Search Results
Results 551 - 600 of 1746
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Quinones Richard - - 2004
PURPOSE: To evaluate the intraocular pressure- (IOP-) lowering efficacy of bimatoprost 0.03% (Lumigan, Allergan, Inc.) monotherapy in the treatment of patients with glaucoma or ocular hypertension not currently using ocular hypotensives. METHODS: Open-label, community-based, multicenter evaluation. Patients (n = 6767) who, according to their physicians, required IOP lowering were prescribed ...
Kokaze Akatsuki - - 2004
BACKGROUND: Mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism has been reported to be associated with longevity in Japanese individuals, with experimental findings concluding that mt5178 A is an anti-atherogenic genotype. The aim of this study was to determine whether mt5178 A/C polymorphism influences intraocular pressure (IOP), and its relationship with ...
Choplin Neil - - 2004
In glaucoma and ocular hypertension, clinically relevant intraocular pressure lowering due to a new medication is frequently defined as at least a 15% or 20% reduction from baseline intraocular pressure. This report compares the percentages of treated patients achieving such reductions in intraocular pressure after 6 months of treatment with ...
Barriga F J - - 2004
Changes in intraocular pressure (IOP) elicited by a Valsalva manoeuvre were studied in 11 male patients (mean age 39.8 years) suffering from episodic cluster headache (CH), and 12 healthy male controls (mean age 39.9 years). The tests were performed at rest and while exhaling hard through a mouthpiece connected to ...
Taner Pelin - - 2004
PURPOSE: To investigate the retrobulbar hemodynamic changes occurring in light and darkness in patients with early stages retinitis pigmentosa (RP). METHODS: Eleven early stages RP patients were enrolled in the study. The peak systolic velocity (PSV), end-diastolic velocity (EDV), pulsatility index (PI) and resistivity index (RI) of the ophthalmic artery ...
Chiba Tatsuya - - 2004
PURPOSE: To conduct a 12-month prospective study on the occurrence of latanoprost-induced iridial pigmentation and eyelash change in Japanese patients with glaucoma METHODS: Seventy-five patients (75 eyes) were enrolled in the study. Photographs of the iris and eyelashes were taken under identical conditions before and after treatment. Three glaucoma specialists ...
Fuchsjäger-Mayrl Gabriele - - 2004
PURPOSE: There is evidence that altered optic nerve head (ONH) blood flow may play a role in the development and progression of glaucoma. In the present study, the baseline characteristics were examined in a study population participating in a clinical trial in which the ocular hemodynamic effects of timolol and ...
Gabelt B'Ann T - - 2004
PURPOSE: To determine in normotensive cynomolgus monkeys, the effects of topical 8-iso prostaglandin (PG)E(2) on intraocular pressure (IOP), aqueous humor formation (AHF), uveoscleral outflow (Fu), and total and trabecular outflow facility. METHODS: IOP was measured by Goldmann applanation tonometry under ketamine anesthesia after single or twice-daily topical treatments with 8-iso ...
Chew Paul T K - - 2004
OBJECTIVE: To demonstrate that the intraocular pressure (IOP)-reducing effect of latanoprost once daily is at least as good as that of timolol twice daily in patients with chronic angle-closure glaucoma (CACG). DESIGN: Randomized, double-masked, multicenter 12-week study. PARTICIPANTS: In all, 137 patients with unilateral or bilateral CACG were treated with ...
Altintaş Ozgül - - 2004
OBJECTIVE: To evaluate the effects of menopause and hormone replacement therapy (HRT) on the quality and amount of tear, intraocular pressure (IOP) and retrobulbar blood flow velocities. PATIENTS AND METHODS: Twenty women aged between 40 and 50 years, free of ocular and systemic diseases and planning to receive HRT were ...
Karabatakis V E - - 2004
PURPOSE: To examine the effects of jogging on intraocular pressure (IOP), blood pressure (BP), and heart rate (HR). METHODS: Twenty-nine healthy individuals-25 athletes and 4 untrained-were studied. IOP, systolic and diastolic BP, and HR were measured before and just after 20 minutes of jogging (submaximal--70%--aerobic exercise). RESULTS: IOP decreased after ...
He Jianfeng - - 2004
PURPOSE: To summarize the clinical manifestation of thyroid-associated ophthalmopathy (TAO) with elevated intraocular pressure (IOP), and to analyze the contributing factors. METHODS: One hundred and six cases (188 eyes) of ocular hypertension in 339 cases (597 eyes) with TAO were collected from 1994 to 2001 and their clinic manifestations were ...
Reitsamer Herbert A - - 2004
PURPOSE: To test whether exogenous dopamine can cause choroidal vasodilation and to identify the mediating receptors in anesthetized rabbits. METHODS: Mean arterial pressure (MAP), intraocular pressure (IOP), and orbital venous pressure (OVP) were measured by direct cannulation of the central ear artery, the vitreous, and the orbital venous sinus, respectively. ...
Hosking S L - - 2004
AIM: To determine the ocular haemodynamic response to gas perturbations in glaucoma. METHODS: Intraocular pressure (IOP), systemic systolic and diastolic blood pressure (SBP and DBP), and retrobulbar blood flow velocities, measured by colour Doppler imaging (CDI), were recorded at two visits. CDI was used to measure peak systolic and end ...
Tsai Yi-Yu - - 2004
We report combined trabeculectomy and vitrectomy in a 66-year-old woman with combined-mechanism glaucoma. Trabeculectomy supplemented with mitomycin-C was done first. Before the scleral and conjunctival flap were sutured, an anterior vitrectomy was performed via the peripheral iridectomy until a pathway between the anterior chamber and aqueous pool in the vitreous ...
Sponsel William E - - 2004
PURPOSE: To assess visual and circulatory responses to treatment with topical beta adrenergic antagonists. DESIGN: Institutional prospective randomized clinical trial in normal adults. METHODS: Twenty adults (36 (mean) +/- 8 (S.D.) years) underwent repeated baseline perimetry (Humphrey 30-2), contrast sensitivity (Vector Vision), perimacular microcirculatory studies (Oculix blue-field entoptic simulator), intraocular ...
McMurphy Rose M - - 2004
OBJECTIVE: To determine effects of atracurium on intraocular pressure (IOP), eye position, and arterial blood pressure in eucapnic and hypocapnic dogs anesthetized with isoflurane. ANIMALS: 16 dogs. PROCEDURE: Ventilation during anesthesia was controlled to maintain Paco2 at 38 to 44 mm Hg in group- I dogs (n = 8) and ...
Lee Anne J - - 2004
PURPOSE: To quantify prevalence of asymmetric intraocular pressure (IOP) and assess associations with undiagnosed open-angle glaucoma. DESIGN: Population-based cross-sectional study. METHODS: Participants underwent applanation tonometry. Intraocular pressure asymmetry was defined for differences > or = 3 mm Hg; open-angle glaucoma was diagnosed if glaucomatous optic disk and field changes were ...
Nakanishi Megumi - - 2004
We evaluated changes in ocular hemodynamics induced by nipradilol, an NO donor, applied as an eye drop. Eight volunteers underwent color Doppler imaging for measurement of hemodynamic parameters in the central retinal artery (CRA) and ophthalmic artery (OA) after instillation of nipradilol. Intraocular pressure (IOP) and systemic blood pressure were ...
Naruse Shigeta - - 2004
PURPOSE: To evaluate the applicability of pressure phosphene tonometry in measuring intraocular pressure (IOP) after laser in situ keratomileusis (LASIK). SETTING: Baptist Eye Clinic, Kyoto, Japan. METHODS: Thirty-six eyes of 22 consecutive patients who had had LASIK for myopia were enrolled in this prospective comparative study. The mean age of ...
Vallance James H - - 2004
PURPOSE: To ascertain whether the Honan intraocular pressure reducer (HIPR) has an effect on the preoperative intraocular pressure (IOP), surgeon's assessment of anesthesia, and patients' analgesic experience when sub-Tenon's anesthesia is used for routine cataract surgery. SETTING: Princess Alexandra Eye Pavilion, Edinburgh, Scotland. METHOD: Forty-five eyes of 45 patients having ...
Kobayashi Hiroshi - - 2004
PURPOSE: To evaluate the ocular hypotensive response of bunazosin hydrochloride 0.01% administered as adjunctive therapy in patients with glaucoma who were already receiving latanoprost 0.005% or timolol 0.5%. METHODS: Patients with primary open angle glaucoma who had received latanoprost (n = 60) or timolol (n = 60) for 6 months ...
Davies Leon N - - 2004
PURPOSE: To determine the feasibility of taking intra-ocular pressure (IOP) readings with Goldmann-type applanation tonometer probe covered with cling film to avoid transmission of Creutzfeldt-Jakob disease (CJD). METHODS: Data were collected on two occasions from the right eyes of 30 healthy subjects using a Perkins applanation tonometer. On each occasion, ...
Nomura Hideki - - 2004
PURPOSE: To investigate the relationship between intraocular pressure (IOP) and refractive errors after adjusting for age, central corneal thickness (CCT), and other related factors. METHODS: IOP, CCT and refractive errors were measured in the right eyes of 1855 subjects, aged 40-82 years, in a cross-sectional study design. Subjects were divided ...
Hoffmann Esther M - - 2004
The new Ocular Dynamic Contour Tonometer (DCT), investigational device supplied by SMT (Swiss Microtechnology AG, Switzerland) allows simultaneous recording of intraocular pressure (IOP) and ocular pulse amplitude (OPA). It was the aim of this study to compare the IOP results of this new device with Goldmann tonometry. Furthermore, IOP and ...
Niazi Muhammad Khizar - - 2004
BACKGROUND: This study was conducted to compare the effects on intraocular pressure and side effects of monotherapy with either latanoprost or dorzolamide in patients with open angle glaucoma, pseudoexfoliation glaucoma or ocular hypertension. METHODS: Sixty patients with open angle glaucoma or ocular hypertension were recruited to a 3-month study. Previous ...
Gupta Vinod Kumar - - 2004
Rise of intracranial pressure (ICP) is currently presumed to underlie benign cough headache (BCH). Cough normally increases ICP but very few patients develop BCH. Children, young adults and females are rarely affected. Reduction of ICP by lumbar puncture (LP) or indomethacin offers variable therapeutic success. BCH can persist for several ...
Ahmed Shabeer - - 2004
OBJECTIVE: To determine the optimal angle between the handle and instrument shaft for endoscopic suturing. DESIGN: A rocker handle needle driver was used to investigate the 0 degrees, 40 degrees, and 80 degrees handle-to-shaft angles. The standard task entailed closure of a 50-mm enterotomy in a nonliving porcine small-bowel model. ...
Shiramizu Kevin M - - 2004
PURPOSE: To report two cases of ocular perforation during chalazion removal procedures leading to severe vision loss. DESIGN: Observational case series. METHODS: Two patients presented with unilateral decreased vision after chalazion removal procedures. Complete ophthalmologic examinations were performed. RESULTS: Examination revealed a cherry red spot and perforation site in the ...
Harada Yuichiro - - 2004
PURPOSE: To determine the clinical efficacy of corneal elasticity (CE) measurements as an index of intra-ocular pressure(IOP). The considerable body of evidence linking elevated intra-ocular pressure (IOP) to glaucomatous conditions, points to the importance of the accurate and reliable measurement of IOP for diagnosis, prevention and post treatment assessments. Recently ...
Nakai M M School of Science & Engineering, Waseda University, Tokyo, - - 2004
A tonometer is used to measure ocular pressure either by shooting a short blast of compressed air onto the cornea or by applying pressure directly to the cornea. At present, the tonometer is the primary instrument available for measuring ocular pressure. However, measuring ocular pressure by such means can either ...
Giuffrida Stefania - - 2003
The role of nitric oxide (NO) in neuronal degeneration of glaucoma is well established, and drugs to inhibit NO production have been introduced in preclinical studies. The present experiments were made to investigate the pharmacological efficacy of a topical formulation of the nonselective nitric oxide synthase (NOS) inhibitor, nitro-L-arginine methyl ...
Schmidt Karl-Georg - - 2003
PURPOSE: Malfunction in peripapillary hemodynamics has been suggested to play a major part in the pathogenesis of primary open-angle glaucoma (POAG). The aim of this study was to determine whether topically applied brimonidine can influence blood hemodynamic characteristics associated with the perioptic short posterior ciliary arteries (SPCAs), central retinal artery ...
Coleman Anne L - - 2003
PURPOSE: To compare the efficacy and safety of topical bimatoprost (LUMIGAN; Allergan, Inc., Irvine, CA) once daily with that of topical combined timolol and dorzolamide (Cosopt; Merck and Co, Inc., Whitehouse Station, NJ) twice daily. DESIGN: Prospective, randomized, double-masked, multicenter clinical trial. PARTICIPANTS: One hundred seventy-seven patients with a diagnosis ...
Kerr Jan - - 2003
PURPOSE: To compare pulsatile ocular blood flow measurements in untreated ocular hypertensive (OHT) subjects and primary open-angle glaucoma (POAG) patients. DESIGN: A prospective observational study in an institutional setting. METHODS: A total of 97 subjects were recruited to the study (50 ocular hypertensives, 24 glaucoma patients, and 23 normal subjects). ...
Aihara Makoto - - 2003
PURPOSE: To assess aqueous humor dynamics in mouse eyes. METHODS: Aqueous humor dynamics of NIH Swiss White mouse were assessed with an injection and aspiration system, using fine glass microneedles. Intraocular pressure (IOP) was measured by a microneedle connected to a pressure transducer. Episcleral venous pressure (EVP) was measured by ...
Thomas Ravi - - 2003
PURPOSE: To report the progression of ocular hypertension (OHT) to primary open angle glaucoma (POAG) during a 5-year follow up of a population-based sample. METHODS: Twenty-nine patients diagnosed to have OHT and 110 randomly selected normals from a population-based study in 1995 were invited for ocular examination in 2000. All ...
Aihara Makoto - - 2003
PURPOSE: To measure the episcleral venous pressure (EVP) of the mouse eye and to investigate the effect of body position on EVP and intraocular pressure (IOP). METHODS: A microneedle connected to a pressure transducer was used to measure IOP in NIH Swiss white mice. To measure EVP, a reservoir connected ...
Singleton Chasidy D - - 2003
BACKGROUND: Intraocular pressure (IOP) may be partially under systemic vascular control. This study examined whether a correlation exists between blood and intraocular pressures in patients with autonomic dysfunction. METHODS AND RESULTS: Eleven patients with 3 types of confirmed autonomic dysfunction (multiple system atrophy, pure autonomic failure, and baroreflex failure) were ...
Mor-Mur M - - 2003
Vacuum-packaged cooked sausages were treated at 500 MPa for 5 or 15 min at mild temperature (65 °C). Colour, texture and yield of pressure-treated sausages were evaluated, and compared to those of sausages treated with a conventional heat pasteurisation (80-85 °C for 40 min). Colour attributes did not change. Pressurised sausages were ...
Stewart William C - - 2003
OBJECTIVE: To determine whether a topical ophthalmic diclofenac sodium formulation containing a proprietary polymeric drug delivery system (ISV-205), when dosed concomitantly with 1% prednisolone acetate, is effective in blocking the intraocular pressure (IOP) response in humans. DESIGN: This was a multicenter, prospective, double-masked, parallel, vehicle-controlled study. We included 136 first-degree ...
Lundmark P O - - 2003
To investigate the effect of negative inspiratory effort, as generated by the Mueller manoeuvre, on intraocular pressure (IOP) and pulsatile ocular blood flow (POBF) in healthy young adults. Seven volunteers with no history of systemic or ocular disease were recruited (mean age 30.7 years, range 25-40 years, M/F: 4/3). After ...
Erdöl Hidayet - - 2003
OBJECTIVE: To assess the effect of pericardial effusion on intraocular pressure (IOP). PATIENTS AND METHODS: Twenty-two patients with pericardial effusion were enrolled into the study. The average pericardial effusion was 2245 +/- 257 cc, and the mean IOP was 26.1 +/- 2.1 mm Hg in the initial examination. Pericardial effusion ...
Arend Oliver - - 2003
PURPOSE: The purpose of this prospective, randomized, cross-over study was to investigate and compare the microcirculatory effects of timolol, dorzolamide and latanoprost in newly diagnosed primary open-angle glaucoma (POAG) patients. Haemodynamics were assessed using fluorescein angiography by means of a scanning laser ophthalmoscope (SLO). Visual function and visual field indices ...
Chakeres Donald W - - 2003
PURPOSE: To determine if increasing static magnetic field strength exposures up to 8 Tesla (T) affect vital signs or electrocardiograms (ECGs) in normal human volunteers. MATERIALS AND METHODS: We studied 25 normal subjects, consisting of 19 men and six women, ages 24-53 years. The vital signs and ECGs of the ...
Foster Paul J - - 2003
PURPOSE: To examine the relationship between intraocular pressure (IOP), anthropomorphic, demographic, socioeconomic, systemic, and ocular factors and glaucomatous optic neuropathy (GON) in Chinese people. METHODS: Chinese people (n = 2000), aged 40 to 79 years, were selected from the Singapore electoral register. Of the 1717 considered eligible for examination, 1232 ...
Liu John H K - - 2003
We estimated diurnal and nocturnal levels of ocular perfusion pressure at rest in both young and older adults in a clinical sleep laboratory. Measurements of blood pressure and intraocular pressure (IOP) were obtained every 2 hours for 24 consecutive hours in 16 healthy young adults (ages 18-25 years) and 16 ...
Köybaşioğlu Ahmet - - 2003
BACKGROUND: To compare pharyngoesophageal segment (PES) pressure values in total laryngectomy patients with and without pharyngeal neurectomy (PN) in the early postoperative period. METHODS: Forty-five previously untreated laryngeal carcinoma patients were enrolled into this prospective randomized study. Twenty of them underwent total laryngectomy with PN, and 25 underwent total laryngectomy ...
Bhan Archana - - 2003
PURPOSE: To establish the repeatability of ocular blood flow (OBF) pneumotonometry and its agreement with Goldmann tonometry. DESIGN: Instrument evaluation study. PARTICIPANTS: Ten female healthcare professionals. METHODS: Intraocular pressure (IOP) was measured by one experienced ophthalmologist in both eyes of 10 healthy female subjects on 10 different occasions at the ...
Kałuzny Jakub J - - 2003
PURPOSE: To establish the efficacy and safety of timolol maleate/dorzolamide fixed combination (TDFC) versus timolol maleate/pilocarpine fixed combination (TPFC), each given twice daily, in primary open-angle glaucoma or ocular hypertensive patients. METHODS: In this prospective, multicentred, double-masked trial, 37 patients were treated twice daily with timolol for 4 weeks. They ...
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