Search Results
Results 401 - 450 of 2281
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Saleh F N - - 2003
AIMS: A relation between left ventricular hypertrophy and parathyroid hormone (PTH) has been described in patients with end stage renal disease and secondary hyperparathyroidism. In vitro studies indicate a hypertrophic effect of PTH on cardiomyocytes. The purpose of this study was to examine the relation between PTH and left ventricular ...
Nelson O Lynne - - 2003
OBJECTIVE: To evaluate cardiac function parameters in a group of active and hibernating grizzly bears. DESIGN: Prospective study. ANIMALS: 6 subadult grizzly bears. PROCEDURE: Indirect blood pressure, a 12-lead ECG, and a routine echocardiogram were obtained in each bear during the summer active phase and during hibernation. RESULTS: All measurements ...
Nkado R N - - 2003
Systemic hypertension, High Blood Pressure (HBP) is common in Nigeria with up to 10 to 15% prevalence among adults. HBP is readily complicated by left ventricular hypertrophy (LVH), recognised to herald a series of adverse outcomes in cardiovascular health. In order to device a method of assessment of LVH that ...
Olariu A - - 2003
AIMS: The scope of this study was to assess the potential value of pulmonary venous flow diastolic deceleration time to predict end-diastolic pressure and stratify patients with regard to elevation of left ventricular end-diastolic pressures. METHODS AND RESULTS: In 174 consecutive patients, pulmonary venous flow diastolic deceleration time was determined ...
Watanabe M - - 2003
We assessed the clinical utility of using diastolic tricuspid annular velocities obtained by Doppler tissue imaging as a noninvasive index of right ventricular function in patients with congenital heart disease. Doppler tissue imaging at the tricuspid annulus and pulsed Doppler echocardiography of the right ventricular inflow were performed in 71 ...
Piper Cornelia - - 2003
BACKGROUND AND AIM OF THE STUDY: Different patterns of fibroblast-mediated remodeling of the extracellular matrix (ECM) might be expected between patients with pressure- and volume-induced left ventricular hypertrophy. METHODS: Patients with chronic pressure-overload due to aortic stenosis (AS, n = 19) and chronic volume-overload due to either aortic regurgitation (AR, ...
Sakata Yasushi - - 2003
Angiotensin II type 1 receptor (AT(1)R) blockade attenuates left ventricular relaxation abnormality and myocardial stiffening in a model of hypertensive diastolic heart failure, but the mechanisms remain unclear. To test the hypothesis that such benefits are provided by modulation of the quantitative or qualitative changes, or both, in Ca2+ regulatory ...
Hanton Gilles - - 2004
Doppler and M-mode echocardiography (EC) were used to investigate the effects of minoxidil on the cardiac function of the dog and potentially to clarify the pathogenesis of cardiac lesions, in particular the necrotic lesion in the left ventricle and the haemorrhagic lesion in the right atrium. Groups of three dogs ...
Zaha V - - 2003
BACKGROUND: Clinical heart failure is generally preceded by hypertrophy. Many animal models (e. g. toxic heart failure models) do not consider this hypertrophy. We set out to develop a heart failure model in rats by inducing pressure-overload hypertrophy. METHODS: We induced coarctation of the aortic arch with a tantalum clip ...
Chetboul V - - 2003
The objective of this study was to determine intra- and inter-observer variability of echocardiographic measurements in awake cats. Four observers with different levels of experience in echocardiography performed 96 echocardiographic examinations in four cats on four different days over a 3-week period. The examinations were randomized and blinded. The maximum ...
Veyrat Colette - - 2003
The purpose of this study was 1. to define relationships between myocardial velocities according to phases and the range of dynamic phasic changes in controls using tissue Doppler echocardiography (TDE); 2. to compare the usefulness of dynamic changes vs. peak velocities alone on controls and patients. Peak velocity changes between ...
Vieillard-Baron Antoine - - 2003
It has long been known that there are cyclic changes in arterial pressure during mechanical ventilation. They are caused by cyclic changes in both the right and left ventricular stroke output, occurring in opposite phases. As a result, arterial pulse pressure is increased during inspiration and decreased during expiration. A ...
Gill D S - - 2003
G1 and G4 acetylcholinesterase (AChE) molecular forms were separated in different regions of guinea-pig heart. The activities of both were highest in the left side of the left ventricle (LV(L)). The reversible anticholinesterase physostigmine, or saline, was administered continuously for six days. In saline-treated animals the activity of both molecular ...
Searleman Alan - - 2003
Differences in abilities and preferences exist between left-handers who both write and throw with their left hands (consistent left-handers) and those who write with their left hand but prefer to throw with their right (inconsistent left-handers). It is also known that many left-handers are pressured to switch to right-hand writing, ...
Schmidt Eric A - - 2003
OBJECTIVE: The authors evaluated with bilateral transcranial Doppler (TCD) ultrasonography the norm of interhemispheric difference for several cerebrovascular hemodynamic parameters. METHODS: Forty-four volunteers (33 male, 11 female; average age = 21 years; range, 20-23 years) were studied. The authors recorded bilateral systolic, diastolic, and mean flow velocity (FV) and noninvasive ...
Hartgens F - - 2003
Since the abuse of androgenic-anabolic steroids (AAS) has been associated with the occurrence of serious cardiovascular disease in young athletes, we performed two studies to investigate the effects of short-term AAS administration on heart structure and function in experienced male strength athletes, with special reference to dose and duration of ...
Hasnat A K - - 2003
OBJECTIVE: The understanding of pathophysiology and cellular mechanisms of chronic heart failure requires the creation of appropriate and accurately characterized animal models, thus enabling meaningful evaluation of evolving medical and surgical therapies. METHODS: The left anterior descending and its diagonal branch were ligated in 12 sheep to induce left ventricular ...
Zhou Yu-Qing - - 2003
Developmental changes in left and right ventricular diastolic filling patterns were determined noninvasively in isoflurane-anesthetized outbred ICR mice. Blood velocities in the mitral and tricuspid orifices were recorded in 16 embryos at days 14.5 (E14.5) and 17.5 of gestation (E17.5) using an ultrasound biomicroscope and also serially in three groups ...
Varagic Jasmina J Hypertension Research Laboratory, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, - - 2003
Omapatrilat has potent enzymatic inhibitory effects on the angiotensin-converting enzyme and neutral endopeptidase. The prolonged effects of this inhibition on systemic and regional hemodynamics, cardiovascular mass, and hydroxyproline concentration in spontaneously hypertensive rats were studied. The contribution of endogenous bradykinin on the cardiovascular actions of omapatrilat in this genetic model ...
Rossi Marcos A - - 2003
OBJECTIVES: To evaluate the morphometric and ultrastructural alterations of the heart produced by long-term inhibition of nitric oxide (NO) synthase with N(omega)-nitro-l-arginine methyl ester (l-NAME) and to examine whether the changes are caused by l-NAME-induced hypertension or a lack of NO. METHODS: Male Wistar rats were divided randomly into three ...
Nadar Sunil - - 2003
The recent Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) study was conducted in patients with essential hypertension with electrocardiogram evidence of left ventricular hypertrophy. This showed that losartan compared to atenolol resulted in a significant reduction in the primary endpoint of cardiovascular morbidity and mortality, as well as a ...
Dalibon Nicolas - - 2003
OBJECTIVE: To assess the accuracy of respiratory-induced systolic pressure variation and its components to detect low left ventricular preload. DESIGN: Prospective study. SETTING: University hospital. PARTICIPANTS: Sixty-seven patients undergoing major surgery under general anesthesia. INTERVENTIONS: Transesophageal echocardiographic measurements during apnea and mechanical ventilation. MEASUREMENTS AND MAIN RESULTS: Respiratory-induced systolic pressure ...
Kaneko Yasuyuki - - 2003
BACKGROUND: Obstructive sleep apnea subjects the failing heart to adverse hemodynamic and adrenergic loads and may thereby contribute to the progression of heart failure. We hypothesized that treatment of obstructive sleep apnea by continuous positive airway pressure in patients with heart failure would improve left ventricular systolic function. METHODS: Twenty-four ...
Sedmera David - - 2003
During embryonic and fetal development, the ventricular myocardium increases its mass principally by adding new cells (hyperplasia), while postnatally, it does so mainly through increase of cell size (hypertrophy). Switching between these two mechanisms of adaptation to increasing functional demand occurs in the early neonatal period. We investigated the response ...
Gökçe Mustafa - - 2003
The objective of this study was to evaluate the effect of hormone replacement therapy (HRT) regimens on left ventricular diastolic function by using mitral pulsed wave Doppler (MPWD) and tissue Doppler velocities (TDE). Seventy-eight postmenopausal women with normotensive and impaired diastolic left ventricular filling were included in the study. All ...
Akinboboye Olakunle O - - 2003
BACKGROUND: The aim of this study was to identify the best correlate of myocardial oxygen demand (MVO(2)) in patients with hypertension induced left ventricular hypertrophy (LVH), and to examine whether relationships between these surrogates and MVO(2) differed between patients with LVH and control subjects. METHODS: We measured MVO(2) by positron ...
Leeuwenburgh Boudewijn P J - - 2003
OBJECTIVE: Right ventricular pressure overload occurs in several types of (congenital) heart disease, as well as in pulmonary disease. Clinical outcome in some of these patient groups might in part be related to left ventricular loading conditions. The effects of left ventricular unloading on the function of the hypertrophic right ...
Zakopoulos N A - - 2003
BACKGROUND: Raynaud's phenomenon is often the first symptom and occurs eventually in more than 95% of patients with systemic sclerosis (SSc). Angiographic studies disclose narrowing and obstruction of the digital arteries, which on autopsy histologic study show prominent subintimal connective tissue proliferation without inflammation, as well as adventitial fibrosis. It ...
Kolettis T M - - 2003
To examine the effects of baseline left ventricular function on the haemodynamic and catecholamine responses to ventricular tachycardia. Experimental cohort study. Cardiac catheterisation laboratory in tertiary referral centre. 24 patients (19 male, 5 female; mean (SD) age, 59 (10) years) without coronary artery disease, divided into two groups with normal ...
Passino Claudio - - 2003
OBJECTIVE: The aim of this study was to investigate the influence of circadian behavior of blood pressure, left ventricular hypertrophy, and autonomic function on QTc interval duration in untreated hypertensive patients. DESIGN: Hypertensive patients underwent simultaneous blood pressure and ECG 24-h ambulatory monitoring. Patients were classified into two groups on ...
Mansoor George A - - 2003
The present study determined the relationships between ambulatory blood pressure, left ventricular mass, body mass index, and other clinical and demographic variables to left atrial size in previously untreated hypertensive and normotensive subjects. Left atrial size was measured uni-dimensionally using M-mode echocardiography in 58 newly diagnosed never-treated hypertensive patients (office ...
Rivera Ivan Romero - - 2003
OBJECTIVE: To study echocardiographic parameters of left ventricular systolic function and valvar regurgitation under pharmacological influence in mildly symptomatic patients with chronic mitral regurgitation (MR). METHODS: We carried out a double-blind placebo controlled study in 12 patients with MR, mean aged 12.5 years old, who were randomized in 4 phases: ...
Paraskevaidis Ioannis A - - 2003
OBJECTIVE: Changes in left ventricular geometry and shape are prominent characteristics of cardiomyopathy. The aim of this study was to investigate left ventricular geometry and shape changes after inotropic stimulation in patients with chronic nonischemic dilated cardiomyopathy. METHODS: A low infusion rate echocardiography-dobutamine study was performed in 35 consecutive patients ...
Di Bello Vitantonio - - 2003
BACKGROUND: Ultrasonic backscatter parameters were analyzed in hypertensive patients and divided into groups according to both severity of left ventricular hypertrophy (LVH) (group A: no LVH [n=52]; B: mild to moderate LVH [n=55]; and C: severe LVH [n=10]) and left ventricular geometry (normal geometry [n=44]; concentric remodeling [n=8]; concentric hypertrophy ...
Novelli Gian Paolo - - 2003
OBJECTIVE: To evaluate the differences and similarities in diastolic function and left ventricular geometry in gestational and essential hypertension. METHODS: Thirty-nine consecutive gestational hypertensive pregnant women in the third trimester of gestation (GH), 40 nonpregnant essential hypertensive women (EH), and 38 normotensive nonpregnant women (N) matched for age were enrolled ...
Kong Chiew H - - 2003
AIM: To identify factors contributing to the development and progression of left ventricular hypertrophy (LVH) in patients on high-flux haemodialysis. METHOD: Fifty patients without clinical cardiac disease underwent baseline echocardiography, related measurements and follow-up studies 6-12 months later. RESULTS: Residual urea clearance was lower (0.7 +/- 1.1 vs. 2.2 +/- ...
Bolliger Kimberly - - 2003
Until recently, most clinical trials associated with heart failure have studied systolic dysfunction. With the escalating geriatric population and dramatic increases in costs related to cardiovascular management regimens, more attention is being given to understanding diastolic failure induced by uncontrolled hypertension and cardiomyopathies. Researchers have demonstrated that the compensatory mechanisms ...
Chetboul Valérie - - 2003
Systemic hypertension was diagnosed in 58 of 188 untreated cats referred for evaluation of suspected hypertension-associated ocular, neurologic. cardiorespiratory, and urinary disease, or diseases frequently associated with hypertension (hyperthyroidism and chronic renal failure). Hypertensive cats were significantly older than normotensive subjects (13.0 +/- 3.5 years versus 9.6 +/- 5.0 years; ...
Dubrava J - - 2003
BACKGROUND: End-stage renal failure patients on haemodialysis (HD) suffer from increased risk of sudden cardiac death. Abnormal late potentials (LP) on signal-averaged electrocardiogram (SAAECG) has proved valuable for identification of increased risk of malignant ventricular tachyarryhythmias in various settings of patients. Abnormalities in LP were reported in HD patients, but ...
Cheitlin Melvin D - - 2003
With aging there are changes in the cardiovascular system, which result in alterations in cardiovascular physiology. The changes in cardiovascular physiology must be differentiated from the effects of pathology, such as coronary artery disease, that occur with increasing frequency as age increases. The changes with age occur in everyone but ...
Cittadino Máira - - 2003
BACKGROUND: Hypertension is the most important and well established risk factor for atherosclerosis. The vascular and cardiac remodeling present in refractory hypertensive patients are related to endothelial dysfunction, a key factor in early atherogenesis and cardiovascular disease. However the mechanistic relationship among biochemical endothelial function markers, cardiovascular remodeling, and refractory ...
Vasquez Alejandro - - 2003
The aryl hydrocarbon receptor (AhR), a ligand activated transcription factor, is the receptor for the polycyclic aromatic hydrocarbons found in tobacco smoke, polychlorinated biphenyls, and the environmental pollutant, dioxin. To better understand the role of the AhR in the heart, echocardiography, invasive measurements of aortic and left ventricular pressures, isolated ...
Kyuma Michifumi - - 2002
The precise etiological basis of transient left ventricular apical ballooning without coronary artery stenosis (ampulla or so-called 'takotsubo' cardiomyopathy) remains unknown, so the present study examined the acute effects of intravenous propranolol (2-4 mg) in 3 female patients (age range, 61-76 years) with the condition. Although one patient who did ...
Roos Kenneth P - - 2002
BACKGROUND: Ventricular remodeling is a consistent feature of the heart's response to hypertrophic stimuli and progression to failure. One cytoskeletal structure in ventricular cardiac myocytes, microtubules, make up only a small proportion of tissue protein but are an essential component for growth in cells. The response of microtubules to different ...
Carabello Blase A - - 2002
Cardiac hypertrophy has long been recognized as one of the heart's mechanisms for compensating a pressure or volume overload. This compensation has often been viewed as a feedback loop in which the concentric hypertrophy, which develops in pressure overload, normalizes wall stress while the eccentric hypertrophy, which develops in volume ...
Pasipoularides Ares D - - 2002
OBJECTIVE: Limitations in clinical understanding of right ventricular relaxation can be attributed to the paucity of information from basic studies in animal models of right ventricular disease. This study examined, in the conscious state, right ventricular relaxation dynamics under normal conditions (n = 15) and in subacute (2-5 weeks) canine ...
Grandi Anna M - - 2002
Experimental studies demonstrated that mineralocorticoid antagonists prevent or reverse myocardial fibrosis. Therefore, we tested the hypothesis that the aldosterone antagonist canrenone can improve left ventricular diastolic function in essential hypertension. Using digitized M-mode echocardiography and 24-hour blood pressure monitoring (ABPM), we realized a prospective, randomized, controlled study on 34 never-treated ...
Lamont Leigh A - - 2002
OBJECTIVE: To evaluate the effects of medetomidine on dynamic left ventricular outflow tract (LVOT) obstruction in cats with left ventricular hypertrophy. DESIGN: Clinical trial. ANIMALS: 6 domestic shorthair cats with echocardiographic evidence of dynamic LVOT obstruction. PROCEDURE: Cats were restrained in lateral recumbency, and baseline M-mode and Doppler echocardiographic examinations ...
Indolfi Ciro - - 2002
BACKGROUND: Patients with cardiac hypertrophy are at increased cardiovascular risk. It has been hypothesized that hydroxymethylglutaryl coenzyme A reductase inhibitors may exert beneficial effects other than their cholesterol-lowering actions. The aims of the study were to assess the in vivo effects of simvastatin (SIM) on cardiac hypertrophy and on Ras ...
Sharma G V R K - - 2002
BACKGROUND: Measurement of left ventricular filling pressure (LVFP) provides an accurate assessment of left ventricular failure. Clinical and radiographic methods of estimating LVFP are unreliable. The noninvasive method of analyzing the decline in the arterial pressure during the strain phase of the Valsalva maneuver may be used to directly measure ...
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