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Chaturvedi Lakshmi S LS Department of Surgery, Michigan State University, Lansing, MI, - - 2012
Traumatic brain injury induces a neuroinflammatory response frequently associated with increased intracranial pressure. The aim of this study was to investigate the effects of alcohol and increased extracellular pressure on murine BV-2 microglial proliferation and cytokine responses to lipopolysaccharide (LPS) stimulation. BV-2 cells were cultured under 0 or 30 mm ...
Wood Matthew - - 2013
Transportation vehicles, whether they are passenger vehicles or heavy trucks and transport vehicles, rely upon rubber tires to negotiate the roadways and surfaces on which they are driven. These tires have the potential of sudden rupture resulting from various causes including but not limited to over-pressurization, sidewall failures, or punctures ...
Lv Faqin - - 2012
BACKGROUND: This research aimed to study the assessment of local muscle microcirculation perfusion of extremities that underwent crush injuries by using contrast-enhanced ultrasonography (CEUS). METHODS: A total of 28 New Zealand rabbits were anesthetized by using intramuscular pentobarbital sodium (30 mg/kg). A balloon cuff device was used to create crush ...
de Rougemont O - - 2012
BACKGROUND & AIMS: The aim of this study was to identify protective mechanisms of cold machine perfusion in liver grafts donated after cardiac death. METHODS: Pig livers exposed to 60 min warm ischemia were cold stored for 7 h or treated after 6 h cold storage by 1 h hypothermic ...
Satou Ryousuke R Department of Physiology and Hypertension and Renal Center of Excellence; Tulane University Health Sciences Center; New Orleans, LA - - 2012
The renin-angiotensin system (RAS) plays important roles in blood pressure control and tissue disease. An inappropriate local angiotensin II elevation in the kidneys leads to the development of hypertension, tissue damage and chronic injury. Studies have demonstrated that the JAK-STAT pathway mediates angiotensin II-triggered gene transcription. The JAK-STAT pathway in ...
Gingell-Littlejohn M - - 2012
Delayed graft function (DGF) is a major issue in kidney transplantation and is associated with reduced graft and patient survival. The condition results from the summative effects of multiple injurious processes associated with transplantation with many underlying factors being nonmodifiable. Reducing cold ischemic time and machine perfusion have decreased the ...
McWilliams R Stewart - - 2012
The structural and chemical properties of the bi-molecular, hydrogen-bonded, nitrogen-rich energetic material triaminoguanidinium 1-methyl-5-nitriminotetrazolate C(3)H(12)N(12)O(2) (TAG-MNT) have been investigated at room pressure and under high pressure isothermal compression using powder x-ray diffraction and Raman and infrared spectroscopy. A stiffening of the equation of state and concomitant structural relaxation between 6 ...
Heaton James T - - 2012
OBJECTIVES/HYPOTHESIS: Vocal fold (VF) injections of viscous materials are typically performed using hand-operated syringes or injection guns; however, these methods can be imprecise due to accumulation of pressure, effort-related tremor, and poor feedback regarding injection volume and rate. STUDY DESIGN: Apparatus development with laboratory bench-top and animal model testing. METHODS: ...
Kalkan B - - 2012
The compressibility and phase stability of Y bB(2) are investigated under high pressure using high-resolution synchrotron x-ray diffraction in a diamond anvil cell. The bulk modules of high purity Y bB(2) is obtained as ∼182 GPa using the Birch-Murnaghan equation of state. The patterns measured up to 20 GPa and the pressure ...
Ma Jun - - 2012
A miniature fiber-tip pressure sensor was built by using an extremely thin graphene film as the diaphragm. The graphene also acts as a light reflector, which, in conjunction with the reflection at the fiber end-air interface, forms a low finesse Fabry-Perot interferometer. The graphene based sensor demonstrated pressure sensitivity over ...
Byard Roger W - - 2013
The commercial fishing industry has one of the highest injury and mortality rates of all occupational areas. This results from the nature of the work involving vessels often manned by only a few individuals who are working with heavy-duty equipment in dangerous environments at all hours. Economic pressures may force ...
Pavan Barbara - - 2012
NMR is the technique of election to probe the local properties of materials. Herein we present the results of density functional theory (DFT) ab initio calculations of the NMR parameters for fluorapatite (FAp), a calcium orthophosphate mineral belonging to the apatite family, by using the GIPAW method (Pickard and Mauri, ...
Quraishi Abdul Haque M AH Government Medical College, 22, Vijaynagar, Chhaoni, Nagpur 440013 - - 2014
High pressure injection injury of the hand looks rather innocuous but has the potential of affecting the function. The radiological picture is quite alarming and it gives a fair idea about the extent of the damage. The description and the images which follow, emphasize the need for an early and ...
Hikal Walid M - - 2012
Non-isothermal measurements of thermodynamic parameters and vapor pressures of low-volatile materials are favored when time is a crucial factor to be considered, such as in the case of detection of hazardous materials. In this article, we demonstrate that optical absorbance spectroscopy can be used non-isothermally to estimate the thermodynamic properties ...
Bennani Vincent - - 2012
Handling properties of cordless gingival displacement materials is not well understood, resulting in incorrect use. Insufficient displacement of the gingival margin may result in a poor impression. This study investigated the pressure generated by a cordless displacement paste with respect to different techniques. Two chambers with dimensions of 5 × ...
Enmark Martin - - 2012
Enantiomeric separation of omeprazole has been extensively studied regarding both product analysis and preparation using several different chiral stationary phases. In this study, the preparative chiral separation of omeprazole is optimized for productivity using three different columns packed with amylose tris (3,5-dimethyl phenyl carbamate) coated macroporous silica (5, 10 and ...
Sun Zhimei - - 2012
With the advent of big synchrotron facilities around the world, pressure is now routinely placed to design a new material or manipulate the properties of materials. In GeTe, an important phase-change material that utilizes the property contrast between the crystalline and amorphous states for data storage, we observed a reversible ...
Wang Yi - - 2012
Objective: To investigate the material properties of normal and degenerated intervertebral discs (IVDs) and examine the effect of degenerative changes on IVD pathology. Methods: A computer-based online search was undertaken to identify English articles about material properties of IVDs published from January 1950 to 2011 in PubMed database. The retrieved ...
Vanhecke D - - 2012
We describe how high-pressure freezing of infectious biological material can safely be accomplished with the help of membrane carriers. The method described is easy to perform; however, careful manipulations are required. Existing safety regulations must still be followed. However, the procedure reduces the risk of dissemination of infectious material.
Sun Liling - - 2012
Pressure has an essential role in the production and control of superconductivity in iron-based superconductors. Substitution of a large cation by a smaller rare-earth ion to simulate the pressure effect has raised the superconducting transition temperature T(c) to a record high of 55 K in these materials. In the same way ...
Flower Oliver - - 2012
Several different classes of sedative agents are used in the management of patients with traumatic brain injury (TBI). These agents are used at induction of anaesthesia, to maintain sedation, to reduce elevated intracranial pressure, to terminate seizure activity and facilitate ventilation. The intent of their use is to prevent secondary ...
Tan Robert - - 2012
We are developing an in vivo pressure sensor that measures the change in conductance of a deformable electrolyte-filled catheter resulting from external pressure. The sensor design and materials are easily scaled and inexpensive. The compact, in vivo nature of the device may result in the compact instrumentation being unobtrusively affixed ...
Sen Indu I Anaesthesia and Intensive Care Department, Post Graduate Institute of Medical Education and Research, Chandigarh, - - 2012
Posttraumatic intravasation of fat and debris can lead to a cascade of events. Hydroxyethyl starches (HES) markedly suppress neutrophil influx by decreasing pulmonary capillary permeability and facilitating tissue oxygenation by improving microcirculation. It was hypothesized that in hypoxemic femur injury patients undergoing operative stabilization, HES administration will prevent the deterioration ...
Malkoun Mario - - 2011
Current heel protection devices used in the operating room do not comply with the consensus document of the European and National (North American) Pressure Ulcer Advisory Panels. A complying prototype has been tested. Prospective cohort study comparing interface pressures. While using the prototype device, the heel interface pressure is significantly ...
Dell'italia Louis J - - 2011
The title of the proposed series of reviews is Translational Success Stories. The definition of "translation" according to Webster is, "an act, process, or instance of translating as a rendering of one language into another." In the context of this inaugural review, it is the translation of Tigerstedt's and Bergman's(1) ...
Matsui Yuko - - 2011
DESIGN is a seven-item (depth, exudates, size, inflammation/infection, granulation, necrosis, and pocket) monitoring scale for pressure ulcers developed in 2002 by the scientific education committee of the Japanese Society of Pressure Ulcers. DESIGN is a very useful tool for chronological monitoring of each pressure ulcer, but a key limitation of ...
Su Chao-Ton - - 2011
Pressure ulcer is a serious problem during patient care processes. The high risk factors in the development of pressure ulcer remain unclear during long surgery. Moreover, past preventive policies are hard to implement in a busy operation room. The objective of this study is to use data mining techniques to ...
Dastouri Pouya - - 2011
Negative-pressure wound therapy applied with a porous foam interface has been shown to accelerate granulation-tissue formation when a cyclic application mode of suction is applied, but the optimal waveform has not been determined. The authors hypothesized that changes in the suction waveform applied to wounds would modulate the biological response ...
Borgquist Ola - - 2011
Currently available research suggests that negative pressure wound therapy (NPWT) creates a moist wound healing environment, drains exudate, reduces tissue edema, contracts the wound edges, mechanically stimulates the wound bed, and influences blood perfusion at the wound edge, which may lead to angiogenesis and the formation of granulation tissue. Although ...
Mouës C M - - 2011
Topical negative pressure (TNP) therapy has become a useful adjunct in the management of various types of wounds. However, the TNP system still has characteristics of a "black box" with uncertain efficacy for many users. We extensively examined the effectiveness of TNP therapy reported in research studies. A database search ...
Knudsen Cathrine Wold - - 2011
Background. Pressure sores are common and affect 10-20% of all institutionalized patients. Health personnel should have sufficient knowledge of prevention, evaluation and treatment. Material and methods. This article is based on a non-systematic search in Medline and EMBASE, and the authors' own clinical experience. Results. The causes of pressure sores ...
Kuffler Damien P - - 2011
Wounds have always afflicted humanity causing pain, suffering and death, and for thousands of years humans have tested and developed various techniques for their ability to induce wound healing. Hyperbaric oxygen therapy (HBOT) refers to placing a patient or their extremity in a chamber in which the pressure is raised ...
Stephen-Haynes Jackie - - 2011
This article identifies the importance of pressure ulcers currently within the UK, the challenge of providing care and the impact on patients who develop them. In the Wound Expo 2010 pressure ulcer zone the educators explored the most significant challenge of pressure area care within their clinical environment from 180 ...
Haynes Jackie Stephen - - 2011
Ask health professionals about the development of pressure ulcers and you will likely find a consistent view that they are preventable; however, historically there has been an attitude of fault finding and denial among health professionals about the issue. Indeed, Judy Waterlow once joked to me that pressure ulcers must ...
Cook Leanne - - 2011
Venous leg ulcers can be highly exuding and moisture management is often challenging. The emergence of super-absorbent dressings have been marketed as a tool to manage high levels of exudate, in combination with compression therapy, for the management of venous leg ulcers. Compression bandages are designed to give precise amounts ...
Harada Kazuhiko - - 2011
Pressure ulcers are one of the most common complications in elderly, incontinent or paralyzed patients. For the healing of pressure ulcers, the development of granulation tissue and reepithelialization are required. Adrenomedullin (AM), an endogenous vasodilator peptide, is reported to stimulate the proliferation and migration of various cells including endothelial cells, ...
Yang Ching-Hsiang - - 2011
Pressure sore reconstruction is quite difficult for plastic surgeons because of long-term high recurrence rates. We designed a freestyle perforator-based flap for pressure sore reconstruction considering pressure sore recurrence and further reconstruction. We used a handheld Doppler device to locate a perforator position just adjacent to the pressure ulcer. In ...
Stojadinovic Olivera - - 2011
The incidence of nonhealing wounds (diabetic foot, pressure, venous, and arterial ulcers) is reaching epidemic proportions, underscoring the need for new treatment modalities. Understanding hair follicle biology and its potential to accelerate wound healing may offer new treatment strategies. In this issue, Ansell et al. show that wounds on anagen ...
Jaul Efraim - - 2011
Local (extrinsic) and systemic (intrinsic) risk factors for the development of pressure ulcers over bony prominences such as the sacrum, coccyx, ischium, gluteal area, and leg area (heels) have been extensively studied and documented. Several case studies have described (but little is known about) pressure ulcers in atypical anatomical locations. ...
Bode Maj Kenneth - - 2011
This prospective, randomized, blinded pilot study determined if a difference was present in the histology and apoptotic rate of articular cartilage after application of a negative pressure wound therapy (NPWT) device to an uninjured joint surface compared to a control side using Capra hircus goats. The goats were euthanized at ...
Sung T Y - - 2011
This study investigated 151 patients undergoing cardiac surgery to determine whether measurement of regional cerebral oxygen saturation (rS(c)O(2)) using near-infrared spectroscopy (NIRS) can indicate a low haematocrit after initiation of hypothermic cardiopulmonary bypass (CPB). Haematocrit, rS(c)O(2), haemoglobin level, arterial partial pressures of carbon dioxide and oxygen, systemic blood pressure, and ...
Sung Young Hee - - 2011
We sought to determine the factors affecting pressure ulcer (PU) healing in an acute care facility in Korea. Data were collected between October 1, 2006, and September 30, 2007, regarding PU status and factors hypothesized to influence wound healing. We developed a form that queried factors thought to affect PU ...
Kieser D C - - 2011
l O bjective: To determine the efficacy of negative pressure wound therapy (NPWT), when used in combination with compression bandaging, for healing chronic resistant venous ulcers. l Method: In this pilot study, seven patients (with a total of 12 chronic resistant venous ulcers) received adjunctive NPWT and compression bandaging for ...
Orgill Dennis P - - 2011
Over the last 15 years, negative-pressure wound therapy has become commonly used for treatment of a wide variety of complex wounds. There are now several systems marketed, and additional products will be available in the near future. Many clinicians have noted a dramatic response when negative-pressure wound therapy technology has ...
Sell Scott A - - 2011
Chronic pressure ulcers affect patient health, emotional state, and quality of life, causing considerable morbidity and mortality in addition to contributing to significant health care costs from lengthy hospitalizations to advanced home care and surgical care costs. The conventional treatment of these wounds can be slow due to their chronic ...
Kiessling Arndt H - - 2011
Vacuum-assisted closure (VAC) of complex infected wounds has recently gained popularity among various surgical specialties. The system is based on the application of negative pressure by controlled suction to the wound surface. The effectiveness of the VAC System on microcirculation and the promotion of granulation tissue proliferation are proved. No ...
Lindstedt Sandra - - 2011
Higher closure rates of the open abdomen have been reported with negative pressure wound therapy (NPWT) than with other wound management techniques. However, the method has occasionally been associated with increased development of fistulae. We have previously shown that NPWT induces ischemia in the underlying small intestines close to the ...
Lindstedt Sandra - - 2011
There are increasing reports of deaths and serious complications associated with the use of negative pressure wound therapy (NPWT), of which right ventricular heart rupture is the most devastating. The use of a rigid barrier has been suggested to offer protection against this lethal complication by preventing the heart from ...
Malmsjö Malin - - 2011
Negative pressure wound therapy (NPWT) has remarkable effects on the healing of poststernotomy mediastinitis. Foam is presently the material of choice for NPWT in this indication. There is now increasing interest in using gauze, as this has proven successful in the treatment of peripheral wounds. It is important to determine ...
Garvin Jeffrey L JL Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA. - - 2011
NaCl absorption along the nephron is regulated not just by humoral factors but also by factors that do not circulate or act on the cells where they are produced. Generally, nitric oxide (NO) inhibits NaCl absorption along the nephron. However, the effects of NO in the proximal tubule are controversial ...
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