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Mose Frank Holden FH Department of Medical Research, University Clinic in Hypertension and Nephrology, Holstebro Hospital, Holstebro, - - 2014
Clinical trials suggest that statins have beneficial effects on the cardiovascular system independent from their cholesterol lowering properties. In patients with chronic kidney disease stage II-III, we tested the hypothesis that atorvastatin increased systemic and renal nitric oxide (NO) availability using L-N(G) -monomethyl arginine (L-NMMA) as an inhibitor of NO ...
Giani Jorge F JF Departments of Biomedical Sciences and Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, - - 2014
The existence of a complete and functional renin-angiotensin system along the nephron is widely recognized. However, its precise role in blood pressure control and, by extension, hypertension is still uncertain. While most investigators agree that overexpressing RAS components along the nephron results in hypertension, two important issues remain: whether the ...
Velasco Alejandro A Hypertension Section, Cardiology Division, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390-8586, - - 2014
Endocrine hypertension is an important secondary form of hypertension, identified in between 5% and 10% of general hypertensive population. Primary aldosteronism is the most common cause of endocrine hypertension, accounting for 1%-10% in uncomplicated hypertension and 7%-20% in resistant hypertension. Other less common causes of endocrine hypertension include Cushing syndrome, ...
Ivy Jessica R JR British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, - - 2014
The regulation of extracellular fluid volume by renal sodium excretion lies at the centre of blood pressure homeostasis. Renal perfusion pressure can directly regulate sodium reabsorption in the proximal tubule. This acute pressure natriuresis response is a uniquely powerful means stabilizing long-term blood pressure around a set point. By logical ...
Peixoto Aldo J AJ Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut - - 2014
The evaluation of causes of hypertension in young adults with a family history of hypertension needs to be methodical to identify potentially treatable causes. Renal- and renovascular imaging and measurement of plasma aldosterone and plasma renin activity are at the core of this evaluation in most patients. Pertinent aspects of ...
Bayliss George G Division of Kidney Diseases and Hypertension, Rhode Island Hospital, APC 9, 593 Eddy St., Providence, RI, 02906, USA, - - 2014
Resistant hypertension in diabetes is associated with poor cardiovascular and renal outcomes. This brief review will examine the definitions and epidemiology of resistant hypertension and consider the differences between apparent resistant hypertension and truly resistant or refractory hypertension. It will review the role of the sympathetic nervous system in resistant ...
Townsend Raymond R RR Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, Philadelphia, - - 2014
Device-based interventions to lower drug-resistant hypertension have made the management of this disorder more complicated. In this review, we will focus on developments in this approach to blood pressure care which have appeared over the last year in a published or abstract form. Much of the recent literature in this ...
Tosun Murat M Department of Histology Embryology, Afyon Kocatepe University, Campus of Ali Cetinkaya, 03200, Afyonkarahisar, Turkey, - - 2014
Laparoscopic surgery techniques have been increasingly preferred to classic laparotomy by surgeons since 1987. However, this method may have some side effects on different intraabdominal organs including kidneys. The aim of this study is to evaluate the effects of different pressures of CO2 on p53 related apoptosis in kidneys. Totally ...
Böhm Michael M From the Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany (M.B., D.L., C.U., F.M.); and Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia (M.E.). - - 2014
Hypertension imposes a major burden of morbidity and mortality and is associated with sympathetic nervous system overactivity. Renal sympathetic denervation has been shown to reduce office blood pressure, ambulatory blood pressure, and sympathetic activity in patients with resistant hypertension. Therefore, the procedure has attracted a lot of attention. Beyond blood ...
Nicholl David D M DD University of Calgary, Calgary, Alberta, Canada ; - - 2014
Rationale: Obstructive sleep apnea (OSA) has been associated with kidney function loss, which may be related to changes in the renin angiotensin system (RAS). Objectives: To determine the effect of continuous positive airway pressure (CPAP) for patients with OSA on renal hemodynamics at baseline and in response to Angiotensin II ...
Vink Eva E EE aDepartment of Nephrology bDepartment of Cardiology cDepartment of Vascular Medicine dDepartment of Radiology eJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The - - 2014
In renal denervation (RDN), a wide range in the blood pressure (BP)-lowering effect has been reported. On the basis of the current knowledge of pathophysiology, we hypothesized that the BP-lowering effect of RDN would be inversely related to kidney function. Second, we investigated whether direct and indirect variables of the ...
Moodley Kogi K Department of Human Physiology, School of Basic Medical Sciences, Faculty of Health - - 2014
Tulbaghia violacea has been used traditionally for the treatment of several ailments, including hypertension. The herb has been shown to haveantihypertensive properties which have been attributed to its angiotensin- converting enzymeinhibitory (ACEI) activity. It could, therefore, prove beneficial in ameliorating renal pathologyassociated with hypertension. To evaluate the effects of long-term ...
Prisco Sasha Z SZ From the Human and Molecular Genetics Center (S.Z.P., J.W.P., A.B.S., N.C.Y., M.J.H., C.C.H., H.J.J., M.J.F., J.L.) and Departments of Physiology (S.Z.P., J.W.P., A.B.S., N.C.Y., M.J.H., H.J.J., M.J.F., J.L.), Pediatrics (H.J.J.), and Dermatology (J.L.), Medical College of Wisconsin, - - 2014
Previously, we found that transferring 6.1 Mb of salt-sensitive (SS) chromosome 12 (13.4-19.5 Mb) onto the consomic SS-12(BN) background significantly elevated mean arterial pressure in response to an 8% NaCl diet (178±7 versus 144±2 mm Hg; P<0.001). Using congenic mapping, we have now narrowed the blood pressure locus by 86% ...
Pao Alan C AC aDivision of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford bVeterans Affairs Palo Alto Healthcare System, Palo Alto, California, - - 2014
Dr Arthur Guyton hypothesized that the capacity of the kidney to excrete sodium ultimately dictates long-term changes in blood pressure. This model has had a profound influence on our understanding of blood pressure regulation. The goal of this article is to review a selection of classic studies and highlight more ...
Kota Sunil Kumar SK Department of Endocrinology, Medwin Hospital, Hyderabad, - - 2014
Liddle's syndrome is a rare cause of secondary hypertension. Identification of this disorder is important because treatment differs from other forms of hypertension. We report an interesting case of a 35-year-old lady, a known diabetic and hypertensive patient, who presented with features of hypertensive encephalopathy. The family history was unremarkable. ...
Machino Takeshi T Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, - - 2014
We aimed to investigate the anti-hypertensive effect of radiofrequency (RF) renal denervation (RDN) in an animal model of hypertension. RF energy was delivered with opening abdomen to bilateral renal arteries through a 2Fr catheter in 8 spontaneously hypertensive rats (SHR) and 8 Wistar-Kyoto rats (WKY). Sham operation was performed in ...
Verwoert Germaine C GC Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The - - 2014
Recent evidence suggests that the type I 3β-hydroxysteroid dehydrogenase, a steroidogenic enzyme encoded by the HSD3B1 gene, could be involved in aldosterone production and that genetic variation in HSD3B1 is associated with blood pressure. These findings challenge the long-standing hypothesis that all adrenocortical steroidogenesis is executed by the type II ...
Ji Hong H From the Department of Medicine and Center for the Study of Sex Differences in Health, Aging, and Disease (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.) and Department of Pharmacology and Physiology and Center for Development of Radioligands (R.C.S.), Georgetown University, Washington, DC; Department of Experimental Pharmacology and Toxicology, School of Pharmaceutical Science, Jilin University, Changchun, Jilin, People's Republic of China (X.L.); Biorepository and Biochemistry Laboratory, MedStar Health Research Institute, Hyattsville, MD (J.G.U.); Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.); Department of Physiology and the Evelyn F. McKnight Brain Institute, University of Arizona at Tucson (M.H.); Department of Pharmaceutical Sciences, College of Pharmacy, Nova South Eastern University, Fort Lauderdale, FL (R.C.S.); Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada (M.A.Z., S.E.D.); Department of Immunology, University of Toronto, Toronto, Ontario, Canada (M.A.Z., S.E.D.); and Women's College Research Institute, Toronto, Ontario, Canada (S.E.D.). - - 2014
Studies suggest T cells modulate arterial pressure. Because robust sex differences exist in the immune system and in hypertension, we investigated sex differences in T-cell modulation of angiotensin II-induced increases in mean arterial pressure in male (M) and female (F) wild-type and recombination-activating-gene-1-deficient (Rag1(-/-)) mice. Sex differences in peak mean ...
Chrysant George S GS INTEGRIS Heart Hospital, Oklahoma City, - - 2014
The Safety and Effectiveness Study of the Herculink Elite Renal Stent to Treat Renal Artery Stenosis (HERCULES) trial is a prospective, multicenter trial evaluating the safety, effectiveness, and durability of the RX Herculink Elite renal stent system (Abbott Vascular, Abbott Park, IL) in select patients with atherosclerotic renal artery stenosis ...
Papanastasiou Labrini L Department of Endocrinology and Diabetes Center, 'G Genimatas' General Hospital, - - 2014
The prevalence of primary aldosteronism (PA) in hypertensive patients varies according to diagnostic testing and ascertained normal cut-offs. The aim of this case-control study was to confirm the high prevalence of PA in a large hypertensive population and evaluate the anti-hypertensive effect of mineralocorticoid receptor antagonists (MRA) treatment. We investigated ...
Kemp Brandon A BA Department of Medicine, University of Virginia Health - - 2014
Rationale: Compound 21 (C-21) is a highly selective non-peptide AT2 receptor (AT2R) agonist. Objective: To test the hypothesis that renal proximal tubule AT2Rs induce natriuresis and lower blood pressure (BP) in Sprague-Dawley rats and mice. Methods and Results: In rats, AT2R activation with intravenous C-21 increased urinary sodium (Na(+)) excretion ...
Esler Murray D MD Baker IDI Heart and Diabetes Institute, Monash University, 75 Commercial Road, Melbourne, Victoria 3004, Australia - - 2014
The aim of this study was to determine long-term results of renal artery denervation for treatment of treatment-resistant hypertension in the SYMPLICITY HTN-2 study. SYMPLICITY HTN-2 randomized 106 subjects with treatment-resistant hypertension to renal denervation or medical therapy alone. At 6 months, 37 control subjects crossed over to renal denervation. ...
Pollow Dennis P DP From the Department of Physiology (D.P.P., M.J.R.-A., H.L.B., M.H.), Sarver Heart Center (D.P.P., H.L.B., M.H.), Department of Immunobiology (J.U., J.N.-Z.), and Evelyn McKnight Brain Institute (M.H.), University of Arizona, Tucson; and Department of Medicine and Center for the Study of Sex Differences in Health, Aging, and Disease, Georgetown University, Washington, DC - - 2014
There is extensive evidence that activation of the immune system is both necessary and required for the development of angiotensin II (Ang II)-induced hypertension in males. The purpose of this study was to determine whether sex differences exist in the ability of the adaptive immune system to induce Ang II-dependent ...
Coffman Thomas M - - 2014
An essential link between the kidney and blood pressure control has long been known. Here, we review evidence supporting the premise that an impaired capacity of the kidney to excrete sodium in response to elevated blood pressure is a major contributor to hypertension, irrespective of the initiating cause. In this ...
Bo S S Department of Medical Science University of Turin, Turin, Italy - - - 2014
The association between high-normal blood pressure and the impairment of renal function is highly controversial. We analysed the contribution of high-normal blood pressure on incident impaired renal function. The study was performed in a population-based cohort of 1307 subjects free of diabetes, cardiovascular and renal disease at baseline, who attended ...
Aronova Anna A Anna Aronova, Thomas J Fahey III, Rasa Zarnegar, Department of Surgery, Weill Cornell Medical College/New York Presbyterian Hospital, New York, NY 10021, United - - 2014
Hypertension causes significant morbidity and mortality worldwide, owing to its deleterious effects on the cardiovascular and renal systems. Primary hyperaldosteronism (PA) is the most common cause of reversible hypertension, affecting 5%-18% of adults with hypertension. PA is estimated to result from bilateral adrenal hyperplasia in two-thirds of patients, and from ...
Utsumi Takanobu T Department of Urology, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura-shi, Chiba, 285-8741, Japan, - - 2014
Primary aldosteronism is the most common curable cause of secondary hypertension. Despite resection, however, many patients with primary aldosteronism continue to require antihypertensive drugs to control their blood pressure. Although many patients with primary aldosteronism want to know the postoperative probability of hypertension cure before surgery, there are no predictive ...
Galli T T TT Master's and Doctoral Programs in Physical Therapy, Universidade Cidade de São Paulo (UNICID), - - 2014
Pain is a negative factor in the recovery process of postoperative patients. It causes pulmonary alterations and complications, and it also affects functional capacity. Several studies have investigated the effects of transcutaneous electrical nerve stimulation (TENS) during the postoperative period. However, no studies have assessed the effects of TENS on ...
Bonfig Walter W Division of Pediatric Endocrinology & Diabetology, Department of Pediatrics, Technische Universität München; Division of Pediatric Endocrinology & Diabetology, Department of Pediatrics, Ludwig Maximilian Universität - - 2014
Infants with congenital adrenal hyperplasia (CAH) require higher doses of fludrocortisone (FC) due to physiological mineralocorticoid resistance. The adequacy of mineralocorticoid replacement should be closely monitored to avoid hypertension. To evaluate blood pressure (BP) in infants with CAH due to 21-hydroxylase deficiency. 33 patients (18f/15m) diagnosed by newborn screening were ...
Jin Chunhua C Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, - - 2014
The metabolic syndrome (MetS) and chronic kidney disease are global health issues. The MetS induces hypertension (HTN) and commonly results in renal damage. The optimal therapy for HTN in the MetS is unknown. Thiazide diuretics are first line therapy; however, these drugs may have untoward effects. This study investigated the ...
Inoue T T Center for Maternal-Fetal and Neonatal Medicine, National Center for Child Health and Development, Tokyo, - - 2014
A case of fetal neuroblastoma of the right adrenal gland, with rapid development of hydrops fetalis due to catecholamine-induced cardiomyopathy, is reported. A fetus with a right suprarenal mass detected during ultrasonography at 32 weeks gestation progressively developed into hydrops fetalis by 35.2 weeks gestation. An emergent cesarean section was ...
Egan Brent M BM Department of Medicine, Care Coordination Institute, Greenville Health System, University of South Carolina School of Medicine, Greenville, - - 2014
Apparent treatment-resistant hypertension (aTRH), defined as uncontrolled blood pressure using 3 or more antihypertensive medications or controlled using 4 or more antihypertensive medications, affects approximately 30% of uncontrolled and 12% of controlled blood pressure (BP) patients. aTRH is used when pseudoresistance cannot be excluded (eg, BP measurement artifacts, mainly office ...
Takenaka Tsuneo T International University of Health and Welfare, Department of Medicine, Minato, Tokyo, - - 2014
Background/Aims: Vitamin D increases renal expression of klotho in normotensive rats. Klotho reduces oxidative stress. Methods: In this study, we aimed to determine if vitamin D would suppress oxidative stress using 4 groups of hypertensive rats: uninephrectomized, stroke-prone, spontaneously hypertensive rats fed a high-salt (6%) diet (controls; C); those treated ...
Zicha J J Institute of Physiology Academy of Sciences of the Czech Republic, Prague, Czech Republic. - - 2014
The objective of the current study was to search for genetic determinants associated with antihypertensive effects of angiotensin-converting enzyme (ACE) inhibitor captopril. Linkage and correlation analyses of captopril-induced effects on blood pressure (BP) with renal transcriptome were performed in the BXH/HXB recombinant inbred (RI) strains derived from spontaneously hypertensive rat ...
Demerath Theo T 1University of - - 2014
The renin-angiotensin-aldosterone system and cardiac natriuretic peptides (atrial and B-type natriuretic peptide, ANP / BNP) are opposing control mechanisms for arterial blood pressure. Accordingly, an inverse relationship between the plasma concentrations of renin (PRC) and ANP exists in most circumstances. However, PRC and ANP levels are both elevated in renovascular ...
Kaze Francois Folefack - - 2014
Preeclampsia and eclampsia, which are the most frequent hypertensive disorders in pregnancy, are associated with renal involvements. We aimed to assess the time trend in blood pressure levels, renal function and proteinuria after delivery, and investigate their determinants in Cameroonian women with severe preeclampsia and eclampsia. This was a prospective ...
Yokota Kei K Division of Cardiovascular Medicine, Department of Medicine, School of Medicine, Jichi Medical University, Tochigi, Japan; Department of Nephrology, Iwakuni Medical Center, Yamaguchi, Japan; Department of Nephrology and Hypertension, School of Medicine, St. Marianna University, Kanagawa, - - 2014
The authors previously reported that the visit-to-visit variability of blood pressure is correlated with renal function decline in nondiabetic chronic kidney disease. Little is known about the association between visit-to-visit variability and renal function decline in patients with diabetic chronic kidney disease. The authors retrospectively studied 69 patients with diabetic ...
Ohsawa Masato M Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, - - 2014
Angiotensin II type 1 receptor (AT1R)-associated protein (ATRAP) promotes AT1R internalization along with suppression of pathological activation of tissue AT1R signaling. However, the functional significance of ATRAP in renal sodium handling and blood pressure regulation under pathological stimuli is not fully resolved. Here we show the blood pressure of mice ...
Bakri Mahinur M The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, - - 2014
In traditional Chinese medicine, Nitraria sibirica Pall. (Nitrariaceae) is used to treat hypertension. This study determined the effects of the total alkaloids of the leaves of Nitraria sibirica (NSTA) on blood pressure and albuminuria in mice treated with angiotensin II and a high-salt diet (ANG/HS). Adult mice were divided into ...
Kumar Manish M Senior Resident, Department of Pharmacology, IGIMS , Sheikhpura, Patna-14, Bihar, India - - 2014
Angiotensin Converting Enzyme Inhibitors (ACEI) and Angiotensin Receptor Blockers (ARBs) has been a major therapeutic advance in the management of hypertensive patients. This study was designed to compare adverse effects on renal markers in treatment with two commonly used drugs Perindopril and Telmisartan in cases of Hypertension. This was an ...
Ulu Arzu A *Department of Entomology and Comprehensive Cancer Center; #School of Veterinary Medicine, Anatomy, Physiology and Cell Biology, University of California, Davis, - - 2014
: Mediators of anti-hypertensive actions of docosahexaenoic acid (DHA) are largely unknown. The omega-3 epoxide of DHA, 19, 20-EDP (epoxydocosapentaenoic acid) is metabolized by soluble epoxide hydrolase (sEH), which also metabolizes the anti-inflammatory and anti-hypertensive arachidonic acid (ARA) epoxides, EETs (epoxyeicosatrienoic acids). Based in part on plasma levels of EDPs ...
Messerli Franz H FH From the Division of Cardiology, Mount Sinai Roosevelt Hospital, Icahn School of Medicine (F.H.M.), and the Leon H. Charney Division of Cardiology, New York University School of Medicine (S.B.) - both in New - - 2014
Ever since Schlaich et al.(1) first reported on a patient with a blood pressure of 161/107 mm Hg (despite treatment with seven different antihypertensive drugs) that decreased to 127/81 mm Hg after renal denervation, the medical community has been enamored with this procedure. Resistant hypertension evolved into a fashionable diagnosis, ...
Bhatt Deepak L DL From Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School (D.L.B., L.M.), Boston University School of Public Health (R.D.), and Harvard Clinical Research Institute (R.D., L.M.) - all in Boston; Piedmont Heart Institute, Atlanta (D.E.K.); the Division of Cardiology, Henry Ford Hospital (W.W.O.), and Wayne State University and the Detroit Medical Center (J.M.F.) - all in Detroit; Baptist Cardiac and Vascular Institute, Miami (B.T.K.); New York Presbyterian Hospital, Columbia University Medical Center, and Cardiovascular Research Foundation, New York (M.B.L.); Medtronic CardioVascular, Santa Rosa, CA (M.L., M.N., S.A.C.); University of Alabama at Birmingham, Birmingham (S.O.); Prairie Heart Institute, Springfield, IL (K.R.-S.); Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.A.C., R.R.T.); and University of Chicago Medicine, Chicago - - 2014
Prior unblinded studies have suggested that catheter-based renal-artery denervation reduces blood pressure in patients with resistant hypertension. We designed a prospective, single-blind, randomized, sham-controlled trial. Patients with severe resistant hypertension were randomly assigned in a 2:1 ratio to undergo renal denervation or a sham procedure. Before randomization, patients were receiving ...
Halleck Fabian F Institut für Klinische Pharmakologie und Toxikologie, Charité - Universitätsmedizin Berlin , Campus Mitte, Berlin , Germany - - 2014
Abstract Objective: The aim of the present study was to compare the preventive impact of treatment with a vasopeptidase inhibitor (VPI) with an angiotensin-receptor blocker (ARB) on left ventricular (LV) function and renal damage in rats with renal failure after 5/6 renal ablation (Nx). Methods: Rats (n = 15-20, each group) underwent ...
Reddi Alluru S AS Department of Medicine, Division of Nephrology and Hypertension, Rutgers, New Jersey Medical School , Newark, NJ , - - 2014
Abstract Background: Resistant hypertension is simply defined as failure to control blood pressure <140/90 mmHg in an adherent non-diabetic patient with normal kidney function despite the use of optimal doses of three antihypertensive agents, including a diuretic. Also, control of blood pressure in any adherent patient with more than four antihypertensive ...
Persu Alexandre A Pole of the Cardiovascular Research, Institut de Recherche Expérimentale et - - 2014
Based on the SYMPLICITY studies and CE (Conformité Européenne) certification, renal denervation is currently applied as a novel treatment of resistant hypertension in Europe. However, information on the proportion of patients with resistant hypertension qualifying for renal denervation after a thorough work-up and treatment adjustment remains scarce. The aim of ...
Zhou Wen-Ting WT Department of Pharmacology, Xinjiang Medical University, Urumqi 830011, P. R - - 2014
Cydonia oblonga Mill. (COM) is used in traditional Uyghur medicine to treat or prevent cardiovascular disease. In a previous study COM leaf extracts were found to be active in renal hypertensive rats (RHR). The present study tests the dose-dependence of the effect of ethanol leaf extracts on hypertension and on ...
Nakabayashi Keita K Department of Chemistry, Division of Material Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192 - - 2014
The temperature-induced stepwise neutral-ionic (N-I) phase transition in the covalently bonded donor-acceptor chain compound [Ru2 (2,3,5,6-F4 PhCO2 )4 DMDCNQI]⋅ 2(p-xylene) (2,3,5,6-F4 PhCO2 (-) =2,3,5,6-tetrafluorobenzoate; DMDCNQI=2,5-dimethyl-N,N'-dicyanoquinodiimine) was systematically tuned over a wide temperature range using two techniques: 1) A chemical technique based on doping with a less-active donor unit [Ru2 (II,II) (F5 ...
Bakker Hanneke H The Generation R Study Group, Erasmus Medical Center, Rotterdam, The - - 2014
Subclinical impaired kidney growth and function in childhood may lead to kidney diseases and high blood pressure in adulthood. We assessed the cross-sectional associations of childhood characteristics with kidney size and function in a multi-ethnic cohort. This study was embedded in a population-based cohort study of 6,397 children with a ...
Rini Brian I BI Cleveland Clinic Taussig Cancer Institute, Cleveland Clinic Main Campus, Mail Code R35, 9500 Euclid Avenue, Cleveland, 44195, OH, USA, - - 2014
Inhibitors of the vascular endothelial growth factor (VEGF) pathway frequently induce hypertension when used to treat patients with advanced renal cell carcinoma (RCC). This analysis characterizes hypertension and hypertension-related events in patients treated with the VEGF pathway inhibitors axitinib or sorafenib in the AXIS trial. AXIS was a randomized phase ...
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