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Results 401 - 450 of 772
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Schoemaker J H - - 1995
BACKGROUND: Assuming that flavonoids have anti-oxidative properties and may protect against abnormal skin reactions in erythropoietic protoporphyria (EPP), we investigated whether systemic treatment with hydroxyethylrutosides (2.7 g/day) could decrease skin sensitivity to blue light in a 37-year-old female patient who suffered from EPP. DESIGN AND RESULTS: Before treatment, skin exposure ...
Gifford R W RW - - 1995
BACKGROUND: There are now more than 31 million people 65 years of age or older in the United States, at least half of whom have systolic blood pressure 140 mm Hg or higher or diastolic blood pressure 90 mm Hg or higher or both. By the year 2050, 16 million ...
Hawkins D W - - 1994
OBJECTIVE: To evaluate the clinical use and adverse effects of enalapril and lisinopril in elderly hypertensive subjects. DESIGN: A multi-center, retrospective, drug use evaluation survey. SETTING: Ambulatory care clinics at 14 VA and 14 academic medical centers. PATIENTS: 422 elderly (> 60 years of age) patients with hypertension and no ...
Fotherby M D - - 1994
The effect of withdrawing or continuing anti-hypertensive therapy on orthostatic blood pressure change in elderly hypertensive subjects was examined. Subjects meeting criteria for therapy withdrawal had supine and standing blood pressure measurements taken on treatment, and at 1, 3, 6, 9 and 12 months off treatment whilst receiving standard non-pharmacological ...
Fahey T - - 1994
BACKGROUND: It is not known whether the results from randomized controlled trials influence general practitioners' knowledge of and attitudes to clinical practice. AIM: This study set out to assess general practitioners' knowledge of and attitudes to the management of hypertension in patients aged 65 years and over after the publication ...
Kawachi I - - 1994
Stroke is a major cause of death and disability in developed countries. The incidence of stroke increases exponentially with age, yet, traditionally, many medical practitioners have been reluctant to treat hypertension in older patients. Since 1991, the results of 3 major trials--the British Medical Research Council (MRC) trial of treatment ...
Bulpitt C J - - 1994
A positive relationship between blood pressure and mortality at the age of 60 to 69 years becomes a negative relationship in men over the age of 75 years and in women over the age of 85 years, with hypertensive individuals living longer. This negative relationship in very old people probably ...
Tonkin A L - - 1994
OBJECTIVES: Given the reported relationship between systolic hypertension and orthostatic hypotension in the elderly, to test the hypothesis that systolic hypertension causes impairment of the cardiovascular reflex function additional to the effects of age alone. DESIGN: Responses were compared in normotensive healthy young (n = 12) and elderly (n = ...
Giannattasio C - - 1994
AGEING AND MECHANISMS OF BLOOD PRESSURE CONTROL: Ageing is associated with functional and structural alterations to the cardiovascular system. Evidence is accumulating, however, that ageing also determines major changes in the effectiveness of mechanisms involved in blood pressure control and that this represents an important determinant of the cardiovascular changes ...
Cushman W C - - 1994
Hypertension is the most important risk factor for cardiovascular events in the elderly, and it is present in more than 50% of the American population over 60 years of age. Both systolic and diastolic blood pressure are directly related to increasing cardiovascular risk and systolic pressure becomes even more important ...
Shimada K - - 1994
PATHOPHYSIOLOGY OF HYPERTENSION: Blood pressure increases with advancing age in most developed countries. The pathophysiology of elderly hypertension is characterized by changes in the structure and function of the cardiovascular system. Changes in arterial structure lead to a decrease in aortic compliance, which augments the aortic pressure component generated by ...
Forette F - - 1994
SUITABILITY OF CALCIUM ANTAGONISTS FOR THE ELDERLY: The efficacy and safety of calcium antagonists have been clearly demonstrated in elderly hypertensive patients. In a double-blind placebo-controlled study in 31 elderly hypertensives treated with nicardipine, we found no consistent electrocardiogram changes, nor in the heart rate, plasma levels of potassium, sodium ...
Kuramoto K - - 1994
PREVALENCE OF HYPERTENSION IN ELDERLY JAPANESE PATIENTS: Data collected from post-mortem information at the Tokyo Metropolitan Geriatric Hospital showed that the overall prevalence of hypertension in Japanese patients aged over 60 years was 53%; one-third of these elderly hypertensives had isolated systolic hypertension. Isolated systolic and systolodiastolic hypertension were each ...
Thijs L - - 1994
This paper presents a meta-analysis of eight outcome trials of antihypertensive drug treatment in elderly hypertensive patients, and uses the results of these trials to discuss day-to-day issues in the treatment of elderly hypertensive patients. META-ANALYSIS: In an intention-to-treat analysis, cardiovascular mortality was decreased on average by 22% (95% confidence ...
Campbell N R - - 1994
Accurate, reproducible blood pressure readings are more difficult to obtain in the elderly. Elderly patients have more variable blood pressure, show a reduction in blood pressure following meals, and can have postural hypotension, discrepancies in blood pressure between arms, auscultatory gaps and 'pseudohypertension', all of which can mislead clinicians regarding ...
Flack J M - - 1994
Blood pressure (BP), particularly systolic blood pressure (SBP), rises with advancing age. Isolated systolic hypertension is the most common type of hypertension (HTN) phenotype after age 70. Moreover, at similar BP levels the absolute risk for CVD is several fold higher in elderly than in young patients. End-organ damage is ...
Agüero Torres H - - 1994
Data from the total urban elderly population (75 years and older) in Kungsholmen, Stockholm, were used to calculate age- and sex-specific prevalence of hypertension. Blood pressure was measured as part of the examination in the population survey (the Kungsholmen Project). The blood pressure of 1751 elderly people and any antihypertensive ...
Isoyama S - - 1994
Heart disease in older individuals can be characterised as the result of 2 processes, hypertension and atherosclerosis, which are the major causes of heart failure in the elderly population. The aging heart undergoes changes at the molecular, cellular and organ levels. These age-related changes may then be modulated by pathological ...
Lipsitz L A - - 1994
1. The aim of this study was to determine the effects of caffeine on haemodynamic and neurohumoral responses to meal ingestion in elderly patients with a history of symptomatic postprandial hypotension. 2. Postprandial hypotension is a common disorder of blood pressure regulation in the elderly, associated with falls and syncope. ...
Bloomfield Robert L. - - 1994
In this review article, the authors cover the pathophysiology of elevated blood pressure in the elderly. Isolated systolic hypertension and pseudo-hypertension are noted. Some of the large treatment trials are discussed. Nonpharmacologic and pharmacologic management are covered. Neurologic aspects of hypertension in this population are discussed in some detail. Additional ...
Tomlinson B - - 1994
The benefits of treating isolated systolic hypertension (ISH) have been established, but the most appropriate choice of drug is still uncertain. For this reason, a sustained-release formulation of isradipine was compared with spirapril in a double-blind randomized study in elderly Chinese patients with ISH. The dosage was titrated if necessary ...
Marantz P R - - 1994
Although left ventricular filling tends to occur in late diastole in the elderly, the clinical significance of this change is unclear. To determine the prevalence of diastolic filling delay and its relationship to congestive heart failure (CHF) in the elderly, we studied 114 community-living elderly volunteers (median age 75, 37% ...
Ekbom T - - 1994
OBJECTIVES: To observe blood pressure, cardiovascular events, and total mortality after withdrawing antihypertensive treatment for elderly patients. DESIGN: Multicentre observational study. SETTING: Sweden. A 5-year follow-up of 333 elderly hypertensive patients, aged 70-84 years (mean age 75.2 +/- SD 3.8 years, 68% females). In all, 74 out of the 333 ...
Trenkwalder P - - 1994
OBJECTIVE: To assess the prevalence of hypertension and isolated systolic hypertension and the level of awareness, treatment and control of hypertension, in a population aged over 65 years. DESIGN: Cross-sectional survey of the total population aged > or = 65 years of two Bavarian villages with a representative age distribution. ...
St John A - - 1994
The relationship between calcitrophic hormones and blood pressure has been investigated in 583 elderly subjects who were untreated for hypertension. Univariate analysis demonstrated that serum parathyroid hormone, calcitriol, albumin and calcium were correlated significantly with mean blood pressure (r = +0.15, +0.10, +0.14 and +0.11, respectively), as were body mass ...
Potter J F - - 1994
Cardiovascular disease remains the major cause of death in elderly people, with hypertension the main treatable risk factor. Despite this there has been little consensus with regard to assessment or treatment of the elderly hypertensive patient. Several recent large intervention trials have shown blood pressure (BP) reduction in elderly patients ...
Pearce K A - - 1994
Hypertension affects most elderly Americans. In eight major randomized, controlled trials evaluating the treatment of hypertension in the elderly, drug therapy for high blood pressure (including isolated systolic hypertension) has been shown to prevent fatal and nonfatal strokes and coronary events. The relative reduction in strokes was greater than that ...
- - 1994
Raised blood pressures in the elderly and the increased prevalence of hypertension in this population are not benign occurrences and should not be viewed as a normal or inevitable consequence of aging. In fact, the relation of systolic and diastolic blood pressures to cardiovascular events is generally more pronounced in ...
Atkinson G - - 1994
To evaluate whether circadian rhythms in blood pressure and heart rate are influenced by age, we analyzed 24-h ambulatory blood pressure and heart rate recordings from 31 patients with primary hypertension. Data were collected during hospitalization, after a drug-free run-in period. Set times were administered for lights-on, meals, and lights-off. ...
Abernethy D R - - 1994
Pharmacokinetic and pharmacodynamic data were compared between elderly and young patients with hypertension who received single intravenous doses of amlodipine, a dihydropyridine calcium antagonist, followed by oral administration of amlodipine up to 10 mg once daily for 12 weeks. After intravenous administration, elderly patients had prolonged elimination half-life values (58 ...
Kostis J B - - 1994
Ventricular ectopic activity was recorded at baseline in 5.6% of the 12-lead electrocardiograms and 8.2% of the 2-minute rhythm strips of 4674 subjects with isolated systolic hypertension (systolic blood pressure 160 to 219 mm Hg, diastolic blood pressure < 90 mm Hg) participating in the Systolic Hypertension in the Elderly ...
Tracy R E - - 1994
Numerous reports have accumulated from around the world throughout the twentieth century of small, remote, self-sufficient populations that do not show a rise of blood pressure with age. Knowing that renocortical arteriosclerosis, a defining feature of hypertensive nephrosclerosis, is a close commensurate of blood pressure, it can be predicted that ...
Linde T - - 1994
The ability of erythrocytes to undergo deformation may be of importance to erythrocyte survival and to blood flow resistance. In a previous study a decreased deformability was demonstrated in the erythrocytes of uraemic patients treated with recombinant human erythropoietin (rhEPO). Erythrocyte deformability is, at least partly, determined by the intracellular ...
Black H R - - 1993
The highest prevalence of hypertension is now recognized to exist in the elderly segment of the population. With the completion of several large-scale studies, several of our assumptions regarding elderly hypertensive patients have changed. It is now clear that the elderly have shown the greatest benefit from antihypertensive therapy. This ...
Lindholm L H - - 1993
Several studies have demonstrated an increased risk of cardiovascular disease (CVD) in relation to high blood pressure in elderly patients aged below 70-75, whereas the risk seemed to decline with age in the older elderly. Early studies on the effect of treatment of mild to moderate hypertension in the elderly ...
Lipsitz Lewis A. - - 1993
Syncope is a common and highly morbid syndrome with unique features in the elderly population. Syncope in the elderly is more likely due to the accumulation of multiple pathological conditions which threaten cerebral oxygen delivery, then to single diseases. Furthermore, age-related changes in blood pressure homeostasis make older patients more ...
Dahlöf B - - 1993
Hypertension is increasingly common with advancing age and a risk factor for all kinds of cardiovascular complications. Moreover, cardiovascular disease is a major cause of morbidity and mortality in the elderly. The Swedish Trial in Old Patients with Hypertension (STOP-Hypertension) was set up by the Swedish Hypertension Society to investigate ...
Celis H - - 1993
A meta-analysis is presented of 8 therapeutic trials in elderly hypertensive patients. In an intention-to-treat analysis, cardiovascular mortality was decreased on average by 22% (95% confidence interval ranging from -32% to -10%). This decrease was explained by both a reduction in coronary mortality by 26% (-40% to -9%) and in ...
Kinirons M T - - 1993
The psychomotor and cardiovascular effects of minaprine 100 mg, a novel antidepressant, were compared with amitriptyline 25 mg, as a positive control, and placebo in a single dose randomised double-blind crossover trial using an automated psychomotor test battery (APT), postural sway (PS), blood pressure (BP) and pulse in nine young ...
Hashimoto H - - 1993
Acute changes in blood pressure and heart rate during cigarette smoking were investigated in 10 elderly subjects aged 75.6 +/- 4.8 (mean +/- SD) years and in 10 non-elderly subjects aged 35.6 +/- 10.5 years. All subjects were healthy normotensive men with no cardiovascular disease. While each subject smoked two ...
Herpin D - - 1993
Interest in isolated systolic hypertension in the elderly has increased in the last few years. The definition of this disorder remains controversial: according to most authors, the systolic blood pressure has to be above 160 mm Hg and the diastolic under 90 mm Hg. The prevalence depends on number of ...
Barenbrock M - - 1993
Hypertension is a major complication in kidney transplantation and contributes to the high cardiovascular mortality of renal transplanted recipients. The aim of the present study was to evaluate the therapeutic effect of phlebotomy on blood pressure in posttransplant hypertension associated with erythrocytosis. In 12 renal transplanted patients (7 male, 5 ...
Glynn R J - - 1993
The authors examined whether changing attitudes and approaches to modifying blood pressure during the 1980s affected the previously described pattern of increasing systolic blood pressure in the elderly which continues through the ninth decade of life. In 1982-1983, a door-to-door census identified 4,497 community-dwelling residents of East Boston, Massachusetts aged ...
Treluyer J M - - 1993
Fourteen hypertensive patients hospitalized in a paediatric intensive care unit were studied to evaluate safety and hypotensive efficacy of intravenous nicardipine. Systolic and diastolic blood pressure significantly decreased 1 h after the beginning of the treatment (1 microgram/kg per minute). Mean decrease in systolic blood pressure during the first 24 ...
Djordjević V - - 1993
Long-term follow-up evaluation of biofiltration treatment in 7 patients is presented. These patients experienced frequent episodes of hypotension during acetate hemodialysis. A 3-year biofiltration treatment reduced by 43% episodes of symptomatic hypotension and produced a significant increase in the pretreatment pH and plasma bicarbonate levels. The beta 2-microglobulin level was ...
Lakatta E G - - 1993
Effective treatment of hypertension in the elderly requires an understanding of both the progressive course of the disease and the impact of aging on the cardiovascular system, including physiological, genetic, lifestyle, and environmental factors. Review of the literature that has attempted to define the impact of an "aging process" on ...
Shorten G D - - 1993
A study was performed to evaluate histamine release, as well as potential cardiovascular and cutaneous sequelae, following bolus administration of atracurium in elderly patients. In 15 patients, using a radioenzymatic technique, plasma histamine concentrations were measured in venous blood samples obtained before and after induction of anaesthesia with thiopentone and ...
Alexander L J - - 1993
BACKGROUND: National Health Care Issues-II deals with two reports of tremendous importance to national health, the results of the Systolic Hypertension in the Elderly Program (SHEP) and the results of the Trials of Hypertension Prevention, Phase I (TOHP-I). Both of these issues have tremendous impact on the systemic and ocular ...
Applegate W B - - 1993
In elderly patients, elevation of systolic blood pressure represents a more serious risk than elevation of diastolic blood pressure. Major trials of antihypertensive therapy in the elderly include the Systolic Hypertension in the Elderly Program, the Swedish Trial of Older Patients with Hypertension, the Medical Research Council Trial, and the ...
Davenport A - - 1993
We investigated the effect of membrane bio-incompatibility on cardiovascular stability in 10 patients with combined acute hepatic and renal failure during 44 isovolemic intermittent machine hemofiltration treatments, using a polyamide membrane in 24 and a polyacrylonitrile membrane in 20. Cardiac output decreased by 14 +/- 2% during polyamide treatment compared ...
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