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Joosten Alexandre A Department of Anesthesiology and Perioperative Care, University of California, Irvine, 101 The City Drive South, Orange, CA 92868, USA; Department of Anesthesiology and Critical Care, Erasme University Hospital, Free University of Brussels, 808 Lennick Road, Brussels 1070, - - 2015
There is still no "universal" consensus on an optimal endpoint for goal directed therapy (GDT) in the critically ill patient. As in other areas of medicine, this should help providers to focus on a more "individualized approach" rather than a protocolized approach to ensure proper patient care. Hemodynamic optimization needs ...
Linder Jonathan R - - 2014
We sought to determine whether heart rate variability (HRV), blood pressure (BP) variability, and baroreceptor-heart rate reflex sensitivity can be reliably assessed using finger volume pulse waveforms obtained from the commercially available EndoPAT device. Non-invasive BP (Finometer Pro as a non-invasive standard) and finger volume (EndoPAT) waveforms were recorded in ...
Bae Sanghyuk S From the Department of Preventive Medicine and Environmental Health Center, College of Medicine (S.B., Y.-C.H.), and Institute of Environmental Medicine, Medical Research Center (Y.-C.H.), Seoul National University, Jongrogu, Seoul, Republic of - - 2014
Bisphenol A (BPA) is a chemical used in plastic bottles and inner coating of beverage cans, and its exposure is almost ubiquitous. BPA has been associated with hypertension and decreased heart rate variability in the previous studies. The aim of the present study was to determine whether increased BPA exposure ...
Poliacek Ivan I Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin - - 2014
Background and purpose. We tested the hypothesis that nicotine (NIC), which acts peripherally to promote coughing, might inhibit reflex cough at a central site. Experimental approach. NIC was administered via the vertebral artery (ia) to the brainstem circulation and by microinjections into a restricted area of the caudal ventral respiratory ...
Drobná M M Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovak Republic. - - 2014
We studied the effects of the H(2)S donor Na(2)S on the mean arterial blood pressure (MAP) and heart and breathing rates of anaesthetised Wistar rats in the presence and absence of captopril. Bolus administration of Na(2)S (1-4 micromol/kg) into the right jugular vein transiently decreased heart and increased breathing rates; ...
Chaswal M M Department of Physiology, Hamdard Institute of Medical Sciences & Research, Jamia Hamdard, New Delhi, India. - - 2014
Nitric oxide (NO) plays a crucial role not only in regulation of blood pressure but also in maintenance of cardiac autonomic tone and its deficiency induced hypertension is accompanied by cardiac autonomic dysfunction. However, underlying mechanisms are not clearly defined. We hypothesized that sympathetic activation mediates hemodynamic and cardiac autonomic ...
Millar Philip J PJ University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, - - 2014
-Muscle sympathetic activation in heart failure with reduced ejection fraction (HFrEF) has been attributed, on the basis of multi-unit recordings, to attenuated inhibitory feedback from stretch-sensitive cardiopulmonary mechanoreceptors. However, such preparations integrate two populations of single-units exhibiting directionally opposite firing when atrial pressure is perturbed. We tested the hypothesis that ...
Naeije Robert R Dept of Cardiology, Erasme University Hospital, Brussels, Belgium. Dept of Experimental, Diagnostic and Specialty Medicine (DIMES), Bologna University Hospital, Bologna, Italy. - - 2014
Pulmonary arterial hypertension (PAH) is a right heart failure syndrome. In early-stage PAH, the right ventricle tends to remain adapted to afterload with increased contractility and little or no increase in right heart chamber dimensions. However, less than optimal right ventricular (RV)-arterial coupling may already cause a decreased aerobic exercise ...
Alian Aymen A AA Department of Anesthesiology, Yale University School of Medicine, New Haven, CT, USA. Electronic address: - - 2014
The photoplethysmographic (PPG) waveform, also known as the pulse oximeter waveform, is one of the most commonly displayed clinical waveforms. First described in the 1930s, the technology behind the waveform is simple. The waveform, as displayed on the modern pulse oximeter, is an amplified and highly filtered measurement of light ...
Shimizu Shuji S Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan, - - 2014
A hybrid procedure combining bilateral pulmonary artery banding with ductal stenting has recently been used as stage I palliation for hypoplastic left heart syndrome. However, the advantage of the hybrid procedure over the Norwood procedure on ventricular energetics remains unclear. To clarify this, we performed a computational analysis with a ...
Kato Takao T Takao Kato, Department of Cardiology, Juntendo University School of Medicine, Tokyo 113-8421, - - 2014
Heart failure (HF) is a life-threatening disease and is a growing public health concern. Despite recent advances in pharmacological management for HF, the morbidity and mortality from HF remain high. Therefore, non-pharmacological approaches for HF are being developed. However, most non-pharmacological approaches are invasive, have limited indication and are considered ...
Carley Andrew N AN Program in Integrative Cardiac Metabolism, Center for Cardiovascular Research, University of Illinois at Chicago College of Medicine, Chicago, IL; Department of Physiology and Biophysics, University of Illinois at Chicago College of Medicine, Chicago, - - 2014
-The failing heart displays increased glycolytic flux that is not matched by a commensurate increase in glucose oxidation. This mismatch induces increased anaplerotic flux and inefficient glucose metabolism. We previously found adult transgenic mouse hearts expressing the fetal troponin I isoform, (ssTnI) to be protected from ischemia by increased glycolysis. ...
Camporeale Angelo A Eli Lilly Italia, Sesto Fiorentino, - - 2014
The safety profile of atomoxetine in the treatment of attention deficit hyperactivity disorder has been studied in many clinical trials. We performed an integrated safety analysis of 15 clinical trials in adults with attention deficit hyperactivity disorder. The analysis pooled patient data into three groups: acute placebo-controlled trials; long-term placebo-controlled ...
Yan X Sherwin XS Scientific Affairs, A.W. Spears Research Center, Lorillard Tobacco Company, Greensboro, NC, United States. Electronic address: - - 2014
The development of electronic cigarettes (e-cigs) has the potential to offer a less harmful alternative for tobacco users. This clinical study was designed to characterize e-cig users' exposure to nicotine, and to investigate the acute effects of e-cigs on the hemodynamic measurements (blood pressure and heart rate) in comparison with ...
Oldenburg Olaf O Department of Cardiology, Heart and Diabetes Centre North Rhine-Westphalia, University Hospital, Ruhr University Bochum, Georgstrasse 11, D-32545, Bad Oeynhausen, Germany, - - 2014
Adaptive servo-ventilation (ASV) is a positive pressure ventilator support system to normalize ventilation in patients with Cheyne-Stokes respiration (CSR). The latest generation enhanced ASV device (PaceWave™; ResMed) has a new feature-auto-adjustment of EPAP. This study tested the hypothesis that enhanced ASV with auto-adjustment of EPAP (PaceWave™) is non-inferior to conventional ...
Broch Kaspar - - 2014
Abstract Objectives: Diastolic dysfunction is a major cause of morbidity in heart transplant recipients. A reliable, non-invasive marker of left ventricular (LV) filling pressure would simplify follow-up in these patients. We aimed to test the validity of echocardiographic indices of LV filling pressure in a contemporary population of heart transplant ...
Cooper Leroy L LL Cardiovascular Engineering, Inc., Norwood, MA & Rhode Island Hospital, W. Alpert Medical School of Brown University, Providence, - - 2014
-Elevated blood pressure is the leading modifiable risk factor for cardiovascular disease (CVD) and premature death. The blood pressure waveform consists of discrete hemodynamic components, derived from measured central pressure and flow, which may contribute separately to risk for an adverse outcome. However, pressure-flow measures have not been studied in ...
Schmidli Jürg J Dept of Cardiovascular Surgery, Bern University Hospital, 3010, Bern, Switzerland, - - 2014
The Barostim neo(TM) system is a novel implantable device that activates the carotid baroreflex. It decreases the sympathetic activity and inhibits the renin system, which results in reduced blood pressure and heart rate. In patients with resistant hypertension, electrically activation of the baroreflex leads to an average decrease in systolic ...
Baik Nariae N Division of Neonatology, Medical University, Graz, - - 2014
Background: The fetal-to-neonatal transition is a complex process that includes changes in cardiac and respiratory systems. Objective: The aim of this study is to review the different methods of cardiocirculatory monitoring during the immediate neonatal transition period. Methods: A systematic search of PubMed and Ovid Embase was performed using the ...
Schernthaner Christiana C Department of Cardiology, Salzburger Landeskliniken, Paracelsus Private Medical University, Muellner Hauptstraße 48, 5020, Salzburg, Austria, - - 2014
Arrhythmogenic right ventricular dysplasia (ARVD) is often associated with progressive right ventricular dysfunction. Although heart transplantation (HTx) is suggested in these patients, indication and optimal timing for listing can be challenging. The study comprises four patients (two male, range: 37-56 years) with advanced ARVD who were considered for HTx. Standard ...
Laborde Sylvain S German Sport University Cologne, Institute of Psychology, Germany. Electronic address: - - 2014
There is growing evidence illustrating the negative aspects of reinvestment on everyday life, however its underlying mechanisms remain unclear. The main aim of this study was to empirically clarify the relationship between reinvestment and working memory (WM). A secondary aim was to investigate the contribution of high-frequency heart rate variability ...
Oldenburg Olaf O Department of Cardiology, Heart and Diabetes Center NRW, University Hospital, Ruhr University Bochum, Georgstrasse 11, 32545, Bad Oeynhausen, Germany, - - 2014
In patients with heart failure (HF), Cheyne-Stokes respiration (CSR) is characterized by chronic hyperventilation (HV) with low arterial partial pressure of carbon dioxide (pCO2). It is still unclear whether this HV represents a compensatory response to HF or an independent comorbidity. This study investigated the hemodynamic effects of HV in ...
Deng Alan Y AY Research Centre, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, - - 2014
Heart failure accounts for a significant portion of heart diseases. Molecular mechanisms gradually emerge that participate in pathways leading to left ventricular dysfunction in common systolic heart failure (SHF) and diastolic heart failure (DHF). A human genome-wide association study (GWAS) identified two markers for SHF and no GWAS on DHF ...
Esfandiari Sam S Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, - - 2014
Chronic heart rate (HR) reduction in the treatment of heart failure (HF) with systolic dysfunction is beneficial, but the immediate mechanical advantages or disadvantages of altering HR are incompletely understood. We examined the effects of increasing HR on early and late diastole in humans with and without HF. We studied ...
Holland Maureen M Blood Pressure & Heart Research Centre, Stepping Hill Hospital, Stockport, Cheshire, SK2 7JE, - - 2014
No universally accepted guideline exists for measurement of blood pressure for patients confined to bed. The aim was to establish areas of technique that might be open to standardization to improve measurement reliability similar to those used for office BP measurements. In-patient blood pressure measurement (IPBPM) was closely observed in ...
Tanaka Kunihiko K Kunihiko Tanaka, MD, PhD, is Professor; Shiori Tokumiya, is Undergraduate Student; and Yumiko Ishihara, is Undergraduate Student, Department of Radiological Technology, Gifu University of Medical Science, Japan. Yumiko Kohira, MS, is Assistant Professor, Department of Nursing, Gifu University of Medical Science, Gifu, Japan. Tetsuro Katafuchi, PhD, is Professor, Department of Radiological Technology, Gifu University of Medical Science, - - 2014
Change in posture from supine to standing induces a footward fluid shift. This shift might decrease arterial pressure (AP) and induce orthostatic hypotension. To prevent decrease in AP, compression stockings are recommended, but the effects of various lengths have not been compared. The aim was to compare AP and heart ...
Kurtz Theodore W TW Department of Laboratory Medicine, University of California, San Francisco, San Francisco, - - 2014
Few studies have systematically investigated whether daily patterns of arterial blood pressure over 24 h are mediated by changes in cardiac output, peripheral resistance, or both. Understanding the hemodynamic mechanisms that determine the 24 h patterns of blood pressure may lead to a better understanding of how such patterns become ...
Cheng Xinqi X Department of Anesthesiology, First Affiliated Hospital of Anhui Medical University, Hefei, - - 2014
The aim of this study was to compare the effects of anesthesia by dexmedetomidine and propofol on the hemodynamics and oxygen balance in children with complex congenital heart disease who were undergoing cardiac surgery. Fifty-seven children were randomized to receive either a continuous infusion of propofol (6-8 mg/kg/h) or dexmedetomidine (0.5-0.7 μg/kg/h) ...
Pokharel Yashashwi Y From the Department of Medicine, Michael E. DeBakey Veterans Affairs Hospital, Houston, TX (S.S.V., B.B., V.N.); Baylor College of Medicine, Houston, TX (Y.P., W.S., G.E.T., S.S.V., R.C.H., B.B., C.M.B., V.N.); Department of Medicine, Methodist DeBakey Heart Center, Houston, TX (Y.P., S.S.V., R.C.H., C.M.B., V.N.); Department of Medicine, University of Texas Southwestern Medical Center, Dallas (J.A.d.L.); Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX (S.S.V., B.B., C.M.B., V.N.); Department of Medicine, Johns Hopkins University, Baltimore, MD (C.E.N., J.C.); Department of Medicine, University of Mississippi Medical Center, Jackson (T.H.M.); National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (J.D.W.); Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill (G.H.); Department of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston (E.A.B.); and Department of Medicine, Harvard Medical School, Boston, MA - - 2014
Based on observational studies, there is a linear increase in cardiovascular risk with higher systolic blood pressure (SBP), yet clinical trials have not shown benefit across all SBP categories. We assessed whether troponin T measured using high-sensitivity assay was associated with cardiovascular disease within SBP categories in 11 191 Atherosclerosis Risk ...
Wang Fan - - 2014
High-density lipoprotein (HDL) has been shown to confer cardiovascular protection in clinical and epidemiologic studies. Emerging evidence suggests that many of the cardioprotective functions of HDL may be due to the phospholipid sphingosine-1-phosphate (S1P). HDL-S1P binds to S1P receptors in the heart, activating PI3K/Akt signaling and myocyte survival. PI3K/Akt is ...
Brant Sarah M SM Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address: - - 2014
Donation after circulatory determination of death (DCDD) involves variable definitions of death among hospitals, and DCDD hearts are not generally considered for transplantation. The definition can affect ischemic times, and machine perfusion preservation appears promising for recovery of DCDD hearts. The purpose of the current study was to investigate the ...
D'Alto Michele M Department of Cardiology, Second University of Naples - Monaldi Hospital, Naples, Italy. Electronic address: - - 2014
The differential diagnosis between pre- and postcapillary pulmonary hypertension (PH) is of major therapeutic relevance and thus requires optimal clinical probability assessment with echocardiography. We prospectively analyzed 152 consecutive patients referred to a PH center over a 1-year period undergoing quasi-simultaneous (within 1 hour) echocardiography and right heart catheterization. Echocardiography was ...
Wolf Andrew R AR Centre for Structural and Congenital Heart Disease, Rush University Medical Centre, Chicago, IL, - - 2014
Perioperative monitoring of ventilation, gas exchange, heart rate, blood pressure, and other basic physiological measures give important information on the well-being of the child in the perioperative period. However, despite this level of surveillance, perioperative events that appear to be unheralded still occur. Improvements in alarms and alarm design combined ...
Mokra D D Department of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 4 Mala Hora St., SK-03601, Martin, Slovakia, - - 2014
Anti-inflammatory drugs are increasingly used for treatment of neonatal meconium aspiration syndrome (MAS), but their adverse effects are poorly known. Therefore, the aim of this study was to evaluate the effects of the antioxidant N-acetylcysteine on cardiovascular parameters in an animal model of MAS. Oxygen-ventilated rabbits were intratracheally instilled 4 ...
Asensio Enrique E Hospital Medica TEC 100. - - 2014
Syncope is a common symptom and most patients have a neurally mediated origin. These patients have to be studied with a careful history and a physical exploration that should include simple manoeuvers such as blood pressure recordings in decubitus and in standing position. These tools can suggest a diagnosis in ...
Prieto Isabel I Unit of Physiology Department of Health Sciences, University of Jaén, Jaén, - - 2014
The renin-angiotensin system (RAS) plays a major role in the control of blood pressure (BP) and water balance by coordinating brain, heart and kidney functions, connected with each other by hormonal and neural mechanisms through the autonomic nervous system (ANS). The RAS function may be monitored by the study of ...
Poelzl G G Clinical Division of Cardiology, Innsbruck Medical University, - - 2014
Elevated levels of fibroblast growth factor 23 (FGF23) are associated with incident heart failure in individuals with or without chronic kidney disease. We aimed to investigate the association between serum FGF23 concentrations and disease severity and long-term outcome in patients with stable heart failure. Serum levels of C-term FGF23 (Ct-FGF23) ...
Adamson Philip B PB Heart Failure Institute at Oklahoma Heart Hospital, Oklahoma City, OK - - 2014
-No treatment strategies have been demonstrated to be beneficial for the population for patients with heart failure and preserved ejection fraction. -The CHAMPION Trial was a prospective, single-blinded, randomized controlled clinical trial testing the hypothesis that hemodynamically guided heart failure management decreases decompensation leading to hospitalization. Of the 550 patients ...
Zeng Shi S Department of Ultrasonography, The Second Xiangya Hospital, Central South University, No.139 Middle Renmin Road, Changsha, Hunan, 410011, P.R. - - 2014
This study investigated the volume of intracranial structures in fetuses with complex congenital heart disease (CHD). Total intracranial volume (TIV), frontal lobe volume (FLV), thalamus volume (TV) and cerebellum volume (CV) were compared prospectively in 73 fetuses with CHD and 168 normal fetuses using 3D ultrasound combined with Virtual Organ ...
Roeth Nathan A NA Departments of - - 2014
Because heart rate affects ventricular filling, the aim of the present study was to assess the effects of increasing heart rate and tidal volume on stroke volume variability to determine whether this dynamic index is heart-rate dependent. Prospective, randomized study. Single university hospital. Eighteen vascular surgery patients having general anesthesia ...
Estep Jerry D JD Houston Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, Texas. Electronic address: - - 2014
Hemodynamics assessment is important for detecting and treating post-implant residual heart failure, but its accuracy is unverified in patients with continuous-flow left ventricular assist devices (CF-LVADs). We determined whether Doppler and 2-dimensional transthoracic echocardiography reliably assess hemodynamics in patients supported with CF-LVADs. Simultaneous echocardiography and right heart catheterization were prospectively ...
Liang Ruijuan R aDepartment of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing bDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & School of Basic Medicine Peking Union Medical College, - - 2014
Comprehensive studies have confirmed that particulate matter air pollution could trigger myocardial infarction, heart failure and reduce heart rate variability; however, its effect on blood pressure (BP) remains controversial. Therefore, we did a systematic review and meta-analysis to investigate the association and its magnitude between exposure to PM2.5 and BP. ...
Marques Nicole Ribeiro NR Department of Anesthesiology, The University of Texas Medical Branch, Galveston, - - 2014
Objective To determine if passive leg raising (PLR) significantly increases cardiac output in a cohort of healthy pregnant women during the third trimester. Study Design Using a noninvasive monitor, baseline hemodynamic measurements for arterial blood pressure, systolic and diastolic blood pressure, heart rate, cardiac output, cardiac index, stroke volume, and systemic vascular ...
Koenig Steven C SC 1Department of Cardiovascular and Thoracic Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY 40202 2Department of Bioengineering, University of Louisville, Louisville, KY 40202 3APK Advanced Medical Technologies, 575 14th Street NW, Atlanta, GA - - 2014
APK Advanced Medical Technologies (Atlanta, GA) is developing a sutureless beating heart (SBH) left ventricular assist device (LVAD) connector system consisting of anchoring titanium coil, titanium cannula with integrated silicone hemostatic valve, coring and delivery tool, and LVAD locking mechanism to facilitate LVAD inflow surgical procedures. Feasibility testing was completed ...
Morishita Masako M School of Public Health, University of Michigan, Ann Arbor, Michigan, - - 2014
Although fine particulate matter (PM) air pollution <2.5 μm in aerodynamic diameter (PM2.5) is a leading cause of global morbidity and mortality, the potential health effects of coarse PM (2.5-10 μm in aerodynamic diameter; PM10-2.5) remain less clearly understood. We aimed to elucidate the components within coarse PM most likely responsible for ...
Catalano Mariella M Research Center on Vascular Diseases and Angiology Unit, University of Milan, Milan, - - 2014
Aortic augmentation index (AIx) is used to investigate arterial stiffness. The authors tested the hypothesis that patients with peripheral arterial disease (PAD) demonstrate a higher AIx and also evaluated several related factors. In 97 patients with PAD, identified by ankle-brachial pressure index (ABPI ≤0.9), and 97 controls (ABPI ≥0.91<1.4), AIx ...
Yeo Khung Keong KK Division of Cardiovascular Medicine, University of California Davis Medical Center, Sacramento, California; Department of Cardiology, National Heart Centre Singapore, Singapore. Electronic address: - - 2014
The rate of concurrent right-heart catheterization (RHC) in patients undergoing left-heart catheterization (LHC) for coronary artery disease (CAD) indications or bilateral heart catheterization (BHC) is recommended as a measure of hospital quality, with higher rates suggesting over utilization. Our aim was to describe the prevalence of BHC and abnormal RHC ...
Blank Doug D Division of Neonatology, UCSD Medical Center, University of California, San Diego, CA, USA. Electronic address: - - 2014
Heart rate is the most important indicator of infant well-being during neonatal resuscitation. The Nellcor Pedi-Cap turns gold when exposed to exhaled gas with CO2>15mmHg. The aim of this study was to determine if Pedi-Cap gold color change during neonatal resuscitation precedes an increase in heart rate in babies with ...
Liao Ru-Jia RJ Department of Pharmacology, School of Medicine, Nantong University, Nantong, - - 2014
Our previous studies show that protein phosphatase 1γ (PP1γ) exacerbates cardiomyocyte apoptosis through promotion of Ca(2+) /calmodulin-dependent protein kinase δ (CaMKIIδ) splicing. Here we determine the role of PP1γ in abdominal aorta constriction (AAC)-induced hypertrophy and remodeling in rat heart. Systolic blood pressure (SBP) and echocardiographic (Echo) measurements were used ...
Parkes M M University of Birmingham, Senior Lecture, Exercise and Rehabilitation Sciences, Edgbaston, UNITED - - 2014
objectives: While there is recent interest in using repeated deep inspiratory breath-holds, or prolonged single breath-holds, to improve radiotherapy delivery, breath-holding has risks. There are no published guidelines for monitoring patient safety and there is little clinical awareness of the pronounced blood pressure rise and the potential for gradual asphyxia ...
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