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Downey Laura A LA From the Department of Anesthesiology, Pain, and Perioperative Medicine, Stanford University Medical Center, Stanford, California. Laura A. Downey, MD, is currently affiliated with the Department of Anesthesia, Boston Childrens Hospital Boston, Boston, Massachusetts. Kevin P. Blaine, MD, MPH, is currently affiliated with the Critical Care Medicine Department of the National Institutes of Health Clinical Center, Bethesda, - - 2014
Central venous cannulation is technically challenging in obese patients. We hypothesized that positive end-expiratory pressure (PEEP) increases the size of the internal jugular vein (IJV) in obese adults. The circumference and cross-sectional area of the IJV were measured in obese patients under general anesthesia at PEEP 0, 5, and 10 ...
Pischedda V V Institut Lumière Matière, UMR5306 Université Lyon 1-CNRS, Université de Lyon 69622 Villeurbanne cedex, - - 2014
In this article we study the alkali metal-intercalated 2D polymeric Li4C60 and the monomeric Li12C60 under pressure up to 40 GPa at room temperature, using x-ray diffraction and Raman spectroscopy. Li4C60 undergoes several transitions in the studied pressure range. At pressures lower than 8 GPa, we observed changes in both diffraction patterns ...
Murdolo Giuseppe G Department of Internal Medicine, Assisi Hospital, Via Valentin Muller 1, I-06081, Assisi, Perugia, Italy, - - 2014
Obesity can be regarded as an energy balance disorder in which inappropriate expansion and dys-function of adipose tissue lead to unfavorable outcomes. Even in the absence of hypertension, adiposity induces structural and functional changes in the heart through hemodynamic and non hemodynamic factors. In the "obese" heart, besides the growth ...
Kaakinen Marika M Institute of Health Sciences, University of Oulu, Oulu, Finland Biocenter Oulu, Oulu, Finland Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, Imperial College London, London, - - 2014
Fetal and postnatal growth have been associated with adult blood pressure (BP), but findings about the relative importance of growth at different stages of life on BP are inconsistent. The study population comprised 5198 participants from the Northern Finland Birth Cohort 1966 with data on birth weight, height and weight ...
VanGennep D D Department of Physics, University of Florida, Gainesville, FL 32611, - - 2014
We report measurements of Shubnikov-de Haas oscillations in the giant Rashba semiconductor BiTeI under applied pressures up to ∼2 GPa. We observe one high frequency oscillation at all pressures and one low frequency oscillation that emerges between ∼0.3-0.7 GPa indicating the appearance of a second small Fermi surface. BiTeI has a conduction ...
Cossio-Bolaños Marco M Departamento de Ciencias de la Actividad Física, Universidad Católica del Maule, Talca, - - 2014
Introduction. Obesity is the main risk factor for arterial hypertension andis associatedwitha higher morbidity, both in the short and long term. Objectives. To compare anthropometric and blood pressure indicators in terms of the nutritional status, to verify the relationship between nutritional status and blood pressure, and to establish the prevalence ...
Kawada Noritaka N Health Care Center, Osaka University, Toyonaka, Japan. Electronic address: - - 2014
In adults, gender and obesity play significant roles in the regulation of blood pressure (BP). This study investigated the effects of gender and body mass index (BMI) on BP during adolescence. A cross-sectional and longitudinal study involving 6838 students under twenty years old (median, eighteen years old; male, 4624; female, ...
Shi Juan J Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), China; Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Rui-jin Hospital, Shanghai Jiao-Tong University School of Medicine, - - 2014
Obesity has been associated with increased common carotid artery (CCA) intima-media thickness (IMT), a measure of subclinical atherosclerosis. We assessed the association between genetic predisposition to obesity and CCA IMT. The study included 428 young Chinese adults with CCA IMT measured using a high-resolution B-mode tomographic ultrasound system. We created ...
Gu Q Q 1] Erasmus Medical Center, Department of Internal Medicine, University Medical Center Rotterdam, Rotterdam, The Netherlands [2] Department of Endocrinology, Zhongshan Hospital Fudan University, Shanghai, - - 2014
Proprotein convertase subtilisin/kexin-type 1 (PCSK1) activates precursors pro-opiomelanocortin (POMC), proinsulin and prorenin. We investigated if common variants in the PCSK1 gene influence blood pressure and risk of hypertension. Additionally, we investigated the risk of obesity and type 2 diabetes (T2D). In the Rotterdam Study (RS1), a prospective, population-based cohort (n=5974), ...
Foraker Randi E RE 1 Comprehensive Cancer Center, The Ohio State University , Columbus, - - 2014
Abstract Background: Low-fat and low-carbohydrate weight-loss diets can have a beneficial effect on longitudinal measures of blood pressure and blood lipids. We aimed to assess longitudinal changes in blood pressure and blood lipids in a population of premenopausal women. We hypothesized that results may differ by level of adherence to ...
Hermann Andreas A School of Physics and Astronomy and Centre for Science at Extreme Conditions, The University of Edinburgh, Edinburgh EH9 3JZ, United - - 2014
We discuss the high-pressure phases of crystalline lithium hydroxide, LiOH. Using first-principles calculations, and assisted by evolutionary structure searches, we reproduce the experimentally known phase transition under pressure, but we suggest that the high-pressure phase LiOH-III be assigned to a new hydrogen-bonded tetragonal structure type that is unique amongst alkali ...
Dou Xiuming X State Key Laboratory of Superlattices and Microstructures, Institute of Semiconductors, Chinese Academy of Sciences , P.O. Box 912, Beijing 100083, - - 2014
Few-layer molybdenum disulfide (MoS2) is advantageous for application in next-generation electronic and optoelectronic devices. For monolayer MoS2, it has been established that both the conduction band minimum (CBM) and the valence band maximum (VBM) occur at the K point in the Brillouin zone. For bilayer MoS2, it is known that ...
Varughese Amy G AG Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Louisiana State University Health Sciences Center (LSUHSC), 1542 Tulane Avenue, New Orleans, LA, 70112, USA, - - 2014
Obesity is prevalent worldwide and associated with co-morbidities that result in increased cardiovascular risk. Hypertension is the most prevalent obesity comorbidity associated with increased cardiovascular risk. Obesity hypertension is a distinct subtype of essential hypertension. While endogenous Cushing's syndrome is an uncommon cause of both obesity and hypertension, the recent ...
Ward Natalie C NC aUniversity of Western Australia, School of Medicine & Pharmacology, Royal Perth Hospital bSchool of Surgery and Pathology cWestern Australian Institute for Medical Research, University of Western Australia, Perth, Western Australia, - - 2014
Genetic background partly determines the efficacy of interventions to lower blood pressure (BP). The CYP4F2 and CYP4A11 enzymes are renal 20-hydroxyeicosatetraenoic acid (20-HETE) synthases that regulate BP. Gene variants of CYP4F2 and CYP4A11 associate with hypertension and stroke. We showed that a gene variant of CYP4F2 but not CYP4A11 was ...
Ando K K Department of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 Japan. - - 2014
Salt sensitivity of blood pressure (BP) is increased in hypertension associated with obesity and/or metabolic disorders. Reversely, patients with salt-sensitive hypertension often reveal metabolic disorders. Thus, salt excess and overeating, which are major bad dietary habits in civilized men and women, strengthen the effect to increase BP each other. Actually, ...
Ramesh Karuppannan - - 2014
Amorphous solids prepared from their melt state exhibit glass transition phenomenon upon heating. Viscosity, specific heat and thermal expansion coefficient of the amorphous solids show rapid changes at the glass transition temperature (Tg). Generally, application of high pressure increases the Tg and this increase (a positive dTg/dP ) has been ...
Tsai Ying-Ying YY Charlie Norwood VA Medical Center, One Freedom Way, Augusta, GA 30904 - - 2014
Aldosterone is the mineralocorticoid that is responsible for sodium retention, thus increased blood volume and pressure. Excessive production of aldosterone results in high blood pressure, as well as renal disease, stroke, and visual loss via both direct effects and effects on blood pressure. Weight gain is often associated with increased ...
Devidas T R TR Materials Science Group, Indira Gandhi Centre for Atomic Research, Kalpakkam-603102, - - 2014
Noting that BiI3 and the well-known topological insulator (TI) Bi2Se3 have the same high symmetry parent structures, and that it is desirable to find a wide-band gap TI, we determine here the effects of pressure on the structure, phonons and electronic properties of rhombohedral BiI3. We report a pressure-induced insulator-metal ...
Straznicky Nora E NE Laboratories of 1 Human - - 2014
Context: Insulin resistance and sympathetic nervous system overactivity are closely associated and contribute to cardiovascular risk. Objective: To test the hypotheses that pharmacological improvement in insulin sensitivity would (1) attenuate sympathetic neural drive and (2) enhance neuronal norepinephrine uptake. Participants and Methods: A randomised double-blind trial was conducted in 42 ...
Araneta M R MR University of California San Diego, Department of Family and Preventive Medicine, LaJolla, California, USA - - - 2014
To assess the feasibility of a 12 week Zumba Fitness. pilot study and temporal changes in components of the Metabolic Syndrome (MetS) among sedentary, obese women with at least two MetS components. Participants attended Zumba Fitness classes twice a week for 12 weeks. Feasibility was measured by recruitment rates, subject ...
Chirinos Julio A JA From the Philadelphia Veterans Affairs Medical Center (J.A.C., I.G.), Perelman School of Medicine, University of Pennsylvania-Hospital of the University of Pennsylvania (J.A.C., I.G., D.J.R., T.A.W., R.T., G.M., H.S., P.B., A.I.P.), Monell Chemical Senses Center (K.T.), Temple University School of Medicine (G.D.F.), and University of Pennsylvania School of Nursing (J.C., A.L.H.) - all in - - 2014
Obesity and obstructive sleep apnea tend to coexist and are associated with inflammation, insulin resistance, dyslipidemia, and high blood pressure, but their causal relation to these abnormalities is unclear. We randomly assigned 181 patients with obesity, moderate-to-severe obstructive sleep apnea, and serum levels of C-reactive protein (CRP) greater than 1.0 ...
Yonekura Yuriko Y Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki, Chuo-ku, Kobe, Hyogo, 650-0017, - - 2014
This study aimed to describe the influences of larger physical constitutions including obesity on the amount of urine protein excretion (AUPE) in primary glomerulonephritis. The distinct effects on the AUPE in various types of glomerulonephritis were evaluated. Using the database of the Japan Renal Biopsy Registry (J-RBR) from 2007 to ...
Boardman Helen F HF School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK, - - 2014
Background Obesity is a growing problem in England with one quarter of the adult population being obese and around 60 % being overweight or obese. Given the high costs of treating obesity-related conditions such as coronary heart disease and type-2 diabetes the UK Government aims to reduce obesity through public health ...
Yan W L WL a Department of Clinical Epidemiology , Children's Hospital of Fudan University , Shanghai , - - 2014
Objectives. To investigate whether the levels of blood pressure and fasting glucose differ among Chinese children of three different ethnicities (i.e., Uyghurs, Kazakhs, and Hans) and whether the differences are explained by childhood obesity. Methods. A school-based cross-sectional study was conducted in a large three ethnic pediatric population (n = ...
Kochueva M M Kharkiv Medical Academy of Postgraduate Education; Sumy Outpatient hospital №3; Sumy State University, - - 2014
Arterial hypertension combined with obesity is a very common form of comorbid disease in most countries all over the world. The combination of these diseases is characterized by mutual burdening of remodelling processes in important target organs, what greatly increases the risk of cardiovascular complications and death. The mechanisms of ...
Freitas Isabelle Magalhães G IM UFJF, Juiz de Fora, MG, - - 2014
To test the hypothesis that obese normotensive children and adolescents present impaired cardiac autonomic control compared to non-obese normotensive ones. For this cross-sectional study, 66 children and adolescents were divided into the following groups: Obese (n=31, 12±3 years old) and Non-Obese (n=35, 13±3 years old). Obesity was defined as body ...
Dzenkeviciūte Vilma V Clinic of internal medicine, oncology and family medicine, Vilnius University Medical Faculty, Vilnius, Lithuania, - - 2014
Herein, we investigate the anthropometric, biochemical and left ventricle (LV) geometry changes following the laparoscopic adjustable gastric banding (LAGB) operation in morbidly obese individuals. Eighty-three morbidly obese participants (mean age, 46.1 ± 11.5 years; 30.1 % men), scheduled for elective LAGB were examined before and 12 months after the surgery. LV geometry and diastolic function ...
Seravalle Gino G From the Istituto Auxologico Italiano, Milan, Italy (G.S., G.M.); Clinica Medica, Department of Health Science (M.C., M.V., R.D., G.G.) and Chirurgia II (P.P., V.G.), University of Milano-Bicocca, Monza, Italy; Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Milan, Italy (G.M., G.G.); and IRCCS Multimedica, Sesto San Giovanni, Milan, Italy - - 2014
Weight loss improves insulin sensitivity and exerts sympathomodulatory effects. No data, however, are available on the effects of the weight loss induced by vertical sleeve gastrectomy on sympathetic neural drive, insulin sensitivity, and their reciprocal cross talks. In 10 severe obese hypertensives (age, 54.0±2.3 years [mean±SEM]), we measured sphygmomanometric blood ...
Polat Mustafa M Department of Family Medicine,Dışkapı Yıldırım Beyazıt Training and Research Hospital,Irfan Basbug cad - - 2014
Recent studies have reported an increasing prevalence of childhood hypertension. Obesity is probably the most important risk factor. The relationship between hypertension and BMI in children has not been studied in Ankara, which is the second largest city in Turkey. Cross-sectional study analysing direct data on height, weight and blood ...
Tailakh Ayman K AK California State University, Los Angeles, CA, USA - - 2014
The aim of this study was to examine the relationship between acculturation, medication adherence, lifestyle behaviors (e.g., physical activity, nutrition, weight control), and blood pressure control among hypertensive Arab Americans. The study utilized a cross-sectional descriptive design. A convenience sample of 126 participants completed questionnaires and had measures of blood ...
Wakerley Br B The Oxford Headache Centre, Department of Neurology, John Radcliffe Hospital, UK - - 2014
Idiopathic intracranial hypertension or pseudotumour cerebri is primarily a disorder of young obese women characterised by symptoms and signs associated with raised intracranial pressure in the absence of a space-occupying lesion or other identifiable cause. The overall incidence of idiopathic intracranial hypertension is approximately two per 100,000, but is considerably ...
Reisin Efrain E aSection of Nephrology and Hypertension, Louisiana State University Health Science Center, New Orleans, Louisiana bDivision of Nephrology/Hypertension, Mayo Clinic, Rochester, Minnesota cCoordinating Center for Clinical Trials, The University of Texas School of Public Health, Houston, Texas dDivision of Endocrinology, Kaiser Permanente of Georgia and Emory University School of Medicine, Atlanta, Georgia eThe National Heart, Lung, and Blood Institute, Bethesda, Maryland fCenter for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, Wisconsin gHoward University Hypertension and Lipid Clinic, Howard University Hospital, Washington, District of Columbia hVeterans Affairs Medical Center and Wright State University Veterans Affairs Campus, Dayton, Ohio, - - 2014
Epidemiologically, there is a strong relationship between BMI and blood pressure (BP) levels. We prospectively examined randomization to first-step chlorthalidone, a thiazide-type diuretic; amlodipine, a calcium-channel blocker; and lisinopril, an angiotensin-converting enzyme inhibitor, on BP control and cardiovascular outcomes in a hypertensive cohort stratified by baseline BMI [kg/m; normal weight ...
Sarzani Riccardo R Internal Medicine and Geriatrics, "Hypertension Excellence Centre" of the European Society of Hypertension, Department of Clinical and Molecular Sciences, University "Politecnica delle Marche", Italian National Research Centre on Aging "U. Sestilli", IRCCS-INRCA, via della Montagnola n. 81, 60127, Ancona, Italy, - - 2014
The worldwide prevalence of obesity has nearly doubled, with an increase in obesity-related cardiovascular disease and mortality. Several factors are involved in the genesis of hypertension and hypertensive heart disease (HHD) in overweight/obesity. This review is focused on bridging factors between excessive adiposity and HHD, presenting a unifying hypothesis of ...
Rodríguez-Moran Martha M Biomedical Research Unit, Mexican Social Security Institute, Durango, - - 2014
We undertook this study to determine the efficacy of oral magnesium supplementation in the improvement of the metabolic profile and blood pressure in metabolically obese, normal-weight (MONW) individuals. A total of 47 MONW individuals with hypomagnesemia were enrolled in clinical a randomized double-blind placebo-controlled trial. Individuals in the intervention group ...
Cui Hengbo - - 2014
The pressure dependence of the resistivities of a single-component molecular conductor, [Ni(hfdt)2] (hfdt = bis(trifluoromethyl)tetrathiafulvalenedithiolate) with semiconducting properties at ambient pressure was examined. The four-probe resistivity measurements were performed up to ~10 GPa using a diamond anvil cell (DAC). The low-temperature insulating phase was suppressed above 7.5 GPa and the ...
Larsen R N RN Baker IDI Heart and Diabetes Institute, Melbourne, Australia. Electronic address: - - 2014
To compare the effect of 7 h of prolonged sitting on resting blood pressure with a similar duration of sitting combined with intermittent brief bouts of light-intensity or moderate-intensity physical activity. Overweight/obese adults (n = 19; aged 45-65 years) were recruited for a randomized three-treatment crossover trial with a one-week washout between treatments: ...
da Silva Alexandre A AA Department of Physiology and Biophysics, Mississippi Center for Obesity Research, and Cardiovascular-Renal Research Center, The University of Mississippi Medical Center, Jackson, - - 2014
Excess weight gain is the most significant, preventable cause of increased blood pressure (BP) in patients with primary (essential) hypertension and increases the risk for cardiovascular and renal diseases. In this review, we discuss the role of the brain melanocortin system in causing increased sympathetic activity in obesity and other ...
Tobias Joseph D JD Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, 700 Children's Drive, Columbus, 43205, OH, USA, - - 2014
During perioperative care, the continuous measurement of blood pressure (BP) provides superior physiological monitoring compared to intermittent techniques, especially for patients with comorbid conditions such as severe obesity. The current study prospectively assesses the accuracy of a continuous, noninvasive BP device in severely obese adolescents and young adults. The technology ...
Flynn Colleen C Division of Endocrinology, Diabetes and Metabolism/ASH Comprehensive Hypertension Center, University of Chicago Medicine, Chicago, IL. Electronic address: - - 2014
The prevalence of both obesity and hypertension are increasing worldwide. Hypertension is a common consequence of obesity. Increased central adiposity is associated with increased aldosterone levels and blood pressure in human beings. A number of small studies have shown an association between obesity-mediated hypertension and mechanisms directly linked to increased ...
Steier Joerg J King's College London School of Medicine, King's Health Partners, King's College Hospital, , London, - - 2014
Severe obesity causes respiratory morbidity and mortality. The impact of obesity on the mechanics of breathing is not fully understood. We undertook a comprehensive observational study of lung volumes and elasticity in nine obese and nine normal weight subjects, seated and supine, during spontaneous breathing. Seated and supine total lung ...
Pirozzi Kelly K Chief Resident, Temple University Hospital Podiatric Surgical Residency Program, Temple University Hospital, Philadelphia, - - 2014
An increasing body of evidence has implicated obesity as having a negative effect on the development, treatment, and outcome of lower extremity pathologic entities, including diabetic foot disease. The objective of the present study was to increase the body of knowledge with respect to the effects of obesity on foot ...
Lambert Elisabeth A EA Human Neurotransmitters, Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, - - 2014
Obesity is associated with elevated cardiovascular mortality, which may be attributed, in part, to sympathetic nervous system (SNS) activation and an associated poor metabolic profile. We examined the effects of laparoscopic adjustable gastric band (LAGB) on SNS activity and cardiovascular profile when the initial weight loss of 10%, corresponding to ...
Pilhatsch Maximilian M Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, - - 2014
We studied whether suppressed secretion of the orexigenic peptide ghrelin might be involved in the anorexigenic effects of nicotine. Fifty healthy non-smokers chewed gums containing 2 mg nicotine, or no nicotine in a double-blind randomised crossover design in two independent studies. Plasma nonacylated ghrelin was not significantly affected by nicotine after ...
Toyoshima Hideaki H Health Care Center, Anjo Kosei - - 2014
Background: Chronic mental stress has been reported to be directly or inversely proportional to blood pressure (BP). To explain this inconsistent relationship, we assumed effect-modification by body mass index (BMI). Methods and Results: We examined 1,673 Japanese male local government employees who were not taking antihypertensive drugs or had no history of ...
Chopra Ishveen I Research Assistant, Department of Pharmacy Administration, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA. - - 2014
Background: Hypertension and dyslipidemia are the most prevalent cardiovascular risk factors, with approximately 30 million patients in the United States having these concomitant conditions. Further, the presence of high body mass index (BMI) has a negative effect on the achievement of blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) targets. ...
Zhao Yanyan Y Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital, Zhengzhou University , Zhengzhou , China - - 2014
Abstract We investigated blood nesfatin-1 levels in hypertension patients. We found that fasting plasma nesfatin-1 levels were significantly higher in hypertension patients than in control groups, especially in overweight/obese hypertension patients (4.5 ± 2.1 versus 3.3 ± 1.1 ng/ml, p < 0.01). Body mass index, systolic blood pressure and diastolic blood pressure were indeed positively correlated with ...
Kuwabara Masanari M 1] Division of Regenerative Medicine and Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Sciences, Yonago, Japan [2] Department of Cardiology, Toranomon Hospital, Tokyo, Japan [3] Department of Cardiology, St Luke's International Hospital, Tokyo, - - 2014
The cause and effect relationship between serum uric acid levels and hypertension can be difficult to evaluate because antihypertensive drugs sometimes affect uric acid levels. This cross-sectional study investigated the relationship between serum uric acid levels and hypertension in a general, healthy Japanese population who were not receiving medication for ...
Chen Changbo C State Key Laboratory of Superhard Materials, College of Physics, Jilin University, Changchun 130012, People's Republic of - - 2014
High-pressure structures of MH2 (M = V, Nb) are explored through ab initio evolutionary methodology. As the same main group metal hydrides, VH2 and NbH2 adopt the same tetragonal structure with space group Fm-3m at low pressures. However, at high pressures VH2 and NbH2 possess Pnma and P63mc phases differently. ...
Alayoubi Alaadin A Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe , Monroe, LA , USA - - 2014
Abstract Recently there has been a growing interest in vitamin E for its potential use in cancer therapy. The objective of this work was therefore to formulate a physically stable parenteral lipid emulsion to deliver higher doses of vitamin E than commonly used in commercial products. Specifically, the objectives were ...
Pfeiffer Christine M CM National Center for Environmental Health, CDC, Atlanta, - - 2014
Little information is available on temporal trends in sodium intake in the U.S. population using urine sodium excretion as a biomarker. Our aim was to assess 1988-2010 trends in estimated 24-h urine sodium (24hUNa) excretion among U.S. adults (age 20-59 y) participating in the cross-sectional NHANES. We used subsamples from ...
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