Search Results
Results 251 - 300 of 1746
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Varma Rohit - - 2008
PURPOSE: To evaluate whether inter-visit intraocular pressure (IOP) range, which reflects extreme and potentially damaging IOP fluctuations, provides additional information on IOP control compared to mean IOP. DESIGN: Post hoc analysis of Xalatan/Lumigan/Travatan study data, a masked-evaluator, randomized, parallel-group comparison of 12-week efficacy of latanoprost, bimatoprost, and travoprost in open-angle ...
Chang Yo-Chen - - 2008
The purpose of this study was to investigate the incidence and timing of elevation in intraocular pressure (IOP) after intravitreal injection of triamcinolone acetonide (IVTA). This was a retrospective observational case series that included 52 eyes from 52 patients. All patients received intravitreal injection with 4 mg of triamcinolone acetonide. ...
Greller Andrew L - - 2008
OBJECTIVE: To determine effects of the topically applied calcium-channel blocker flunarizine on intraocular pressure (IOP) in clinically normal dogs. ANIMALS: 20 dogs. PROCEDURES: Baseline diurnal IOPs were determined by use of a rebound tonometer on 2 consecutive days. Subsequently, 1 randomly chosen eye of each dog was treated topically twice ...
Rolle T T Department of Clinical Physiopathology, Section of Ophthalmology, Eye Clinic, University of Torino, Torino, Italy. - - 2008
To compare the effect of dorzolamide hydrochloride 2%, timolol maleate 0.5%, and their fixed combination on intraocular pressure (IOP)and retinal and optic nerve head haemodynamics in primary open-angle glaucoma patients. Twenty-eight patients with early moderate glaucomatous damage treated with β-blockers (>6 months) with IOP values ranging from 18 to 22 ...
Ba-Abbad Rola A - - 2008
Bilateral optic disc swelling in children is a relatively uncommon sign with a wide array of differential diagnoses. We describe a boy with bilateral optic disc swelling referred as a case of papilledema. However, upon careful ocular fundus examination, detection of discrete retinal nerve fiber layer and pigment epithelial changes ...
Alagoz Gürsoy - - 2008
BACKGROUND: This study compares intraocular pressure (IOP)-lowering efficacy and retrobulbar hemodynamic effects of bimatoprost and travoprost in patients with newly diagnosed open-angle glaucoma. METHODS: Patients were randomly assigned to one of two treatment groups (bimatoprost group, n = 36; travoprost group, n = 46). IOP levels were measured with Goldmann ...
Stewart William C - - 2008
PURPOSE: To assess the cost-effectiveness of treating ocular hypertension (OHT) in the United States. DESIGN: A Markov model was constructed to perform a cost-effectiveness analysis. PARTICIPANTS: Patients with OHT. METHODS: The health states considered were stable OHT and glaucoma. Practice patterns for the model were derived from the Ocular Hypertension ...
Grus Franz H - - 2008
Elevated intraocular pressure does not explain glaucoma in all patients, but there is information that autoimmune mechanisms may be involved in this disorder. This review attempts to reveal the findings about specific changes in autoantibody profiles in glaucoma patients and their possible role in glaucoma. Considering that these changes in ...
Vetrugno Michele - - 2008
The purpose of this review is to discuss the topics relevant to the use of intraocular pressure-lowering strategies, which remains the first line in the management of glaucoma. Estimates of blindness from glaucoma and identification of risk factors remain of interest for all ophthalmologists. New functional tests offer promise for ...
Hodge W G - - 2008
AIM: To systematically review the literature on the efficacy and harm of prostaglandin analogues (PGAs) compared to brimonidine and dorzolamide in treating elevated intraocular pressure (IOP). METHODS: Keywords were searched in major literature databases to identify relevant randomised clinical trials (RCTs) of PGAs for ophthalmic use. The study quality of ...
Diaz Alberto A Department of Physics (Optometry), University of Minho, Braga, - - 2008
The purpose of this study was to assess the accuracy of the ICare tonometer, using the Perkins applanation tonometer (AT) as the reference, in a sample population being treated with travaprost 0.004% for glaucoma. Twenty-eight consecutive patients with open-angle glaucoma or ocular hypertension who had been receiving travaprost 0.004% to ...
Morrison John C JC Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA. - - 2008
Rats are becoming an increasingly popular model system for understanding mechanisms of optic nerve injury in primary open-angle glaucoma (POAG). Although the anatomy of the rat optic nerve head (ONH) is different from the human, the ultrastructural relationships between astrocytes and axons are quite similar, making it likely that cellular ...
Januleviciene Ingrida - - 2008
PURPOSE: Current evidence indicates that alteration in ocular blood flow may be relevant in open-angle glaucoma (OAG) patients independent of intraocular pressure (IOP). Presently, the lack of an adequate methodology capable of assessing all vascular beds limits the clinical role of blood flow parameters in glaucoma management. We aimed to ...
Kotliar Konstantin E - - 2008
PURPOSE: We investigated whether retinal branch arteries in healthy subjects, and non-treated and treated primary open-angle glaucoma (POAG) patients show irregular local patterns during dynamic reaction to acute increases of different magnitudes in intraocular pressure (IOP). METHODS: Nine POAG patients and nine age-matched normal volunteers were examined with the retinal ...
Rotchford Alan P - - 2007
PURPOSE: To describe a modified technique for combined cataract and glaucoma drainage surgery involving a small flap (micro) trabeculectomy combined with phaco-emulsification (PMT). To assess the level of intraocular pressure (IOP) control achieved by this procedure in comparison with microtrabeculectomy (MT) alone. METHODS: In this retrospective controlled case series records ...
Romppainen Timo - - 2007
PURPOSE: Corneal collagen cross-linking (CCL) with riboflavin and ultraviolet A irradiation has recently been introduced for treatment of corneal ectasia. Yet a CCL-induced increase in corneal rigidity may interfere with intraocular pressure (IOP) measurements. In an investigation of the effect of CCL on the accuracy of IOP measurements, IOP readings ...
Sonty Sriram - - 2008
PURPOSE: We aimed to investigate the safety and efficacy of dorzolamide/timolol fixed combination (DTFC) in timolol responders with ocular hypertension or open-angle glaucoma who switched to DTFC because of insufficient control on latanoprost. METHODS: We carried out a prospective, open-label cohort study with an active-historical control in which qualifying patients ...
Holcombe David J - - 2008
PURPOSE: To investigate the relationship between intraocular pressure (IOP), retinal glutamate transport and retinal hypoxia during acute IOP elevations of varying magnitude. METHODS: Female Dark Agouti rats were anaesthetized by ketamine/xylazine/acepromazine (10/5/0.5 mg/kg i.p.). The anterior chamber was cannulated with a 30-gauge needle attached to a saline reservoir. The target ...
Costagliola Ciro - - 2008
PURPOSE: To evaluate the circadian effects on intraocular pressure (IOP) and ocular perfusion pressure (OPP) of 0.5% timolol or 0.005% latanoprost in Caucasian patients affected by normal-tension glaucoma (NTG). PATIENTS AND METHODS: In this crossover trial, 30 consecutive NTG subjects underwent three 24-hour assessments of IOP, blood pressure (BP), heart ...
Mozaffarieh Maneli - - 2007
Classic glaucoma treatment focuses on intraocular pressure (IOP) reduction. Better knowledge of the pathogenesis of the disease has opened up new therapeutical approaches. Whereas most of these new avenues of treatment are still in the experimental phase, others, such as magnesium, gingko, salt and fludrocortisone, are already used by some ...
Kim Min-Su - - 2007
The effects of electroacupuncture (EA) on intraocular pressure (IOP) and hemodynamic parameters were evaluated in isoflurane anesthetized 10 (5 males, 5 females) normal mongrel dogs (8.1-9.8 kg, 6-8 years old). After determination of baseline IOP and hemodynamic parameters (cardiac index, systolic arterial pressure, diastolic arterial pressure, heart rate and systemic ...
Grozdanic Sinisa D - - 2007
PURPOSE: To characterize the timing and extent of functional recovery in healthy canine eyes exposed to acute elevation of intraocular pressure (IOP). METHODS: Acute elevation of IOP was induced in 14 healthy Beagles by elevating IOP above the levels of systolic blood pressure for 60 min (average elevation was between ...
Mirza Salman - - 2007
PURPOSE: To report bilateral ocular hypertension in association with ocular sarcoidosis. METHODS: Case note review of patients with a diagnosis of sarcoidosis-related uveitis. RESULTS: The authors identified 5 patients who fulfilled the diagnostic criteria for ocular sarcoidosis and who had intraocular pressures of > 40 mmHg in each eye. CONCLUSIONS: ...
Walick Kristina S - - 2007
STUDY DESIGN: Parallel group design. OBJECTIVE: Compare the intraocular pressure responses in the prone flat versus prone Trendelenburg's position. SUMMARY OF BACKGROUND DATA: Postoperative vision loss (PVL) complicates approximately 0.05% of spine surgeries. Prone positioning is considered a risk factor because it increases intraocular pressure, which may decrease perfusion pressure ...
Taylor Nicole R - - 2007
OBJECTIVE: To record intraocular pressure (IOP) of three different dog breeds following administration of one drop of 1% tropicamide. ANIMALS: Three dog breeds -- Golden Retrievers (n = 20), Siberian Huskies (n = 20) and English Cocker Spaniels (n = 36) -- were studied. PROCEDURE: IOPs were measured using a ...
Robert Yves C A - - 2007
This article reviews briefly three important aspects of tonometry: physics, physiology, and glaucoma. With respect to the physical principles of tonometry, deformation of the globe is a key component: force tonometers measure intraocular pressure (IOP) by deforming the globe whereas pressure tonometers do not. Pressure tonometers can provide measurements that ...
Galassi Fernando - - 2008
BACKGROUND: Previous investigations have shown that vascular factors are involved in pseudoexfoliative glaucoma (XFG). The present study aims at comparing ocular perfusion pressure (OPP), diastolic ocular perfusion pressure (dOPP), and retrobulbar haemodynamics in pseudoexfoliative glaucoma and primary open-angle glaucoma (POAG). METHODS: Forty-seven XFGs, 41 POAGs, and 38 healthy controls were ...
Markovskaya Anna - - 2008
Nucleotides can modify intraocular pressure (IOP). We have tested the ability of uridine-5'-diphosphate, UDP, for modulating IOP in New Zealand white rabbits. Uridine 5' diphosphate, UDP, reduced IOP by 82.9+/-2.6% compared to control. Dose-response analysis demonstrated a concentration dependent pattern which presented a pD(2) value of 7.57+/-1.45, equivalent to an ...
Pourjavan Sayeh - - 2007
PURPOSE: The Pascal dynamic contour tonometer (DCT) allows measurement of intraocular pressure (IOP) independently of corneal properties. It records, simultaneously, haemodynamic IOP fluctuations and the difference between the systolic and the diastolic IOP corresponding to the ocular pulse amplitude (OPA). The OPA indirectly reflects choroidal perfusion and could be considered ...
Liu Quan - - 2007
PURPOSE: To determine whether oxidative adduct formation or heme oxygenase-1 (HO-1) expression are altered in retinal ganglion cell (RGC) cultures exposed to elevated hydrostatic pressure and in a mouse model of glaucoma. METHODS: Cultured RGC-5 cells were subjected to 0, 30, 60, or 100 mm Hg hydrostatic pressure for 2 ...
Leung Andrea K - - 2007
A 67-year-old woman with a 30-year history of dysthyroid orbitopathy and diplopia had an inadvertent injection of botulinum toxin type A into the vitreous cavity. Full pupil mydriasis and an intraocular pressure (IOP) of 50 mm Hg in the right eye were noted after the injection. An attack of acute ...
Diafas Savvas - - 2007
To evaluate progression rates with dorzolamide compared with other hypotensive agents in primary open-angle glaucoma. Patients who were treated over 5 years with dorzolamide versus other hypotensive agents were reviewed. The groups were matched by intraocular pressure, cardiovascular history, and age. In 50 matched pairs, 2 (4%) of dorzolamide and ...
Mohammed Haider M - - 2007
OBJECTIVE: To evaluate the effects of silibinin hemisuccinate on the normal intraocular pressure (IOP) in rabbits. METHODS: This study took place in the Department of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad during the period from January to June 2005. Twenty-five New Zealand white rabbits weighing 1.5-2.5 kg ...
Lam Andrew - - 2007
PURPOSE: To compare intraocular pressure (IOP) obtained from the ocular response analyzer (ORA) and Goldmann applanation tonometer (GAT) on a group of normal Chinese. METHODS: One hundred twenty-five normal subjects were recruited, with one eye randomly selected for this study. Each eye was measured first with the noncontact tonometer ORA, ...
Queirós A - - 2007
PURPOSE: To compare central and peripheral intraocular pressure (IOP) readings obtained with rebound tonometry. METHODS: Intraocular pressure was measured on the right eye of 153 patients (65 males, 88 females), aged from 21 to 85 years (mean +/- S.D., 55.5 +/- 15.2 years) with the ICare rebound tonometer at centre, ...
Xu Liang - - 2007
PURPOSE: To assess the relation of arterial blood pressure (BP) and intraocular pressure (IOP) in an adult population not using glaucoma medications. DESIGN: Cross-sectional population-based study. METHODS: The Beijing Eye Study 2006, a population-based, cross-sectional cohort study, included 3,253 subjects (age, 45 years or more). The mean age was 60.4 ...
Law Simon K - - 2007
The goal of treatment for open-angle glaucoma or ocular hypertension is to improve quality of life through reduction of intraocular pressure (IOP) to preserve visual function. Prostaglandins, as a newer class of ocular hypotensive agents, have been shown to be effective in IOP reduction by the primary mechanism of action ...
Almubrad Turki M - - 2007
Contact tonometry is generally considered more accurate than non-contact tonometry in the assessment of intraocular pressure (IOP). This study was designed to investigate the effect of ocular anesthesia, a pre-requisite for contact tonometry, on the IOP in a sample of visually normal subjects. In a random sample of 120 young ...
SHARMA, SUNIL
The present study was carried out to investigate the effect of benazepril on corneal permeation in goat cornea and its effect on experimentally induced acute and chronic glaucoma in rabbits. Acute glaucoma was produced by i.v. infusion of 5% glucose (15 mL/kg) in rabbits, whereas chronic glaucoma was induced by ...
Koz Ozlem Gurbuz - - 2007
PURPOSE: To study the effect of three prostaglandin F(2)-alpha (PG) analogues on retrobulbar blood flow velocity in previously untreated patients with primary open-angle glaucoma (POAG) or ocular hypertension (OHT), using colour Doppler ultrasound. METHODS: Sixty newly diagnosed patients with POAG or OHT were randomly assigned to travoprost 0.004% (n = ...
Zhang Xiulan - - 2007
Throughout the body, mechanical perturbations are transduced into neurochemical signals by the release of ATP from non-neuronal cells. As an increased intraocular pressure (IOP) can initiate mechanical changes, we hypothesized that extracellular levels of ATP might be increased in the anterior chamber of human patients with primary acute angle closure ...
Nordmann Jean-Philippe - - 2007
BACKGROUND: Intraocular pressure (IOP) fluctuation over 24 hours is an independent risk factor for glaucoma progression. Nighttime lOP measurement is not routine practice. OBJECTIVE: The aim of this study was to predict, using a Bayesian network (BN), the likelihood of a nighttime IOP peak >18 mm Hg based on daytime ...
Chan Kenny - - 2007
PURPOSE: Successful management of glaucoma and ocular hypertension requires patient compliance with the therapeutic regimen. Because ocular discomfort affects compliance, we compared the comfort of brimonidine 0.2%/timolol 0.5% and dorzolamide 2%/timolol 0.5%. METHODS: In this single-centre, randomized, double-masked, internally controlled/paired-eye study, 30 subjects without a significant ocular surface disease received ...
Polska Elzbieta - - 2007
PURPOSE: To test the hypothesis that human choroidal blood flow (ChBF) may depend, not only on ocular perfusion pressure (OPP), but also on absolute mean arterial pressure (MAP) and intraocular pressure (IOP). METHODS: There were two study days in an open design. On the first day, OPP was varied by ...
Shimazaki Atsushi - - 2007
To evaluate the pharmacological characteristics of SA12590, a new oxime-derivative of the ethacrynic acid (ECA) derivative SA9000, we examined both its ocular hypotensive effects (in ocular normotensive cats and cynomolgus monkeys) and its potential corneal toxicity (in rats). A 50 microl topical administration of 3% SA12590 significantly reduced intraocular pressure ...
Beneyto Pedro - - 2007
This is a descriptive study designed to assess the predictive value of intraocular pressure (IOP) measurement in GPs' offices in an urban healthcare site using Tono-pen XL. A total of 2044 patients, aged > or =40 years, were enrolled by consecutive sampling from patients visiting the GP. Those participants who ...
Prashar A A School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, - - 2007
Intraocular pressure (IOP), an important risk factor for glaucoma, is a continuous trait determined by a complex set of genetic and environmental factors that are largely unknown. Genetic studies in laboratory animals may facilitate the identification of genes that affect IOP. We examined the use of the rebound tonometer for ...
Tomidokoro Atsuo - - 2007
PURPOSE: To evaluate central corneal thickness (CCT) in a Japanese population and to describe the relationship between CCT and other factors. DESIGN: Population-based cross-sectional study. METHODS: Reliable CCT measurements were obtained using specular-type pachymetry from 2,868 persons 40 years or older selected randomly from the population of Tajimi City. RESULTS: ...
Spiliotopoulos Christos - - 2007
The effect of systemic steroid administration on intraocular pressure (IOP) is well established. However less attention has been paid to the effect of steroids when administered in a nasal spray. We conducted a study to investigate a possible association between nasal steroids and elevated IOP in 54 patients who were ...
Stewart W C - - 2008
PURPOSE: To determine the predictive value of early Phase trials (I-II) for the ocular hypotensive efficacy observed in Phases III and IV. DESIGN: A review of published literature. METHODS: This study evaluated 12 medicines in 65 articles in the literature with at least two phases available. RESULTS: For medicines with ...
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