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Plumhans Cédric - - 2012
Completely implantable access ports for high pressure contrast media injection have been in use in clinical routine for a relatively short time. The purpose of our study was to compare a high pressure port system with a standard port system with regard to implantation and complications. In 94 oncological patients ...
Hussain Syed Aqeel - - 2012
To observe the safety of trans-jugular pressure-monitoring catheter insertion at a tertiary care teaching hospital in Rawalpindi, Pakistan. The observational study was carried out at the Armed Forces Institute of Cardiology/National Institute of Heart Diseases, Rawalpindi, from January 1, 2004 to March 31, 2010. All patients electively scheduled to undergo ...
Vidal Denham Lori - - 2012
Properties of a piezoelectric polymeric angioplasty balloon that may decrease the problems of acute closure and restenosis are evaluated in this study. Polyvinylidene difluoride (PVDF), a piezoelectric and pyroelectric polymer, has sufficient strength to serve as a standard angioplasty balloon as well as functioning as an ultrasonic transmitter and/or receiver. ...
Mueller Martin M MM Departments of Obstetrics and Gynaecology, University Hospital and University of Bern, Switzerland. - - 2012
Measurements of maximum urethral closure pressure (MUCP) are a part of urodynamic investigations preceding an incontinence surgery and a part of urethral function tests. The aim of the study was to compare maximum urethral closure pressure determined by a microtip catheter with those measured by an air-charged catheter. A prospective ...
Colah S - - 2012
We describe a cost-effective, reproducible circuit in a porcine, ex vivo, continuous warm-blood, bi-ventricular, working heart model that has future possibilities for pre-transplant assessment of marginal hearts donated from brain stem dead donors and hearts donated after circulatory determination of death (DCDD).In five consecutive experiments over five days, pressure volume ...
Shingu Yasushige - - 2012
Background: Total stroke work (TSW) is used for the estimation of cardiac efficiency in mitral regurgitation (MR). We should be cautious about the interpretation of this parameter, especially when it is assessed by non-invasive methods such as echocardiography. Methods and Results: For the calculation of regurgitant stroke work, regurgitant volume ...
Kobayashi Hiroshi - - 2013
Objective This study was designed to identify why the central blood pressure (cSBP) values obtained using the catheter method tend to be higher than brachial systolic blood pressure (bSBP) values obtained using the cuff method. Methods This study enrolled 20 patients who underwent coronary angiography (CAG) (mean age, 68.9 years; ...
Parker Kim H - - 2012
This study is based on the hypothesis that the pressure within the arterial network can be usefully decomposed as the sum of a reservoir pressure and an excess pressure. The reservoir pressure waveform is defined to be the same in each vessel but delayed by the wave travel time from ...
Kelly A - - 2012
Reduced cardiac contractility has been associated with disrupted myocardial Ca(2+) signalling. The 1,4 benzothiazepine K201 (JTV-519) acts on several Ca(2+) handling proteins and improves cardiac contractility in vivo in a variety of animal models of myocardial dysfunction. However, it is unclear whether this improvement depends on the systemic effects of ...
Zamir M - - 2012
In a premature ventricular contraction (PVC), a systolic blood pressure peak is missing during the affected cardiac cycle, leading to a prolonged reduction in blood pressure which is then followed by a large burst of sympathetic outflow. In a normal ventricular contraction, it is generally believed that peak carotid and ...
Sawatsky Andrew - - 2012
BACKGROUND: Patellofemoral joint pain is a common knee disorder, but its underlying causes remain unknown. One proposed mechanism is an imbalance in force in the knee extensor muscles. Specifically, the vastus medialis and vastus lateralis are thought to play a crucial role in proper patellar tracking, and weakness in vastus ...
Wölkart G - - 2012
Adipose triglyceride lipase (ATGL) has been identified as a rate-limiting enzyme of mammalian triglyceride catabolism. Deletion of the ATGL gene in mice results in severe lipid accumulation in a variety of tissues including the heart. In the present study we investigated cardiac function in ATGL-deficient mice and the potential therapeutic ...
Zeqiri Nexhmi - - 2012
Biochemical and physiological mechanisms by which lead affects the cardiovascular system by increasing blood pressure are still unknown. But it is believed that the increased arterial pressure disturbance is caused as a result of the concentration of intracellular calcium ions (Ca). The study had the purposes of analyzing the effect ...
Reems Miryam M - - 2012
Central venous pressure (CVP), an estimate of right atrial pressure, has been used to assess cardiac preload and volume status in critically ill patients, assist in the diagnosis of right-sided heart failure, and guide fluid resuscitation. It is determined by the interaction between cardiac function and venous return. CVP measurements ...
Lee Wai - - 2012
A 9-year-old girl had hypertension (systolic blood pressure of 125 mm Hg) noted at an annual well child visit. An ultrasound study demonstrated a large right renal cystic mass. A partial nephrectomy was performed. The surgical specimen was 9.7 × 9.4 × 6.4 cm and weighed 413.2 g. The tumor ...
Jones James P JP Division of Nephrology, Department of Medicine, St. Luke's-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA. - - 2012
Although prior studies have shown that frequent hemodialysis (HD) can lead to improved control of dry weight in end-stage renal disease patients, there are no clinical studies examining whether this can improve blood pressure (BP) control and can also shorten the dialysis time needed to achieve satisfactory removal of small ...
Rood Kara M KM Bridgeport Hospital, Yale New Haven Health System, Bridgeport, CT 06610, - - 2012
Insertion of intrauterine pressure catheters is a routine procedure performed in labor and delivery departments, with few associated complications. There are several reports of maternal and neonatal morbidity associated with the use of intrauterine pressure catheters and their rare adverse outcomes. We report an unusual case of uterine hypertonicity resulting ...
Frohlich Edward D - - 2012
This review discusses cardiac consequences of pressure overload. In response to elevated pressure, the ventricular hypertrophy compensates for the increased wall stress. However, the ventricular hypertrophy involves numerous structural adaptations that may lead to ventricular dysfunction and, eventually, heart failure. Particular emphasis is placed on molecular mechanisms that govern the ...
Fujita Masashi - - 2012
In the two-cell stage embryos of Caenorhabditis elegans, the contact surface of the two blastomeres forms a curve that bulges from the AB blastomere to the Pā‚ blastomere. This curve is a consequence of the high intracellular hydrostatic pressure of AB compared with that of Pā‚. However, the higher pressure ...
Hannawi Bashar - - 2012
Chronic mesenteric ischemia is a rare disorder in the United States. Frequently, its symptoms correlate poorly with the angiographically apparent degree of mesenteric artery stenosis. Measuring the pressure gradient with a small-caliber catheter is an established means of determining whether a particular stenosis is flow-limiting, thus guiding the interventional decision ...
Matthesen Solveig K - - 2011
Background. Potassium is the main intracellular cation, which contributes to keeping the intracellular membrane potential slightly negative and elicits contraction of smooth, skeletal and cardiac muscle. A change in potassium intake modifies both cardiovascular and renal tubular function. The purpose of the trial was to investigate the effect of dietary ...
Brugts J J - - 2011
Abstract  We present a case of acute respiratory insufficiency with right-to-left atrial shunting under normal intracardiac pressures discovered several days after aortic surgery for aortic dissection. We discuss the possible mechanisms and management of right-to-left atrial shunting through an atrial septum defect with normal intracardiac pressures following cardiac surgery. (J ...
Bishu Kalkidan - - 2011
In vitro studies suggest that phosphorylation of titin reduces myocyte/myofiber stiffness. Titin can be phosphorylated by cGMP-activated protein kinase. Intracellular cGMP production is stimulated by B-type natriuretic peptide (BNP) and degraded by phosphodiesterases, including phosphodiesterase-5A. We hypothesized that a phosphodiesterase-5A inhibitor (sildenafil) alone or in combination with BNP would increase ...
Guadagnoli Jutta A JA College of Osteopathic Medicine, Touro University Nevada, Henderson, NV 89014, - - 2011
In hearts of higher invertebrates as well as vertebrates, the work performed by the ventricle is a function of both rate and contractility. Decapod crustaceans experience a hypoxia-induced bradycardia that is thought to result in an overall reduction in cardiac work; however, this hypothesis has not yet been tested and ...
Maruvada S - - 2011
Tissue-mimicking materials (TMMs) can provide a convenient, stable, and reproducible means for testing high intensity focused ultrasound (HIFU) devices. When TMMs containing thermal sensors are used to measure ultrasound-induced temperature rise, it is important that measurement results reasonably represent those that occur in biological tissue. Therefore the aim of this ...
Kwiatek Monika A MA Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, - - 2012
This study aimed to apply novel high-resolution manometry with eight-sector radial pressure resolution (3D-HRM technology) to resolve the deglutitive pressure morphology at the esophagogastric junction (EGJ) before, during, and after bolus transit. A hybrid HRM assembly, including a 9-cm-long 3D-HRM array, was used to record EGJ pressure morphology in 15 ...
Chan Gregory S H - - 2012
Assessment of spontaneous slow waves in the peripheral blood volume using the photoplethysmogram (PPG) has shown potential clinical value, but the physiological correlates of these fluctuations have not been fully elucidated. This study addressed the contribution of arterial pressure and muscle sympathetic nerve activity (MSNA) in beat-to-beat PPG variability in ...
Choi Hyun-Min - - 2011
This study determined whether an elevated muscle metaboreflex contributes to the excessive blood pressure response to exercise in postmenopausal women. Thirty healthy female volunteers were studied (15 postmenopausal and 15 premenopausal). Stroke volume, heart rate, cardiac output (CO), systolic blood pressure, diastolic blood pressure, and total vascular conductance (TVC) were ...
Maybauer Marc O - - 2011
ABSTRACT: This experimental animal study investigates the effects of combined recombinant human activated protein C (rhAPC) and ceftazidime on cardio-pulmonary function in acute lung injury and severe sepsis. Twenty-one sheep (37±2 kg) were operatively prepared and randomly allocated to either the sham, control, or treatment group (n=7 each). Single treatments ...
Cheng Guangmao - - 2012
Formation of a dense microtubule network that impedes cardiac contraction and intracellular transport occurs in severe pressure overload hypertrophy. This process is highly dynamic, since microtubule depolymerization causes striking improvement in contractile function. A molecular etiology for this cytoskeletal alteration has been defined in terms of type 1 and type ...
Krediet C T Paul - - 2011
We assessed the timing of vagal and sympathetic factors that mediate hypotension during CSM (carotid sinus massage) in patients with carotid sinus hypersensitivity. We hypothesized that a fall in cardiac output would precede vasodepression, and that vasodepression would be exaggerated by head-up tilt. We performed pulse contour analyses on blood ...
Cingolani Oscar H OH Division of Cardiology, Department of Medicine, Department of Biomedical Engineering, The Johns Hopkins University Medical Institutions, Baltimore, MD 21205, - - 2011
One of the physiological mechanisms by which the heart adapts to a rise in blood pressure is by augmenting myocyte stretch-mediated intracellular calcium, with a subsequent increase in contractility. This slow force response was first described over a century ago and has long been considered compensatory, but its underlying mechanisms ...
Chatpun Surapong S Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093-0412, - - 2012
This study evaluated the hypothesis that exogenous nitric oxide (NO) supplementation during acute hemodilution with plasma expander (PE) provides beneficial effects on cardiac function. Acute hemodilution in golden Syrian hamsters was induced by a 40% of blood volume exchange with dextran 70 kDa. Intravascular NO supplementation after hemodilution was accomplished ...
Bartelds Beatrijs - - 2011
AIMS: Right ventricular (RV) dysfunction is a major determinant of long-term morbidity and mortality in congenital heart disease. The right ventricle (RV) is genetically different from the left ventricle (LV), but it is unknown as to whether this has consequences for the cellular responses to abnormal loading conditions. In the ...
Grøndal N - - 2011
AIM: The objective of the study was to evaluate the impact of the cardiac cycle on ultrasound measurements of abdominal aortic aneurysm (AAA) diameters. METHODS: In total, 603 AAAs detected by screening were investigated with respect to the maximal systolic and diastolic anterior-posterior aortic diameters during the cardiac cycle using ...
Moulton Michael J - - 2011
A theoretical model is used to simulate the dynamics of the left ventricle (LV) through all phases of the cardiac cycle, including interactions between myocardial contractility and ventricular pressure generation and effects of preload and afterload. The ventricle is represented as a cylinder containing helical muscle fibres with non-linear passive ...
Querido Jordan S - - 2011
This study tested the hypothesis that acute isocapnic hypoxia results in persistent resetting of the baroreflex to higher levels of muscle sympathetic nerve activity (MSNA), which outlasts the hypoxic stimulus. Cardiorespiratory measures were recorded in humans (26 ± 1 yrs; n = 14; 3 female) during baseline, exposure to 20 ...
From Aaron M - - 2011
Knowledge of cardiac filling pressures is critical in the diagnosis and management of patients with dyspnea or heart failure. Echocardiography and B-natriuretic peptide (BNP) testing are commonly used to estimate these pressures, but their incremental value beyond physical examination remains unknown. Right and left heart filling pressures were prospectively estimated ...
Ryan Kathy L - - 2011
The spectral power of low frequency oscillations of systolic arterial pressure (SAP(LF)) has been used as a non-invasive surrogate of muscle sympathetic nerve activity (MSNA) in both experimental and clinical situations. For SAP(LF) to be used in this way, a relationship must exist between SAP(LF) and MSNA within individuals during ...
Kushnir V M VM Division of Gastroenterology, Washington University School of Medicine, St. Louis, MO 63110, - - 2011
High resolution manometry (HRM) has demonstrated two distinct smooth muscle contraction segments in the esophageal body; changes in these segments typify certain esophageal disorders. We investigated segmental characteristics in subgroups of non-cardiac chest pain (NCCP). 32 NCCP subjects were segregated into a GERD group (ambulatory pH testing off antisecretory therapy ...
Malfitano Christiane - - 2011
ABSTRACT: Activation of renin-angiotensin system has been linked to cardiovascular and autonomic dysfunctions in diabetes. Experiments were performed to investigate the effects of angiotensin-converting enzyme inhibitor Enalapril (ACEI) on cardiac and autonomic functions in diabetic rats. Diabetes was induced by streptozotocin (50 mg/kg), and rats were treated with Enalapril (1 ...
Akimoto Toshinari - - 2011
The neural interaction between the cardiopulmonary and arterial baroreflex may be critical for the regulation of blood pressure during orthostatic stress. However, studies have reported conflicting results with some indicating increases and others decreases in cardiac baroreflex sensitivity (i.e., gain) with cardiopulmonary unloading. Thus, the effect of orthostatic stress induced-central ...
Rajamannan Nalini M NM Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. - - 2011
Atherosclerosis and osteoporosis are the leading causes of mortality and morbidity in the World. Recent epidemiologic studies have demonstrated that these disease processes develop in parallel. Evidence indicates that hyperlipidemia plays a paradoxical role in both disease processes. However, the mechanism is not understood. This prospectus hypothesizes the role of ...
Buckley Maria M - - 2011
There is evidence that in cardiac failure there is defective baroreceptor reflex control of sympathetic nerve activity. Often, cardiac failure is preceded by a state of cardiac hypertrophy where there may be enhanced performance of the heart. This study investigated whether in two different models of cardiac hypertrophy there was ...
Rindler Tara N - - 2011
The α(2)-isoform of Na,K-ATPase (α(2)) is thought to play a role in blood pressure regulation, but the specific cell type(s) involved have not been identified. Therefore, it is important to study the role of the α(2) in individual cell types in the cardiovascular system. The present study demonstrates the role ...
Tschakovsky Michael E - - 2011
The cause(s) of initial orthostatic hypotension (transient fall in blood pressure within 15 s upon active rising) have not been established. We tested the hypothesis that this hypotension is due to local vascular phenomena in contracting leg muscles from the brief effort of standing up. Seventeen young healthy subjects (2 ...
Goldstein Bryan H - - 2011
Fetal cardiac intervention for critical aortic stenosis (AS) with evolving hypoplastic left heart syndrome is performed in an attempt to maintain a biventricular circulation postnatally. The procedure has been hindered by technical challenges and poor candidate selection. We report here the novel use of a pressure guidewire during aortic valvuloplasty ...
Johnson Keven R - - 2011
In mammals, natriuretic peptides (NPs) lower blood pressure, reduce blood volume and broadly inhibit cardiovascular remodeling. NPs are often referred to as cardiac hormones, though they also have integral roles in regulating vascular tone, endothelial remodeling and inhibiting vascular smooth muscle cell hypertrophy. Two NPs [atrial (ANP) and C-type (CNP)] ...
Taneike Manabu - - 2011
Calpains make up a family of Ca(2+)-dependent intracellular cysteine proteases that include ubiquitously expressed μ- and m-calpains. Both are heterodimers consisting of a distinct large catalytic subunit (calpain 1 for μ-calpain and calpain 2 for m-calpain) and a common regulatory subunit (calpain 4). The physiological roles of calpain remain unclear ...
Zhao Xin - - 2011
We examined a novel therapeutic approach for hypertension, a small-molecule direct inhibitor of smooth muscle myosin, CK-2018448 (CK-448), which is an N,N'-alkylurea (U.S. Patent Publication 2009-0275537 A1) in conscious dogs with renal hypertension and compared its efficacy with that of a calcium channel blocker, amlodipine. Dogs were instrumented with a ...
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