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Azak Alper A Department of Nephrology, Ankara Education and Research Hospital, Ankara, - - 2014
Chronic Heart Failure (CHF) is highly prevalent and is associated with high morbidity and mortality rates. It has been well established that excessive intake of sodium chloride (salt) induced hypertension in some populations. Although salt seems to induce cardiovascular diseases through elevation of blood pressure, it has also been indicated ...
Safar M E ME Centre de Diagnostic et de Thérapeutique, Hôpital Hotel Dieu, 1 Place du Parvis Notre Dame, 75004, Paris, France, - - 2014
In recent years, treatment strategies for hypertension have often focused on combination therapies that include diuretics and renin angiotensin aldosterone system blockers such as angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. However, in clinical practice, a significant number of patients do not respond completely to these combination treatments, and long-term ...
Botella Pablo P Departamento de Física Aplicada-ICMUV, Universidad de Valencia , MALTA Consolider Team, Edificio de Investigación, C. Dr. Moliner 50, 46100 Burjassot, - - 2014
The high-pressure behavior of CaWO4 was analyzed at room temperature by Raman spectroscopy. Pressure was generated using a diamond-anvil cell and Ne as pressure-transmitting medium. The pressure range of previous studies has been extended from 23.4 to 46.3 GPa. The experiments reveal the existence of two reversible phase transitions. The ...
Li Xiao C XC The University of Mississippi Medical - - 2014
Caveolin 1 (CAV-1) functions not only as a constitutive scaffolding protein of caveolae but also as a vesicular transporter and signaling regulator. In the present study, we tested the hypothesis that CAV-1 knockout (CAV-1 KO) inhibits AT1 (AT1a) receptor-mediated uptake of angiotensin II (ANG II) in the proximal tubule and ...
Parati Gianfranco G Department of Health Sciences, University of Milano-Bicocca, Milan, Italy Department of Cardiovascular Neural and Metabolic Sciences, S.Luca Hospital, Istituto Auxologico Italiano, IRCCS, Milan, Italy - - 2014
Many hypertensive subjects travel to high altitudes, but little is known on ambulatory blood pressure (ABP) changes and antihypertensive drugs' efficacy under acute and prolonged exposure to hypobaric hypoxia. In particular, the efficacy of angiotensin receptor blockers in this condition is unknown. This may be clinically relevant considering that renin-angiotensin ...
Fagernaes C F CF Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, - - 2014
During the past decade, several population-based studies have found an inverse association between blood pressure (BP) and headache. However, most of them have a cross-sectional design or lack a validated definition of a headache-free population at baseline. Therefore, additional population-based studies using a clearly defined headache-free population and a prospective ...
Giridharan Guruprasad A GA 1Department of Bioengineering, University of Louisville, Louisville, KY; 2College of Mechanical Engineering, Purdue University, West Lafayette, IN; and 3Section of Cardiothoracic Surgery, Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, Indianapolis, - - 2014
Mechanical circulatory support - either ventricular assist device (VAD, left-sided systemic support) or cavopulmonary assist device (CPAD, right-sided support) - has been suggested as treatment for Fontan failure. The selection of left- vs. right-sided support for failing Fontan has not been previously defined.Computer simulation and mock circulation models of pediatric ...
Mironova Elena E Department of Physiology, University of Texas Health Science Center, San Antonio, Texas, - - 2014
Discretionary control of Na(+) excretion is a key component of the regulation of arterial blood pressure in mammals. Sodium excretion is fine-tuned in the aldosterone-sensitive distal nephron by the activity of the epithelial Na(+) channel (ENaC). Here, ENaC functions as a final effector of the renin-angiotensin-aldosterone system (RAAS) during negative ...
Webb Alastair J S AJ From the Stroke Prevention Research Unit, Oxford University, Oxford, United - - 2014
Visit-to-visit variability in systolic blood pressure (SBP) is associated with an increased risk of stroke and was reduced in randomized trials by calcium channel blockers and diuretics but not by renin-angiotensin system inhibitors. However, time of day effects could not be determined. Day-to-day variability on home BP readings predicts stroke ...
Devatkal Suresh S Central Institute of Postharvest Engineering and Technology (ICAR), Ludhiana, India - - 2014
High-pressure processing (300 MPa for 5 min) as a non-thermal post-processing intervention was employed to improve the shelf life and qualities of cooked refrigerated chicken nuggets. Pomegranate peel extract (1%) was also used as a source of natural antioxidant and antimicrobial in chicken nuggets. Microstructure, microbial profile, instrumental colour, texture profile and ...
Donnelly Joseph J Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Box 167, Cambridge, CB2 0QQ, UK, - - 2014
Increased blood glucose and impaired pressure reactivity (PRx) after traumatic brain injury (TBI) are both known to correlate with unfavorable patient outcome. However, the relationship between these two variables is unknown. To test the hypothesis that increased blood glucose leads to increased PRx, we retrospectively analyzed data from 86 traumatic ...
Schaich Chris L CL Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, North Carolina Hypertension & Vascular Research Center, Wake Forest School of Medicine, Winston-Salem, North - - 2014
We investigated acute and chronic effects of CB1 cannabinoid receptor blockade in renin-angiotensin system-dependent hypertension using rimonabant (SR141716A), an orally active antagonist with central and peripheral actions. In transgenic (mRen2)27 rats, a model of angiotensin II-dependent hypertension with increased body mass and insulin resistance, acute systemic blockade of CB1 receptors ...
Frantti J J Finnish Research and Engineering, Jaalaranta 9 B 42, 00180 Helsinki, - - 2014
Piezoelectric materials respond to external stimuli by adjusting atomic positions. In solid-solutions, the changes occurring in atomic scale are very complex since the short- and long-range order are different. Standard methods used in diffraction data analysis fail to model the short-range order accurately. Pressure-induced cation displacements in ferroelectric Pb(Zr0.45Ti0.55)O3 perovskite ...
Wu You Y Stevens Institute of - - 2014
With proteinaceous-liquid flooding of discrete alveoli, a model of the edema pattern in the acute respiratory distress syndrome, lung inflation over expands aerated alveoli adjacent to flooded alveoli. Theoretical considerations suggest that the over-expansion may be proportional to surface tension, T. Yet recent evidence indicates proteinaceous edema liquid may not ...
Zhao Liang L Department of Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University, 400037, Chongqing, - - 2014
Intestinal ischemia-reperfusion injury is one of the main factors leading to multiple organ failure after resuscitation of prolonged hemorrhagic shock; however, the current conventional fluid resuscitation still cannot effectively reduce intestinal injury caused by prolonged hemorrhagic shock. To investigate the effect of ECMO resuscitation on alleviating intestinal ischemia-reperfusion injury in ...
Ryu Jiwon J 0000-0003-0251-7858 Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, - - 2014
It is known that blood pressure variability (BPV) can independently affect target organ damage (TOD), even with normal blood pressure. There have been few studieson chronic kidney disease (CKD) patients. We evaluated the relationship between BPV and TOD in a cross-sectional, multicenter study on hypertensive CKD patients. We evaluated 1,173 ...
Griffin Karen A KA From the Departments of Medicine (K.A.G., A.P., A.K.B.) and Pathology (M.P.), Loyola University Chicago and Hines VA Hospital, Maywood, IL; Department of Medicine, University of Illinois Hospital, Chicago, IL (N.L.); and Department of Pathology, University of Texas Health Science Center, San Antonio, (M.A.V.). - - 2014
Most patients with essential hypertension do not exhibit substantial renal damage. Renal autoregulation by preventing glomerular transmission of systemic pressures has been postulated to mediate this resistance. Conversely, malignant nephrosclerosis (MN) has been postulated to develop when severe hypertension exceeds a critical ceiling. If the concept is valid, even modest ...
Fu Zhi Qing ZQ First Department of Geriatric Cardiovascular Diseases, Chinese PLA General Hospital, Beijing, - - 2014
The call for early detection of hypotension creates a heavy demand for new methods that can monitor trends in blood pressure (BP) levels continuously and noninvasively. Photoplethysmography (PPG) is widely used in hemodynamic analysis. We assessed the feasibility of toe PPG in tracing BP trends using BP readings obtained by ...
Fitzgerald C - - 2014
High-pressure water injuries of the oropharynx are uncommon but can cause significant injury and airway compromise when they occur. A small number of cases of high-pressure water injury of the oropharynx have been presented in the literature, detailing a range of effects and outcomes. We describe the first reported case ...
Husain Kazim K Kazim Husain, Leon Ferder, Department of Physiology, Pharmacology and Toxicology, Ponce School of Medicine and Health Sciences, Ponce, PR 00732, United - - 2014
Epidemiological, preclinical and clinical studies established the association between high alcohol consumption and hypertension. However the mechanism through which alcohol raises blood pressure remains elusive. Several possible mechanisms have been proposed such as an imbalance of the central nervous system, impairment of the baroreceptors, enhanced sympathetic activity, stimulation of the ...
Khan Md Abdul Hye MA Department of Pharmacology & Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA, - - 2014
Angiotensin II type 1 receptor blockers (ARBs) are widely used in treating hypertension. In the present study, we tested the hypothesis that a novel ARB, azilsartan medoxomil (AZL-M) will prevent renal and cardiovascular injury in the spontaneously hypertensive obese rat (SHROB), a model of cardiometabolic syndrome. Male SHROB were treated ...
Johnson Richard J RJ Division of Nephrology, Eastern Colorado Health Care System, Department of Veteran Affairs, 12700 East 19th Avenue, Room 7015, Aurora, CO 80045, - - 2014
An epidemic of chronic kidney disease (CKD) in Mesoamerica is providing new insights into the mechanisms by which salt and water might drive hypertension and CKD. Increasingly, evidence suggests that recurrent dehydration and salt loss might be a mechanism that causes CKD, and experimental studies suggest a key role for ...
Salcedo Levilester L Department of Colorectal Surgery and Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio, USA; Summa Cardiovascular Institute and Northeast Ohio Medical University, Akron, Ohio, USA; Advanced Platform Technology Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, - - 2014
This research demonstrates the regenerative effects of mesenchymal stem cells (MSCs) on the injured anal sphincter by comparing anal sphincter pressures following intramuscular and serial intravascular MSC infusion in a rat model of anal sphincter injury. Fifty rats were divided into injury (n = 35) and no injury (NI; n ...
Neuberger Eric J EJ Department of Neurology and Neurosciences, Rutgers New Jersey Medical School, Newark, New - - 2014
Traumatic brain injury (TBI) can occur from physical trauma from a wide spectrum of insults ranging from explosions to falls. The biomechanics of the trauma can vary in key features, including the rate and magnitude of the insult. Although the effect of peak injury pressure on neurological outcome has been ...
Lavieri Nicolas A NA Department of Animal Science, Iowa State University, Ames, Iowa 50011-3150, - - 2014
A sublethally injured bacterial cell has been defined as a cell that survives a stress such as heating, freezing, acid treatment, or other antimicrobial intervention but can repair the cellular damage exerted by the stressor and later regain its original ability to grow. Consequently, sublethally injured cells are not likely ...
Romero-Franco Natalia N Department of Health Sciences, University of Jaén, - - 2014
[Purpose] The aim of this study was to analyze stabilometry in athletes during an indoor season in order to determine whether injured athletes show different stabilometric values before injury than non-injured athletes in two different training periods (volume and pre-competition periods). [Subjects] The subjects were 51 athletes from Unicaja athletic ...
Camporesi Enrico M - - 2014
Therapeutic mechanisms of action for hyperbaric oxygen (HBO2) therapy are based on elevation of both the partial pressure of inspired O2 and of the hydrostatic pressure. This last mechanism contributes to a compression of all gas-filled spaces in the body (Boyle's Law) and is relevant to treat conditions where gas ...
Doaei Saeid S PhD Candidate, Faculty Member, School of Health, North Khorasan University of Medical Sciences, Bojnurd, - - 2014
Salt sensitivity of blood pressure (BP) is an independent risk factor for cardiovascular morbidity. Up to 50% of patients with essential hypertension are salt-sensitive, as manifested by a rise in BP with salt intake. Several genetic variations have been identified as being associated with salt sensitivity. The present study aimed ...
Li Bing Cang - - 2014
Objective: To study blast-induced traumatic brain injury (bTBI) characteristics in confined space. Methods: The goats were placed at the column-like buildings with trinitrotoluene (TNT) as the source of the blast wave. The pressure was recorded at 2-8 m from the explosion center. The systemic physiology, electroencephalogram (EEG), serum level of ...
Williams Monica M Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, - - 2014
Blood pressure can vary considerably during anesthesia. If blood pressure falls outside the limits of cerebrovascular autoregulation, children can become at risk of cerebral ischemic or hyperemic injury. However, the blood pressure limits of autoregulation are unclear in infants and children, and these limits can shift after brain injury. This ...
Patel Meeta M Department of Infection, Immunity and Inflammation, University of Leicester, Transplant Group, Leicester General Hospital, Leicester, - - 2014
Ex vivo normothermic perfusion (EVNP) can reverse some of the detrimental effects of ischemic injury. However, in kidneys with warm and cold ischemic injury the optimal perfusion pressure remains undetermined. The aim of this study was to evaluate the effects of two different arterial pressures during EVNP. Porcine kidneys underwent static ...
Sterenborg Thomas B - - 2014
Despite the increasing use of pre- and posthydration protocols and low-osmolar instead of high-osmolar iodine-containing contrast media, the incidence of contrast-induced nephropathy (CIN) is still significant. There is evidence that contrast media cause ischemia-reperfusion injury of the medulla. Remote ischemic preconditioning (RIPC) is a non-invasive, safe, and low-cost method to ...
Ehrmann Brett J BJ Division of Pediatric Nephrology, Department of Pediatrics, C.S. Mott Children's Hospital, University of Michigan Health System, Ann Arbor, - - 2014
Reports of the burden of hypertension in hospitalized children are emerging, but the prevalence and significance of this condition within the PICU are not well understood. The aims of this study were to validate a definition of hypertension in the PICU and assess the associations between hypertension and acute kidney ...
Howells Tim T Section of Neurosurgery, Department of Neuroscience, Uppsala University Hospital, 751 85, Uppsala, Sweden, - - 2014
The objective of this study was to identify the optimal frequency range for computing the pressure reactivity index (PRx). PRx is a clinical method for assessing cerebral pressure autoregulation based on the correlation of spontaneous variations of arterial blood pressure (ABP) and intracranial pressure (ICP). Our hypothesis was that optimizing ...
Sameshima Naoki N Department of Pathology, Faculty of Medicine, University of - - 2014
Aim: To clarify the contribution of hemodynamic factors to the onset of plaque erosion in smooth muscle cell (SMC)-rich atherosclerotic plaque. Methods: We developed a rabbit model of SMC-rich atherosclerotic plaque with various degree of stenosis induced by incomplete ligation and generated three-dimensional models of five rabbit femoral arteries based ...
Peters Greg G , 37610 College Drive #201, Palm Desert, CA, 92211, USA, - - 2014
High-pressure paint gun injuries are potentially devastating injuries that require emergent surgical incision and drainage. They result from erroneous equipment operation and accidental injection of a variety of substances at pressures high enough to breach the skin. The largely benign superficial appearance masks the extent of the underlying injury. In ...
Rosenwasser Melvin P - - 2014
The severity of high-pressure injection injuries to the hand is often underappreciated on initial presentation. These injuries require urgent and thorough surgical débridement. Despite the advances in our understanding of this injury type and the decline in amputation rates, the risk of long-term morbidity with diminished function and chronic symptoms ...
Tran Loi V LV Intensive Care Unit, Holy Cross Hospital, Silver Spring, - - 2014
Traumatic brain injury continues to be a major socioeconomic problem, costing the United States $76.5 billion in the year of 2000. Despite the advances in the field of medicine, there are still no definitive treatments for traumatic brain injury. Goal of therapy is still gearing toward supportive cares such as ...
Sarwar Umran U Welsh Centre for Burns and Plastic Surgery, Swansea, - - 2014
High-pressure injection (HPI) injuries are an uncommon mechanism of trauma. The clinical effects of the HPI injury depend upon a number of variables including the pressures involved, chemical toxicity, quantity of material injected and its temperature. Evidence within the literature has shown that delay in identifying and treating such injuries ...
Wu Chunxiao C Cardiovascular Diseases Center, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China ; China Heart Institute of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100091, - - 2014
Background. Blood pressure variability (BPV) independent of average blood pressure is related to cardiovascular damage. Meanwhile, BPV is also associated with measures of endothelial injury. Decoction, a traditional used form of Traditional Chinese Medicine (TCM), is inconvenient to prepare, carry, and store. Dispensing granules is now developing as an alternative ...
Trnka Peter P Department of Paediatrics and Child Health, The University of Queensland , Brisbane, QLD , Australia ; Department of Paediatrics, Mater Children's Hospital , Brisbane, QLD , - - 2014
Reninoma (juxtaglomerular cell tumor) is a rare cause of renin-mediated hypertension. Reninomas are usually diagnosed in adolescents and young adults with occasional reports in younger children. Patients typically present with a long history of headaches leading to a diagnosis of severe hypertension that responds well to antihypertensive treatment targeting the ...
Rosier Sébastien - - 2013
In patients suffering from brain injury, end-tidal PCO2 (PETCO2) monitoring is controversial but transcutaneous PCO2 (PtcCO2), which is noninvasive and utilizes real-time display, may be an alternative method. We hypothesized that PtcCO2 would be more accurate than PETCO2 for monitoring PaCO2 in severe brain injury patients. A prospective observational study ...
Hwabejire John O - - 2013
We have previously shown that the extent of traumatic brain injury (TBI) in large animal models can be reduced with early infusion of fresh frozen plasma (FFP), but the precise mechanisms remain unclear. In this study, we investigated whether resuscitation with FFP or normal saline differed in their effects on ...
Knowles A - - 2013
Heels are at increased risk of injury due to the posterior prominence and lack of padding over the calcaneus. Pressure injuries, once established, are extremely costly, both in terms of the detrimental effect on psychosocial wellbeing and threat to life, as well as financially due to length of hospital stay ...
Franklyn-Miller Andrew - - 2013
Injury in initial military training is common with incidences from 25 to 65% of recruits sustaining musculoskeletal injury. Risk factors for injury include extrinsic factors such as rapid onset of high volume training, but intrinsic factors such as lower limb biomechanics and foot type. Prediction of injury would allow more ...
Cao Zhixiu - - 2013
To clarify whether tolerance to irrigation pressure could be modified over varying degrees of kidney obstruction during the endoscopic treatment of kidney stones in a rat model. A total of 126 rats were randomly allocated into 2 experimental groups and a control group. The experimental groups underwent a surgical procedure ...
Narotam Pradeep K PK Union Hospital Neuroscience, 1530 N, 7th Street, suite 500, Terre Haute, IN, 47807, USA. - - 2013
Controversy exists on the role of hyperoxia in major trauma with brain injury. Hyperoxia on arterial blood gas has been associated with acute lung injury and pulmonary complications, impacting clinical outcome. The hyperoxia could be reflective of the physiological interventions following major systemic trauma. Despite the standard resuscitation of patients ...
Latimer Sharon - - 2013
Pressure injuries burden patients and healthcare organisations, with some preventative practices having little impact on prevalence reduction. Patient participation in care may be an effective pressure injury prevention strategy, yet patient preferences are unknown. The aim of this interpretive study was to describe patients' perceptions of their current and future ...
Amsdell Simon L - - 2013
High-pressure injection injury to the hand and upper extremity is a rare but very serious clinical entity. The objective of this article was to review the current available literature and highlight important topics. A PubMed literature search was undertaken with the terms "high pressure injection injuries," "injection injuries," "finger injection ...
Barnetson Bob B Athabasca University, Edmonton, Alberta, Canada. - - 2013
Legislators in the Canadian province of Alberta have successfully resisted pressure to increase state injury-prevention efforts. This study seeks to identify the narratives used by legislators to manage political pressure for increased injury-prevention efforts. Narrative analysis of legislative transcripts from 2000 to 2012. Three narratives are identified in the data: ...
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