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de Franchis Roberto R Gastroenterology Unit, Department of Clinical and Biomedical Sciences, Luigi Sacco University Hospital, University of Milan, Via G. B. Grassi 74, Milan 20157, Italy. Electronic address: - - 2014
Assessing the presence of clinically significant portal hypertension and esophageal varices is clinically important in cirrhosis. The reference standard techniques to assess the presence of portal hypertension and varices are the measurement of the hepatic vein pressure gradient and esophagogastroduodenoscopy, respectively. Some newer methods have shown a good performance, but ...
Müller Michaela M Department of Gastroenterology, German Diagnostic Clinic, Wiesbaden, - - 2014
Nitric oxide (NO) is an important inhibitory mediator of esophageal function and its lack leads to typical features of achalasia. In contrast, the role of intramuscular interstitial cells of Cajal (ICC-IM) and vasoactive intestinal peptide (VIP) in lower esophageal sphincter (LES) function is still controversial. Therefore, we examined the function ...
Schaub Nora N Barts and the London School of Medicine and Dentistry, Queen Mary University of - - 2014
Nausea is the subjective unpleasant sensation that immediately precedes vomiting. Studies using barostats suggest that gastric fundus and lower esophageal sphincter (LES) relaxation precede vomiting. Unlike barostat, high-resolution manometry (HRM) allows less invasive, detailed measurements of fundus pressure (FP) and axial movement of the gastro-esophageal junction (GEJ). Nausea was induced ...
Liao Donghua D Giome Academia, Institute of Clinical Medicine, Aarhus University Hospital, Skejby, Brendstrupgaardsvej, 8200, Aarhus, Denmark, - - 2014
Differences in contraction characteristics between primary and secondary peristalsis have only been scarcely studied. Recently new measures of contractile activity in the human esophagus were developed. The study aims were to use combined manometry and impedance planimetry [pressure-cross-sectional area (P-CSA)] recordings from healthy volunteers to examine esophageal peristalsis, and, furthermore, ...
Lan Yue Y *Department of Rehabilitation Medicine, The Third Affiliated Hospital †Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, - - 2014
The objective of the current study was to examine the correlation between high-resolution manometric and videofluoroscopic measurements of the swallowing function. In such cases in which manometric analysis is not feasible, it would be ideal if information regarding pressure during swallowing could be inferred from a videofluoroscopic swallowing study (VFSS) ...
Lin Tuo T Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, - - 2014
Solid-state high-resolution manometry (HRM) is fast becoming the gold standard for studying pharyngeal and esophageal motility. However, very few studies have ever evaluated the effect of bolus volume on the physiology of swallowing using HRM. We aimed to determine the effect of bolus volume on pressure, duration and velocity of ...
Hasan Y Y Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, - - 2014
The standard protocol for esophageal manometry involves placing the patient in the supine position with head turned to left (supine head left [SHL]) while evaluating liquid bolus swallows. Routinely, semisolid or solid boluses are not evaluated. Currently, the daily American diet includes up to 40% solid or semisolid texture. Thus ...
Weijenborg P W PW Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The - - 2014
Esophageal high-resolution manometry (HRM) allows accurate evaluation of esophageal motility. Normal values for HRM were established in the United States and several new parameters were introduced since. We aimed to provide a complete set of normal values for HRM obtained in a European population, including all current metrics used to ...
Peng Lihua L *Chinese PLA General Hospital, Beijing, China †Department of Medicine, Division of Gastroenterology, Washington University School of Medicine, St. Louis, - - 2014
Globus is commonly encountered in clinical practice, but high-resolution manometry (HRM) characteristics are incompletely characterized. We evaluated HRM metrics in globus subjects, compared with age-matched and sex-matched dysphagia subjects and healthy controls. Twenty-four subjects with globus (53.3±2.3 y, 58% female) were compared with 24 age-matched and sex-matched subjects with nonobstructive ...
Shin G H GH GI Section, Department of Medicine, Temple University School of Medicine, Philadelphia, PA, - - 2014
Esophageal acid retention in a hiatal hernia (HH) may play a role in gastro-esophageal reflux. The aims of this study were to determine the prevalence of bolus retention (BR) in HH and to compare pressure profiles in patients with HH with BR in the hernia to those with bolus clearance ...
Rommel N N Translational Research Center for Gastrointestinal Diseases (TARGID), KU Leuven, Leuven, Belgium; Neurogastroenterology and Motility, Gastroenterology, University Hospital Leuven, Leuven, Belgium; Neurosciences, ExpORL, KU Leuven, Leuven, - - 2014
Diagnostic evaluation of non-achalasia esophageal dysphagia remains challenging because of a lack of a clear relationship between symptoms, esophageal contraction patterns, and esophageal bolus flow. This study evaluates a novel approach to pressure-impedance analysis called automated impedance manometry (AIM) analysis in relation to bolus characteristics, Chicago classification metrics, bolus perception, ...
O'Rourke Ashli A Department of Otolaryngology - Head and Neck Surgery, Evelyn Trammell Institute for Voice and Swallowing, Medical University of South Carolina, 135 Rutledge Avenue, Suite 1130, Charleston, SC, 29425, USA, - - 2014
The purpose of our study was to evaluate whether swallowing maneuvers designed to impact pharyngeal physiology would also impact esophageal physiology. Healthy volunteers underwent high-resolution manometry while performing three randomized swallowing maneuvers with and without a 5-ml bolus: normal swallowing, Mendelsohn maneuver, and effortful swallowing. We examined esophageal parameters of ...
Bhatia Nidhi N Department of Anaesthesia & Intensive Care, PGIMER, Chandigarh, - - 2014
In 1961, Sellick popularized the technique of cricoid pressure (CP) to prevent regurgitation of gastric contents during anesthesia induction. In the last two decades, clinicians have begun to question the efficacy of CP and therefore the necessity of this maneuver. Some have suggested abandoning it on the grounds that this ...
Luo Linli - - 2013
To determine the lowest effective cuff pressure of the esophageal obstruction tube to prevent reflux of gastric contents in rabbits. Twenty-two New Zealand white rabbits (2.0-2.5 kg) were anesthetized. An esophageal obstruction tube, an esophageal observation tube, and a gastric tube were inserted into the esophagus and stomach, respectively. Normal saline ...
Mayaud Louis - - 2013
We have developed a software that automatically calculates respiratory effort indices, including intrinsic end expiratory pressure (PEEPi) and esophageal pressure-time product (PTPeso). The aim of this study was to validate this software. The software first identifies respiratory periods. Then, pressure or flow waveforms with artifacts are automatically excluded from analyses. ...
Brochard Laurent - - 2013
Esophageal pressure measurement well estimates pleural pressure. The interpretation of absolute values is often debated for various reasons, but the changes in pressure measured are considered very accurate provided that a number of precautions are taken. The information provided by these measurements is unique in nature and has an enormous ...
Jovanović Igor D ID Clinical Hospital Center "Bezanijska kosa" Belgrade, Serbia. - - 2013
A paper presented a case of esophageal achalasia with both type 2 and type 3 achalasia found in the same patient. High resolution impedance manometry of esophagus was performed. Liquid swallows induced panesophageal pressurization (achalasia type 2), whereas viscous swallows led to compartmentalized pressurization--distal two thirds of esophagus (achalasia type ...
Saikawa Daisuke - - 2013
Thoracoscopic esophagectomy for esophageal cancer performed using two-lung ventilation in the prone position has many advantages, such as convenient anesthesia induction and maintenance, and good oxygenation. We examined the safety of surgery and anesthetic management by following chronological changes in intraoperative respiration and hemodynamics. We focused on the most recent ...
Banerjee Rupa - - 2013
Electrical stimulation therapy (EST) has been shown to increase lower esophageal sphincter (LES) pressure in animals; however, data on the effect of EST on LES pressure in patients with gastroesophageal reflux disease (GERD) are lacking. The aim of our study was to investigate the effect of EST on LES pressure ...
Rohof W O - - 2013
Automated impedance manometry pressure-flow analysis (AIM analysis) determines pressure measurements relative to bolus flow and has to date shown subtle variations in esophageal motility in relation to dysphagia. In this study, we assessed intra- and inter-rater reproducibility of AIM metrics derived using purpose designed software. Fifty patients referred for evaluation ...
Zhang Xiujing - - 2013
Most recent studies using high-resolution manometry were based on supine liquid swallows. This study was to evaluate the differences in esophageal motility for liquid and solid swallows in the upright and supine positions, and to determine the percentages of motility abnormalities in different states. Twenty-four asymptomatic volunteers and 26 patients ...
Basseri Benjamin - - 2013
In high-resolution manometry lower esophageal sphincter pressure (LESP) is measured relative to intragastric pressure, however Gastric Marker™ (GM) location used to determine resting LESP is not well established with hiatal hernia (HH). We test the hypothesis that measured resting LESP varies with HH based on GM location. Subjects with HH ...
Silva Luciana C - - 2013
The motility of the pharynx, upper esophageal sphincter (UES), and proximal esophagus is still poorly understood. These structures have anatomical and functional peculiarities that hinder the accurate study of their motility with the technology traditionally available. High-resolution manometry (HRM) has characteristics that make it more suitable for the study of ...
Matsubara Keigo - - 2013
To measure the swallowing pressure (SP) of normal subjects using a 2.64-mm-diameter high-resolution manometry (HRM) catheter with 36 circumferential sensors. Repeated measures with subjects serving as controls. Thirty healthy subjects swallowed water at different temperatures and volumes to examine the maximum SP at the velopharynx, meso-hypopharynx, upper esophageal sphincter (UES), ...
Wauters L - - 2013
Pneumatic dilation of the lower esophageal sphincter (LES) in achalasia has an unappreciated effect on upper esophageal sphincter (UES) function. We studied UES pressure patterns at baseline and alterations in UES parameters resulting from therapy. High-resolution manometry (HRM) tracings from 50 achalasia patients, seen at a tertiary center between January ...
Juan Junerose J Department of Medicine, University of Wisconsin, Madison, Wisconsin Geriatric Research Education Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, - - 2013
Isometric progressive resistance oropharyngeal (I-PRO) therapy improves swallowing function; however, current devices utilize a single sensor that provides limited information or are prohibitively expensive. This single-subject study presents results of I-PRO therapy, detraining, and maintenance using the 5-sensor Madison Oral Strengthening Therapeutic (MOST) device combined with upper esophageal sphincter (UES) ...
Lin Z - - 2013
This study aimed to evaluate the spatial variation in esophageal distensibility in normal subjects using a novel multichannel functional luminal imaging probe (FLIP). Ten healthy subjects (four men, age 21-49 years) were evaluated during endoscopy with a high-resolution impedance planimetry probe (FLIP) positioned through the esophagogastric junction (EGJ) and distal 10 cm ...
Gulati Gaurav - - 2013
1) To compare two published methods for estimating pleural pressure, one based on directly measured esophageal pressure and the other based on chest wall elastance. 2) To evaluate the agreement between two published positive end-expiratory pressure optimization strategies based on these methods, one targeting an end-expiratory esophageal pressure-based transpulmonary pressure ...
Eichler Lars - - 2013
Esophageal pressure (Pes) is a surrogate for intrapleural pressure. Measuring Pes during mechanical ventilation allows for positive end-expiratory pressure adjustments by transpulmonary pressure (PL), which has been shown to improve oxygenation and outcome in acute respiratory distress syndrome patients. In morbidly obese patients, we saw progressively increasing PL measurements, although ...
Rhee Kwangwon - - 2013
Achalasia is a primary motility disorder of esophagus. Many parameters represent esophageal function and morphologic changes, but their interrelationship is not yet established. We hypothesized that esophageal body would need to generate unusual pressure to empty the food bolus through the non-relaxing lower esophageal sphincter in patients with achalasia; therefore, ...
Hoon Lim Kyoung K Kyoung Hoon Lim, Department of Anesthesiology and Pain Medicine, Chungbuk National University Hospital, Republic of - - 2013
Objective : Esophageal stethoscope has the advantage of being non-invasive, easily placed and capability to monitor the heart sound. This study was designed to determine whether the ratio of S1 to S2 analyzed by esophageal stethoscope and wireless bluetooth transmission can be accurate indicator that express the correlation with blood ...
Vicentine F P P - - 2013
The comparison between idiopathic achalasia (IA) and Chagas' disease esophagopathy (CDE) may evaluate if treatment options and their outcomes can be accepted universally. This study aims to compare IA and CDE at the light of high-resolution manometry. We studied 86 patients with achalasia: 45 patients with CDE (54% females, mean ...
Gulati Gaurav - - 2013
OBJECTIVES:: 1) To compare two published methods for estimating pleural pressure, one based on directly measured esophageal pressure and the other based on chest wall elastance. 2) To evaluate the agreement between two published positive end-expiratory pressure optimization strategies based on these methods, one targeting an end-expiratory esophageal pressure-based transpulmonary ...
Bogte A - - 2013
Esophageal high-resolution manometry (HRM) is a novel method to assess esophageal motility. Several software and hardware systems are currently available. A set of normal values for HRM parameters was established in the US, using proprietary tactile-sensing catheter technology (Given Imaging). We wished to determine normal values for HRM performed with ...
Radtke J - - 2013
BACKGROUND AND PURPOSE: The calcium-activated potassium channel KCa 3.1 is expressed in the vascular endothelium where its activation causes endothelial hyperpolarization and initiates endothelium-derived hyperpolarization (EDH)-dependent dilations. We here investigated whether pharmacological activation of KCa 3.1 dilates skeletal muscle arterioles and whether myoendothelial gap junctions formed by connexin40 (Cx40) are ...
Kempf Jennifer - - 2013
Objective-To evaluate the use of high-resolution manometry (HRM) in awake and sedated dogs and to assess potential effects of a standard sedation protocol. Animals-22 Beagles. Procedures-An HRM catheter with 36 pressure sensors was inserted intranasally in each dog. After an adaption period of 5 minutes, each set of measurements included ...
Reis Nathália - - 2013
To evaluate and correlate the amplitude of esophageal contractions triggered by swallowing water with dynamic extension and habitual, strong and weak sound intensity in total laryngectomees wearing a tracheoesophageal prosthesis. Thirty total laryngectomees using tracheoesophageal voice with a phonatory prosthesis were evaluated by measuring the amplitude of contractions in the ...
Park Sang Hi - - 2013
Esophageal stethoscope is less invasive and easy to handling. And it gives a lot of information. The purpose of this study is to investigate the correlation of blood pressure and heart sound as measured by esophageal stethoscope. Four male beagles weighing 10 to 12 kg were selected as experimental subjects. After ...
Scerrino Gregorio - - 2013
ObjectiveSwallowing and voice impairment are common after thyroidectomy. We evaluated short-term functional changes in esophageal motility in a series of patients who had undergone total thyroidectomy. Several studies have investigated these symptoms by means of interviews or questionnaires.Study DesignProspective study.SettingAcademic research.Materials and MethodsThirty-six consenting patients were prospectively recruited. Eligibility criteria ...
Xiao Y - - 2013
Cough and throat clearing might be difficult to differentiate when trying to detect them acoustically or manometrically. The aim of this study was to assess the accuracy of acoustic monitoring for detecting cough and throat clearing, and to also determine whether these two symptoms present with different manometric profiles on ...
Chen Chien-Lin - - 2013
INTRODUCTION: Patients with non-obstructive dysphagia (NOD) report symptoms of impaired esophageal bolus transit without evidence of bolus stasis. In such patients manometric investigation may diagnose esophageal motility disorders however many have normal motor patterns. We hypothesised that patients with NOD would demonstrate evidence of high flow-resistance during bolus passage which ...
Chen Chien-Lin - - 2013
BACKGROUND: Secondary peristalsis contributes to clearance of retained refluxate or material from the esophagus. AIM: The goal of our study was to investigate the effects of hydrochloric acid (HCl) on physiological characteristics of esophageal secondary peristalsis in healthy adults. METHODS: After recording esophageal motility baseline for primary peristalsis, secondary peristalsis ...
Ashkenazi Eyal - - 2013
Portal hypertension is the leading cause of morbidity and mortality in liver cirrhosis. Complications of portal hypertension in cirrhotic patients include esophageal and gastric varices, portal hypertensive gastropathy, ascites, hepatorenal syndrome, hepatopulmonary syndrome and portopulmonary hypertension. The hepatic venous pressure gradient should be at least 10 mmHg for esophageal varices ...
Gyawali C P - - 2013
Esophageal motor function is highly coordinated between central and enteric nervous systems and the esophageal musculature, which consists of proximal skeletal and distal smooth muscle in three functional regions, the upper and lower esophageal sphincters, and the esophageal body. While upper endoscopy is useful in evaluating for structural disorders of ...
Roman Sabine S Department of Digestive Physiology, Edouard Herriot Hospital, Pavillon H, 5 place d’Arsonval, 69437 Lyon, CEDEX 03, France. - - 2013
Although successful treatment of achalasia depends on alleviating the obstruction at the esophagogastric junction, the postintervention contractile and pressurization pattern may also play a role in outcome. To determine whether myotomy that alleviates the esophagogastric junction outflow obstruction in achalasia might improve peristalsis. Retrospective study from August 1, 2004, through ...
Carlson Dustin A DA Department of Medicine, Feinberg School of Medicine, Northwestern University, Suite 3-150, 251 East Huron, Chicago, IL 60611, - - 2013
Although conventional manometry set the basis for the diagnosis of esophageal motility disorders, the large axial spacing between recording sites leaves large portions of the esophagus unevaluated and vulnerable to movement artifact. However, continuous spatiotemporal representations of pressure through the esophagus recorded with high-resolution manometry offers greater detail and improved ...
Regan J - - 2012
Background  This paper aims to measure upper esophageal sphincter (UES) distensibility and extent and duration of UES opening during swallowing in healthy subjects using EndoFLIP(®) . Methods  Fourteen healthy subjects (20-50 years) were recruited. An EndoFLIP(®) probe was passed trans-orally and the probe balloon was positioned across the UES. Two 20-mL ...
Nguyen N Q - - 2012
Background  Automated integrated analysis of impedance and pressure signals has been reported to identify patients at risk of developing dysphagia post fundoplication. This study aimed to investigate this analysis in the evaluation of patients with non-obstructive dysphagia (NOD) and normal manometry (NOD/NM). Methods  Combined impedance-manometry was performed in 42 patients ...
Kessing B F - - 2012
Background  Esophageal impedance monitoring has made it possible to distinguish two types of belches, designated gastric and supragastric. We aimed to compare the esophageal pressure characteristics during supragastric belches and gastric belches using combined high-resolution manometry and impedance monitoring. Methods  We included 10 patients with severe and frequent belching. Combined ...
Lee Tae Hee - - 2012
To evaluate the effects of the phosphodiesterase type 5 (PDE5) inhibitor vardenafil on esophageal function, including bolus transit, using multichannel intraluminal impedance and esophageal manometry (MII-EM). Sixteen healthy volunteers (15 men) underwent an MII-EM study including 10 liquid swallows and 10 viscous swallows in a seated position after fasting. Then, ...
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