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Results 351 - 400 of 1711
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Badzyńska B - - 2006
Acetylcholine (Ach) could serve as a selective renal medullary vasodilator in studies of the mechanism of arterial pressure regulation; however, effects of intramedullary Ach infusion were disparate. In anesthetized rats, the total renal blood flow (RBF) was measured by renal artery probe, and local perfusion of the cortex (CBF), outer ...
Landry D W - - 2006
Most patients with end-stage renal disease (ESRD) maintained on hemodialysis have chronic hypertension. However, hypotension is a frequent complication of hemodialysis, probably because of impaired baroreflex function. Less frequently, increases in pressure can be a complication of hemodialysis. Detailed studies of patients with these abnormalities in arterial pressure during hemodialysis ...
Magalhães João Carlos G - - 2006
Dietary sodium may contribute to hypertension and to cardiovascular and renal disease if a primary deficiency of the kidney to excrete sodium exists. In order to investigate whether chronic 1% NaCl in the drinking water changes blood pressure and renal haemodynamics in juvenile Wistar rats subjected to prenatal malnutrition, an ...
Wuerzner Grégoire - - 2006
Lower-body negative pressure (LBNP) induces a progressive activation of neurohormonal systems and a renal tubular and haemodynamic response that mimics the renal adaptation observed in congestive heart failure. Both angiotensin II receptor blockers and beta-blockers have been shown to reduce morbidity and mortality in patients with congestive heart failure. To ...
Griffin Karen A - - 2006
Substantial evidence indicates that hypertension is a major contributor to the development of end-stage renal disease in most patients. However, such risk ranges from being fairly low in essential hypertension to a marked increase in susceptibility to hypertensive injury in patients with chronic kidney disease, including diabetic nephropathy. Studies in ...
Tiryaki Ozlem - - 2007
We herein report on a 29-year-old woman who presented with edema and proteinuria. In light of her blood pressure differences and, finally, with the angiographic findings, Takayasu arteritis (TA) was the diagnosis. Renal biopsy showed focal segmental glomerulosclerosis (FSGS) and other possible etiologic alternatives were excluded. This was a very ...
Chen Chun-guang - - 2006
AIM: To investigate the effects of magnesium lithospermate B (MLB) isolated from Salviae miltiorrhizae on renal microcirculation, and renal and systemic hemodynamics in Sprague-Dawley rats. METHODS: MLB (10, 30, and 60 mg/kg) was injected intravenously and renal blood flow (RBF), renal cortical microperfusion (RCM), and systemic hemodynamic function parameters including ...
Brantsma Auke H - - 2006
The hypothesis that high urinary albumin excretion (UAE; indicating mild renal damage) may precede development of hypertension was tested, and the relation among UAE, GFR, and development of hypertension was investigated. Data of 4635 patients of a prospective cohort study who participated in an extensive screening in 1997 to 1998 ...
Penkalla Ralf - - 2006
INTRODUCTION: Peritubular renal microcirculation has not been directly visualized in acute ureteral obstruction. Therefore, we used epiilluminescence intravital microscopy and an animal model for the assessment of microvascular perfusion. MATERIALS AND METHODS: In group 1 (n = 5) the left kidney of Wistar rats was exteriorized and placed on a ...
Raptis Lampros - - 2006
We present an 80-year-old woman, with a history of well-controlled hypertension and atrial fibrillation, who suffered from back pain and elevated blood pressure for 2 weeks prior to admission. At physical examination, a low-pitched systolic heart murmur was heard in the tricuspid area and there was mild tenderness in the ...
Novikov Iu V - - 2006
To determine the characteristics of renal vascular system adaptation to venous congestion, the right heart overload was induced in 32 puppies by surgical narrowing of the pulmonary trunk. The animals were followed up over the period as long as 2 years. Twenty-three puppies showed compensation of the functionally overloaded right ...
Escobar Cristina - - 2006
The prevalence of 20 diseases was studied in a representative sample of 3619 individuals in Chile. Twelve percent of the participants were younger than 25, 63% were 25-64 years old, and 25% were at least 65 years old. Thirty-four percent had high blood pressure, 60% were aware of their condition, ...
Harris Raymond C - - 2006
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the treatment of pain and inflammation. Nonselective NSAIDs inhibit both cyclooxygenase (COX)-1 and COX-2. Nephrotoxicity of nonselective NSAIDs has been well documented. The effects of selective COX-2 inhibitors on renal function and blood pressure are attracting increasing attention. In the kidney, COX-2 ...
Loutzenhiser Rodger - - 2006
PURPOSE OF REVIEW: The ability of the kidney to autoregulate renal blood flow and glomerular filtration rate has long been viewed as existing to prevent fluctuations in blood pressure from causing parallel fluctuations in renal function and distal delivery of filtrate. This review, however, points out that the primary consequence ...
Ardiles L G - - 2006
Injury of the renal tubulointerstitial compartment is recognized to play an important role in hypertension. Its damage may in turn, impair the activity of vasodepressor systems, like the kallikrein-kinin, in blood pressure regulation. The overload proteinuria model induces tubulointerstitial injury with activation of the renin-angiotensin system, but renal kallikrein and ...
Diskin Charles J - - 2006
The objective of the present study was to retrospectively examine whether the addition of minoxidil to patients who were already treated with maximum doses of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers but who had not achieved target blood pressures, has any detrimental effect on proteinuria or renal function or ...
O’Connell, Amanda Elizabeth
This thesis reports the effects of an altered intrauterine environment on the offspring&#146;s&#13;renal, cardiovascular and renin angiotensin systems. After a midgestational asphyxial&#13;episode in fetal sheep (30 min total umbilical cord occlusion at 90 days; term 150 days)&#13;the hydrops that resulted had not completely resolved by 130 days. While the heart ...
Remuzzi Giuseppe - - 2005
The renin-angiotensin-aldosterone system (RAAS) is a well known regulator of blood pressure (BP) and determinant of target-organ damage. It controls fluid and electrolyte balance through coordinated effects on the heart, blood vessels, and Kidneys. Angiotensin II (AII) is the main effector of the RAAS and exerts its vasoconstrictor effect predominantly ...
Hauser Balázs - - 2005
The aim of this study was to investigate the effects of intrarenal administration of the cyclooxygenase-2 inhibitor parecoxib during suprarenal aortic cross-clamping. In a prospective, controlled, blinded, randomized manner, 16 anesthetized and mechanically ventilated pigs were instrumented to measure systemic and right kidney hemodynamics, oxygen exchange, and metabolism. During 45 ...
Just Armin - - 2005
This rat renal blood flow (RBF) study quantified the impact of nitric oxide synthase (NOS) inhibition on the myogenic response and the balance of autoregulatory mechanisms in the time domain following a 20 mmHg-step increase or decrease in renal arterial pressure (RAP). When RAP was increased, the myogenic component of ...
Rahman Mahboob - - 2005
Current national guidelines recommend aggressive lowering of blood pressure (< 130/80 mm Hg) in patients with chronic kidney disease (CKD). In this paper, we summarize recent clinical trial data evaluating the effect of lower blood pressure goals on renal outcomes. The epidemiologic data relating blood pressure to progression of kidney ...
Tanemoto Masayuki - - 2005
We describe a case of renovascular hypertension that was caused by renal artery dissection after an angiographic evaluation of the lower extremities. Retention of contrast medium in the affected kidney even 1 day after the procedure caused us to suspect renal artery dissection. Magnetic resonance angiography revealed irregular streaks in ...
Cozzi Francesco - - 2005
PURPOSE: We studied the natural history of renal function following removal of different amounts of renal mass in a cohort of children with unilateral renal tumors. MATERIALS AND METHODS: We compared kidney function and blood pressure before and after surgery in 26 patients with unilateral renal tumors treated with nephrectomy ...
López-Hernández Francisco J - - 2006
Strong evidence supports the idea that total peripheral resistance (TPR) is increased in all forms of human and experimental hypertension. Although the etiological participation of TPR in the origin and long-term maintenance of hypertension has been extensively debated, it now seems clear that the renal, nonadaptive, infinite gain-working, pressure-sensitive natriuresis ...
Rocha-Singh Krishna - - 2005
OBJECTIVES: This study sought to define the safety and durability of renal stenting after suboptimal/failed renal artery angioplasty in patients with suspected renovascular hypertension. BACKGROUND: Few prospective multicenter studies have detailed the safety, efficacy, and long-term clinical benefits of renal artery stent revascularization in hypertensive patients with aorto-ostial atherosclerotic renal ...
Brown C A - - 2005
The clinical, hemodynamic, and pathologic features of hypertensive encephalopathy in two cats with reduced renal mass are described. The cats developed a progressive syndrome of lethargy, ataxia, blindness, stupor, and seizures following an abrupt increase in blood pressure associated with a surgical reduction in renal mass. The cats had severe ...
de Sousa Alves Renata - - 2005
Tityus serrulatus, popularly known as yellow scorpion, is one of the most studied scorpion species in South America and its venom has supplied some highly active molecules. The effects of T. serrulatus venom upon the renal physiology in human showed increased renal parameters, urea and creatinine. However, in perfused rat ...
Ritz Eberhard - - 2005
The relationship between the kidney and hypertension is complex. The kidney is both culprit and victim. Renal disease and even renal structural abnormalities (nephron underdosing) lead to hypertension. On the other hand, blood pressure (even blood pressure values in the range of normotension) accelerates a progressive loss of renal function ...
Peng Zhi-Yong - - 2005
OBJECTIVE: To determine the dose-response effects of noradrenaline on the systemic and renal circulations during septic shock. DESIGN AND SETTING: Prospective controlled experiment in a university animal laboratory. SUBJECTS: Eight anaesthetized dogs. INTERVENTIONS: Transonic flow probes were surgically placed on the aorta via a left lateral thoracotomy and on the ...
Wuerzner Grégoire - - 2005
BACKGROUND: Lower body negative pressure (LBNP) has been shown to induce a progressive activation of neurohormonal systems, and a renal tubular and hemodynamic response that mimics the renal adaptation observed in congestive heart failure (CHF). As beta-blockers play an important role in the management of CHF patients, the effects of ...
Santos Claudia M - - 2005
For both practical and methodological reasons, mice have been the most widely employed species for development of transgenic and gene knockin and knockout animals. However, basic behavioral and physiology control and regulatory mechanisms in mice are not well characterized. To broaden our understanding of the processes maintaining body fluid and ...
Nussinovitch Naomi - - 2005
The development of hypertension was examined several years after an episode of Henoch-Schönlein purpura (HSP) in children with or without urinary abnormalities or hypertension at diagnosis. Medical records of 155 children (mean age 6.8+/-2.3) with HSP from 1969 to 1997 were reviewed for a specific description of renal involvement, blood ...
Garovic Vesna - - 2005
Hypertension produced by renal artery occlusive disease is an important secondary form of hypertension. Clinicians commonly encounter forms of renal arterial disease of varying severity, many of which are of little hemodynamic significance when first detected. Experimental studies emphasize that transient activation of the renin-angiotensin-aldosterone system is necessary for initiation ...
Satonaka Hiroshi - - 2005
The objective of the present study was to compare the effects of imidapril hydrochloride, an angiotensin converting enzyme inhibitor, and dilazep hydrochloride, an antiplatelet agent, on urinary protein excretion and renal function in patients with chronic glomerulonephritis. Imidapril (2.5 or 5 mg/day) or dilazep (300 or 450 mg/day) was administered ...
Derchi Lorenzo E - - 2005
BACKGROUND: Mild renal dysfunction (MRD) is an often overlooked but relatively common condition in patients with primary hypertension (PH), and is associated with high cardiovascular morbidity and mortality. Whether MRD is also associated with abnormalities in renal vascular resistance is currently unknown. METHODS: Two hundred ninety-one untreated patients with PH ...
Sahin Sinan - - 2006
OBJECTIVE: To evaluate the clinical and technical results of renal artery stenting for the treatment of renovascular hypertension and renal failure in patients with solitary functioning kidney. MATERIALS AND METHODS: Fifteen patients with solitary functioning kidney underwent renal artery stenting and were followed up for 12-60 months. Before the procedures, ...
Miao Chao-Yu - - 2005
OBJECTIVE: This study aimed to determine whether the alteration of the pressure natriuresis seen in Lyon genetically hypertensive (LH) rats occurs early, and the possible involvement in this alteration of the most important extra-renal factors that influence natriuresis. METHODS: In LH rats and their normotensive (LL) controls, acute pressure natriuresis ...
Kura Naoki - - 2005
We report a rare case of asymptomatic adrenal medullary hyperplasia detected by chance with intraoperative hypertension during surgery for ipsilateral renal cell carcinoma. A 41-year-old male visited our hospital with a complaint of left flank pain. He had normal blood pressure and plasma catecholamine level was within normal limits. Ultrasonogram ...
Evans Roger G - - 2005
1. It is well established that pressure natriuresis plays a key role in long-term blood pressure regulation, but our understanding of the mechanisms underlying this process is incomplete. 2. Pressure natriuresis is chiefly mediated by inhibition of tubular sodium reabsorption, because both total renal blood flow and glomerular filtration rate ...
Kovacikova Lubica - - 2005
A 35-day-old infant admitted with cardiogenic shock was hypertensive shortly after initial resuscitation therapy. The hypertension did not respond to increasing doses of sodium nitroprusside. An abnormal blood flow in the right renal artery was detected by pulsed Doppler ultrasonography, and a prompt blood pressure response to oral captopril suggested ...
Osborn John W - - 2005
1. It has been hypothesised that the 'set-point' for the long-term control of mean arterial (MAP) resides within the kidney. In this model, the set-point of the 'chronic renal function curve' establishes the steady state relationship between renal perfusion pressure and urinary excretion of sodium and water, which, in turn, ...
Guild Sarah-Jane - - 2005
1. With increasing evidence that the sympathetic nervous system plays a critical role in the development of hypertension, focus is turning to how these signals translate to a chronic increase in arterial pressure. 2. The kidney's role in the control of salt and water homeostasis makes it an obvious target ...
Bourgoin Aurélie - - 2005
OBJECTIVE: To measure the effects of increasing mean arterial pressure on oxygen variables and renal function in septic shock. DESIGN: Prospective, open-label, randomized, controlled study. SETTING: Medical-surgical intensive care unit of a tertiary care teaching hospital. PATIENTS: Twenty-eight patients with a diagnosis of septic shock who required fluid resuscitation and ...
Baguet Jean-Phillippe - - 2005
OBJECTIVE: High blood pressure is almost constant in renal transplant patients for whom dysautonomia is frequently described. The main objective of this study was to analyse the variations in blood pressure and heart rate recorded by ambulatory measurement during changes in position in renal transplant patients. METHODS: Thirty-nine non-diabetic renal ...
Mendelsohn Michael E - - 2005
Blood pressure abnormalities are thought to originate from intrinsic changes in the kidney, a concept that has been largely unchallenged for more than 4 decades. However, recent molecular, cellular, and transgenic mouse studies support an alternative hypothesis: primary abnormalities in vascular cell function can also directly cause abnormalities of blood ...
Martin Julie S - - 2005
PURPOSE: Increased pressures within renal interstitial fluid, as associated with a number of renal pathologies, could affect cell function and gene expression. The long-term objective of this research is to elucidate kidney cell responses to pathological hydrostatic pressures. MATERIALS AND METHODS: In vitro studies were performed in 2 kidney cell ...
Gilbert Jeffrey S - - 2005
Pregnant ewes were fed either a 50% nutrient-restricted (NR; n= 8) or a control 100% (C; n= 8) diet from day 28 to day 78 of gestation (dGA; term = 150 dGA). Lambs were born naturally, and fed to appetite throughout the study period. At 245 +/- 1 days postnatal ...
Sindhu Ram K - - 2005
Chronic renal failure (CRF) is associated with oxidative stress, the precise mechanism of which is yet to be elucidated. The present study was undertaken to investigate in renal insufficiency the expression of catalase and glutathione peroxidase, which play a critical role in antioxidant defense system by catalyzing detoxification of hydrogen ...
von Wussow Ursula - - 2005
Although the structure and function of erythropoietin (Epo) are well documented, the mechanisms of the regulation of the renal synthesis of Epo are still poorly understood. Especially, the description of the localization and function of the O(2)-sensitive sensor regulating the renal synthesis of Epo is insufficient. A body of evidence ...
Alexander Barbara T - - 2005
Low birth weight is a risk factor for the subsequent development of hypertension in humans. We previously reported that reduced uterine perfusion in the pregnant rat results in growth-restricted offspring predisposed to the development of hypertension. The purpose of this study was to determine whether the sympathetic nervous system plays ...
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