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Esler Murray M Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Vic 8008, - - 2014
The 6-year anniversary of the first catheter-based renal denervation procedure for resistant hypertension has passed, and the 3-year follow-up results of the Symplicity HTN-1 are now published. At the 'end of the beginning', it is timely to reflect on the observations to-date for this revolutionary therapy, and to predict the ...
Dong Hui H Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, - - 2014
As a novel device-based approach targeting the renal sympathetic nerves, percutaneous renal denervation (RDN) has been shown to be effective and safe for reducing blood pressure. However, while considerable data on RDN have been obtained from Western populations, there is limited findings from East Asian populations. The purpose of this ...
Afsar Baris B Division of Nephrology, Department of Internal Medicine, Konya Numune State Hospital, Division of Nephrology, Konya, Turkey. - - 2014
Introduction. It has been demonstrated that kidney length is associated with office blood pressure (BP) measurements. Several studies support that ambulatory BP measurements in comparison to conventional BP better correlate with hypertensive target organ damage, and that the lack of nocturnal dip in BP (nondipping) is related to an increase ...
Blanc Mathieu M Radiology Department, Faculté de Médecine et des Science de la Santé de l'Université de Sherbrooke, Centre Hospitalier de l'Université de Sherbrooke (CHUS), Sherbrooke, - - 2014
We report a very rare case of renal lymphangiectasia, an accumulation of lymph in the renal lymphatic system secondary to obstruction. Our patient presented to his family doctor for an annual check-up which resulted with high blood pressure and polycythemia. An ultrasound was performed and revealed a large right perirenal ...
Eladari Dominique D Department of Physiology, Hopital Européen Georges Pompidou, AP-HP, 56 rue Leblanc, 75015, Paris, France, - - 2014
Sodium absorption by the distal part of the nephron, i.e., the distal convoluted tubule, the connecting tubule, and the collecting duct, plays a major role in the control of homeostasis by the kidney. In this part of the nephron, sodium transport can either be electroneutral or electrogenic. The study of ...
West Crystal A CA 1 University of Florida College of Medicine, United - - 2014
Normal pregnancy is a state marked by avid Na retention and plasma volume expansion (PVE). Insufficient PVE results in the compromised maternal state of intrauterine growth restriction which afflicts ~5% of all pregnancies. We have recently shown that renal in vivo epithelial sodium channel (ENaC) activity in the late pregnant ...
Zygner Wojciech W Division of Parasitology, Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786, Warsaw, Poland, - - 2014
Canine babesiosis is a tick-borne disease caused by parasites of the genus Babesia. Tumour necrosis factor alpha (TNF-α) is a cytokine that plays a role in the pathogenesis of canine babesiosis. In this study, the authors determined the concentration of serum TNF-α in 11 dogs infected with Babesia canis and ...
Siddiqi Laima L Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The - - 2014
Imaging of the kidney using blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) presents a major opportunity to examine differences in tissue oxygenation within the cortex and medulla applicable to human disease. The aim of this study was to evaluate BOLD signals before and after treatment with RAS inhibitors ...
Armaganijan Luciana - - 2014
Background: Systemic hypertension is an important public health problem and a significant cause of cardiovascular mortality. Its high prevalence and the low rates of blood pressure control have resulted in the search for alternative therapeutic strategies. Percutaneous renal sympathetic denervation emerged as a perspective in the treatment of patients with ...
Torun Dilek D Department of Nephrology, Faculty of Medicine, Başkent University, Adana Teaching and Medical Research Center, Adana-Turkey. - - 2014
Resistant hypertension is defined as blood pressure that remains above 140/90 mm Hg despite the concurrent use of optimal dose of 3 antihypertensive agents of different classes. Ideally, 1 of these 3 agents should be a diuretic agent. The etiology of resistance hypertension is multifactorial. Successful treatment requires identification and ...
Angeli Fabio - - 2014
Renin-angiotensin-system (RAS) is an enzymatic cascade that plays a pivotal role in the development of arterial hypertension, kidney disease and cardiovascular disease. Inhibition of the RAS with angiotensin converting enzyme (ACE) inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs) has proved to be a successful strategy for the treatment of hypertension ...
Fargali Samira S *Department of Neuroscience, †Department of Geriatrics, ‡Department of Neurology, §Graduate School of Biomedical Sciences, and ∥Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, - - 2014
Secretion of proteins and neurotransmitters from large dense core vesicles (LDCVs) is a highly regulated process. Adrenal LDCV formation involves the granin proteins chromogranin A (CgA) and chromogranin B (CgB); CgA- and CgB-derived peptides regulate catecholamine levels and blood pressure. We investigated function of the granin VGF (nonacronymic) in LDCV ...
Ahmed Rezwan - - 2014
Pheochromocytomas are catecholamine secreting tumours of the adrenal gland, discovered in 0.1% of patients with hypertension. Our case highlights an atypical presentation of pheochromocytoma in a patient with Neurofibromatosis type 1 who developed cardiogenic shock with multi-organ failure. The patient demonstrated reversible dilated cardiomyopathy during her hospital stay, and her ...
Saraswat Megha S MS SPP SPTM, SVKM's NMIMS, Mumbai, Maharashtra, - - 2014
Hypertensive nephropathy is moving up the charts to number 2 after diabetic nephropathy in terms of diagnostic frequency cited as causing end stage renal disease (ESRD). Hypertensive nephropathy was produced in mildly hypertensive C57BL/6-(hREN)/(hAGT) double transgenic (dTG) mice with 20mg/kg of cyclosporine A (CsA) administered subcutaneously (sc) daily for 28 ...
Kaiser Lukas L Department of Cardiology, Asklepios Klinik St. Georg, Hamburg, - - 2014
Aims: To prove the efficacy and safety of renal sympathetic denervation as a new treatment option for patients suffering from resistant hypertension in a real-world setting. Methods and results: This single-centre real-world registry included 93 patients who underwent renal denervation employing the Symplicity system. Patients were followed for six months. ...
Rossi Gian Paolo GP Department of Medicine-DIMED, Internal Medicine 4, University Hospital, University of Padua, Via Giustiniani 2, 35126, Padua, Italy, - - 2014
Primary aldosteronism is the most common form of endocrine hypertension and is highly prevalent among patients with difficult to control high blood pressure. In the presence of a high sodium intake primary aldosteronism carries has detrimental effects on the cardiovascular system, which translate into an excess rate of cardiovascular events. ...
Zhou Wenting W Department of Pharmacology, Xinjiang Medical University, 393 Xinyi road, 830011 Urumqi, Xinjiang, People's Republic of China - - 2014
Quince, Cydonia oblonga Mill. (COM), is used in traditional Uyghur medicine to treat or prevent cardiovascular diseases. Uyghur people have greater longevity and lower blood pressure than other central Asian populations. We therefore tested COM fruit and leaf extracts on blood pressure and rheology in renal hypertensive rats (RHR). Two-kidney, ...
Gossios Thomas D TD 11st Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, - - 2014
Resistant hypertension, defined as failure to reach blood pressure (BP) goals despite treatment with ≥3 antihypertensive agents, one of which is a diuretic, bears a significant risk of cardiovascular complications. Strong evidence exists, implicating the overactivation of the sympathetic nervous system (SNS) in the pathogenesis of resistant hypertension through complex ...
Schneider Markus P MP Department of Nephrology and Hypertension, University of Erlangen-Nuremberg, Erlangen, - - 2014
To summarize the available evidence on whether a lower blood pressure (BP) treatment target can ameliorate the progression of nondiabetic chronic kidney disease (CKD), and prevent cardiovascular events in CKD patients. The three prospective, randomized controlled trials which addressed the question of progression of CKD suggest that a lower BP ...
Vitzthum Helga H University Medical Center Hamburg-Eppendorf, - - 2014
A network of kinases including WNKs, SPAK, and Sgk1 is critical for the independent regulation of K+ and Na+ transport in the distal nephron. Angiotensin II is thought to act as key hormone to orchestrate these kinases to switch from K+ secretion during hyperkalaemia to Na+ reabsorption during intravascular volume ...
Cirillo Massimo M Department of Medicine and - - 2014
Short-term effects of chlorthalidone are unknown in low kidney function. The effects of 8-week treatment with 25-mg chlorthalidone on the top of ongoing treatment were compared between control hypertensives and low kidney function hypertensives as assessed by estimated glomerular filtration rate <60 mL/min×1.73 m(2). Screening period consisted of 2 visits ...
Dubb Sukhpreet Singh SS Imperial College, London, - - 2014
We present a young, lean, female patient following surveillance by the general practitioner for abnormally high blood pressure readings. Her grandmother died at a young age because of hypertension which shows her family has significant history for hypertension. Her symptoms and signs included feeling hot and nauseous following exercise, sweating ...
Yan Jie J Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, - - 2014
Gestational diabetes mellitus (GDM) is increasing rapidly worldwide. Previous animal models were established to study consequences of offspring after exposure to severe intrauterine hyperglycemia. In this study we are aiming to characterize the blood pressure levels and renal function of male offspring obtained from diabetic mothers with moderate hyperglycemia. We ...
Takenaka Tsuneo T Department of Medicine, International University of Health and Welfare , Minato, Tokyo , Japan - - 2014
Abstract Hypertension is a well-known cardiovascular risk. Patients with end-stage renal diseases frequently suffer hypertension. Furthermore, daily variations of blood pressure are relatively large in patients treated with hemodialysis, partly due to ultrafiltration. Twenty hypertensive patients with end-stage renal diseases whose blood pressure was controlled by a single antihypertensive agent, ...
Wuerzner G G Lausanne University Hospital, SWITZERLAND; - - 2014
Transcatheter (or percutaneous) renal denervation is a novel technique developed for the treatment of resistant hypertension. So far, only one randomised controlled trial has been published, which has shown a reduction of office blood pressure. The Swiss Society of Hypertension, the Swiss Society of Cardiology, The Swiss Society of Angiology ...
Peco-Antić Amira - - 2014
Renal hypertension is one of the earliest and the most prevalent complications of pediatric chronic kidney disease (CKD). Among renal patients, hypertension is frequently underdiagnosed and undertreated. For casual blood pressure measurement, the best method is auscultatory, while for ambulatory blood pressure measurement, oscillometric method is the most commonly used. ...
Glazar Wojciech - - 2014
Epidemiological data show that chronic kidney disease (CKD) is a serious social problem and nowadays is included amongst civilisation diseases. Knowing the relation between decrease in the number of nephrons and progressing kidney damage caused by it, we can treated each nephrectomy from medical reasons as a risk factor for ...
Borg Morten K MK Department of Biomedicine, Aarhus University, Aarhus, - - 2014
Cardiovascular disease is the leading cause of death in patients with end stage renal disease (ESRD). The vasodilator mechanisms in small resistance arteries are in earlier studies shown to be reduced in patients with end stage renal disease. We studied whether endothelium dependent vasodilatation were diminished in ESRD patients and ...
Girişgen Ilknur I Division of Pediatric Nephrology, Department of Pediatrics, Adnan Menderes University Faculty of Medicine, Aydın, Turkey. - - 2014
Primary hypertension is the most important risk factor for chronic kidney disease in adulthood. However, the role of hypertension in kidney damage in childhood is not known exactly. The aim of this study was to evaluate the ambulatory blood pressure measurements of healthy children diagnosed as hypertensive with routine office ...
Wang Jie J Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, - - 2014
To assess the effect of kidney-tonifying (KT) Chinese herbal formula for senile hypertension (SH). A total of five databases (CENTRAL, Pubmed, CBM, CNKI, and VIP) were searched for published and unpublished randomized controlled trials (RCTs) up to November 30th, 2013. We included RCTs that confoundedly addressed the effect of KT ...
Kumar Prabhat P Department of Medicine, PGIMER & Dr Ram Manohar Lohia Hospital, New Delhi, - - 2014
Extra-adrenal pheochromocytomas (EAPs) are rare catecholamine-secreting tumours. The patient commonly present with headache, palpitation, anxiety, diaphoresis, raised blood pressure and heart rate which can be sustained or episodic and less commonly Raynaud's phenomenon. We present a case of an adult woman who presented with unilateral upper limb acrocyanosis and hypertension ...
Hargovan Milan M School of Medicine, King's College London, London, - - 2014
The renin-angiotensin aldosterone system is a critical mechanism for controlling blood pressure, and exerts most of its physiological effects through the action of angiotensin II. In addition to increasing blood pressure by increasing vascular resistance, angiotensin II also stimulates aldosterone secretion from the adrenal gland. Aldosterone acts to cause an ...
Tomiyama Hirofumi H Second Department of Internal Medicine, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, - - 2014
This minireview provides current summaries of beta-blocker use in the management of hypertension and/or chronic kidney disease. Accumulated evidence suggests that atenolol is not sufficiently effective as a primary tool to treat hypertension. The less-than-adequate effect of beta-blockers in lowering the blood pressure and on vascular protection, and the unfavorable ...
Nakamura Motonobu M Department of Internal Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, - - 2014
Sodium-coupled bicarbonate absorption from renal proximal tubules (PTs) plays a pivotal role in the maintenance of systemic acid/base balance. Indeed, mutations in the Na(+)-HCO3 (-) cotransporter NBCe1, which mediates a majority of bicarbonate exit from PTs, cause severe proximal renal tubular acidosis associated with ocular and other extrarenal abnormalities. Sodium ...
Miloradović Zoran Z Department of Cardiovascular Physiology, Institute for Medical Research, University of Belgrade, 11129 Belgrade, - - 2014
Acute kidney injury (AKI) is associated with significant morbidity and mortality in hypertensive surroundings. We investigated superoxide radical molecules influence on systemic haemodynamic and kidney function in spontaneously hypertensive rats (SHR) with induced postischemic AKI. Experiment was performed in anesthetized adult male SHR. The right kidney was removed, and left ...
Patel Hitesh C HC National Institute of Health Research (NIHR), Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, United - - 2014
Resistant hypertension is, by definition, a challenge to most physicians treating hypertension. Renal sympathetic denervation has shown promising early results in treating this condition. The SYMPLICITY HTN-3 is the most recent trial to report the effects of this technique on resistant hypertension. This review discusses this study and its surprising ...
Capdevila Jorge H JH Vanderbilt University Medical School, United - - 2013
Hypertension is a major risk factor for cerebral, cardiovascular, and renal disease and its prevalence and devastating consequences raises a need for new strategies for its early diagnosis and treatment. We show here that lack of a Cyp2c44 epoxygenase causes dietary salt sensitive hypertension, a common form of the human ...
Meng Lin L Department of Nephrology, Second Affiliated Hospital to Tianjin University of Traditional Chinese Medicine , Tianjin , - - 2013
Abstract Background: Chronic kidney disease (CKD) is a world-wide public health problem. Hypertension is both a cause and a complication of CKD, and a risk factor for progression of kidney disease. The effect of salt intake on blood pressure (BP) and the salt sensitivity in non-dialysis patients with CKD were ...
Rudemiller Nathan N Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226. - - 2014
The CD3 ζ chain (CD247), a gene involved in T-cell signaling, has been shown to associate with blood pressure in human genetic studies. To test the functional role of CD247 in hypertension and renal disease, zinc-finger nucleases targeting CD247 were injected into Dahl salt-sensitive (SS/JrHsdMcwi) embryos. The resulting 11-bp frameshift ...
Moes Arthur D - - 2013
SLC12A3 encodes the thiazide-sensitive sodium chloride cotransporter (NCC), which is primarily expressed in the kidney, but also in intestine and bone. In the kidney, NCC is located in the apical plasma membrane of epithelial cells in the distal convoluted tubule. Although NCC reabsorbs only 5 to 10 % of filtered sodium, ...
Sugama Ikuko - - 2013
The aim of this study was to determine whether antioxidant therapy could relieve hypertension and retard the progression of renal damage in advanced-stage hypertensive rats. Twenty-four-week-old spontaneously hypertensive stroke-prone rats were treated for 8 weeks with the superoxide dismutase mimetic tempol, low-dose or high-dose candesartan (an angiotensin receptor blocker), or ...
Drawz Paul E PE Division of Renal Diseases and Hypertension, Department of Medicine, University of Minnesota Medical School , Minneapolis, Minnesota, - - 2013
Early identification of chronic kidney disease (CKD) provides an opportunity to implement therapies to improve kidney function and slow progression. The goal of this article is to review established and developing clinical therapies directed at slowing progression. The importance of controlling blood pressure will be discussed along with the target ...
Rodríguez-Iturbe Bernardo - - 2013
Hypertension affects more than one-third of the adult population of the world. However, the cause of high blood pressure is unknown in the vast majority of patients, classified as patients with essential hypertension. Evidence accumulated over the past decade supports the participation of inflammation in the development of experimental hypertension. ...
Eleid Mackram F - - 2014
Hypertension is the leading cause of mortality worldwide. Effective therapies are needed for resistant hypertension, a common condition characterized by inadequate blood pressure control despite 3 or more medications, which is associated with increased cardiovascular mortality. Percutaneous catheter-based renal denervation is a promising new treatment offering the potential to improve ...
Krum Henry H Monash Centre of Cardiovascular Research and Education in Therapeutics, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, Australia. Electronic address: - - 2014
Renal denervation (RDN) with radiofrequency ablation substantially reduces blood pressure in patients with treatment-resistant hypertension. We assessed the long-term antihypertensive effects and safety. Symplicity HTN-1 is an open-label study that enrolled 153 patients, of whom 111 consented to follow-up for 36 months. Eligible patients had a systolic blood pressure of ...
Moody William E WE Birmingham Cardio-Renal Group, Centre for Clinical Cardiovascular Science, Nuffield House, Queen Elizabeth Hospital Birmingham, Birmingham, United - - 2014
There is strong evidence of an association between chronic kidney disease (CKD) and cardiovascular disease. To date, however, proof that a reduction in glomerular filtration rate (GFR) is a causative factor in cardiovascular disease is lacking. Kidney donors comprise a highly screened population without risk factors such as diabetes and ...
Manakshe Gajendra - - 2013
Uncontrolled Hypertension(HTN) accounts for significant morbidity and mortality. Despite newer drugs hypertension remains uncontrolled in approximately a third of the patients. The overall prevalence of hypertension in adults > 20 years was 30% in men and 34% in women in 2002. We report 2 patients with uncontrolled hypertension in whom ...
Bodas Prasad - - 2013
Renal disease is a known contributor to mortality in adults with sickle cell disease (SCD) and renal abnormalities are evident in childhood. Hyperfiltration (evidenced by elevated glomerular filtration rate, GFR) occurs in children with SCD early in disease. However, the incidence of low GFR (<90 ml/min/1.73 m2) suggestive of chronic ...
Kansui Yasuo - - 2013
Abstract Strict control of blood pressure is important to prevent cardiovascular disease, although it is sometimes difficult to decrease blood pressure to target levels. The aim of this study was to investigate the clinical characteristics of resistant hypertension evaluated by ambulatory blood pressure monitoring. One hundred in-hospital patients, whose 24-hour ...
Yoshida Shigetaka - - 2013
The renin-angiotensin-aldosterone system (RAAS) plays pivotal roles in the pathogenesis of chronic kidney disease (CKD) progression. Aliskiren, a direct renin inhibitor, inhibits the rate-limiting step of the RAAS without any alternative pathway. It is proven to reduce albuminuria in CKD patients treated with angiotensin blockade. However, there are few reports ...
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