Search Results
Results 301 - 350 of 1745
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Kotliar Konstantin - - 2007
PURPOSE: Intravitreal injections are used extensively to treat retinal diseases. Performing an intravitreal injection increases intraocular volume by the amount of fluid brought into the eye. Whether this influences intraocular pressure (IOP) was investigated here. METHODS: A biomechanical model relying on 3-dimensional elasticity theory was developed to determine the short-term ...
Levkovitch-Verbin Hani - - 2008
OBJECTIVE: To investigate whether eyes with glaucoma or exfoliation syndrome without glaucoma are prone to exhibit intraocular pressure (IOP) elevation shortly after cataract surgery and, if so, whether timolol maleate 0.5% reduces these spikes. DESIGN: Prospective randomized double-masked clinical trial. PARTICIPANTS: One hundred twenty-two patients with normal eyes, medically well-controlled ...
Fu Qing-Ling - - 2008
AIMS: Recent studies have showed that erythropoietin (EPO) is a neuroprotectant for central nerve system neurons in addition to being a hematopoietic cytokine in response to hypoxia. In this study, we investigate the role of the EPO/EPO receptor (EPOR) system in the rat retina after ocular hypertension injury that mimics ...
Taner Pelin - - 2007
PURPOSE: The aim of this study was to investigate the effects of vardenafil on systemic blood pressure, intraocular pressure (IOP), and orbital hemodynamics. METHODS: Twenty-one (21) volunteers suffering erectile dysfunction, with an average age of 51.5 +/- 6.2 years, were enrolled into the study. Brachial blood pressures and IOP were ...
Timothy C O - - 2007
This study was designed to determine the effects of cigarette smoking on intra ocular pressure and arterial blood pressure of normotensive young male adults. Fifty male students (who met the screening conditions and devoid of obvious ocular pathology and systemic diseases and non-smokers) had their intra ocular pressure (IOP) measured ...
Quaranta Luciano - - 2007
Levobetaxolol is a cardioselective beta-blocker that has been demonstrated to reduce intraocular pressure in patients affected with primary open-angle glaucoma and ocular hypertension. Levobetaxolol may be an effective neuroprotectant because of its great capacity to block sodium and calcium influx, which might confer a neuroprotective activity. Experimental and clinical studies ...
Mark Harry H - - 2007
A theoretical model demonstrates the influence of the globe's size on the effects of its intraocular pressure (IOP) and on its motility. Large globes seem more susceptible to the damaging consequences of elevated IOP, and move with greater difficulty than small ones. Routine measurement of axial length (AxL) may accordingly ...
- - 2007
OBJECTIVE: To characterize the safety, tolerability, and pharmacokinetics of the pegylated anti-vascular endothelial growth factor (VEGF) aptamer pegaptanib sodium in subfoveal choroidal neovascularization secondary to age-related macular degeneration (AMD). DESIGN: Prospective 2-cohort study: (1) open-label cohort and (2) randomized, double-masked, uncontrolled multicenter trial. PARTICIPANTS: In the combined cohorts, 147 subjects ...
Puras Gustavo - - 2007
BACKGROUND: Although it has been suggested that ergot derivatives may play a role in antiglaucoma therapy, little attention has been paid to the ocular hypotensive action of these drugs. Having previously reported that topical natural ergot alkaloids ergocristine alpha-ergocryptine and ergocornine dose-dependently reduce intraocular pressure in ocular normotensive and alpha-chymotrypsin-induced ...
Iliev Milko E - - 2007
Several conversion tables and formulas have been suggested to correct applanation intraocular pressure (IOP) for central corneal thickness (CCT). CCT is also thought to represent an independent glaucoma risk factor. In an attempt to integrate IOP and CCT into a unified risk factor and avoid uncertain correction for tonometric inaccuracy, ...
Mozaffarieh Maneli - - 2007
Glaucoma is becoming recognised as a condition for which not only elevated intraocular pressure (IOP), but also non-pressure-dependent risk factors, are responsible. Better knowledge of the pathogenesis has opened up new therapeutic approaches that are often referred to as non-IOP-lowering treatment. These new avenues of treatment, some of which are ...
Bradley Jay C - - 2007
PURPOSE: To analyze the course of intraocular pressure (IOP) during lamellar microkeratotomy (LMK) in enucleated human eyes using 3 microkeratome systems. SETTING: Department of Ophthalmology, Texas Tech University Health Sciences Center, Lubbock, Texas, U.S.A. METHODS: Sixteen enucleated human globes were cannulated through the optic nerve, and IOP was recorded continuously ...
McMonnies Charles W - - 2007
PURPOSE: To examine the corneal shape and ocular refraction under conditions of increased intraocular pressure (IOP) and to consider the possible influences of direct digital forces, corneal thickness, limbal and scleral rigidity, and the duration and frequency of IOP loading on the results. METHODS: Forces applied digitally to the temporal ...
Moreno-Montañés Javier - - 2007
PURPOSE: To compare the intraocular pressure (IOP) measurements obtained with the rebound tonometer (RT) and the Goldmann handheld tonometer (GT) in normal and altered corneas. METHODS: A total of 208 normal corneas and 50 corneas with pathologies were included in this prospective study. All measurements were randomly obtained by 1 ...
Martinez Antonio - - 2007
PURPOSE: To compare the efficacy and tolerability of a once daily evening dose of the latanoprost/timolol fixed combination (LTFC) with that of a once-daily evening dose of the bimatoprost/timolol fixed combination (BTFC) in patients with open-angle glaucoma with elevated intraocular pressure (IOP) insufficiently responsive to monotherapy with prostaglandin analogues/prostamides. DESIGN: ...
Minami Masahiro - - 2007
PURPOSE: To investigate the effects of high infusion pressure in conjunction with pars plana vitrectomy (PPV) on retinal morphology and function in rabbits. METHODS: Pars plana vitrectomy was performed under urethane (0.8 mg/kg) anaesthesia in the right eye of albino rabbits following phacoemulsification and aspiration (PEA). The left eyes were ...
Shemesh Gabi - - 2007
PURPOSE: To compare pressure phosphene tonometry with Goldmann applanation tonometry for measuring intraocular pressure (IOP) before and after LASIK. METHODS: Forty-three (18 men and 25 women) consecutive healthy patients underwent complete pre- and postoperative LASIK ophthalmologic assessments including manifest and cycloplegic refraction, keratometry, and central corneal thickness. Three repetitive sets ...
Mansberger Steven L - - 2007
OBJECTIVE: To compare the intraocular pressure (IOP) responses of self-identified African American and white participants in the Ocular Hypertension Treatment Study to therapeutic trials of topical, nonselective beta-adrenergic antagonists or prostaglandin analogues. METHODS: Multivariate models that adjusted for baseline IOP and corneal thickness were used to estimate IOP response by ...
Somner John E A - - 2007
PURPOSE: To investigate changes of intraocular pressure on ascent to high altitude. METHODS: The Apex 2 medical research expedition provided the opportunity to measure intraocular pressure (IOP) and central corneal thickness (CCT) in 76 healthy lowlanders. They all arrived in La Paz, Bolivia (altitude, 3700 m), where they spent 4 ...
Martinez A - - 2007
The objective of this study was to compare the effect of the latanoprost/timolol fixed combination (LTFC) and the dorzolamide/timolol fixed combination (DTFC) on the retrobulbar haemodynamic and intraocular pressure (IOP) in patents with open-angle glaucoma (OAG). This was a prospective, examiner masked, randomised and crossover study. Participants were 32 consecutive ...
Mundorf Thomas - - 2007
This study was undertaken to evaluate the ocular hypotensive efficacy of brimonidine Purite 0.15% (Alphagan P 0.15%; Allergan, Inc., Irvine, Calif) given as adjunctive therapy with latanoprost 0.005% (Xalatan; Pfizer Inc., New York, NY( to patients with open-angle glaucoma or ocular hypertension. In this multicenter, open-label, prospective evaluation, the intraocular ...
Lafaut A-S - - 2007
PURPOSE: This study compared the variability of intraocular pressure (IOP) measurements taken with pulse synchronized pneumotonometry (PNT) and with routine PNT (without pulse synchronization) and evaluated the agreement between PNT and Goldmann applanation tonometry (GAT). METHODS: In this prospective study, 148 eyes from 78 patients were enrolled. Patients were randomized ...
Ruokonen Peter Christian - - 2007
BACKGROUND: Two new tonometers have been introduced that are based on the impedance principle. Both the TGDc-01 (transpalpebral measurement) and the iCare (corneal measurement) do not require corneal anaesthesia. The present work presents an evaluation of both devices. METHODS: Comparative measurements using one of the new tonometers and applanation tonometry ...
Ozturk Faruk - - 2007
PURPOSE: To compare the ocular hypotensive efficacy and safety of topical bimatoprost and timolol-dorzolamide combination in patients with primary open-angle glaucoma (POAG) or ocular hypertension during 6 months of treatment. METHODS: A sample of 65 patients with a diagnosis of POAG or ocular hypertension were randomized to receive either bimatoprost ...
Kiel Jeffrey W - - 2007
The aim of this study was to assess the effects of acute systemic, nonselective alpha-adrenergic blockade on aqueous flow. This study used pentobarbital-anesthetized rabbits (n=7), in which the following parameters were measured: mean arterial pressure, carotid blood flow, heart rate, intraocular pressure (IOP), orbital venous pressure (OVP), ciliary blood flow, ...
Zeitz Oliver - - 2007
BACKGROUND: Altered regulation of vascular tone and particularly vasospasms are thought to be a risk factor for the progression of primary open angle glaucoma (POAG). Apoptosis of retinal ganglion cells and possibly vascular tone regulation in glaucoma might be caused by oxidative stress. The aim of the present study was ...
Schaller B J - - 2007
A systematic clinical neuroscience protocol is described for the use to examine the trigemino-cardiac reflex (TCR) response in humans. Target neurosurgical conditions are operations that require manipulations around the peripheral and central part of the trigeminal nerve and its branches, e.g. the cerebellopontine angle or the sellar region. To assess ...
Eichenbaum Kenneth D - - 2007
We prospectively compared dynamic contour tonometry (DCT) to Goldmann (GAT) and hand-held tonometry (HHT) in normal, ocular hypertension, and glaucoma populations. Both measurements were made on each patient within a 5-minute period during routine office exams over 4 months. While DCT is in good overall agreement with GAT and HTT, ...
Hernández-Verdejo José L - - 2007
PURPOSE: To compare real-time intraocular pressure (IOP) during laser in situ keratomileusis (LASIK) in porcine eyes using two types of microkeratomes. METHODS: An interventional, prospective study of two microkeratomes: a Moria 2 (Moria group) and an IntraLase femtosecond laser (IntraLase Corp., Irvine, CA; IntraLase group). These devices were used to ...
Lewis Richard A - - 2007
PURPOSE: To compare the safety and efficacy of travoprost 0.004% without benzalkonium chloride (BAC) to that of the marketed formulation of travoprost 0.004% in patients with open-angle glaucoma or ocular hypertension. METHODS: The study was a double-masked, randomized, parallel group, multicenter, noninferiority design. Adult patients with open-angle glaucoma or ocular ...
Henness Sheridan - - 2007
Ocular carteolol (Mikelan), Teoptic, Ocupress) is a nonselective beta-adrenoceptor antagonist with intrinsic sympathomimetic activity (ISA). Ocular carteolol effectively reduces intraocular pressure (IOP) in patients with open-angle glaucoma (OAG) or ocular hypertension (OH). Twice-daily administration of standard carteolol has generally similar IOP-lowering efficacy to other ocular beta-adrenoceptor antagonists such as timolol, ...
Holló Gábor - - 2007
In the last decade topically applied prostaglandin F2alpha analogues (bimatoprost, latanoprost, travoprost and unoprostone) have become widely used as a means to reduce elevated intraocular pressure in patients with glaucoma and ocular hypertension. These molecules all have similar side-effect profiles, which include both side effects that occur frequently (e.g., conjunctiva ...
Thelen Ulrich - - 2007
PURPOSE: The purpose of this prospective observational trial was to report the analysis of the midterm efficacy, safety, and discontinuation rates of a cohort of ocular hypertensive patients treated with latanoprost in Germany. METHODS: A subanalysis of patients with ocular hypertension who were previously treated on latanoprost monotherapy and continued ...
Choi Jaewan - - 2007
PURPOSE: To investigate systemic and ocular hemodynamic risk factors for glaucomatous damage in eyes with normal tension glaucoma (NTG). METHODS: Each patient with diagnosed NTG underwent 24-hour monitoring of intraocular pressure (IOP) and blood pressure (BP), scanning laser polarimetry (GDx-VCC), and a Humphrey visual field (HVF) examination. Multivariate regression models ...
Chiu Kin - - 2007
Glaucoma is one of the major causes of blindness in the world. Elevated intraocular pressure is a major risk factor. Laser photocoagulation induced ocular hypertension is one of the well established animal models. This video demonstrates how to induce ocular hypertension by Argon laser photocoagulation in rat.
Acosta Ana C - - 2007
BACKGROUND AND OBJECTIVES: To validate accuracy and reproducibility of the Perkins tonometer, pneumatonometer, and Tono-Pen XL (Medtronic Solan, Jacksonville, FL) in estimating intraocular pressure (IOP) in rabbits. MATERIALS AND METHODS: IOP was increased from 5 to 50 mm Hg in 5-mm increments. Measurements were compared to readings of two digital ...
Dresher Russell P RP Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA 01609 USA. - - 2007
Wireless sensing has shown potential benefits for the continuous-time measurement of physiological data. One such application is the recording of intraocular pressure (IOP) for patients with glaucoma. Ultra-low-power circuits facilitate the use of inductively-coupled power for implantable wireless systems. Compact circuit size is also desirable for implantable systems. As a ...
Duggal Priya P Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA. - - 2007
To identify genetic loci that control intraocular pressure (IOP). We performed a genomewide scan of IOP, using 486 pedigrees ascertained through a population-based cohort, the Beaver Dam Eye Study. Linkage analysis was performed using the modified Haseman-Elston regression models and variance components linkage analysis. Seven regions of interest were identified ...
Nickells Robert W RW Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53706, USA. - - 2007
Recent reports from large clinical trials have clearly demonstrated that lowering intraocular pressure (IOP) in persons with ocular hypertension has a beneficial effect on reducing the progression of glaucomatous disease. Few studies of this effect have been conducted in controlled laboratory settings, however, none have been conducted using non-human primates, ...
Kiuchi Takahiro - - 2007
PURPOSE: To investigate the effect of various ocular hypotensive eyedrops on the intraocular pressure (IOP) fluctuations caused by the postural change in patients with normal-tension glaucoma (NTG). DESIGN: Randomized crossover single-blind study. METHODS: Twenty-four eyes of 24 newly diagnosed NTG patients were enrolled. One of the three eyedrops including timolol ...
Pierscionek B K - - 2007
AIM: To measure corneal and scleral radii of curvature in response to intraocular pressure (IOP). METHODS: Using digital photographic profile images of 16 fresh porcine eyes, the curvatures of the cornea and sclera were determined in response to five consecutive incremental 100 mul saline intravitreal injections. IOP was measured and ...
Vistamehr Setareh - - 2006
PURPOSE: To evaluate a screening protocol for detection of individuals with a higher risk of chronic open angle glaucoma for which a complete glaucoma evaluation is indicated. PATIENTS AND METHODS: African Americans over 40 years of age in New Haven, CT. In the screening phase, volunteers filled out a questionnaire ...
Tavares Ivan M - - 2006
PURPOSE: To examine the variability and to evaluate the influence of the Ocular Hypertension Treatment Study (OHTS) on the criteria for published definition of ocular hypertension (OH). DESIGN: Systematic literature review. METHODS: All articles about OH published between January 1995 and July 2005 from the 3 clinical journals of ophthalmology ...
Punjabi Omar S - - 2006
Interindividual variability of central corneal thickness has been found to be a source of error for conventional Goldmann applanation tonometry. The dynamic contour tonometer represents a potentially new technology for non-invasive and direct intraocular pressure (IOP) measurement, and has been proposed to accurately measure the true IOP irrespective of the ...
Greenfield David S - - 2007
OBJECTIVE: To explore the relationship between asymmetric baseline intraocular pressure (IOP) and asymmetric visual field (VF) loss in the Low-Pressure Glaucoma Treatment Study. DESIGN: Randomized, multicenter, controlled clinical trial. PARTICIPANTS: Low-pressure glaucoma (LPG) patients 30 years or older were identified. Exclusion criteria included an untreated pressure > 21 mmHg, advanced ...
Konstas A G P - - 2007
To evaluate the diurnal intraocular pressure (IOP) control and safety of bimatoprost versus latanoprost in exfoliative glaucoma (XFG). One eye of 129 consecutive patients with XFG (mean (SD) age 66.5 (8.3) years) was included in this prospective, observer-masked, three-centre, crossover comparison. After a 4-6 week medicine-free period patients were randomised ...
Gherghel D - - 2008
PURPOSE: To evaluate the effect of latanoprost 0.005% on the optic nerve head (ONH) and retinal circulation of newly diagnosed and previously untreated primary open-angle glaucoma (POAG) patients. METHODS: Twenty-two newly diagnosed and previously untreated POAG patients (mean age+/-SD: 68.38+/-11.92 years) were included in this longitudinal open-label study. Patients were ...
Kurita Naoyuki - - 2006
PURPOSE: To investigate the correlation of ocular perfusion pressure (OPP) with general and localized visual field damage in normal-tension glaucoma (NTG) patients. METHODS: Correlations between OPP, blood pressure, age, intraocular pressure, refractive error, and extent of visual field damage in the eye with the worst mean deviation (MD) were investigated ...
He Zheng - - 2006
PURPOSE: To evaluate the recovery of retinal function after acute IOP elevation. METHODS: The electroretinogram (ERG) was measured before, during, and after IOP increased to 50 and 70 mm Hg at different durations in anesthetized, dark-adapted rats (n = 5-7). Signals were collected for dim and bright flashes (-4.95 and ...
Noecker Robert J - - 2006
OBJECTIVE: To compare the intraocular pressure-lowering efficacy and safety of topical bimatoprost 0.03% with that of travoprost 0.004% for the treatment of black patients with open-angle glaucoma (OAG) and ocular hypertension (OHT). RESEARCH DESIGN AND METHODS: Multicenter, prospective, randomized, investigator-masked trial of 94 black patients previously diagnosed with OAG or ...
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