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Wang Mofei M Department of Physiology II, Kanazawa Medical University, Uchinada Ishikawa 920-0293, Japan; Department of Colorectal surgery, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, - - 2014
Systemic anaphylaxis is life-threatening, and its pathophysiology is not fully clarified. Mice are frequently used for experimental study on anaphylaxis. However, the hemodynamic features and mechanisms of mouse anaphylactic hypotension remain unknown. Therefore, we determined mechanisms of systemic and pulmonary vascular response to anaphylactic hypotension in anesthetized BALB/c mice by ...
Chen Cheng-Hsien CH Division of Nephrology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, - - 2014
Epithelial-mesenchymal transition (EMT) occurs in stressed tubular epithelial cells, contributing to renal fibrosis. Initial mechanisms promoting EMT are unknown. Pressure force is an important mechanism contributing to the induction and progression of renal fibrogenesis in ureteric obstruction. In our study of cultured rat renal tubular cells (NRK-52E) under 60 mmHg ...
Maset Angelo Luiz AL Department of Neurosurgery, FUNFARME, São José do Rio Preto, SP; Founder and Owner for Ventura Biomedica Ltda, - - 2014
Ventriculoperitoneal shunts are supplied with long peritoneal catheters, most commonly between 80 and 120 cm long. ISO/DIS 7197/2006([15]) shunt manufacturing procedures include peritoneal catheter as an integrate of the total resistance. Cutting pieces of peritoneal catheters upon shunt implantation or revision is a common procedure. We evaluated five shunts assembled ...
Carugo D - - 2013
Fluid dynamics in the obstructed and stented ureter represents a non-trivial subject of investigation since, after stent placement, the urine can flow either through the stent lumen or in the extra-luminal space located between the stent wall and the ureteric inner wall. Fluid dynamic investigations can help understanding the phenomena ...
Jakobsen Jørn Skibsted - - 2013
The experiments performed in this PhD thesis were conducted at the Institute of Experimental Surgery, Skejby Hospital, Aarhus, Denmark and at the Laboratory of Animal Science, Odense University Hospital, Denmark. The thesis is based on 3 peer review articles published in international journals and a review. Diagnostic or therapeutic endoscopic ...
Chen Cheng-Hsien - - 2012
Statins are reported to alleviate renal fibrosis in animal models with ureteral obstruction. However, the molecular mechanism of this antifibrotic effect is still unclear. Pressure force is an important mechanism contributing to induction and progression of tubulointerstitial fibrogenesis in ureteric obstruction. In this study, we investigated the influence of rosuvastatin ...
Wang Agnes J AJ Department of Surgery, Division of Urology, Duke University Medical Center, Durham, NC 27713, - - 2013
Abstract Background and Purpose: Topical chemotherapy for urothelial cancer is dependent on adequate contact time of the chemotherapeutic agent with the urothelium. To date, there has not been a reliable method of maintaining this contact for renal or ureteral urothelial carcinoma. We evaluated the safety and feasibility of using a ...
He Rongrui - - 2012
Flexible Si p-i-n junction fibers made by high pressure chemical vapor deposition offer new opportunities in textile photovoltaics and optoelectronics, as exemplified by their photovoltaic properties, gigahertz bandwidth for photodetection, and ability to waveguide light.
Arnaud Françoise - - 2012
An advanced hemostatic dressing, Rapid Trauma Hemostat (RTH), was developed using nano-engineered inorganic nanofibers with hemostatic surface properties. Yorkshire swine were treated with RTH or Combat Gauze (CBG) to stop bleeding from either an arterial puncture (G-RTH and G-CBG) or a liver lobe laceration (L-RTH and L-CBG). All animals received ...
Nagasawa Tasuku - - 2012
Albuminuria is an indicator of renal injury and is closely linked with cardiovascular disease (CVD). However, the mechanism by which albumin is excreted in the urine remains unclear. As the juxtamedullary region of the kidney is highly susceptible to pressure increase, juxtamedullary injury is observed from an early phase in ...
Phillips Aaron A - - 2012
Significant cardiovascular and autonomic dysfunction occurs after spinal cord injury (SCI). It is now recognized that cardiovascular disease is a leading cause of morbidity and mortality in SCI. Patients with SCI may also suffer severe orthostatic hypotension and autonomic dysreflexia. Baroreflex sensitivity (i.e., the capability of the autonomic nervous system ...
Chalisey Anil A Department of Renal Medicine, Norfolk and Norwich University Hospital, Norwich, - - 2013
Hypertension secondary to hydronephrosis is not commonly reported in the medical literature. Tubuloglomerular feedback and the renin-angiotensin-aldosterone axis are thought to mediate this process. We describe a patient presenting with acute kidney injury and bilateral hydronephrosis secondary to pelvic malignancy in which peripheral venous renin and aldosterone were elevated. Her ...
Yoshida T - - 2012
In this pilot study, we examined how effectively functional electrical stimulation (FES) and passive stepping mitigated orthostatic hypotension in participants with chronic spinal cord injury (SCI). While being tilted head-up to 70 degrees from the supine position, the participants underwent four 10-minute conditions in a random sequence: 1) no intervention, ...
Jones Claire F - - 2012
STRUCTURED ABSTRACT: Study Design. In vivo large animal (pig) model study of cerebrospinal fluid (CSF) pressures following acute experimental spinal cord injury (SCI).Objective. To determine how the CSF pressure (CSFP) and pulse pressure amplitude (CSFPPA) cranial and caudal to the injury site change after an acute SCI with subsequent thecal ...
Helvig Elizabeth I - - 2012
PURPOSE:: To examine the usefulness of high-frequency ultrasound (HFU) to detect heel pressure injury in geriatric medical patients, to compare the prevalence rates of visualized pressure ulcers with the prevalence of hidden injury, and to determine whether HFU could assist in predicting the development of heel pressure injury. SUBJECTS AND ...
Roy Shreyas - - 2012
Established acute respiratory distress syndrome (ARDS) is often refractory to treatment. Clinical trials have demonstrated modest treatment effects, and mortality remains high. Ventilator strategies must be developed to prevent ARDS. Early ventilatory intervention will block progression to ARDS if the ventilator mode (1) maintains alveolar stability and (2) reduces pulmonary ...
Friess Stuart H SH Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, - - 2012
Cerebral perfusion pressure<40 mm Hg following pediatric traumatic brain injury has been associated with increased mortality independent of age, and current guidelines recommend maintaining cerebral perfusion pressure between 40 mm Hg-60 mm Hg. Although adult traumatic brain injury studies have observed an increased risk of complications associated with targeting a ...
Tsaknis George - - 2012
ABSTRACT: INTRODUCTION: Diabetic patients may develop acute lung injury less often than non-diabetics; a fact that could be partially ascribed to the usage of antidiabetic drugs, including metformin. Metformin exhibits pleiotropic properties which make it potentially beneficial against lung injury. We hypothesized that pretreatment with metformin preserves alveolar capillary permeability ...
Bowles Alfred P - - 2012
Primary objective: To determine whether neurophysiologic parameters-intracranial pressure (ICP), mean arterial pressure (MAP), cerebral perfusion pressure (CPP), partial brain tissue oxygenation (PbtO(2)) and pressure reactivity index (PRx, calculated)-captured during the management of traumatic brain injury (TBI) have a relationship to patient outcome. Research design: A retrospective analysis of neurophysiologic data ...
Van Aken Hugo K - - 2012
PURPOSE OF REVIEW: In patients with traumatic brain injury (TBI), dysfunction of the neurovascular unit ('blood-brain barrier') is a common finding, resulting in maldistribution of water and osmoles within the brain. The purpose of the present article is to review the underlying physiology of osmolality and fluid therapy in TBI. ...
Berry Clare A - - 2012
Background:Compared to constant respiratory rate (RR) and tidal volume (V(T)) during controlled mechanical ventilation (CV), variable ventilation (VV) using the same breath-to-breath minute volume but variable V(T) and respiratory rates enhances ventilation efficiency in preterm lambs. We hypothesized that if V(T) was adjusted to target permissive hypercarbia, VV would result ...
De Prost N - - 2012
The experimental evidence that ventilator could injure lungs through the application of excessive endinspiratory volumes and transpulmonary pressures has led to major changes in the clinical management of patients suffering from the acute respiratory distress syndrome (ARDS). The prevention of ventilator-induced lung injury has become one of the main goals ...
Pegolo Patrícia Traballi de Carvalho - - 2012
Introduction: Dilation of urinary tract occurs without the presence of obstruction. Diagnostic methods that depend on renal function may elicit mistaken diagnosis. Whitaker (1973) proposed the evaluation of urinary tract pressure submitted to constant flow. Other investigators proposed perfusion of renal pelvis under controlled pressure, making the method more physiological ...
Lu Cheng-Wei - - 2012
This study applied multiscale entropy analysis to investigate the correlation between the complexity of intracranial pressure waveform and outcome after traumatic brain injury. Intracranial pressure and arterial blood pressure waveforms were low-pass filtered to remove the respiratory and pulse components and then processed using a multiscale entropy algorithm to produce ...
Wadsworth Brooke M - - 2012
OBJECTIVE: To investigate the effect of an elasticated abdominal binder on respiratory, voice and blood pressure outcomes for people with a motor complete acute tetraplegia during the first year after injury. DESIGN: Randomized cross over study. SETTING: Large university-affiliated referral hospital. PARTICIPANTS: Consenting participants (n=14, 13 men and 1 woman) ...
Sahota Inderjeet S - - 2012
Orthostatic hypotension (OH) is a debilitating condition affecting individuals with spinal cord injury (SCI) that may be associated with cerebral hypoperfusion. We studied orthostatic cerebral control in individuals with SCI with different levels and severities of injury to spinal cardiovascular autonomic pathways. We measured beat-to-beat cardiovascular and cerebrovascular responses to ...
Dealey Carol - - 2012
Pressure ulcers are considered to be a key quality indicator and healthcare providers in England are required to report local pressure ulcer rates. However, there is a lack of standardisation in reporting due to lack of national guidance. The Tissue Viability Society has sought to develop consensus amongst all concerned ...
Duckworth Josh L - - 2012
As more data is accumulated from Operation Iraqi Freedom and Operation Enduring Freedom (OEF in Afghanistan), it is becoming increasing evident that traumatic brain injury (TBI) is a serious and highly prevalent battle related injury. Although traditional TBIs such as closed head and penetrating occur in the modern battle space, ...
McInnes Elizabeth - - 2012
OBJECTIVES: To examine the effects on healing of pressure relieving support surfaces in the treatment of pressure injury. DESIGN: Systematic review. DATA SOURCES: Cochrane Wound Group Specialised Register, The Cochrane Central Register of Controlled Trials, Ovid MEDLINE, Ovid EMBASE and EBSCO CINAHL. The reference sections of included trials were searched ...
Bhardwaj Atul - - 2012
Good news for the heart: The chronic use of rofecoxib causes adverse cardiovascular complications that prompted its withdrawal from the market. We recently modified rofecoxib into an NO-releasing, potent anti-inflammatory drug. Herein we describe the beneficial anti-hypertensive effects of the NO-releasing SO(2) NHOH COX-2 pharmacophore on blood pressure and its ...
Cubit Katrina - - 2012
Pressure injuries are key clinical indicators of care standard. In Australia, pressure injuries increase length of hospital stay by 4·31 and cost $285 million annually. This pilot study examined the effectiveness of sacral dressing in reducing the prevalence of pressure injuries in older, high-risk patients. A non randomised one-sample experimental ...
Oh Hyun Soo - - 2012
Oh HS, Jeong HS, Seo WS. International Journal of Nursing Practice 2012; 18: 295-302 Non-infectious hyperthermia in acute brain injury patients: Relationships to mortality, blood pressure, intracranial pressure and cerebral perfusion pressure The present study was conducted to investigate the frequency of hyperthermia during the first 72 h after acute brain ...
Nakanishi Yoshie - - 2012
A bucket-type transpelvic socket was fabricated for a man with paraplegia from spinal cord injury, who underwent right partial pelvic amputation and left hip disarticulation. His main problem was inability to sit due to asymmetrical pelvic shape. We prescribed a transpelvic prosthetic socket to enable him to sit again. The ...
Ley Eric J - - 2012
BACKGROUND: We undertook the current study to determine the impact of elevated admission systolic blood pressure (SBP) on trauma patients without severe brain injury. MATERIALS AND METHODS: We conducted a retrospective review of the Los Angeles County Trauma System database to identify all patients with moderate to severe injuries (injury ...
Sundaramurthy Aravind - - 2012
Blast waves generated by improvised explosive devices (IEDs) cause traumatic brain injury (TBI) in soldiers and civilians. In vivo animal models in conjunction with shock tubes are extensively used in laboratories to simulate field conditions, to identify mechanisms of injury, and to develop injury thresholds. In this paper, we place ...
Goldberg Andrew D - - 2012
Transfusion-Related Acute Lung Injury (TRALI) is the leading cause of transfusion-related mortality in most developed countries. Despite this fact, well-designed investigations on specific management strategies for TRALI are lacking. Indeed, current recommendations are primarily based on data extrapolated from trials of the histo-pathologically similar Acute Lung Injury and Acute Respiratory ...
Hong Caron M - - 2012
Background:Mechanical ventilation (MV) can lead to ventilator-induced lung injury secondary to trauma and associated increases in pulmonary inflammatory cytokines. There is controversy regarding the associated systemic inflammatory response. In this report, we demonstrate the effects of MV on systemic inflammation.Methods:This report is part of a previously published study (Hong et ...
Qureshi Adnan I - - 2012
BACKGROUND: Aggressive systolic blood pressure reduction may precipitate acute renal injury because of underlying hypertensive nephropathy in patients with intracerebral hemorrhage. The study's objective was to determine the rate and determinants of acute renal injury during acute hospitalization among subjects with intracerebral hemorrhage using a post hoc analysis of a ...
Willmore L James - - 2012
Text of Abstract Liability to develop posttraumatic epilepsy (PTE) correlates in a general way with trauma dose. While contusion of the brain produces an admixture of extravasated blood, edema fluid and necrotic tissue at the site of skull trauma and in regions remote from the direct force, an unpredictable cascade ...
Nagasawa Tasuku - - 2012
Vascular endothelial growth factor inhibitors (VEGFi) are known to cause hypertension and renal injury that severely limits their use as an anticancer therapy. We hypothesized that the angiotensin-converting enzyme inhibitor captopril not only prevents hypertension, but also decreases renal injury caused by the VEGFi sorafenib. Rats were administered sorafenib (20 mg/kg ...
Alvisi Valentina - - 2012
OBJECTIVE: To identify the nature of the changes of respiratory mechanics in patients with middle cervical SCI and their correlation with posture. DESIGN: Clinical trial SETTING: Acute Spinal Cord Injury Unit PARTICIPANTS: Thirty four patients with SCI at C4-C5 level studied within 6 months of injury. INTERVENTION: Patients were assessed ...
Jones Claire F - - 2012
Object Spinal cord injury (SCI) often results in considerable permanent neurological impairment, and unfortunately, the successful translation of effective treatments from laboratory models to human patients is lacking. This may be partially attributed to differences in anatomy, physiology, and scale between humans and rodent models. One potentially important difference between ...
Fujita Motoki - - 2012
Traumatic brain injury (TBI) can trigger disturbances of cerebral pressure autoregulation that can translate into the generation of secondary insults and increased morbidity/mortality. Few therapies have been developed to attenuate the damaging consequences of disturbed autoregulatory control, although some suggest that hypothermia may exert such protection. Here we reexamine this ...
Hines-Beard Jessica J Hamilton Eye Institute, Department of Ophthalmology, University of Tennessee Health Science Center, 930 Madison Ave., Ste. 731, Memphis, TN 38163, - - 2012
We developed and characterized a mouse model of primary ocular blast injury. The device consists of: a pressurized air tank attached to a regulated paintball gun with a machined barrel; a chamber that protects the mouse from direct injury and recoil, while exposing the eye; and a secure platform that ...
Ikpeama Louisa Chika - - 2012
This case study discusses the management of type I respiratory failure (RF) secondary to diffuse alveolar-induced acute lung injury. Type I RF occurs with ventilation-perfusion mismatch resulting in inadequate oxygenation. Arterial oxygen saturation is usually less than 90% despite supplemental fraction of inspired oxygen (FIO2) greater than 60%. Type I ...
Hua Shaodong - - 2012
BACKGROUND: The results from experimental and clinical studies have shown that mechanical ventilation (MV) and/or hyperoxia may aggravate a pre-existing lung injury, or even cause lung injury in healthy lungs, despite the fact that it might be the only life-saving intervention available to a patient. The present study was designed ...
George Timothy J TJ Division of Cardiac Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, - - 2012
Ischemia-reperfusion injury is a common complication after lung transplantation. Ischemia-reperfusion injury is thought to be mediated by reactive oxygen species (ROS). Hydrogen sulfide (H(2)S) is a novel agent that has been previously shown to scavenge ROS and slow metabolism. We evaluated the effect of infused H(2)S on the presence of ...
Yoshida Takeshi - - 2012
OBJECTIVE:: We investigated whether potentially injurious transpulmonary pressure could be generated by strong spontaneous breathing and exacerbate lung injury even when plateau pressure is limited to <30 cm H2O. DESIGN:: Prospective, randomized, animal study. SETTING:: University animal research laboratory. SUBJECTS:: Thirty-two New Zealand White rabbits. INTERVENTIONS:: Lavage-injured rabbits were randomly ...
Fei Dongsheng - - 2012
Acute lung injury (ALI) is often associated with sepsis and is the most common cause of acute respiratory failure. The authors evaluated the role of the heme oxygenase (HO)/carbon monoxide (CO) system on lung injury in a cecal ligation and puncture (CLP)-induced mouse model of ALI. The authors established CLP-induced ...
Casal Nuñez José Enrique - - 2012
INTRODUCTION: Our aim is to identify the location and size of the anterior foramina of sacral vertebral bodies and analyse the haemodynamic variables that could influence the haemorrhagic severity of the injury of the presacral venous plexus. MATERIALS AND METHODS: Using computed axial tomography the morphological data of 70 sacral ...
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