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González Germán E GE aDepartment of Internal Medicine, Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Michigan bCardiovascular Pathophysiology Institute, University of Buenos Aires, Argentina cDepartment of Physiology dDepartment of Internal Medicine, Wayne State University eDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan, - - 2015
Inflammation has been proposed as a key component in the development of hypertension and cardiac remodeling associated with different cardiovascular diseases. However, the role of the proinflammatory cytokine interleukin-6 in the chronic stage of hypertension is not well defined. Here, we tested the hypothesis that deletion of interleukin-6 protects against ...
Richter Joel E JE Division of Digestive Diseases and Nutrition, University of South Florida Morsani College of Medicine, Tampa, FL, 33612, USA, - - 2015
High-resolution manometry (HRM) with 36 pressure transducers spanning the esophagus has revolutionized the diagnosis and treatment of esophageal motility disorders, especially with respect to achalasia. The three major contributions of HRM are as follows: (a) Integrated relaxation pressure (IRP) at the esophagus gastric junction (EGJ) >15 mmHg has a sensitivity of ...
Sharma Bharat Bhooshan - - 2014
Imidazole (C3H4N2) is an important biomaterial for material research and applications. Our high pressure Raman spectroscopic investigations combined with ab-initio calculations on crystalline imidazole suggest that C-H---X (X= N, π) and N-H---N inter-molecular hydrogen bonding interactions largely influence the nature of its structural and polymeric transformations under pressure. At pressures ...
Svenningsen Per P Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, - - 2014
Serine proteases, both soluble and cell-attached, can activate the epithelial sodium channel (ENaC) proteolytically through release of a putative 43-mer inhibitory tract from the ectodomain of the γ-subunit. ENaC controls renal Na(+) excretion and loss-of-function mutations lead to low blood pressure, while gain-of-function mutations lead to impaired Na(+) excretion, hypertension, ...
Jasper Ahren W AW Combustion Research Facility, Sandia National Laboratories, MS 9055, Livermore, CA 94551-0969, - - 2014
The ability to predict the pressure dependence of chemical reaction rates would be a great boon to kinetic modeling of processes such as combustion and atmospheric chemistry. This pressure dependence is intimately related to the rate of collision-induced transitions in energy E and angular momentum J. We present a scheme ...
Glenn Denis J DJ UCSF - - 2014
Lipid accumulation in the heart is associated with obesity and diabetes and may play an important role in the pathogenesis of heart failure. The renin-angiotensin system is also thought to contribute to cardiovascular morbidity in obese and diabetic patients. We hypothesized that the presence of lipid within the myocyte might ...
Kurtz Armin A Institute of Physiology, University of Regensburg, Germany. Electronic address: - - 2014
Vascular gap junctions formed by specific connexins proteins Cx37, 40, 43 and 45 are important for proper vascular function. This review outlines that defects of the connexin 40 protein leads to hypertension because of dysfunction of renin secreting cells of the kidney. Thus defects of Cx40 but not of other ...
Chang Hai-Chou HC Department of Chemistry, National Dong Hwa University, Shoufeng, Hualien 974, Taiwan. - - 2014
The pressure-dependent interactions between the ionic liquid mixture ([MPI][I1.5]) and nano-TiO2 surfaces have been studied up to 2.5 GPa. The results of infrared spectroscopic profiles of [MPI][I1.5] and [MPI][I1.5]-nano-TiO2 indicated that no appreciable changes in the C-H stretching bands with the addition of nano-TiO2 were observed under ambient pressure. As ...
Hammer Yosi Y Raymond and Beverly Sackler School of Physics and Astronomy, Tel Aviv University, Tel Aviv 69978, - - 2014
In lattice models, local pressure on a surface is derived from the change in the free energy of the system due to the exclusion of a certain boundary site, while the total force on the surface can be obtained by a similar exclusion of all surface sites. In these definitions, ...
- - 2014
OLDER PEOPLE are being encouraged to seek advice early from local pharmacists if they are 'feeling under the weather'.
Li Jihua J Agriculture Products Processing Research Institute, Chinese Academy of Tropical Agricultural Sciences, Zhanjiang 524001, PR China; National Center of Important Tropical Crops Engineering and Technology Research, Haikou 571101, PR China. Electronic address: - - 2014
Nanocelluloses were prepared from sugarcane bagasse celluloses by dynamic high pressure microfluidization (DHPM), aiming at achieving a homogeneous isolation through the controlling of shearing force and pressure within a microenvironment. In the DHPM process, the homogeneous cellulose solution passed through chambers at a higher pressure in fewer cycles, compared with ...
Krupp Danika D Department of Nutritional Epidemiology, DONALD Study Centre Dortmund, Branch Laboratory of the Faculty of Agriculture, University of Bonn, Bonn, - - 2014
Fruit and vegetable (FV) consumption and salt intake are known dietary influences on blood pressure (BP) in adults, but data on their long-term relevance during growth for later BP are rare. We aimed to examine the independent and concomitant influences of adolescent FV and salt intakes on BP in young ...
- - 2014
A £300 million cash injection to help the NHS cope with winter pressures is little more than a 'sticking plaster' solution, the RCN has said.
Edwards David G DG Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, - - 2014
High dietary salt intake is detrimental in hypertensive and salt-sensitive individuals; however, there are a large number of normotensive salt-resistant individuals for whom dietary salt may also be harmful as a result of the blood pressure-independent effects of salt. This review will focus on the growing evidence that salt has ...
Protz Kerstin K Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf, CWC - Comprehensive Wound Center, Hamburg, - - 2014
Background: Manufacturers' instructions of multi-component compression bandage systems inform that these products can remain up to 7 days during the therapy of venous leg ulcer. This implies that the pressure needed will be sustained during this time. Objective: The present research investigated the persistence of pressure of compression systems over ...
Barros Carolina Lôbo de Almeida CL Liga de Hipertensão Arterial, Faculdade de Medicina, Universidade Federal de Goiás, Goiânia, Goiás, - - 2014
Background: Studies have shown sodium restriction to have a beneficial effect on blood pressure (BP) of hypertensive patients. Objective: To evaluate the impact of light salt substitution for regular salt on BP of hypertensive patients. Methods: Uncontrolled hypertensive patients of both sexes, 20 to 65 years-old, on stable doses of ...
Torres Vicente E VE From the Mayo Clinic College of Medicine, Rochester, MN (V.E.T., M.C.H., P.C.H.); University of Pittsburgh School of Medicine, Pittsburgh (K.Z.A., C.G.M.); Emory University School of Medicine, Atlanta (A.B.C., F.F.R.-O.); University of Colorado Health Sciences Center, Denver (R.W.S., G.B.); Cleveland Clinic, Cleveland (W.E.B.); Beth Israel Deaconess Medical Center (T.I.S., P.G.C.) and Tufts Medical Center (D.C.M., R.D.P.) - both in Boston; Kansas University Medical Center, Kansas City (F.T.W., J.J.G.) and the National Institutes of Health, Bethesda, MD - - 2014
Background Hypertension develops early in patients with autosomal dominant polycystic kidney disease (ADPKD) and is associated with disease progression. The renin-angiotensin-aldosterone system (RAAS) is implicated in the pathogenesis of hypertension in patients with ADPKD. Dual blockade of the RAAS may circumvent compensatory mechanisms that limit the efficacy of monotherapy with ...
Milne Stephen S Department of Respiratory and Sleep Medicine at Westmead Hospital, Westmead, Sydney, NSW 2145, - - 2014
Nasal expiratory resistive valves (Provent(®)) have been proposed as novel therapy for obstructive sleep apnea. We compared pressure measurements from a standard nasal pressure catheter used to assess nasal airflow during sleep with those from nasal expiratory resistive device with attached proprietary nasal pressure cannula. Nasal pressure cannula or Provent(®) ...
Gonzalez Alexis A AA Instituto de Química, Pontificia Universidad Católica de Valparaíso, - - 2014
The intrarenal renin-angiotensin-system (RAS) plays a critical role in the pathogenesis and progression of hypertension and kidney disease. In angiotensin (Ang) II-dependent hypertension, collecting duct renin synthesis and secretion are stimulated despite suppression of juxtaglomerular (JG) renin. This effect is mediated by the Ang II type 1 receptor independent of ...
Han Chao C College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, 310036, China. - - 2014
To improve repeatability and efficiency and to simplify the operation procedure of capillary electrophoresis (CE), a pressurized CE system (p-CE) with injection valve sampling was developed. It consisted of one high-pressure pump, a six-port injection valve, a PEEK cross, a separation and back pressure capillary, an ultraviolet-visible detector and a ...
Johnson Richard J RJ University of Colorado, Denver - - 2014
Primary hypertension is increasingly common and is associated with significant morbidity. Here we review the history of its discovery and rise during the last century with an emphasis on studies trying to identify its cause. Early studies identified a defect in sodium excretion by the kidney as being central to ...
Kirby Anna C AC Department of Obstetrics and Gynecology, Division of Urogynecology, University of Washington Medical Center, 1959 NE Pacific St, Box 356460, Seattle, WA, 98195, USA, - - 2014
This video introduces a 3D high-resolution manometry (HRM) system to the field of urogynecology. We demonstrate how to obtain and interpret dynamic urethral pressures with this measurement system and use it to evaluate pre- and postoperative women. The 3D HRM catheter is ∼12 F; 11 cm of its length has pressure sensors ...
Stephen Joanna M JM Mechanical Engineering Department, Imperial College London, London, - - 2014
Tibial tuberosity (TT) transfer is a common procedure to treat patellofemoral instability in patients with elevated TT-trochlear groove (TG) distances. However, the effects of TT lateralization or medialization on patellar stability, kinematics, and contact mechanics remain unclear. Progressive medialization and lateralization will have increasingly adverse effects on patellofemoral joint kinematics, ...
Garza Amanda E AE From the Division of Endocrinology, Diabetes and Hypertension, Department of Medicine (A.E.G., C.M.R., B.S., J.S.W., R.B., T.Y., B.M., W.M.H., J.R.R., G.K.A., L.H.P., G.H.W.) and Channing Department of Network Medicine (J.L.-S.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Endocrinology, School of Medicine, Pontificia Universidad Catolica De Chile, Santiago, Chile (R.B.); Division of Internal Medicine & Nephrology and School of Internal Medicine, University of L'Aquila, San Salvatore Hospital, V.le San Salvatore, Coppito, Italy (C.F.); and Division of Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City - - 2014
Striatin is a novel protein that interacts with steroid receptors and modifies rapid, nongenomic activity in vitro. We tested the hypothesis that striatin would in turn affect mineralocorticoid receptor function and consequently sodium, water, and blood pressure homeostasis in an animal model. We evaluated salt sensitivity of blood pressure in ...
Knight John J aThe George Institute for Global Health bSydney Medical School, University of Sydney cRoyal North Shore Hospital, Sydney, New South Wales, - - 2014
Because advanced chronic kidney disease (CKD) is often an exclusion criterion for large randomized trials of the management of hypertension, clinical decision making for these patients has relied on a few small, specific studies and much extrapolation. Several blood pressure treatment guidelines have recently been reissued. This review explores the ...
Giraudet C C Laboratoire des Fluides Complexes et leurs Réservoirs, UMR 5150, Université de Pau et des Pays de l'Adour, 64600, Anglet, - - 2014
High-pressure mass diffusion and Soret coefficients of the equimassic 1,2,3,4-tetrahydronaphthalene and n-dodecane binary mixture are obtained from dynamic light scattering analysis of concentration non-equilibrium fluctuations at the steady state of Soret-driven separation. A high-pressure shadowgraph set-up has been developed to investigate thermodiffusion in free medium from atmospheric pressure up to ...
Majumdar Dipanwita D Department of Physics, Bose Institute, 93/1, Acharya Prafulla Chandra Road, Kolkata 700009, - - 2014
The pressure-dependent phonon modes of InAs nanowires have been investigated by Raman spectroscopy under high pressure up to ∼58 GPa. X-ray diffraction measurements show that InAs nanowires at 21 GPa exhibit a phase transition from a wurtzite to an orthorhombic crystal structure, with a corresponding drastic change in the first-order ...
Toda Akiko A Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital, Tokyo, - - 2014
Excess salt intake is a risk factor for increased blood pressure (BP) and hypertension. To prevent hypertension, the reduction of salt intake is promoted in many countries. For people with hypertension or cardiovascular disease (CVD), a more severe restriction of salt intake is indispensable. Japanese individuals consume high quantities of ...
Kutálková Eva E Tomas Bata University in Zlín, Faculty of Technology, Department of Physics and Materials Engineering, Nám. T.G. Masaryka 5555, 76001 Zlín, Czech Republic. - - 2014
High-pressure methods have become attractive tools for investigation of the structural stability of proteins. Besides protein unfolding, dimerization can be studied this way, too. HIV-1 protease is a convenient target of experimental and theoretical high-pressure studies. In this study molecular-dynamics simulations are used to predict the response of HIV-1 protease ...
Zhao Ren R Department of Physiology, Anhui Medical University, Hefei, Anhui, 230032, China; Department of Pharmacology, Anhui Medical University, Hefei, Anhui, 230032, China; Department of Cardiology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230032, - - 2014
High-salt intake is a major risk factor in the development of hypertension. The underlying mechanism of high sodium on the cardiovascular system has received extensive attention. TRPP2 (Polycystin-2) is a Ca(2+) permeable non-selective cation channel that mediates Ca(2+) mobilization to control vascular smooth muscle cells (VSMCs) contraction. Here, we investigated ...
Kim Jeonghyun J a Department of Mechanical Engineering, Graduate School of Engineering , University of Tokyo , Tokyo , - - 2014
In this study, we developed a novel bioreactor to load hydrostatic pressure to promote chondrogenesis of prechondrogenic ATDC5 cells in as little as 3 days. Furthermore, we showed that loading hydrostatic pressure induced the upregulation of PKR, which is known to participate in mechanotransduction in various models.
Bath Philip Mw PM Stroke, Division of Clinical Neuroscience, University of Nottingham, City Hospital Campus, Nottingham, UK, NG5 - - 2014
It is unclear whether blood pressure should be altered actively during the acute phase of stroke. This is an update of a Cochrane review first published in 1997, and previously updated in 2001 and 2008. To assess the clinical effectiveness of altering blood pressure in people with acute stroke, and ...
Suresh R R Centre for Biomedical Engineering, IIT Delhi, Hauz Khas, New Delhi, India Bhaba Atomic Research Centre Visakhapatnam, Andhra Pradesh, - - 2014
Clinical monitoring of planar pressure is vital in several pathological conditions, such as diabetes, where excess pressure might have serious repercussions on health of the patient, even to the extent of amputation. The main objective of this paper is to experimentally evaluate the combined application of the Fibre Bragg Grating ...
Yasutake Kenichiro K Department of Nutritional Sciences, Faculty of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, - - 2014
The objective was to investigate the validity of a self-monitoring device that estimates 24-h urinary salt excretion from overnight urine samples as a tool for education regarding salt restriction. Twenty healthy volunteers consumed test meals for 14 days, with salt content as follows: 10 g (days 1-5); 5 g (days 6-8, 12 ...
Qian Yangyang Y Department of Chemical Engineering for Energy, Key Laboratory of Coal Gasification and Energy Chemical Engineering of Ministry of Education, East China University of Science and Technology, 130#, Meilong Road, Shanghai 200237, PR - - 2014
The pyrolysis of rice husk was conducted in a fixed-bed reactor with a sweeping nitrogen gas to investigate the effects of pressure on the pyrolytic behaviors. The release rates of main gases during the pyrolysis, the distributions of four products (char, bio-oil, water and gas), the elemental compositions of char, ...
Odagiri Takuya T 1 Seirei Hospice, Seirei Mikatahara General Hospital , Shizuoka, Japan - - 2014
Abstract Background: It is important to assess a patient's medical condition noninvasively, particularly in hospice care settings. Objective: The aim of this study was to investigate the reliability of manually measuring the radial pulse pressure and its validity for predicting the systolic blood pressure. Design: An observational study consisting of ...
Fukuyama Takahide T Department of Chemistry, Graduate School of Science, Osaka Prefecture University , Sakai, Osaka 599-8531, - - 2014
The generation of, and subsequent reactions with, 1-silyl-substituted organolithiums with CO was carried out using serially connected flow microreactors. The flow system proved to be quite useful for the carbonylation of silyl-substituted organolithiums under slightly pressurized conditions of CO, which was created conveniently by the use of a back-pressure regulator. ...
Govender M M MM Department of Human Physiology, School of Pathology and Pre-Clinical Sciences, Faculty of Health Sciences, University of Limpopo, Medunsa, Pretoria, South Africa. - - 2014
Oxidative stress is an imbalance between free radicals and antioxidants, and is an important etiological factor in the development of hypertension. Recent experimental evidence suggests that subpressor doses of angiotensin II elevates oxidative stress and blood pressure. We aimed to investigate the oxidative stress related mechanism by which a subpressor ...
Peng Ya-Guang YG From the State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (Y-GP, WL, X-XW, YL, and L-CZ) and the Public Health School, Gansu University of Traditional Chinese Medicine, Gansu, China - - 2014
Clinical trials assessing the effects of salt substitutes on blood pressure (BP) have reported mixed results. A meta-analysis of randomized controlled trials was conducted to evaluate the effect of salt substitutes on BP, including systolic BP (SBP) and diastolic BP (DBP). Studies were identified via systematic searches of the PubMed, ...
Zoerle Tommaso T 1Neuroscience ICU, Department of Anesthesia and Critical Care, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy. 2Department of Pathophysiology and Transplants, University of Milan, Milan, Italy. 3Department of Neuroscience, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. 4Neurosurgery Division, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, - - 2014
To describe mean intracranial pressure after aneurysmal subarachnoid hemorrhage, to identify clinical factors associated with increased mean intracranial pressure, and to explore the relationship between mean intracranial pressure and outcome. Analysis of a prospectively collected observational database. Neuroscience ICU of an academic hospital. One hundred sixteen patients with subarachnoid hemorrhage ...
Lemmer A A State Institute of Agricultural Engineering and Bioenergy, University of Hohenheim, Garbenstraße 9, D-70599 Stuttgart, Germany. Electronic address: - - 2014
The two-stage autogenerative high-pressure digestion technique is a novel and promising approach for the production of gaseous fuels or upgraded biogas. This new technique is described in the patent DE 10 2011 015415 A1 and integrates biogas production, its upgrading and pressure boosting in one process. Anaerobic digestion under elevated ...
Toyoshima Ryo R Department of Chemistry, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan. - - 2014
We investigated the high-density CO adsorption phase formed on a Pt(111) surface when exposed to CO gas of pressure ranging from UHV to 100 mTorr using near-ambient-pressure (NAP)-XPS. Combined results from the NAP-XPS measurements and DFT calculations reveal the adsorption structure of CO molecules in the dense CO overlayer, which ...
Patil J J JJ Department of Anaesthesia and Intensive Care, Airedale General Hospital, Steeton, - - 2014
Animal studies have shown that injection pressures > 75 kPa indicate probable intrafascicular needle tip position. This study describes the flow/pressure characteristics of seven common needle systems. A syringe pump delivered flow rates of 5, 6.67, 10, 13.3, 15 and 20 ml.min(-1) through these needle systems, while keeping the needle tips open to ...
Wang Pengjie P Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, PR China; Beijing Laboratory for Food Quality and Safety, Beijing, PR - - 2015
The effects of lactose on the changes in the composition and size of casein micelles induced by high-pressure treatment and the related mechanism of action were investigated. Dispersions of ultracentrifuged casein micelle pellets with 0-10% (w/v) lactose were subjected to high pressure (400MPa) at 20°C for 40min. The results indicated ...
Thuesen Betina H BH Research Centre for Prevention and Health, Glostrup University Hospital, Denmark - - 2014
Excessive salt intake causes increased blood pressure which is considered the leading risk for premature death. One major challenge when evaluating associations between daily salt intake and markers of non-communicable diseases is that a high daily salt intake correlates with obesity, which is also a well described risk factor for ...
Friedrich S S Nephrologie und Hypertensiologie, Universitätsklinikum Erlangen, Erlangen, - - 2014
We aimed to analyze benefits and risks of aliskiren treatment in older adults (⩾65 years) in clinical practice. Patients (n=14 986) were assigned to either aliskiren (ALIS), an angiotensin-converting-enzyme inhibitor or angiotensin receptor blocker (ACEi/ARB), or an agent not blocking the renin-angiotensin system (non-RAS). Older adults (n=7396) had a longer history ...
Alvine K J KJ Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland, Washington 99354, - - 2014
Degradation of material properties by high-pressure hydrogen is an important factor in determining the safety and reliability of materials used in high-pressure hydrogen storage and delivery. Hydrogen damage mechanisms have a time dependence that is linked to hydrogen outgassing after exposure to the hydrogen atmosphere that makes ex situ measurements ...
Guérout R R Laboratoire Kastler-Brossel, CNRS, ENS, UPMC, Case 74, F-75252 Paris, - - 2014
We carefully reexamine the conditions of validity for the consistent derivation of the Lifshitz-Matsubara sum formula for the Casimir pressure between metallic plane mirrors. We recover the usual expression for the lossy Drude model but not for the lossless plasma model. We give an interpretation of this new result in ...
Berry J D JD Department of Chemical and Biomolecular Engineering, University of Melbourne, Melbourne, Victoria 3010, Australia and Commonwealth Scientific and Industrial Research Organisation (CSIRO) Computational Informatics, Victoria 3169, - - 2014
Analysis tools that quantify the pressure and potential changes occurring over pressure-driven electrokinetic device elements are necessary for the design of optimal laboratory-on-a-chip devices. In this study, the resistance of a nanofluidic silica channel with negatively charged walls containing a 90^{∘} bend to the electroviscous flow of a potassium chloride ...
Sawa Takuma T Department of Cardiovascular Medicine, Hyogo Prefectural Amagasaki - - 2014
Background:In hypertensive patients, left ventricular hypertrophy (LVH) may persist despite satisfactory blood pressure (BP) control. The efficacy of thiazide diuretics in Western countries has been reported, but whether this applies to hypertensive Japanese patients is uncertain.Methods and Results:We randomly assigned 94 patients whose BP was poorly controlled with usual doses of angiotensin-II ...
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