Search Results
Results 151 - 200 of 1746
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Bochmann F - - 2009
BACKGROUND: Intraocular pressure (IOP) measurements using Goldmann applanation tonometry (GAT) are influenced by central corneal thickness (CCT) whereas dynamic contour tonometry (DCT) allows for IOP measurements independent of CCT. After Descemet's stripping automated endothelial keratoplasty (DSAEK) the CCT is, compared to healthy eyes, increased. The objective of this prospective study ...
Zinkernagel Martin S - - 2009
PURPOSE: To investigate the effect of systemic acetazolamide on ocular pulse amplitude (OPA) and on intraocular pressure (IOP). METHODS: We determined OPA, IOP, mean arterial blood pressure and heart rate (HR) in 17 patients suffering from hypertensive primary open-angle glaucoma (htPOAG) and 22 healthy controls. Measurements were taken before and ...
Sit Arthur J - - 2009
Intraocular pressure (IOP) is a dynamic physiologic parameter with regular circadian variations and unpredictable short-term and long-term fluctuations. Current methods of measuring IOP are suboptimal with a typical clinical practice only performing periodic IOP measurements during regular office hours. Diurnal and 24-hour IOP measurements obtained on an in-patient basis can ...
Costa V P - - 2009
Although intraocular pressure (IOP) is considered the main risk factor for the development of glaucoma and the only parameter subject to treatment, there is sufficient evidence to suggest that glaucoma may continue to progress despite lowering patients' IOP to targeted levels. Several studies have implicated vascular risk factors in the ...
Wostyn P - - 2009
Evidence of a link between Alzheimer's disease (AD) and glaucoma has emerged from studies showing that patients with AD may have a significantly increased rate of glaucoma occurrence. In addition, it has been reported that patients with AD exhibit optic nerve degeneration and loss of retinal ganglion cells. In spite ...
Mukisi M M - - 2009
Osteonecrosis of the femoral head (ONFH) is a frequent complication of sickle-cell disease. Numerous studies have demonstrated increased intraosseous pressure (IOP) in idiopathic necrosis and necrosis secondary to corticotherapy or alcohol poisoning. Several reports have testified to the clinical interest of decompression by drilling which, when performed in the early ...
Leske M Cristina - - 2009
PURPOSE OF REVIEW: A possible connection between ocular perfusion pressure and open-angle glaucoma (OAG) has been hypothesized. This review summarizes the scientific rationale for the proposed relationship, presents recent data, and outlines potential implications. RECENT FINDINGS: Population-based epidemiologic studies found strong relationships between low ocular perfusion pressure and OAG prevalence, ...
Jewelewicz Daniel A - - 2009
PURPOSE: To report 4 patients with pigment dispersion syndrome (PDS) who had delayed intraocular pressure (IOP) spikes after pharmacologic pupillary dilation. METHODS: Four patients with a diagnosis of PDS with documented IOP spike after pharmacologic pupillary dilation were included. Study patients were examined before and after pupillary dilation. The amount ...
Sit Arthur J - - 2009
Glaucoma is a leading cause of visual impairment and blindness worldwide. The main risk factor for glaucoma is an elevated intraocular pressure (IOP), which is also the only currently treatable risk factor. Despite its importance, our understanding of IOP is incomplete and our ability to measure IOP is limited. IOP ...
Smith Michael - - 2009
PURPOSE: To investigate the relationship between bleb morphology, recorded using the Indiana Bleb Appearance Grading Scale (IBAGS), and intraocular pressure (IOP) after phacotrabeculectomy. METHODS: Two years postphacotrabeculectomy, a single observer compared bleb morphology to the IBAGS standard photographs in 76 eyes of 76 patients. In addition, the presence or absence ...
Woodward David F - - 2009
PURPOSE: As part of a systematic elucidation of the pharmacology of prostaglandin's (PG) effects on intraocular pressure in the monkey, the prototypical selective prostanoid EP(4) receptor agonist (3,7-dithia PGE(1)) was examined. It was found to be highly efficacious in nonhuman primates, and its mechanism of ocular hypotensive activity was investigated. ...
Leung C K S - - 2009
AIM: To longitudinally investigate retinal ganglion cell (RGC) expression of Thy-1, a cell-surface glycoprotein specifically expressed in RGCs, with a blue-light confocal scanning laser ophthalmoscope, following retinal ischaemia induced by acute elevation of intraocular pressure. METHODS: A blue-light confocal scanning laser ophthalmoscope (bCSLO, 460 nm excitation and 490 nm detection) ...
Johnson Elaine C EC The Kenneth C. Swan Ocular Neurobiology Laboratory, Casey Eye Institute, CERES, Oregon Health and Science University, Portland, OR 97239, USA. - - 2009
The neurotrophin (NT) hypothesis proposes that the obstruction of retrograde transport at the optic nerve head results in the deprivation of neurotrophic support to retinal ganglion cells (RGC) leading to apoptotic cell death in glaucoma. An important corollary to this concept is the implication that appropriate enhancement of neurotrophic support ...
Kyhn Maria Voss - - 2009
The purpose of this study was to establish, and characterize a porcine model of acute, controlled retinal ischemia. The controlled retinal ischemia was produced by clamping the ocular perfusion pressure (OPP) in the left eye to 5 mm Hg for 2 h. The OPP was defined as mean arterial blood ...
Onakoya A O - - 2009
OBJECTIVE: To investigate the association between Primary Open Angle Glaucoma (POAG), Intraocular Pressure (IOP) and systemic hypertension. DESIGN: Cross-sectional, convenient and controlled study. SETTING: Eye Clinic of the Lagos University Teaching hospital, Idi-Araba, Lagos, Nigeria. SUBJECTS: Consecutive newpatients with documented history of hypertension medication of over three months and current ...
Zhao Yune - - 2009
PURPOSE: To investigate the fluctuations of directly measured intraocular pressure (IOP) and induced diastolic ocular perfusion pressure (DOPP) during three simulated steps of phacoemulsification in vivo. METHODS: Twenty-five eyes of 25 patients who underwent phacoemulsification were evaluated. A pressure transducer was inserted into the anterior chamber to measure IOP directly. ...
Blini Mirella - - 2009
OBJECTIVE: To evaluate the intraocular pressure (IOP) lowering efficacy and safety of travoprost 0.004% in patients with open-angle glaucoma or ocular hypertension, poorly controlled with or intolerance to beta-blockers. To record the short-term effect on diastolic ocular perfusion pressure (DOPP). RESEARCH DESIGN AND METHODS: One hundred and three patients with ...
Yu Wenhan - - 2009
PURPOSE: To evaluate the usefulness of the TonoVet rebound tonometer in measuring intraocular pressure (IOP) of monkeys. METHODS: The accuracy of the TonoVet rebound tonometer was determined in cannulated eyes of anesthetized rhesus monkeys where IOP was controlled by adjusting the height of a connected perfusate reservoir. To assess the ...
Baiza-Dur?n Leopoldo Mart?n - - 2009
We compared the efficacy and safety of a new fixed combination of timolol 0.5%/odorzolamide 20%/brimonidine 0.2% in ophthalmic solution versus a fixed combination of timolol 0.5%/dorzolamide 2% in patients with open-angle glaucoma or ocular hypertension. The fixed triple combination was significantly more efficient in mean intraocular pressure reduction from baseline ...
Simader Christian - - 2009
The study was conducted to investigate whether the L-arginine/nitric oxide system plays a role in choroidal blood flow (ChBF) regulation during a decrease in ocular perfusion pressure (OPP). Experiments were performed on 3 days in a randomized double-masked, placebo-controlled, three-way crossover design. On different study days, subjects received intravenous infusions ...
Croxtall Jamie D - - 2009
Brinzolamide 1%/timolol 0.5% fixed combination (brinzolamide/timolol) is a twice-daily eyedrops suspension comprising the carbonic anhydrase-II inhibitor brinzolamide and the beta-adrenergic receptor antagonist timolol. Brinzolamide/timolol produced clinically relevant reductions in mean intraocular pressure (IOP) from baseline and was more effective than brinzolamide or timolol monotherapy in lowering IOP in a 6-month, ...
Xu Liang - - 2009
PURPOSE: To determine prevalence and associated factors of ocular hypertension in the adult Chinese population. METHODS: The Beijing Eye Study, a population-based prevalence study, included 4439 subjects out of 5324 subjects with an age of 40+ years invited to participate (response rate 83.4%). From the 4439 individuals, 4224 (95.2%) subjects ...
Calenda E - - 2009
We report 3 cases of central retinal artery occlusion following peribulbar anesthesia. Those patients were scheduled for retinal detachment repair, removal of a pterygium, and cataract surgery, respectively. In patient 1, a peribulbar anesthesia was performed with 17 ml of ropivacaine and a compression with a Honan's balloon was maintained ...
Curran Monique P - - 2009
Bimatoprost (Lumigan) is a synthetic prostamide that reduces intraocular pressure (IOP) by increasing the outflow of aqueous humour. In patients with open-angle glaucoma or ocular hypertension, long-term treatment (for up to 48 months) with once-daily bimatoprost 0.03% ophthalmic solution was more effective than timolol twice daily in providing a sustained ...
Galanopoulos Anna - - 2009
Elevated intraocular pressure (IOP) is a significant risk factor for the development and progression of glaucomatous optic neuropathy, but increasingly we appreciate that non-pressure dependent factors, are key to our understanding of the pathophysiology of these neurodegenerative diseases, that target the retinal ganglion cell. As we try to expand therapy ...
Beckers Henny J M - - 2009
Brinzolamide 1%/timolol 0.5% is a new fixed-combination for the treatment of open-angle glaucoma or ocular hypertension. Brinzolamide/timolol has a favorable safety profile, with an incidence of ocular burning and stinging <5%. Published data show that brinzolamide 1%/timolol 0.5% and dorzolamide 2%/timolol 0.5% have similar efficacies for lowering intraocular pressure (IOP). ...
Salim Sarwat - - 2009
Noncontact tonometers are useful when regulations preclude use of contact tonometers by medical students and other nonophthalmologists. Our study compared the measurements by the portable, noncontact tonometer (PT100) with Goldmann applanation tonometry (GAT). This was a prospective study of 98 eyes from 98 patients. Intraocular pressure (IOP) was measured by ...
Senthil Sirisha - - 2009
A 22-year-old man with primary pulmonary hypertension presented with dilated episcleral veins and increased intraocular pressures. His increased intraocular pressure was resistant to therapy with topical and systemic anti-glaucoma medications. He developed serous macular detachment in one eye that resolved spontaneously. He later presented with central retinal vein occlusion in ...
Vasconcelos de Moraes Carlos Gustavo - - 2009
The aim of this study was to compare the intraocular pressure (IOP) profile during the modified diurnal tension curve (mDTC) using Goldman applanation tonometry (GAT) and dynamic contour tonometry (DCT) in treated glaucomatous eyes. Eligible subjects were submitted to the mDTC using GAT and DCT in this sequence. IOP measurements ...
Cheng Jin-Wei JW Department of Ophthalmology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, - - 2009
To evaluate the intraocular pressure (IOP)-lowering effects of adjunctive medications when added to 0.005% latanoprost taken once daily. Pertinent publications were identified through systematic searches of PubMed, Embase, and the Cochrane Controlled Trials Register. Randomized clinical trials with over 85% of patients presenting with primary open-angle glaucoma or ocular hypertension ...
Fogagnolo Paolo - - 2009
PURPOSE: To verify whether office-hour measurements in patients in different body positions can estimate the characteristics of 24-hour intraocular pressure (IOP). METHODS: The 24-hour IOP curves of 29 healthy subjects (10 young adults, 19 elderly) and 30 patients with untreated glaucoma were analyzed. Measurements were taken at 9 AM; 12, ...
Nagar M - - 2009
AIMS: To evaluate the effect of selective laser trabeculoplasty (SLT) on intraocular pressure (IOP) control and diurnal tension curves of patients with open-angle glaucoma (OAG) and ocular hypertension (OHT), and to compare this effect with that of latanoprost. METHODS: Forty patients were randomised to receive either SLT or latanoprost. IOP ...
Abe Haruki - - 2009
OBJECTIVE: To evaluate the optic disc characteristics using the Heidelberg retina tomograph (HRT) II in a large sample of normal Japanese subjects. DESIGN: Cross-sectional study. PARTICIPANTS: A total of 3576 eyes of 2036 normal subjects, with good-quality HRT II images, of 6042 eyes of 3021 subjects aged 40 years or ...
Feng Zixia - - 2009
FP-Class prostaglandin analogs have demonstrated utility for the treatment of glaucoma and ocular hypertension. A series of novel FP prostaglandin analogs was designed to optimize topical ocular activity and reduce ocular side-effects by replacing 13-carbon with oxygen. A facile synthesis was successfully developed for synthesis of the 13-oxa prostaglandins from ...
Iyamu E - - 2008
The purpose of the study is to determine whether central corneal thickness (CCT) is a better predictor than intraocular pressure (IOP) in early identification of those at higher risk of developing glaucoma. Sixty-five subjects were categorized into normals, ocular hypertensives and glaucoma subjects based on clinical characteristics of ocular risk ...
Hatanaka Marcelo - - 2008
PURPOSE: To compare the efficacy and tolerability of the fixed combination of timolol maleate 0.5%/brimonidine tartrate 0.2% versus fixed combination of timolol maleate 0.5%/dorzolamide 2% in patients with elevated intraocular pressure (IOP) over 8 weeks. PATIENTS AND METHODS: This 8-week, multicentric, interventional, randomized, open-label, parallel group study was conducted at ...
Park Hae Y - - 2008
The aim of this study was to examine intraocular pressure lowering, change of antiapoptotic molecules expression, and neuroretinal changes by a commercially available dorzolamide 2%/timolol 0.5% combination in a chronic ocular hypertension rat model. Chronic ocular hypertension was induced by three episcleral vein cauterizations. The expression of antiapoptotic molecules and ...
Ishikawa Shusaku - - 2008
To compare the efficacy of brinzolamide in Japanese patients with primary open-angle glaucoma (POAG) or ocular hypertension (OH) after a change from timolol in combination therapy with latanoprost. A 12-week, prospective, open-label, comparative study was performed in 20 patients [11 males and 9 females, mean age of 64.5 +/- 11.0 ...
Russo Andrea - - 2008
Latanoprost is a prostaglandin F2-alpha isopropyl ester prodrug which is rapidly hydrolyzed by esterases in the cornea to the biologically active latanoprost acid. When latanoprost is topically administered into the eye, the cornea seems to act like as a slow-release depot to the anterior segment. One hour after administration maximum ...
Pourjavan S - - 2010
The Pascal dynamic contour tonometer (PDCT) is designed to measure intraocular pressure (IOP) largely independent of the corneal properties. It is equipped with a digital LCD screen that displays the IOP, the ocular pulse amplitude (OPA) and the quality score (Q) of the measurements [range 1 (excellent) to 5 (poor)]. ...
Konstas A G P - - 2009
OBJECTIVE: To evaluate the 24 h efficacy and safety of the travoprost/timolol maleate fixed combination (TTFC) versus travoprost when both are dosed in the evening in primary open-angle glaucoma patients. METHODS: Prospective, double-masked, crossover, active-controlled, randomised 24 h comparison. After a 6 week medicine-free period, patients were randomised to either ...
Xu L - - 2009
PURPOSE: The purpose of the study was to examine a relationship between ocular perfusion pressure and open-angle glaucoma in a population-based setting in China. METHODS: The Beijing Eye Study 2006 is a population-based investigation, which included 3251 subjects (response rate: 73.2%). Mean age was 60.4+/-10.0 years (range, 45-89 years). Glaucoma ...
Kniestedt Christoph - - 2008
The definition of glaucoma has changed over the decades from a simple ocular pressure disease to a systemic disorder of multivariate etiology. Glaucoma may be defined for the individual eye as a chronic ocular disease with various underlying pathophysiologic disorders. However, elevated intraocular pressure (IOP) is still the most important ...
Sit Arthur J - - 2008
Intraocular pressure (IOP) varies dynamically throughout the circadian cycle. IOP elevations during the nocturnal period may be particularly important in the pathogenesis of glaucoma, although sleeping IOP cannot be measured at this time. Additionally, IOP fluctuations may be an independent risk factor for glaucoma. However, not all glaucoma therapies are ...
Bean Gerald W - - 2008
Over the last 12 years, the pharmacological management of glaucoma and ocular hypertension has significantly changed with the introduction of the prostaglandin analogs, specifically, latanoprost, bimatoprost, and travoprost. Their ability to effectively reduce intraocular pressure with once-per-day dosing, their comparable ocular tolerability with timolol, and their general lack of systemic ...
Werne Adam - - 2008
Intraocular pressure, a major risk factor for glaucoma, is known to vary throughout the day, yet glaucoma continues to progress in some patients despite it being well controlled. It is important to understand how other glaucomatous risk factors are affected by circadian variations. The purpose of this review is to ...
Bhattacharya Sanjoy K SK Bascom Palmer Eye Institute, University of Miami, Miami, Florida 33136, USA. - - 2009
To determine the effect of transforming growth factor (TGF)-beta2 treatment on intraocular pressure (IOP), outflow facility, and cochlin expression in vitro in monkey and pig organ-cultured anterior segments (MOCAS and POCAS). MOCAS (rhesus and cynomolgus) or POCAS were infused with media containing 10 ng/mL TGFbeta2 to one segment of each ...
Asejczyk-Widlicka M - - 2008
AIMS: The aim of this study was to measure the elastic moduli of the cornea and sclera and the rigidity of the eyeball. METHODS: Elastic moduli of the cornea and sclera were measured on 22 fresh intact porcine eyes using the relationship between elasticity and changes in pressure and volume ...
Karadag Remzi - - 2008
PURPOSE: To evaluate the effect of short-term hypobaric hypoxic conditions (STHC) on intraocular pressure (IOP) in healthy subjects. METHODS: The study group was comprised of 30 healthy participants (60 eyes) with a mean age of 24.8 years. IOP was measured with a Tono-Pen XL tonometer at ground level (792 m ...
Balaratnasingam Chandrakumar - - 2008
Astrocytes maintain an intimate relationship with central nervous system (CNS) neurons and play a crucial role in regulating their biochemical environment. A rise in neural tissue pressure in the CNS is known to lead to axonal degeneration however the response of astrocytes during the early stages of neural injury has ...
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