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Results 101 - 150 of 1745
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Aihara Makoto - - 2010
An elevated intraocular pressure (IOP) is one of the most important risk factors for the development of glaucoma, which causes progressive optic neuropathy. Lowering IOP is currently the only therapeutic approach to the treatment of glaucoma. Tafluprost, a novel prostaglandin analogue, was recently launched onto the market as an ocular ...
Sniegowski Matthew - - 2010
Anti-vascular endothelial growth factor agents are frequently used to treat a variety of ocular neovascular diseases. While agents like bevacizumab and ranibizumab appear to be safe and effective, there have been reports of severe intraocular inflammation as well as sustained elevation of intraocular pressure (IOP) after single or multiple intravitreal ...
Chow Eric Y EY Purdue University, West Lafayette, IN 47907, USA. - - 2010
There is often a strong correlation between elevated levels of intraocular pressure (IOP) and glaucoma; however, the underlying mechanisms that lead to blindness are not well understood. The key may lie in the study of genetic factors which determine IOP and lead to glaucoma-related blindness. Mice are typically used for ...
Miglior S - - 2010
To compare intraocular pressure (IOP) reductions with fixed-combination (FC) latanoprost/timolol once daily in the evening vsFC dorzolamide/timolol twice daily. This evaluator-masked, multicentre, controlled clinical trial randomized subjects with primary open-angle glaucoma or ocular hypertension with IOP insufficiently responsive to beta-blocker therapy (screening IOP>21 and <37 mm Hg) to FC latanoprost-timolol ...
Vinten Martin - - 2010
PURPOSE: This study aimed to study the pathophysiology of diabetic macular oedema (DMO) by analysis of concomitant changes in macular volume (MV), mean arterial blood pressure (MABP), intraocular pressure (IOP), and retinal artery and vein diameters in response to acute postural changes in patients with DMO and healthy subjects. METHODS: ...
Ren Ruojin - - 2010
To assess whether a low cerebrospinal fluid pressure (CSF-P) is associated with open-angle glaucoma in eyes with normal intraocular pressure (IOP). Prospective, interventional study. The study included 43 patients with open-angle glaucoma (14 with a normal IOP, and 29 with an elevated IOP) and 71 subjects without glaucoma. All patients ...
Selvadurai Deepan - - 2010
PURPOSE: Intraocular pressure (IOP) varies with body position and previous research has indicated that most, but not all, of the variation in IOP is due to changes in episcleral venous pressure (EVP). Positional changes in other aqueous humor dynamic parameters may contribute to the change in IOP. The purpose of ...
Lesin Mladen - - 2009
The aim of this study was to evaluate the effects of extraocular muscle injection of botulinum toxin-A (BTX-A) on intraocular pressure (IOP) and proptosis in patients with ocular motility disturbances in thyroid associated orbitopathy (TAO). In 17 patients (20 eyes) with restrictive strabismus and diplopia, BTX-A injections were applied. Intraocular ...
Espana Edgar M - - 2010
PURPOSE: To evaluate the postoperative changes in intraocular pressure (IOP) following Descemet's stripping with endothelial keratoplasty (DSEK). METHODS: A retrospective chart review of 45 eyes that underwent DSEK for the treatment of corneal edema induced by aphakic or pseudophakic bullous keratopathy (ABK/PBK) and Fuchs' endothelial dystrophy. A mean baseline IOP ...
Patil A Jayaprakash - - 2009
Bimatoprost is a synthetic prostamide analog that is efficacious in the treatment of open-angle glaucoma, ocular hypertension and other forms of glaucoma. It reduces intraocular pressure (IOP) by increasing uveoscleral and trabecular outflow. When used as a 0.03% topical preparation once daily, it demonstrates sustained lowering of IOP of 7 ...
Lanfermann Elena - - 2009
BACKGROUND: This study compared the new Ocuton S*TT-MV to the Ocuton S (former configuration) and GAT. The effect of the reconfiguration on measuring accuracy and device handling of glaucoma patients was evaluated. MATERIAL/METHODS: 101 glaucoma patients performed self-measurements using the old Ocuton S and the Ocuton S*TT-MV. The new Ocuton ...
Oncel Banu - - 2009
PURPOSE: To assess the agreement among ocular response analyzer (ORA), dynamic contour tonometry (DCT), Goldmann applanation tonometry (GAT), and noncontact tonometry (NCT), and to determine the effects of central corneal thickness (CCT) and corneal hysteresis (CH) on intraocular pressure (IOP) measurements with these devices. METHODS: Sixty healthy volunteers were recruited. ...
Lee Kihwang - - 2009
To evaluate the changes in blood pressure and intraocular pressure (IOP) in patients with and without hypertension after intravitreal bevacizumab (Avastin) injection. This study examined 135 (74 nonhypertensive vs. 61 hypertensive) consecutive patients treated with an intravitreal injection of 1.25 mg bevacizumab for retinal vascular diseases prospectively over a 6-month ...
Xu Liang - - 2011
Purpose:  To determine whether anthropomorphic measurements are associated with ocular and general parameters. Methods:  The population-based Beijing Eye Study, which included 4439 participants (age > 40 years) out of 5324 individuals invited to be examined in 2001, was repeated in 2006 with 3251 (73.2% of 4439, or 61.1% of 5324) participants. The ...
Bosch Martina M - - 2010
PURPOSE: Reports on intraocular pressure (IOP) changes at high altitudes have provided inconsistent and even conflicting RESULTS: The purpose of this study was to investigate the effect of very high altitude and different ascent profiles on IOP in relation to simultaneously occurring ophthalmic and systemic changes in a prospective study. ...
Zamora David O - - 2010
To determine the episcleral venous pressure (EVP) responses to nitroprusside (NP) and L-NAME. In anesthetized rabbits (n = 36), arterial pressure and IOP were measured by direct cannulation, and carotid blood flow and heart rate were measured with an ultrasound flowmeter and cardiotachometer. EVP was measured in two groups with ...
Kain Sam - - 2010
AIMS: Central retinal vein pulsation is affected by intracranial pressure (ICP), glaucoma and venous pathology. Its genesis is poorly understood with most models suggesting that intraocular pressure (IOP) fluctuation dominates the rhythm of venous pulsation; however, this has not been explored experimentally. This study planned to measure the timing of ...
Read Scott A - - 2011
Purpose:  This study aimed to investigate intraocular pressure (IOP) measurements taken using the dynamic contour tonometer (DCT) and the non-contact tonometer (NCT) in subjects with keratoconus. Methods:  Intraocular pressure was measured in 20 keratoconus subjects and 20 age-matched control subjects using the DCT and NCT instruments. Central and off-centre measures ...
Read Scott A - - 2010
AIMS: To investigate the change that occurs in intraocular pressure (IOP) and ocular pulse amplitude (OPA) with accommodation in young adult myopes and emmetropes. METHODS: Fifteen progressing myopic and 17 emmetropic young adult subjects had their IOP and OPA measured using the Pascal dynamic contour tonometer. Measurements were taken initially ...
Wang Shuang - - 2009
PURPOSE: To assess the relationship of hypertension with major eye diseases and other ocular parameters. DESIGN: Population-based study. PARTICIPANTS: The Beijing Eye Study is a population-based study that included 4439 Chinese subjects examined at the baseline examination in 2001; there was a follow-up examination in 2006, in which 3251 subjects ...
Martínez Antonio - - 2010
PURPOSE: This study aims to identify progression factors in patients with primary open-angle glaucoma (POAG), including the effects of treatment with dorzolamide 2% or brinzolamide 1%, each added to timolol 0.5%. METHODS: A sample of 161 POAG patients were prospectively randomized to receive either dorzolamide 2% (DT) or brinzolamide 1% ...
Facio Ant??nio Carlos - - 2009
INTRODUCTION AND PURPOSE: Bimatoprost and the fixed combination of latanoprost with timolol maleate are 2 medications widely used to treat glaucoma and ocular hypertension (OHT). The aim of the study is to compare the efficacy of these 2 drugs in reducing intraocular pressure (IOP) after 8 weeks of treatment in ...
Ergin Ahmet - - 2009
PURPOSE: To investigate the respiratory and cardiovascular effects of switching therapy from topical timolol 0.5% to latanoprost 0.005% in elderly patients with glaucoma. METHODS: Twenty-five patients with primary open-angle glaucoma (POAG) who were treated with topical timolol 0.5% were included in the study. The beta-blocker treatment was ended due to ...
Fuchs Susanne - - 2009
This work assessed relationships among intraoral pressure (IOP), electropalatographic (EPG) measures, and consonant sequence duration, in the following obstruents, clusters, and affricates of German: /t/, /sh/, /sht/, and /tsh/. The data showed significant correlations between IOP and percentage of articulatory contact (PC) for all speakers, whereas duration and place of ...
D?az Florentina - - 2010
PURPOSE: To investigate quantitatively the effect of elevated intraocular pressure (IOP) on the microvasculature of the optic nerve with and without topical treatment with two hypotensive drugs, timolol and latanoprost. METHODS: Three groups of rats underwent cauterization of three episcleral veins to produce elevated IOP in the right eye. Two ...
Rigosi Elisa - - 2010
Increased intraocular pressure (IOP) is a major risk factor for glaucoma, and its contribution to neuronal damage appears multi-factorial. An open issue is whether pressure effects on blood vessels contribute to neuronal damage. In particular, little is known about pressure effects on capillaries, which are the site of most metabolic ...
Stewart William C - - 2009
PURPOSE: To evaluate routine intraocular pressure (IOP) control in monotherapy patients in the United States and Germany. METHODS: Meta-analysis of published articles. We included articles that were prospective studies of ocular hypotensive therapies that measured an unaltered (visit 1) IOP on monotherapy before enrolling into a clinical trial. RESULTS: This ...
Poostchi Ali - - 2009
PURPOSE: To assess agreement between the iCare rebound tonometer and Goldmann tonometry and to assess the influence of central corneal thickness and the value of scleral rebound tonometer readings. METHODS: Prospective single-centre cross-sectional study comparing iCare rebound tonometer (RT) intraocular pressure (IOP) readings taken from corneal and scleral locations to ...
Sample Pamela A - - 2009
To identify factors accounting for differences in glaucoma onset and rate of progression between individuals of African descent and European descent. A prospective, multicenter observational cohort study of 1221 participants of African descent and European descent with no glaucoma (normal), suspected glaucoma, and glaucoma. Six hundred eighty-six patient participants in ...
Renard Elisabeth - - 2010
PURPOSE: To characterize the nyctohemeral rhythm of intraocular pressure (IOP) and ocular perfusion pressure (OPP) in patients with newly diagnosed, untreated normal tension glaucoma (NTG). METHODS: Twenty-seven patients with suspected NTG were prospectively included and underwent 24-hour monitoring of IOP and blood pressure (BP), polysomnography, and nailfold capillaropathy. The nyctohemeral ...
Grozdanic Sinisa D - - 2010
To characterize functional and structural changes in a canine model of hereditary primary angle-closure glaucoma. Intraocular pressure (IOP) was evaluated with tonometry in a colony of glaucomatous dogs at 8, 15, 18, 20, and 30 months of age. Retinal function was evaluated using electroretinography (scotopic, photopic, and pattern). Examination of ...
Holló Gábor - - 2009
For the treatment of open-angle glaucoma, the most frequent cause of irreversible visual loss, fixed combinations of different topical intraocular pressure (IOP) lowering molecules have gained an important role in recent years. The use of fixed combinations reduces the number of daily instillations, which promotes adherence to the prescribed medication ...
Awad Hamdy - - 2009
BACKGROUND: Intraocular pressure (IOP) increases in steep Trendelenburg positioning, but the magnitude of the increase has not been quantified. In addition, the factors contributing to this increase have not been studied in robot-assisted prostatectomy cases. In this study, we sought to quantify the changes in IOP and examine perioperative factors ...
Kong Yu X - - 2009
PURPOSE: To examine retinal function using the full-field electroretinogram (ERG) during and after acute intraocular pressure (IOP) elevation in wild-type mice. METHODS: IOP was elevated by anterior chamber cannulation in wild-type C57/BL6 mice. The pressure-function relationship was determined by IOP elevation in steps from baseline to 80 mm Hg. The ...
Dastiridou Anna I - - 2009
PURPOSE: The purpose of this study was to characterize the pressure-volume relation in the living human eye, measure the ocular pulse amplitude (OPA), and calculate the corresponding pulsatile ocular blood flow (POBF) in a range of clinically relevant IOP levels. METHODS: Fifty patients with cataract (50 eyes) were enrolled in ...
Bergmann Joseph - - 2009
Intranasal corticosteroids have become a gold standard in therapy for allergic rhinoconjunctivitis. A direct relationship between topical and systemic corticosteroids and elevated intraocular pressure (IOP) has been recognized for more than 50 years. However, this steroid-induced response is highly variable. Glaucoma is an eye disease caused by an increase in ...
Omoti Afekhide E - - 2009
The exact patho physiological mechanizm of optic nerve damage in glaucoma is not fully understood. To assess the vascular risk factors in open angle glaucoma in African eyes. Prospective multicenter hospital-based study in Edo State, Nigeria. Three hundred and twenty-two glaucoma patients and 184 control subjects were included in the ...
Desalu I - - 2009
OBJECTIVES: Laryngoscopy and tracheal intubation lead to acute elevation in intraocular pressure (IOP); the ocular hypertensive response. The Laryngeal mask airway prevents sudden surges in IOP. We compared IOP changes to the insertion and removal of the Laryngeal mask airway (LMA) and the endotracheal tube (ETT). PATIENTS AND METHODS: Seventy ...
Singh Swita R - - 2009
OBJECTIVES: The use of l-carnosine as an excipient in topical ophthalmic formulations containing gellan gum, a carbohydrate polymer with in-situ gelling properties upon mixing with mammalian tear fluid, was developed as a novel platform to extend precorneal duration. Specific utilisation of l-carnosine as a buffer in gellan gum carrying vehicles ...
Martínez Antonio - - 2009
To compare the effect on the retrobulbar hemodynamics and intraocular pressure (IOP) of dorzolamide 2% and brinzolamide 1%, each added to timolol 0.5% in patients with primary open-angle glaucoma (POAG). 146 POAG patients were prospectively randomized to receive either dorzolamide 2% or brinzolamide 1% BID, each added to timolol 0.5%, ...
Ooi Yen Hoong - - 2009
PURPOSE: Matrix metalloproteinase (MMP)-mediated turnover of extracellular matrix (ECM) affects outflow resistance in the uveoscleral pathway. The balance of MMPs and tissue inhibitors of metalloproteinases (TIMPs) governs the rate of ECM turnover in many tissues. The hypothesis was that a differential effect on MMPs and TIMPs in ciliary body smooth ...
Kerimoglu H - - 2010
To determine whether altered eating habits and periods, especially the pre-dawn meal, during Ramadan fasting have any significant effect on intraocular pressure (IOP), tear secretion, corneal and anterior chamber parameters. IOP, basal tear secretion (BTS), reflex tear secretion (RTS), and Pentacam measurements of 31 healthy volunteers were performed at 0800 ...
Fortune Brad - - 2009
To determine whether acutely elevated intraocular pressure (IOP) alters peripapillary retinal thickness, retinal nerve fiber layer thickness (RNFLT), or retardance. Nine adult nonhuman primates were studied while under isoflurane anesthesia. Retinal and RNFLTs were measured by spectral domain optical coherence tomography 30 minutes after IOP was set to 10 mm ...
Konstas A G P - - 2009
PURPOSE: To evaluate 24-hr intraocular pressure (IOP) and blood pressure (BP) with timolol or latanoprost/timolol fixed combination (LTFC). METHODS: Patients with primary open-angle glaucoma or ocular hypertension with normal blood pressure were randomized to LTFC, dosed each evening, or timolol dosed twice daily in a cross-over design for 8 weeks ...
Kahook Malik Y - - 2009
This retrospective case series reports sustained elevation of intraocular pressure (IOP) after single or repeated intravitreal injections of bevacizumab (Avastin; Genentech, San Francisco, CA) for wet age-related macular degeneration (AMD). All six cases experienced significant and sustained elevation in IOP after single or repeated intravitreal injections of bevacizumab. Initiation or ...
Hsu S-Y SY Department of Ophthalmology, Buddhist Tzu Chi General Hospital, and Institute of Medical Sciences, Hualien 970, - - 2009
To compare intraocular pressure (IOP) readings between Tono-Pen tonometry and GAT, between noncontact tonometry (NCT) and GAT, and between dynamic contour tonometry (DCT) and Goldmann applanation tonometry (GAT). The correlation between IOP reading and possible confounder was identified. This observational cross-sectional study enrolled sixty-two healthy subjects. All IOP and ocular ...
Loftsson Thorsteinn - - 2010
PURPOSE: This study aimed to develop low-viscosity aqueous eyedrops containing enalaprilat and its prodrug enalapril maleate in solution, and to evaluate the eyedrops in rabbits. METHODS: Aqueous eyedrops with hydroxypropyl-beta-cyclodextrin containing 0.01-2.9% (w/v) enalaprilat, 1.0% (w/v) enalapril maleate with cyclodextrin or 0.5% (w/v) timolol were prepared. The eyedrops were administered ...
Comes Núria - - 2009
Elevated intraocular pressure (IOP) is the major risk factor for glaucoma. In the clinic, the response to elevated pressure and thus the risk for development of glaucoma differs among individuals. We took advantage of our ability to subject postmortem human eyes from the same individual to physiological and elevated pressure ...
Peeters Andrea - - 2010
PURPOSE: To estimate the effect of reducing intraocular pressure (IOP) on: (i) the incidence of primary open-angle glaucoma (POAG) in patients with ocular hypertension (OH), and (ii) the progression of glaucoma. METHODS: A meta-analysis of relevant randomized controlled trials was conducted. A literature search was performed to identify trials with: ...
Bochmann F - - 2009
BACKGROUND: Intraocular pressure (IOP) measurements using Goldmann applanation tonometry (GAT) are influenced by central corneal thickness (CCT) whereas dynamic contour tonometry (DCT) allows for IOP measurements independent of CCT. After Descemet's stripping automated endothelial keratoplasty (DSAEK) the CCT is, compared to healthy eyes, increased. The objective of this prospective study ...
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