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Mohan Sailesh - - 2010
Improvements in the diagnosis and treatment of hypertension have been documented in Canada following implementation of a national program to improve hypertension management. To determine whether there are regional variations in not treating diagnosed hypertension with drugs in Canada. Using data from the Canadian Community Health Survey (CCHS) cycle 3.1 ...
Lee Ling-Ling - - 2010
Hypertension is a major public health problem and a key risk factor of cardiovascular diseases. Increased physical activity has been recommended as an important lifestyle modification for the prevention and control of hypertension. However the optimal characteristics for a physical activity programme remain open to debate. Walking is recommended by ...
Thiboutot Jeffrey J Pennsylvania State University College of Medicine, M.S. Hershey Medical Center, Hershey, PA 17033, United - - 2010
Despite the known health risks of hypertension, many hypertensive patients still have uncontrolled blood pressure. Clinical inertia, the tendency of physicians not to intensify treatment, is a common barrier in controlling chronic diseases. This trial is aimed at determining the impact of activating patients to ask providers to make changes ...
Pladevall Manel M Center for Health Services Research, Henry Ford Hospital, One Ford Place 3A, Detroit, MI, USA. - - 2010
Medication nonadherence is common and results in preventable disease complications. This study assessed the effectiveness of a multifactorial intervention to improve both medication adherence and blood pressure control and to reduce cardiovascular events. In this multicenter, cluster-randomized trial, physicians from hospital-based hypertension clinics and primary care centers across Spain were ...
Bottiglieri Sal - - 2011
Hypertension is a common adverse effect of vascular endothelial growth factor (VEGF) signaling inhibitors, such as bevacizumab, with an incidence upwards of 35%. The management of bevacizumab-induced hypertension is important in order to avoid dose interruption/discontinuation and/or end organ damage. The efficacy of antihypertensive medications for this cause of hypertension ...
Margolius David - - 2010
About 32 million Americans have uncontrolled hypertension, and the impending shortage of primary care physicians could result in worsening blood pressure control. The "Treat to Target" approach to hypertension in primary care has the potential to increase hypertension control while off-loading a portion of hypertension management from physicians to other ...
Bramlage Peter - - 2010
Hypertensive patients with cardiovascular (CV) comorbidities are at increased risk, and cardiologists' care should put particular emphasis on controlling blood pressure. Data on blood pressure treatment and control and drug utilization on a global scale, however, are scarce. Aiming to resolve this lack of information, the authors analyzed the data ...
Hummel Diana - - 2010
ACE inhibitors (ACEI) and angiotensin receptor blockers (ARB) are superior to dihydropyridine calcium-antagonists (DHP) with regard to reduction of albuminuria in patients with diabetic nephropathy. It has been argued that with blood pressure outside the targets DHP may exaggerate albuminuria in hypertensive patients. We addressed the question in an observational ...
Chapman Neil - - 2010
The role of alpha-1 adrenoceptor antagonists (alpha-blockers) in the management of hypertension continues to evolve. Recent data support their use as add-on therapy in uncontrolled hypertension when used in combination with all other major classes of antihypertensive drug and there is increasing evidence suggesting that they have modest but significant ...
Mourad Jean-Jacques - - 2010
Combination antihypertensive therapy with an inhibitor of the renin-angiotensin system (RAS) and a calcium channel blocker (CCB) is a rational approach to achieve blood pressure (BP) goals in patients with hypertension, and may provide additional cardiovascular protection compared to other strategies in special populations. This article reviews the rationale for, ...
Selby Joe V JV Division of Research, Kaiser Permanente, 2000 Broadway, Oakland, Calif 94612, USA. - - 2010
Achieving full benefits of blood pressure control in populations requires prompt recognition of previously undetected hypertension. In 2003, the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure provided definitions of hypertension and recommended that single elevated readings be confirmed within 1 ...
Townsend Raymond R - - 2010
Over a century of experience with brachial blood pressure has produced a substantial amount of information on the role of blood pressure as a factor in heart disease, stroke and kidney failure. Successful interventions lowering blood pressure and reducing damage to vital organs testify further to the importance of this ...
Gradman Alan H - - 2010
The goals of antihypertensive therapy include optimal reduction in blood pressure (BP) while providing a favorable tolerability profile that promotes long-term adherence to treatment. For most patients with hypertension, these treatment goals cannot be achieved with monotherapy. When instituted early, however, combination therapy results in more rapid control of BP. ...
Qvarnström M - - 2011
The efficacy of antihypertensive drug therapy is undisputed, but observational studies show that few patients reach a target blood pressure <140/90 mm Hg. However, there is limited data on the drug prescribing patterns and their effectiveness in real practice. This retrospective observational survey of electronic patient records extracted data from 24 Swedish ...
Yokokawa Hirohide - - 2010
The relationship between achieving target blood pressures and medication modification among hypertensive patients in Japan is relatively unknown. We examined the incidence of prescription changes and how the prescription changes influence success rates in achieving target blood pressures in a group of patients with uncontrolled hypertension. This prospective observational cohort ...
Hart Peter D - - 2010
A worldwide epidemic of chronic kidney disease (CKD) exists; hypertensive nephropathy is second only to diabetes as a leading cause of progressive CKD. Due to the increasing morbidity and mortality and escalating costs associated with end-stage renal disease (ESRD), novel therapeutic strategies are needed urgently to maximally reduce albuminuria, control ...
Alam Ozair - - 2010
A number of 5-(4-substituted phenyl)-2-(substituted benzylsulfanyl)-4-(substituted phenyl)-6-methyl-1,4-dihydro-5-pyrimidine carboxamides (1-30) were designed and synthesized keeping in view the structural requirements as suggested in the pharmacophore model for antihypertensive activity. All the synthesized compounds were tested for antihypertensive activity by non-invasive blood pressure (NIBP) measurements (tail-cuff method) in rats. Almost all the ...
Mitobe Michihiro - - 2010
In the tubular cells of patients with polycystic kidney disease (PKD), a reduced intracellular Ca(2+) level accelerates cell proliferation, resulting in cyst formation. Thus, whether calcium channel blockers (CCB) are useful for the treatment of hypertension in patients with PKD is questionable. Thirty-two outpatients with autosomal dominant PKD (ADPKD) were ...
Hur Myung-Haeng - - 2012
The objective of this review is to systematically review the evidence for the effectiveness of aromatherapy in the treatment of high blood pressure. Twelve databases were searched from their inception through December 2009. Controlled trials testing aromatherapy in patients with hypertension of any origin that assessed blood pressure were considered. ...
Bohan Juliane - - 2011
This project measured the effect of a multifaceted intervention on health care provider identification and treatment of undiagnosed hypertensive patients. The intervention comprised provider education, audit, and feedback. The primary outcomes were pre-/postintervention differences in the proportion of patients presenting with elevated blood pressure who were (1) identified, (2) given ...
Woodward A - - 2010
The primary aim was to assess long-term blood pressure in 110 patients with Type 2 diabetes who had achieved optimal blood pressure control during attendance at a protocol-based nurse-led hypertension intensive intervention clinic 7 years previously. The secondary aim was to assess modifiable cardiovascular risk factor status. One hundred and ...
Khosravi Alireza - - 2010
BACKGROUND: This study aimed to investigate the association between hypertension and health-related quality of life in a sample of Iranian adults. METHODS: Samples were selected from the final phase of the Isfahan Healthy Heart Program (IHHP). A structured interview was conducted using a standardized questionnaire to obtain information on demographic ...
Bautista Leonelo E - - 2010
Nonsteroidal anti-inflammatory drugs are known to increase blood pressure and blunt the effect of antihypertensive drugs. Surprisingly, it has been suggested recently that aspirin lowers blood pressure and could be used for preventing hypertension. This review summarizes published data on the effects of aspirin on blood pressure. Trials suggesting that ...
Schlaich Markus P - - 2010
Resistant hypertension is a common and growing clinical problem characterized by failure to achieve target blood pressure levels despite adequate use of at least three antihypertensive agents. Although numerous safe and effective pharmacologic therapies are available to treat elevated blood pressure, novel therapeutic approaches are warranted to improve the management ...
Epstein Benjamin J - - 2010
IMPORTANCE OF THE FIELD: Hypertension is the most common preventable cause of cardiovascular morbidity and mortality. Despite the availability of a multitude of antihypertensive drugs, blood pressure (BP) control rates remain poor in the majority of patients with hypertension due to both patient- and clinician-related factors. The purpose of this ...
Enseleit Frank - - 2010
Resistant hypertension is defined as failure to lower blood pressure to target when a patient adheres to the maximum tolerated doses of three antihypertensive drugs including a diuretic. Notwithstanding the wide availability of several antihypertensive agents and the continued recommendation of dietary and lifestyle modifications, the prevalence of resistant hypertension ...
Axon R Neal - - 2011
Hypertension (HTN) is a major cardiovascular risk factor yet control rates remain suboptimal. Thus, improving recognition, treatment, and control of HTN by focusing on novel populations such as hospitalized patients is warranted. Current consensus guidelines do not address inpatient HTN, and little is known about HTN prevalence or patterns of ...
Hamer Mark M Department of Epidemiology and Public Health, 1-19 Torrington Pl, University College London, London WC1E 6BT, UK. - - 2010
There is conflicting evidence regarding the association of hypertension with psychological distress, such as anxiety and depressive symptoms. The association may be because of a direct effect of the raised blood pressure, adverse effects of treatment, or the consequences of labeling. In a representative study of 33 105 adults (aged ...
Sutton Emily - - 2010
The purpose of this study was to evaluate the reasons physicians provided when the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) guidelines recommending a thiazide diuretic as a first line treatment for hypertension were not followed. A subsample ...
Arguedas José Agustín - - 2010
Hypertension clinical guidelines have recommended a universal target blood pressure of less than 140/90 mmHg, and lower if tolerated. Even lower targets have been set for patients considered at higher cardiovascular risk. Those targets are considered as the blood pressure values below which the greatest clinical benefit is achieved. Our ...
Ghiadoni Lorenzo - - 2010
The increase in type 2 diabetes mellitus is associated to cardiovascular morbidity and mortality. This review focuses on the benefits of the fixed-dose combination of perindopril and indapamide on cardiovascular and renal end points in the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation) trial. ...
Catanzaro Daniel F - - 2010
The renin-angiotensin-aldosterone system (RAAS) plays a major role in blood pressure regulation and is thus an important therapeutic target in the management of hypertension. Angiotensin receptor blockers (ARBs), which interrupt RAAS overactivity by blocking a specific receptor that mediates the pathogenic activity of angiotensin II, represent a major addition to ...
Dresser George K - - 2010
To critically examine the scientific basis of emerging concepts in the monitoring and treatment of hypertension. Effective targeting of treatment strategies requires accurate assessment of blood pressure. Isolated use of manual office blood pressure measurement cannot detect white coat or masked hypertension. New information comparing automated office blood pressure (AOBP) ...
Wyman Marcia - - 2010
Some small clinical trials seem to show that coenzyme Q10 supplements can be used to lower blood pressure and to treat or prevent myalgia caused by hydroxymethylglutaryl coenzyme A reductase inhibitors (statins). However, larger trials are needed to determine if they are truly effective for these purposes. The authors examine ...
Soni Ritu K RK Department of Medicine, University of Pittsburgh Medical Center, PA, - - 2010
With the increasing prevalence of hypertension, there has been a growing interest in understanding the health-related quality of life (HRQOL) of patients with hypertension. Although hypertension is often perceived as asymptomatic, it is associated with impaired HRQOL because of complications or comorbidities, awareness of the diagnosis, and adverse effects from ...
Wadei Hani M - - 2010
Elevated arterial blood pressure is common after kidney transplantation and contributes to shortened patient and allograft survivals and increased fatal and nonfatal cardiovascular events. Unfortunately, current evidence indicates that arterial blood pressure remains poorly controlled in kidney transplant recipients. One concern is how best to evaluate treated levels of arterial ...
Masugata Hisashi - - 2010
EVALUATION OF: Miyashita H, Aizawa A, Hashimoto J et al. Cross-sectional characterization of all classes of antihypertensives in terms of central blood pressure in Japanese hypertensive patients. Am. J. Hypertens. 23(3), 260-268 (2010). Central blood pressure (CBP) more directly imposes mechanical stress on the left ventricle, large arteries and the ...
Consoli Silla M - - 2010
BACKGROUND: Despite clear international guidelines, the achievement of blood pressure (BP) control is still disappointing. OBJECTIVE: To determine whether physicians' perception of hypertension, in general, is related to their patients' BP measures. METHODS AND RESULTS: DUO-HTA is a French cross-sectional survey, which included a representative sample of 346 general practitioners, ...
Sood Nitesh - - 2010
PURPOSE: Evidence regarding combination therapy for the management of hypertension is reviewed. SUMMARY: Numerous clinical trials have demonstrated the importance of early aggressive lowering of blood pressure, especially in patients at high cardiovascular risk. However, one of the difficulties with achieving these blood pressure goals quickly is that monotherapy is ...
Tirapelli Carlos R - - 2010
Plants have always been an exemplary source of drugs and many of the currently available medicines have been directly or indirectly derived from them. For this reason, the research, development and use of natural products as therapeutic agents, especially those derived from plants, have been increasing in recent years. A ...
Barbanti P - - 2010
Progression of episodic migraine to chronic migraine may be related to comorbid medical conditions. In this study, we focused on the role played by arterial hypertension in migraine transformation. Several studies reveal that hypertension is associated with chronic migraine and may induce migraine chronification. Hypertension probably amplifies the effects of ...
DeMaria Samuel S - - 2010
Medical errors have rightly become an important societal and professional issue. While anesthesiology as a specialty has been at the forefront of the patient safety movement it is also subject to the same pressures for efficiency as any other business. Whether this pressure is at odds with the delivery of ...
Williamson Diane G - - 2010
Magnesium sulphate was added to conventional medical therapy in the treatment of persistent severe hypotension and wide QRS complex tachyarrhythmia in an 18-year-old woman presenting with a 1200 mg flecainide overdose. Blood pressure was restored with associated resolution of the electrocardiogram abnormalities.
Correa Vicente V - - 2010
Not all cardiovascular protection provided by statins is explained by their beneficial effects on lipoproteins. Old (e.g., clofibrate) and new (e.g., torcetrapib and ezetimibe) agents, with similar or more intense beneficial effect over lipoproteins, do not reproduce the beneficial effects of statins. Besides their anti-inflammatory and other pleiotropic effects, a ...
Crinson Iain - - 2010
Chronic kidney disease (CKD) is associated with increased cardiovascular mortality and morbidity as well as progression to established renal failure. Interventions in primary care, particularly the lowering of blood pressure in individuals with CKD and proteinuria and diabetes, can slow disease progression. This evidence base is codified in national guidance ...
Ahhmed Abdulatef Mrghni - - 2010
We tested the hypothesis that meat is a source of peptides that are effective at preventing and reducing chronic lifestyle-related diseases (CLSRDs) such as hypertension. This analysis reflects the importance of empowering hypertensive people in quality versus quantity of life issues, and in offering nutritional treatment options rather than medical ...
Debbabi Haytem - - 2010
Microvascular rarefaction and endothelium dysfunction are hallmarks of hypertension. We assessed whether antihypertensive treatments affect the microcirculation and whether the fixed-dose combination perindopril/indapamide (per/ind) modifies the microcirculation of hypertensive patients independently of blood pressure reduction. One hundred ninety-three consecutive patients were enrolled into one of four groups depending on their ...
Milan Alberto - - 2010
Structural remodelling of the heart, known as left ventricular hypertrophy (LVH), is a consequence of systemic hypertension, and is associated with an increased risk of cardiovascular morbidity and mortality. Therefore, particular attention should be paid to the identification, prevention and treatment of this condition in hypertensive patients. LVH seems to ...
Wu Katherine C - - 2010
The incidence and prevalence of systemic hypertension are reaching global epidemic proportions. Despite a diverse pharmacologic armamentarium of agents to treat high blood pressure, suboptimal control remains a significant problem in as many as 43% of patients and this rate has not significantly improved over the past 2 decades. There ...
Wang W W Department of Evidence-Based Medicine, Cardiovascular Institute and Fuwai Hospital, Beijing, PR - - 2011
The Chinese Hypertension Intervention Efficacy Study (CHIEF) is a multi-centre randomized controlled clinical trial comparing the effects of amlodipine+angiotensin II receptor blocker and amlodipine+diuretics on the incidence of cardiovascular events, represented as a composite of non-fatal stroke, non-fatal myocardial infarction and cardiovascular death events in high-risk Chinese hypertensive patients. The ...
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