Search Results
Results 201 - 250 of 1745
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Donnelly Steven J - - 2009
PURPOSE: To determine the influence of intraocular pulse pressure (IOPP) on the presence of spontaneous venous pulsations (SVP) in patients with normal intracranial pressure. DESIGN: Clinic-based cross-sectional study. METHODS: Forty-seven patients without signs and symptoms of elevated intracranial pressure were recruited from a general ophthalmology clinic. Patients with glaucoma or ...
Montero J A - - 2008
PURPOSE: The determination of intraocular pressure (IOP) by noncontact tonometry (NCT) has been reported to be affected by central corneal thickness (CCT) and by the instillation of topical anesthetics. METHODS: In order to determine the influence of topical anesthetics on CCT and IOP measured by NCT, 80 eyes from 49 ...
Ohashi Masaaki - - 2008
PURPOSE: To assess the efficacy of two noninvasive tonometers, TonoLab and TonoPen-XL, in detecting physiological or pharmacological changes of intraocular pressure (IOP) in rat eyes, by comparing them with the microneedle method. METHODS: Sprague Dawley rats, bred under a 12-h light-and-dark cycle, were used. Under systemic anesthesia, eyes were cannulated ...
Zoumalan Christopher I - - 2008
OBJECTIVE: To evaluate orbital pressure (OP), intraocular pressure (IOP), and the effectiveness of canthotomy, cantholysis, and septolysis using an experimental orbital hemorrhage model. METHODS: Expired whole blood was injected into the retrobulbar space of 10 human cadaver orbits. At 1-mL increments, OP, IOP, and globe position were documented. The mean ...
Lee Anne J - - 2008
Lowering IOP is the most readily modifiable risk factor to delay the development and progression of glaucoma (POAG). The fixed combination of brimonidine tartrate 0.2% and timolol maleate 0.5% (FCBT) combines a highly selective alpha2-adrenergic agonist (brimonidine) with a non-selective beta-blocker (timolol). FCBT reduces aqueous production and enhances uveoscleral outflow. ...
Sjaastad Ottar - - 2008
Shortlasting, unilateral, neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) syndrome is a rare headache, described by our group in 1989. This overview presents our early studies of SUNCT pathogenesis. Due to the conspicuous ictal, ocular phenomena, ie, conjunctival injection and tearing, our studies started out with ocular parameters: ...
Berdahl John P - - 2008
To compare intracranial pressure (ICP) in subjects with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG; subset of POAG), and ocular hypertension (OHT) with that in subjects with no glaucoma. The study was a retrospective review of medical records of 62,468 subjects who had lumbar puncture between 1985 and 2007 at ...
Amerasinghe Nishani - - 2008
OBJECTIVE: To describe the distribution and determinants of the optic cup to disc ratio (CDR) in Malay adults in Singapore. METHODS: This population-based, age-stratified study examined 3280 Malay people aged 40 to 80 years in Singapore. Participants underwent a standardized interview and an ocular examination. A slitlamp examination measured the ...
Han Ying - - 2008
A recent study has reported an excellent correlation between intraocular pressure (IOP) and intracranial pressure (ICP), suggesting that measurement of IOP may serve as a noninvasive means to determine ICP. To reexamine the relation between IOP and ICP, we reviewed the medical records of all patients who underwent lumbar puncture ...
Van de Veire Sara - - 2008
PURPOSE: To determine whether the atmospheric pressure (ATM) change experienced during diving can induce changes in the intraocular pressure (IOP) of eyes in a normal population. METHODS: The IOP of 27 healthy volunteers (ages, 23.8 +/- 4.9 years; range, 18-44) was measured with a Perkins applanation tonometer by two independent ...
Morgan W H - - 2008
AIM: To examine the acute effects of wearing swimming goggles upon intraocular pressure (IOP). METHODS: This research consisted of a Pilot study and a Validation study. Holes were drilled into the faces of 13 different goggles to allow IOP measurement by applanation tonometry. IOP was measured before goggles wear, 2 ...
Boyce Brad L - - 2008
The viscoelastic response of bovine corneas was characterized using in vitro inflation (bulge) experiments combined with spatially-resolved deformation mapping via digital image correlation. A complex fixture conforming to the limbal annulus was developed to hold the attached sclera rigid while allowing deformation only in the cornea. A statistical set of ...
Johnson Thomas V - - 2008
OBJECTIVE: To examine how aqueous humor dynamics are affected by exfoliation syndrome (XFS) with or without elevated intraocular pressure (IOP). METHODS: Eighty participants were divided into 4 groups: (1) those with XFS and ocular normotension (n = 25), (2) controls with ocular normotension without XFS, age-matched to group 1 (n ...
Casson Robert J - - 2008
OBJECTIVE: To determine correlates of central corneal thickness (CCT) and its relationship to intraocular pressure (IOP) in a Burmese population. METHODS: We performed a population-based survey of inhabitants 40 years or older in Myanmar; of 2076 participants, data from 1909 nonglaucomatous subjects who underwent ultrasound pachymetry and Goldmann applanation tonometry ...
Polak Marianne Berdugo - - 2008
PURPOSE: To evaluate the antimitotic and toxic effects of 5-chlorouracil (5-CU) and 5-fluorouracil (5-FU) and study their potential to delay filtering bleb closure in the rabbit eye when released by poly(ortho esters) (POE). METHODS: Rabbit Tenon fibroblasts and human conjunctival cells were incubated with various 5-CU and 5-FU concentrations. Antiproliferative ...
Sudheera K S - - 2008
BACKGROUND: Prevention of rise in intraocular pressure (IOP) is essential in patients undergoing surgery for perforated eye injuries. Metoclopramide, a prokinetic agent, is commonly used to hasten gastric emptying in emergency surgeries. AIM: To study the change in IOP after intravenous metoclopramide and to study the influence of metoclopramide on ...
Lee M S - - 2008
Multiple drilling is reported to be an effective treatment for osteonecrosis of the head of femur, but its effect on intra-osseous pressure has not been described. We undertook multiple drilling and recorded the intra-osseous pressure in 75 osteonecrotic hips in 60 patients with a mean age of 42 years (19 ...
Quaranta L - - 2008
AIM: To evaluate 24 h intraocular pressure (IOP) and blood pressure (BP) with bimatoprost or latanoprost in patients with normal-tension glaucoma. DESIGN: Prospective, randomised, crossover, active-controlled, observer-masked study. METHODS: After a 6-week medicine-free period, we randomised patients to either latanoprost or bimatoprost for 8 weeks and then to the opposite ...
Kaback Martin - - 2008
PURPOSE: To compare the safety and intraocular pressure (IOP)-lowering efficacy of brinzolamide 1%/timolol 0.5% fixed combination with brinzolamide 1% or timolol 0.5% alone in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). DESIGN: Randomized, double-masked, parallel group, multicenter study. PARTICIPANTS: Five hundred twenty-three patients were randomized to the study ...
Deokule Sunil - - 2008
Several vascular factors, including systemic hypertension (or high blood pressure [HBP]), ocular perfusion pressure, and nocturnal hypotension, have been identified as risk factors for the development and progression of glaucoma. The results of epidemiologic studies of these factors and their relationships to intraocular pressure (IOP) and open-angle glaucoma (OAG) have ...
May William - - 2008
PURPOSE: To determine the most favorable sutureless incision configuration to minimize extraocular fluid inflow after cataract surgery. SETTING: The Wilmer Eye Institute, Baltimore, Maryland, USA. METHODS: Five fresh human eyes were used in the study. Two 27-gauge needles connected to a saline solution bag and a digital manometer were inserted ...
Yeh Jason - - 2008
Glaucoma is a multifactorial optic neuropathy in which the main therapeutic target is lowering of intraocular pressure (IOP) in order to retard the progression of existing structural and functional damage. The three mainstays of treatment are pharmacologic, laser, and surgical. The primary standard therapy in patients with open-angle glaucoma or ...
Downs J Crawford - - 2008
The optic nerve head (ONH) is of particular interest from a biomechanical perspective because it is a weak spot within an otherwise strong corneo-scleral envelope. The lamina cribrosa provides structural and functional support to the retinal ganglion cell axons as they pass from the relatively high-pressure environment in the eye ...
Quaranta Luciano - - 2008
PURPOSE: To evaluate the effect of the timolol-dorzolamide fixed combination (TDFC) and latanoprost 0.005% on 24-hour intraocular pressure (IOP), systolic (SBP) and diastolic (DBP) blood pressure, and diastolic ocular perfusion pressure (DOPP) in patients with primary open-angle glaucoma (POAG). METHODS: This was an institutional, randomized clinical trial. After a 24-hour ...
Hommer Anton - - 2008
PURPOSE: There is evidence from theoretical models and animal studies that the biomechanical properties of the optic nerve head and the sclera play a role in the pathophysiology of glaucoma. There are, however, only a few data available that demonstrate such biomechanical alterations in vivo. In this study, the hypothesis ...
Memarzadeh Farnaz - - 2008
To evaluate the association of biologic factors with intraocular pressure (IOP) in a Latino population. Population-based cross-sectional study. Latinos 40 years and older (n = 5,958) from the Los Angeles Latino Eye Study without a history of ocular hypotensive treatment underwent an interviewer-administered questionnaire and a complete ocular and clinical ...
Cox J A - - 2008
AIM: To evaluate the efficacy of the fixed combination ocular hypotensive therapies compared with their non-fixed components used concomitantly for lowering intraocular pressure (IOP) in glaucoma and ocular hypertension. METHODS: A systematic review of the literature, up to May 2007, without limits on year or language of publication was performed. ...
Kumar Rajesh S - - 2008
BACKGROUND: To determine whether there is a correlation between peak intraocular pressure (IOP) measured after water drinking test (WDT) and patient's peak daytime IOP. METHODS: Patients who were diagnosed with glaucoma, ocular hypertension and/or glaucoma-like discs were enrolled in this prospective observational pilot study. All subjects underwent daytime IOP measurement ...
Zeitz Oliver - - 2008
BACKGROUND: Systemic antihypertensive treatment in glaucoma patients with hypertension carries the potential risk of an additional deterioration in ocular hemodynamics due to the reduction in ocular perfusion pressure. Nebivolol is a beta1-selective adrenoceptor antagonist with known peripheral vasodilatory effects due to NO-releasing properties. The effect of a switch in systemic ...
Birchall Wayne - - 2008
BACKGROUND: To assess the contribution of scleral flap edge apposition to intraocular pressure (IOP) control in trabeculectomy, using a previously described and validated experimental model of guarded filtration surgery. MATERIALS AND METHODS: Twelve rectangular-flap trabeculectomy operations each with two apical adjustable sutures were performed on six donor human eyes connected ...
Almeida Denise E - - 2008
OBJECTIVE: The aim of the present study was to evaluate the effects of nitrous oxide on IOP and pupillary diameter (PD) of dogs anesthetized with varying desflurane concentrations. ANIMALS STUDIED: Twenty adult Mongrel dogs were used. METHODS: They were anesthetized with propofol (10 mg/kg, IV) and maintained with varying concentrations ...
Kynigopoulos M - - 2008
BACKGROUND: The Ocular Response Analyser (ORA, Reichert Ophthalmic Instruments) is a non-contact applanation tonometer, providing two measures of intraocular pressure (IOP) - IOPg which represents a Goldmann equivalent IOP measure and IOPcc, representing a measure of IOP independent of corneal effects. In addition, the device provides two measures believed to ...
Lim K Sheng - - 2008
To study the effects of 3 prostaglandin analogs, bimatoprost, latanoprost, and travoprost, on aqueous dynamics in the same subjects and to compare techniques of assessing outflow facility. Experimental study (double-masked, placebo-controlled, randomized paired comparison, 4-period crossover). Thirty healthy adult subjects. Bimatoprost, latanoprost, travoprost, or a placebo was administered to the ...
Broadwater Joshua J - - 2008
Objective-To determine the effects of body position on intraocular pressure (IOP) in dogs without glaucoma. Animals-24 healthy dogs with no evidence of glaucoma. Procedures-Dogs underwent ophthalmic examinations to ensure that no IOP-affecting ocular diseases were present. Each dog was sequentially placed in dorsal recumbency, sternal recumbency, and sitting position. For ...
Plange Niklas - - 2008
BACKGROUND: The pathogenesis of normal tension glaucoma (NTG) might be related to impaired autoregulation of ocular blood flow. The purpose of the study is to evaluate retinal haemodynamics by fluorescein angiography and to correlate arteriovenous passage times (AVP) with ocular perfusion pressure in patients with NTG and controls. METHODS: Thirty-five ...
Bayer Atilla - - 2008
PURPOSE: To investigate the effect of air flight on intraocular pressure (IOP). METHODS: Baseline IOP of 25 healthy volunteers was measured at a ground level of 1760 feet above sea level (ASL) using Tono-Pen XL. Measurements were repeated after reaching an altitude of 19,000 feet and then on the second ...
Miura Katsuya - - 2008
PURPOSE: To compare the ocular hypotensive effect and safety of brinzolamide and timolol added to latanoprost monotherapy. METHODS: In prospective randomized fashion, we evaluated the ocular hypotensive effect and safety of brinzolamide or timolol in 1 eye of 32 patients with primary open-angle glaucoma, normal-tension glaucoma, or ocular hypertension who ...
Kirwan Caitriona - - 2008
PURPOSE: To determine the efficacy of the Reichert Ocular Response Analyzer (ORA) to measure intraocular pressure (IOP) following corneal laser refractive surgery. METHODS: Intraocular pressure was measured using Goldmann applanation tonometry preoperatively and 3 months following LASIK and LASEK for all levels of myopia and low levels of hyperopia. In ...
Sit Arthur J - - 2008
Recent research indicates that intraocular pressure (IOP) does not decrease significantly during the nocturnal period, although aqueous humor flow decreases by 50% or more at night. This study was undertaken to investigate whether changes in outflow facility, episcleral venous pressure, or uveoscleral flow at night could account for the nocturnal ...
van Brussel M S - - 2008
A hemodialysis patient is described who was suffering from headache during his dialysis sessions. This was due to a neovascular glaucoma causing an increase in intraocular pressure (IOP) during dialysis sessions. After several months his headache decreased but his IOP measurements remained high with almost similar pre- and post dialysis ...
Uhler Tara A - - 2008
PURPOSE OF REVIEW: To describe the epidemiology of disc hemorrhages and underscore the importance of detecting these markers of potential glaucomatous damage and progression. RECENT FINDINGS: The Ocular Hypertension Treatment Study has confirmed that disc hemorrhages are an independent risk factor in the development of glaucoma. The risk of developing ...
Kim Seung Kab - - 2008
PURPOSE: To determine the normal reference range of pulsatile ocular blood flow (POBF) values in healthy Korean subjects and to find out the factors that may affect them. METHODS: A total of 280 eyes of 280 normal subjects were included in this study. Best corrected visual acuity (BCVA), intraocular pressure ...
Kiekens Stefan - - 2008
PURPOSE: Several reports have demonstrated an association between glaucoma and obstructive sleep apnea (OSA), though the origin of this association remains unknown. In the present study, the influence of OSA and continuous positive airway pressure (CPAP) therapy on intraocular pressure (IOP) and ocular perfusion pressure (OPP) was examined. METHODS: IOP, ...
Iester Michele - - 2008
Primary open-angle glaucoma is a multifactorial optic neuropathy characterized by the progressive loss of retinal ganglion cells and their axons. However, the primary risk factor is elevated intraocular pressure (IOP), which can damage the optic nerve head (ONH) and until now was the only treatable risk factor. Brinzolamide ophthalmic suspension ...
Toker Mustafa Ilker - - 2008
BACKGROUND: To examine the effects of central corneal thickness on the measures obtained from transpalpebral tonometry (Diaton), and to identify correlations between intraocular pressure (IOP) measurements with Diaton and the Goldmann applanation tonometer (GAT). METHODS: In this cross-sectional study, 162 eyes of 81 participants were included. Intraocular pressure measurements were ...
Stewart William C - - 2008
PURPOSE: To evaluate efficacy and safety data of currently available ocular hypotensive medicines derived from 24-hour studies, of similar design, in patients with primary open-angle glaucoma (POAG), exfoliative glaucoma, or ocular hypertension (OH). DESIGN: Meta-analysis of published articles evaluating patients with POAG, exfoliative glaucoma, or OH. METHODS: We included articles ...
Mowafi H A - - 2008
BACKGROUND: Succinylcholine is still recommended for some situations in open globe injuries. However, the use of succinylcholine is associated with an increase in intraocular pressure (IOP). This may be deleterious in open globe injuries. No method has previously been shown to abolish completely this rise in the IOP. We investigated ...
Hofmeister Erik H - - 2008
OBJECTIVE: To determine the effects of propofol or thiopental induction on intraocular pressures (IOP) in normal dogs. STUDY DESIGN: Prospective randomized experimental study. ANIMALS: Twenty-two random-source dogs weighing 19.5 +/- 5.3 kg. METHODS: Dogs were randomly assigned to receive propofol 8 mg kg(-1) IV (group P) or thiopental 18 mg ...
Erdurmus M - - 2009
PURPOSE: To assess the agreement in the measurement of intraocular pressure obtained by dynamic contour tonometer (DCT) and noncontact tonometer (NCT) in patients with glaucoma and ocular hypertension, to investigate the effect of corneal thickness on pressure readings by both instruments, and to assess the reproducibility of dynamic contour tonometer. ...
Varma Rohit - - 2008
PURPOSE: To evaluate whether inter-visit intraocular pressure (IOP) range, which reflects extreme and potentially damaging IOP fluctuations, provides additional information on IOP control compared to mean IOP. DESIGN: Post hoc analysis of Xalatan/Lumigan/Travatan study data, a masked-evaluator, randomized, parallel-group comparison of 12-week efficacy of latanoprost, bimatoprost, and travoprost in open-angle ...
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