a variety of clinical trials, ...
Chrysant Steven G - - 2008
Hypertension is a major risk factor for cardiovascular morbidity and mortality and currently has been estimated at 30% of the US population. Of these, only 36.8% have their blood pressure reduced to recommended levels of lower than 140/90 mmHg for uncomplicated hypertension, or less than 130/80 mmHg for patients with ...
Sarafidis Pantelis A - - 2008
An improvement in the awareness and treatment of hypertension in the United States has occurred, resulting in the best control rates in the world, which unfortunately are far below the goals of Healthy People 2000 or 2010. This failure to achieve blood pressure (BP) goals is attributed to many factors, ...
Trewet Cora Lynn B - - 2008
Management of resistant hypertension (RH), defined as uncontrolled blood pressure on three or more antihypertensive medications including a diuretic, begins initially with identifying and addressing contributors such as medication adherence, lifestyle factors and the use of interfering substances. Evaluation for the "white-coat" phenomenon, or associated conditions and secondary causes such ...
Kohan Donald E - - 2008
Endothelin-1 (ET-1) exerts a wide range of biologic effects that can influence systemic blood pressure. Recent studies indicate that increased activity of the ET system in the vasculature, with resultant activation of primarily ET A receptors, can contribute to hypertension. In contrast, decreased production of ET-1 in the renal medulla, ...
Belsey J D - - 2008
Budgetary pressures within health care systems have led many health care providers to consider the switching of patients on long term anti hypertensive medication to agents with the lowest acquisition price. The long term success of this strategy hinges on price differentials remaining stable, an assumption that may not be ...
Halm Josiah - - 2008
BACKGROUND: Achieving normal blood pressure with antihypertensive medication remains an achievable goal for only approximately equal to 31% of hypertensive patients. Physical activity is a primary lifestyle measure required to lower blood pressure in hypertensive patients, and the US Preventative Services Task force (USPSTF) recommends counseling by health care providers ...
Tobe Sheldon W - - 2008
Achieving control of hypertension prevents target organ damage at both the micro and macrovascular level and is a highly cost effective means of lowering the risk for heart attack and stroke particularly in people with diabetes. Clinical trials demonstrate that blood pressure control can be achieved in a large proportion ...
Basile Jan - - 2008
Hypertension affects almost one-third of adults in the United States, but blood pressure is adequately controlled in only about 50% to 60% of persons with treated hypertension. Abundant clinical trial evidence has shown that antihypertensive therapy significantly reduces the risk of vascular events, and meta-analyses of observational and clinical trials ...
Xue Feng - - 2008
BACKGROUND: In Shanghai there are 1.2 million people with hypertension, many of whom have difficulty in affording medical treatment. Community based, anti-hypertensive clubs have been created to provide health education but education alone is often ineffective. Lifestyle change programmes have shown some potential for reducing blood pressure but in previous ...
Lee Vivian Wy - - 2008
OBJECTIVE: This study aimed to investigate the association between inadequately controlled hypertension, medication use pattern and the incidence of cardiovascular events (CVEs) over 5 years. The cost of hospitalisation associated with inadequately controlled hypertension was estimated. METHODS: This was a retrospective observational study of patients who were diagnosed with hypertension ...
Mebazaa Alexandre - - 2008
Guideline recommendations for the prehospital and early in-hospital (first 6-12 hrs after presentation) management of acute heart failure syndromes are lacking. The American College of Cardiology/American Heart Association and European Society of Cardiology guidelines direct the management of these acute heart failure patients, but specific consensus on early management has ...
Jamerson Kenneth A - - 2008
Various populations with hypertension have been singled out by current treatment guidelines as requiring more specific treatment. These include patients with stage 2 hypertension, black patients, and patients with coexistent diabetes mellitus and coronary heart disease. Hypertension in these groups is often associated with higher risk of cardiovascular morbidity and ...
Varon Joseph - - 2008
Approximately 72 million people in the US experience hypertension. Worldwide, hypertension may affect as many as 1 billion people and be responsible for approximately 7.1 million deaths per year. It is estimated that approximately 1% of patients with hypertension will, at some point, develop a hypertensive crisis. Hypertensive crises are ...
Nakayama Keiko - - 2008
Antihypertensive therapy has been well established to reduce hypertension related morbidity and mortality, but the optimal therapy for Japanese patients remains unknown. The Valsartan Amlodipine Randomized Trial (VART), a prospective randomized open-label trial, was designed to determine whether treatment with an angiotensin II type 1 receptor blocker (valsartan) or a ...
Legrady Peter - - 2008
BACKGROUND/AIMS: In cases of severe primary hypertension not responding to conventional medical therapy, neurovascular pulsatile compression of the rostral ventrolateral medulla on the left side may be considered as an etiological factor in the hypertension. Through neurosurgical decompression, the blood pressure can be reduced in these cases, and the conventional ...
B─âlan H - - 2008
The "manometric" way of considering the general management of high blood pressure (HBP) must remain ancient history. The huge therapeutical armamentarium (over 75 preparations, in 9 different classes) existing nowadays allows us to select the drugs most appropriate for the comorbidities of each case. The BP level target, unanimously considered ...
van der Wel Mark - - 2008
BACKGROUND: Blood pressure does not reach guideline targets in the majority of hypertensive patients. Longitudinal data from general practice records on trends in hypertension management and the influence of guideline changes are lacking. OBJECTIVE: To describe the longitudinal impact of guideline revisions on the process and outcome of hypertension management ...
Addo Juliet - - 2008
The goal of this study was to determine the prevalence of hypertension and establish the levels of detection, treatment, and control among urban civil servants in Ghana. A cross-sectional study was conducted on 1015 urban civil servants aged > or = 25 years from seven randomly selected central government ministries ...
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