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Li Bing Cang - - 2014
Objective: To study blast-induced traumatic brain injury (bTBI) characteristics in confined space. Methods: The goats were placed at the column-like buildings with trinitrotoluene (TNT) as the source of the blast wave. The pressure was recorded at 2-8 m from the explosion center. The systemic physiology, electroencephalogram (EEG), serum level of ...
Williams Monica M Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, - - 2014
Blood pressure can vary considerably during anesthesia. If blood pressure falls outside the limits of cerebrovascular autoregulation, children can become at risk of cerebral ischemic or hyperemic injury. However, the blood pressure limits of autoregulation are unclear in infants and children, and these limits can shift after brain injury. This ...
Sterenborg Thomas B - - 2014
Despite the increasing use of pre- and posthydration protocols and low-osmolar instead of high-osmolar iodine-containing contrast media, the incidence of contrast-induced nephropathy (CIN) is still significant. There is evidence that contrast media cause ischemia-reperfusion injury of the medulla. Remote ischemic preconditioning (RIPC) is a non-invasive, safe, and low-cost method to ...
Ehrmann Brett J BJ Division of Pediatric Nephrology, Department of Pediatrics, C.S. Mott Children's Hospital, University of Michigan Health System, Ann Arbor, - - 2014
Reports of the burden of hypertension in hospitalized children are emerging, but the prevalence and significance of this condition within the PICU are not well understood. The aims of this study were to validate a definition of hypertension in the PICU and assess the associations between hypertension and acute kidney ...
Milzman D D Georgetown University School of Medicine, Washington, - - 2014
Concussions(mTBI) occur at variable reported rates of 1-4 per 100 player games in the NHL. Hypoxia exacerbates neuronal death following mild TBI in animals and Oxygen deprivation leads to greater mitochondrial dysfunction in concussed brains. This study will evaluate the impact of mild hypoxia associated with airline travel on duration ...
Howells Tim T Section of Neurosurgery, Department of Neuroscience, Uppsala University Hospital, 751 85, Uppsala, Sweden, - - 2014
The objective of this study was to identify the optimal frequency range for computing the pressure reactivity index (PRx). PRx is a clinical method for assessing cerebral pressure autoregulation based on the correlation of spontaneous variations of arterial blood pressure (ABP) and intracranial pressure (ICP). Our hypothesis was that optimizing ...
Sameshima Naoki N Department of Pathology, Faculty of Medicine, University of - - 2014
Aim: To clarify the contribution of hemodynamic factors to the onset of plaque erosion in smooth muscle cell (SMC)-rich atherosclerotic plaque. Methods: We developed a rabbit model of SMC-rich atherosclerotic plaque with various degree of stenosis induced by incomplete ligation and generated three-dimensional models of five rabbit femoral arteries based ...
Peters Greg G , 37610 College Drive #201, Palm Desert, CA, 92211, USA, - - 2014
High-pressure paint gun injuries are potentially devastating injuries that require emergent surgical incision and drainage. They result from erroneous equipment operation and accidental injection of a variety of substances at pressures high enough to breach the skin. The largely benign superficial appearance masks the extent of the underlying injury. In ...
Rosenwasser Melvin P - - 2014
The severity of high-pressure injection injuries to the hand is often underappreciated on initial presentation. These injuries require urgent and thorough surgical débridement. Despite the advances in our understanding of this injury type and the decline in amputation rates, the risk of long-term morbidity with diminished function and chronic symptoms ...
Tran Loi V LV Intensive Care Unit, Holy Cross Hospital, Silver Spring, - - 2014
Traumatic brain injury continues to be a major socioeconomic problem, costing the United States $76.5 billion in the year of 2000. Despite the advances in the field of medicine, there are still no definitive treatments for traumatic brain injury. Goal of therapy is still gearing toward supportive cares such as ...
Sarwar Umran U Welsh Centre for Burns and Plastic Surgery, Swansea, - - 2014
High-pressure injection (HPI) injuries are an uncommon mechanism of trauma. The clinical effects of the HPI injury depend upon a number of variables including the pressures involved, chemical toxicity, quantity of material injected and its temperature. Evidence within the literature has shown that delay in identifying and treating such injuries ...
Rosier Sébastien - - 2013
In patients suffering from brain injury, end-tidal PCO2 (PETCO2) monitoring is controversial but transcutaneous PCO2 (PtcCO2), which is noninvasive and utilizes real-time display, may be an alternative method. We hypothesized that PtcCO2 would be more accurate than PETCO2 for monitoring PaCO2 in severe brain injury patients. A prospective observational study ...
Hwabejire John O - - 2013
We have previously shown that the extent of traumatic brain injury (TBI) in large animal models can be reduced with early infusion of fresh frozen plasma (FFP), but the precise mechanisms remain unclear. In this study, we investigated whether resuscitation with FFP or normal saline differed in their effects on ...
Knowles A - - 2013
Heels are at increased risk of injury due to the posterior prominence and lack of padding over the calcaneus. Pressure injuries, once established, are extremely costly, both in terms of the detrimental effect on psychosocial wellbeing and threat to life, as well as financially due to length of hospital stay ...
Franklyn-Miller Andrew - - 2013
Injury in initial military training is common with incidences from 25 to 65% of recruits sustaining musculoskeletal injury. Risk factors for injury include extrinsic factors such as rapid onset of high volume training, but intrinsic factors such as lower limb biomechanics and foot type. Prediction of injury would allow more ...
Cao Zhixiu - - 2013
To clarify whether tolerance to irrigation pressure could be modified over varying degrees of kidney obstruction during the endoscopic treatment of kidney stones in a rat model. A total of 126 rats were randomly allocated into 2 experimental groups and a control group. The experimental groups underwent a surgical procedure ...
Narotam Pradeep K PK Union Hospital Neuroscience, 1530 N, 7th Street, suite 500, Terre Haute, IN, 47807, USA. - - 2013
Controversy exists on the role of hyperoxia in major trauma with brain injury. Hyperoxia on arterial blood gas has been associated with acute lung injury and pulmonary complications, impacting clinical outcome. The hyperoxia could be reflective of the physiological interventions following major systemic trauma. Despite the standard resuscitation of patients ...
Latimer Sharon - - 2013
Pressure injuries burden patients and healthcare organisations, with some preventative practices having little impact on prevalence reduction. Patient participation in care may be an effective pressure injury prevention strategy, yet patient preferences are unknown. The aim of this interpretive study was to describe patients' perceptions of their current and future ...
Amsdell Simon L - - 2013
High-pressure injection injury to the hand and upper extremity is a rare but very serious clinical entity. The objective of this article was to review the current available literature and highlight important topics. A PubMed literature search was undertaken with the terms "high pressure injection injuries," "injection injuries," "finger injection ...
Barnetson Bob B Athabasca University, Edmonton, Alberta, Canada. - - 2013
Legislators in the Canadian province of Alberta have successfully resisted pressure to increase state injury-prevention efforts. This study seeks to identify the narratives used by legislators to manage political pressure for increased injury-prevention efforts. Narrative analysis of legislative transcripts from 2000 to 2012. Three narratives are identified in the data: ...
Chaboyer Wendy - - 2013
Pressure injury guidelines recommend regular repositioning yet patients' mobility and repositioning patterns are unknown. An observational study using activity monitors was undertaken to describe the 24 h activity patterns of 84 hospitalized patients at risk of developing a pressure injury. The vast majority of participants' time was spent in the sedentary ...
Imbriano Louis J - - 2013
Abstract Autoregulation of glomerular capillary pressure via regulation of the resistances at the afferent and efferent arterioles plays a critical role in maintaining the glomerular filtration rate over a wide range of mean arterial pressure. Angiotensin II and prostaglandins are among the agents which contribute to autoregulation and drugs which ...
Probst Tahira M - - 2013
Each year, more than 4 million U.S. workers are injured on the job - several thousand die (Bureau of Labor Statistics, 2008). Despite these staggering numbers, research suggests that they are gross underestimates of the true volume of workplace related illnesses and injuries due to accident under-reporting. Although accident under-reporting ...
Chaudhry Sonia - - 2013
High-pressure injection injuries often have a misleadingly benign presentation. However, it is important to recognize the potential surgical urgency and long-term sequelae associated with these injuries. We present a case of paint gun injection to the palm and review the literature on high-pressure paint injection injuries. The 3 factors most ...
Sirino─člu Hakan - - 2013
Abstract High-pressure injection injuries to the upper extremity cause potentially severe complications that result in multiple operations, amputations, and permanent functional deficits. Early exploration and debridement are the mainstays of treatment for optimal functional recovery. We describe the late presentation of a high-pressure cement injection injury to the hand, its ...
Dougherty Judith E - - 2013
Hyperbaric oxygen therapy has been approved for primary or adjunctive care in 14 indications. A hyperbaric environment exists when a patient's whole body is physically exposed to 100% oxygen and pressure that is greater than one atmosphere absolute. Hyperbaric oxygen therapy works through the ideal gas laws and is effective ...
Jones Claire F - - 2013
Background: Despite considerable effort over the last four decades, research has failed to translate into consistently effective treatment options for spinal cord injury (SCI). This is partly attributed to differences between the injury response of humans and rodent models. Some of this difference could be because humans have a discernible ...
Roberts Derek J - - 2013
Accumulating pre-clinical data suggests that matrix metalloproteinase (MMP) expression plays a critical role in the pathophysiology of secondary brain injury. We conducted a prospective multimodal monitoring study in order to characterize the temporal MMP response after severe traumatic brain injury (TBI) in 8 critically ill humans and its relationship with ...
Ritz Thomas - - 2013
Exposure to feared stimuli in blood-injection-injury (BII)-phobia is thought to elicit a diphasic response pattern, with an initial fight-flight-like cardiovascular activation followed by a marked deactivation and possible fainting (vasovagal syncope). However, studies have remained equivocal on the importance of such patterns. We therefore sought to determine the prevalence and ...
Beloncle François - - 2013
The optimal target blood pressure in septic shock is still unknown. Therefore, in a long-term, resuscitated porcine model of fecal peritonitis-induced septic shock, Corrêa and colleagues tested whether different titrations of mean arterial pressure (50 to 60 and 75 to 85 mm Hg) would produce different effects on sepsis-related organ ...
De Lamo-Castellví Silvia - - 2013
This study used flow cytometry (FC), epifluorescent microscopy (EM), and conventional culture media (PC) to evaluate the potential for high-pressure throttling (HPT) to produce injury in E. coli. E. coli cells suspended at a concentration of approximately 8 log (CFU/mL) in Butterfield's phosphate buffer and UHT skimmed milk, were treated ...
Zammit Christopher C - - 2013
Traumatic brain injury is the most common cause of death and disability in young people, with an annual financial burden of over $50 billion per year in the United States. Traumatic brain injury is defined by both the initial primary injury and the subsequent secondary injuries. Fundamental to emergency department ...
Niles Dana E - - 2013
INTRODUCTION: Single mode, pressure reduction (PR) crib mattresses are increasingly employed in hospitals to prevent skin injury and infection. However, single mode PR mattresses risk large mattress deflection during CPR chest compressions, potentially leading to inadequate chest compressions. HYPOTHESIS: New, dual mode PR crib mattress technology provides less mattress deflection ...
Gefen Amit - - 2013
Pressure ulcer prevention strategies include the prevention, and early recognition, of deep tissue injury (DTI), which can evolve into a Stage III or Stage IV pressure ulcer. In addition to their role in pressure-induced ischemia, shearing forces are believed to contribute substantially to the risk of DTI. Because the visual ...
White Nathan J - - 2013
ABSTRACT: Animal models of combined traumatic brain injury (TBI) and hemorrhagic shock (HS) suggest a benefit of hemoglobin-based oxygen carrier (HBOC)-based resuscitation, but their use remains controversial, and little is known of the specific effects of TBI and high-pressure (large arterial injury) bleeding on resuscitation. We examine the effect of ...
Steele Catriona M - - 2013
The purpose of this study was to measure treatment outcomes in a group of six adults with chronic dysphagia following acquired brain injury, who each completed 24 sessions of tongue-pressure resistance training, over a total of 11-12 weeks. The treatment protocol emphasized both strength and accuracy. Biofeedback was provided using ...
Ralib Azrina M - - 2013
Aims: Treatment of renal anemia with erythropoietic stimulating agents sometimes increases blood pressure. It is uncertain whether this is due to direct vasoconstriction and/or increased red blood cell mass. Materials and methods: We conducted a post-hoc analysis of 160 critically ill patients in the EARLYARF trial with elevated urinary γ-glutamyltranspeptidase ...
Lehman Li-wei H - - 2013
Minimal clinical research has investigated the significance of different blood pressure monitoring techniques in the ICU and whether systolic vs. mean blood pressures should be targeted in therapeutic protocols and in defining clinical study cohorts. The objectives of this study are to compare real-world invasive arterial blood pressure with noninvasive ...
Nakagawa Takashi - - 2013
Although renal denervation (RD) is shown to reduce blood pressure significantly in patients with resistant hypertension, the benefit of RD in prevention of stroke is unknown. We hypothesized that RD can prevent the incidence of stroke and brain injury in hypertensive rats beyond blood pressure lowering. High-salt-loaded, stroke-prone, spontaneously hypertensive ...
Bidani Anil K AK Loyola University and Hines VA Hospital, Maywood, Illinois 60153, USA. - - 2013
Despite apparent blood pressure (BP) control and renin-angiotensin system (RAS) blockade, the chronic kidney disease (CKD) outcomes have been suboptimal. Accordingly, this review is addressed to renal microvascular and autoregulatory impairments that underlie the enhanced dynamic glomerular BP transmission in CKD progression. Clinical data suggest that failure to achieve adequate ...
Espina Laura - - 2012
This work addresses the inactivation achieved with Escherichia coli O157:H7 and Listeria monocytogenes EGD-e by combined processes of high hydrostatic pressure (HHP) and essential oils (EOs) or their chemical constituents (CCs). HHP treatments (175-400MPa for 20min) were combined with 200μL/L of each EO (Citrus sinensis L., Citrus lemon L., Citrus ...
Bruijns Stevan Raynier - - 2012
BACKGROUND: Raised blood pressure (and heart rate (HR)) due to anxiety in a clinical situation is well described and is called the white coat effect (WCE). It is not known whether the pain and anxiety that results from trauma causes a measurable WCE. METHODS: A sample of patients with a ...
Brotfain Evgeni - - 2012
ABSTRACT: Treatment of combined traumatic brain injury and hypovolemic shock, poses a particular challenge due to the possible conflicting consequences. While restoring diminished volume is the treatment goal for hypovolemia, maintaining and adequate cerebral perfusion pressure and avoidance of secondary damage remains a treatment goal for the injured brain. Various ...
Ono Takahiko - - 2012
Oxidative stress and peritubular capillary (PTC) injury are involved in the progression of chronic kidney disease (CKD). We investigated protective effects of Shichimotsu-koka-To (SKT), a Japanese traditional Kampo prescription, against nephrosclerosis and hypertension on a CKD model due to irreversible nephritis. Six-week-old male Wistar rats were subjected to uninephrectomy, and ...
Saraf Sanjay - - 2012
The high-pressure injection injuries are unusual injuries and the extent of tissue damage is often under estimated. They represent potentially disabling forms of trauma and have disastrous effects on tissues if not treated promptly. We present a case of high pressure injection injury to the finger from lubricant oil. The ...
Chaturvedi Lakshmi S LS Department of Surgery, Michigan State University, Lansing, MI, - - 2012
Traumatic brain injury induces a neuroinflammatory response frequently associated with increased intracranial pressure. The aim of this study was to investigate the effects of alcohol and increased extracellular pressure on murine BV-2 microglial proliferation and cytokine responses to lipopolysaccharide (LPS) stimulation. BV-2 cells were cultured under 0 or 30 mm ...
Wood Matthew - - 2013
Transportation vehicles, whether they are passenger vehicles or heavy trucks and transport vehicles, rely upon rubber tires to negotiate the roadways and surfaces on which they are driven. These tires have the potential of sudden rupture resulting from various causes including but not limited to over-pressurization, sidewall failures, or punctures ...
Lv Faqin - - 2012
BACKGROUND: This research aimed to study the assessment of local muscle microcirculation perfusion of extremities that underwent crush injuries by using contrast-enhanced ultrasonography (CEUS). METHODS: A total of 28 New Zealand rabbits were anesthetized by using intramuscular pentobarbital sodium (30 mg/kg). A balloon cuff device was used to create crush ...
de Rougemont O - - 2012
BACKGROUND & AIMS: The aim of this study was to identify protective mechanisms of cold machine perfusion in liver grafts donated after cardiac death. METHODS: Pig livers exposed to 60 min warm ischemia were cold stored for 7 h or treated after 6 h cold storage by 1 h hypothermic ...
Satou Ryousuke - - 2012
The renin-angiotensin system (RAS) plays important roles in blood pressure control and tissue disease. An inappropriate local angiotensin II elevation in the kidneys leads to the development of hypertension, tissue damage and chronic injury. Studies have demonstrated that the JAK-STAT pathway mediates angiotensin II-triggered gene transcription. The JAK-STAT pathway in ...
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