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Roriz Paulo P University of Aveiro, Centre for Mechanical Technology and Automation, Department of Mechanical Engineering, 3810-193 Aveiro, PortugalbINESC-Porto and Faculty of Sciences of the University of Porto, Rua do Campo Alegre, 687, 4150-179, Porto, - - 2014
ABSTRACT. The purpose of the present study was to measure the intradiscal pressure signal of an anesthetized sheep under spontaneous breathing. An ultra-miniature fiber optic high-pressure sensor was implanted into the nucleus pulposus of the fifth lumbar intervertebral using a dorsolateral transforaminal approach. Results suggested the periodicity of the intradiscal ...
Furlanetto Rafael L RL Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, - - 2014
To investigate risk factors for disc hemorrhage detection in the Low-pressure Glaucoma Treatment Study. Cohort of a randomized, double-masked, multicenter clinical trial. Low-pressure Glaucoma Treatment Study patients with at least 16 months of follow-up were included. Exclusion criteria included untreated intraocular pressure (IOP) >21 mm Hg, visual field mean deviation ...
Spiegl U U 1Department of Trauma and Reconstructive Surgery, Spine Center, University of Leipzig, Germany 2BG Trauma Center Murnau, Germany 3Institute of Biomechanics, Paracelsus Medical University Salzburg, Austria 4Institute of Biomechanics, BG Trauma Center Murnau, Germany *have equally - - 2014
Study Design. A biomechanical study calf cadaver studyObjective. The purpose of this study was to determine the intradiscal pressure gradient of bridged healthy intervertebral segments in correlation with intraoperative distraction force.Summary of Background Data. Bisegmental dorsal stabilization and anatomic reduction is a common treatment option for incomplete burst fractures of ...
Boendermaker Bart B Department of Experimental Anatomy, Vrije Universiteit Brussel, Brussel, - - 2014
Eight decades after Penfield's discovery of the homunculus only sparse evidence exists on the cortical representation of the lumbar spine. The aim of our investigation was the description of the lumbar spine's cortical representation in healthy subjects during the application of measured manual pressure. Twenty participants in the prone position ...
Hebelka Hanna H *Department of Radiology, Sahlgrenska University Hospital, SU/M and **Department of Orthopaedics, Sahlgrenska University Hospital, SU/S, University of Gothenburg, Gothenburg - - 2013
Study Design. Observational in vivo clinical studyObjective. To investigate whether intradiscal pressure is transferred to adjacent discs during clinical discography in subjects with discogenic painSummary of Background Data. Despite the introduction of pressure registration in discography, the validity of the method remains controversial. Discography in vivo in anesthetized pigs has ...
Hebelka Hanna - - 2013
In vivo experimental porcine study. To investigate if discography induced pressure increase in adjacent degenerate discs. Despite refinements in the past 2 decades, the validity of discography is debated. Discography in healthy pigs has shown that the pressure increase during disc injection transmits to adjacent discs, a potential source for ...
Meier Michael L - - 2013
The purpose of this study was to develop and test a clinically relevant method to mechanically stimulate lumbar functional spinal units while recording brain activity by means of functional magnetic resonance imaging (MRI). Subjects were investigated in the prone position with their face lying on a modified stabilization pillow. To ...
Kalamatianos T - - 2013
Orexin A (ORX-A) is implicated in the regulation of various physiological processes, including sleep/wake cycles and reward/motivation. The hypothalamic ORX-A neurons project throughout the brain and spinal cord. In the present study we established and compared ORX-A levels in lumbar and ventricular cerebrospinal fluid (CSF) samples, drawn from idiopathic normal ...
Suh Soh Youn - - 2013
Idiopathic intracranial hypertension (IIH) is a condition of raised intracranial pressure (ICP) in the absence of space occupying lesions. ICP is usually measured by lumbar puncture and a cerebrospinal fluid (CSF) pressure above 250 mm H2O is one of the diagnostic criteria of IIH. Recently, we have encountered two patients ...
Williams Ian - - 2013
Confining a system in a small volume profoundly alters its behaviour. Hitherto, attention has focused on static confinement where the confining wall is fixed such as in porous media. However, adaptive confinement where the wall responds to the interior has clear relevance in biological systems. Here we investigate this phenomenon ...
Park Won Man - - 2013
The effects of intervertebral disc (IVD) degeneration on biomechanics of the lumbar spine were analyzed. Finite element models of the lumbar spine with various degrees of IVD degeneration at the L4-L5 functional spinal unit (FSU) were developed and validated. With progression of degeneration, intersegmental rotation at the degenerated FSU decreased ...
Popovich John M JM - - 2013
BACKGROUND CONTEXT: Intervertebral disc and facet joints are the two primary load-bearing structures of the lumbar spine, and altered loading to these structures may be associated with frontal plane spinal deviations. PURPOSE: To determine the load on the lumbar facet joint and intervertebral disc under simulated frontal plane pelvic obliquity ...
Lee Patrick J - - 2013
Despite the evidence suggesting that between 8% and 55% of manual labourers experience thoracic pain, research on spinal loading during occupational tasks has been almost invariably limited to the lumbar spine. In this study, we determined the ratio of thoracic to lumbar compression force and the relative risk of injury ...
Mehraeen Shareghe - - 2013
The advent of aberration correction for transmission electron microscopy has transformed atomic resolution imaging into a nearly routine technique for structural analysis. Now an emerging frontier in electron microscopy is the development of in situ capabilities to observe reactions at atomic resolution in real time and within realistic environments. Here ...
Cabello J - - 2013
OBJECTIVES: To assess the changes of intradiscal pressure at the bridged and at the adjacent levels to a lumbar two-level hybrid instrumentation. INTRODUCTION: The elimination of motion produced by spinal fusion may have potential consequences beyond the index level overloading the juxtaposed spinal motion segments and leading to the appearance ...
Reitmaier Sandra - - 2013
Currently, no studies exist, which attest the suitability of the ovine intervertebral disc as a biomechanical in vivo model for preclinical tests of new therapeutic strategies of the human disc. By measuring the intradiscal pressure in vivo, the current study attempts to characterize an essential biomechanical parameter to provide a ...
Sengupta D K DK Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, - - 2013
Alternatives to conventional rigid fusion have been proposed for several conditions related to degenerative disc disease when nonoperative treatment has failed. Semirigid fixation, in the form of dynamic stabilization or PEEK rods, is expected to provide compression under loading as well as an intermediate level of stabilization. This study systematically ...
Ahuja Munish - - 2012
The study involves mucoadhesive evaluation by formulating buccal discs using fluconazole as the model drug. The effect of compression pressure and gum cordia/lactose ratio on the ex vivo bioadhesion time and in vitro release of fluconazole was optimized using central composite experimental design. It was observed that the response ex ...
Holmes M W R - - 2012
Police officers spend large amounts of time performing duties within a police cruiser and report a high prevalence of musculoskeletal problems. This study evaluated the effects of driver seat and duty belt design on posture, pressure and discomfort. Ten male and 10 female university students attended two sessions involving simulated ...
Huang Yan-di - - 2012
Seated workplaces have greatly increased in China. Many researchers have found that seated work is a risk factor in the development of low-back pain. Backrest can reduce the load on the lower back by transmitting more of the weight from the upper body to the floor via the backrest so ...
Stevens Robert D - - 2012
Sustained intracranial hypertension and acute brain herniation are "brain codes," signifying catastrophic neurological events that require immediate recognition and treatment to prevent irreversible injury and death. As in cardiac arrest, evidence supports the organized implementation of a stepwise management algorithm. Because there are multiple etiologies and many treatments that can ...
Hisashige Akinori - - 2012
BACKGROUND & AIMS: Pressure ulcers not only affect quality of life among the elderly, but also bring a large economic burden. There is limited evidence available for the effectiveness of nutritional interventions for treatment of pressure ulcers. In Japan, recently, a 60-patient randomized controlled trial of nutritional intervention on pressure ...
Ti Y - - 2011
Serum salusin-alpha, is decreased in essential hypertension and acute coronary syndrome. The study is aimed to explore whether serum salusin-alpha is associated with atherosclerosis and left ventricular (LV) diastolic dysfunction in essential hypertension. Echocardiography, carotid ultrasonography, brachial-ankle pulse wave velocity (BaPWV) and serum salusin-alpha levels were determined in 60 hypertensive ...
Lei Yuan - - 2011
The response of cells (e.g., optic nerve head [ONH] cells) to mechanical stress is important in glaucoma. Studies have reported the biological effects of hydrostatic pressure on ONH cells cultured on a rigid substrate. An apparatus, designed to independently vary hydrostatic pressure and gas tension (including oxygen tension) in culture ...
Ling Feng - - 2011
Epithelial dysfunction in lungs plays a key role in the pathogenesis of acute lung injury. The beneficial effects of low potassium dextran glucose solution (LPD) have been reported in lung preservation, and LPD enables injured alveolar pneumocytes to recover. So we hypothesized that systemic administration of LPD may have benefits ...
Strumwasser Aaron - - 2011
Intracranial pressure (ICP) is currently measured with invasive monitoring. Sonographic optic nerve sheath diameter (ONSD) may provide a noninvasive estimate of ICP. Our hypothesis was that bedside ONSD accurately estimates ICP in acutely injured patients. The specific aims were (1) to determine the accuracy of ONSD in estimating elevated ICP, ...
Skirton Heather - - 2011
Aims and objectives.  To compare the accuracy and appropriateness of auscultatory (manual) and oscillometric (automated) devices for measuring blood pressure in clinical settings. Background.  Accurate measurement of blood pressure is integral to early recognition of deterioration in the condition of a patient. Despite recommendations regarding the use of auscultatory devices ...
Merlin Mark A - - 2011
Abstract Objective. We evaluated the benefit of emergency medical services providers? placing a second intravenous (IV) line in the prehospital trauma setting. Our hypothesis was that the placement of a second IV catheter in trauma does not result in an improvement in heart rate, blood pressure, rehospitalizaton rate, or 30-day ...
Bekhet Abir K - - 2011
The number of elders who relocate to retirement communities is increasing exponentially, and their ability to exercise free choice, personal control, and autonomy has been associated with relocation adjustment and positive outcomes in regard to physical, emotional, and social well-being. Although a measure of relocation controllability (the degree of personal ...
Kumarasamy Sivarajan - - 2011
Prediabetes (PreDM) in asymptomatic adults is associated with abnormal circadian blood pressure variability (abnormal CBPV). Systemic inflammation and glycemia influence circadian blood pressure variability. Dahl salt-sensitive (S) rats (n = 19) after weaning were fed either an American (AD) or a standard (SD) diet. The AD (high-glycemic-index, high-fat) simulated customary ...
Moon Hyun Soo - - 2010
Pneumocephalus is a condition which usually results from head trauma. It has been known that iatrogenic pneumocephalus can occur as a complication of positive pressure mask ventilation during induction of anesthesia or ventilatory care for head trauma patients. We report a case of mask ventilation during anesthesia induction in a ...
Rasche Stefan - - 2010
Inhalation of perfluorohexane vapor (PFH) and high-frequency oscillatory ventilation (HFOV) both have been shown to improve lung function in acute lung injury (ALI). Their combination implies synergistic action. The authors investigated technical aspects of PFH vaporization during HFOV and effects on gas exchange in a pilot study of experimental ALI. ...
Han Sang Kyoon - - 2010
CONTEXT: Circulatory shock is a major cause of mortality in glyphosate-surfactant herbicide (GlySH) poisoning, and this condition responds poorly to conventional therapies. We report a case of GlySH poisoning with shock that was refractory to vasopressors but responsive to intravenous fat emulsion (IFE). CASE DETAILS: A 52-year-old man was brought ...
Polglase Graeme R - - 2010
Ureaplasma species are the microorganisms most frequently isolated from women with preterm birth and are associated with an increased risk of bronchopulmonary dysplasia. Initiation of ventilation with high tidal volumes (VT) causes lung injury and inflammation. We investigated whether antenatal colonization with Ureaplasma parvum serovar 3 (UP) would alter the ...
Hammond Paul S - - 2010
A previous paper (Hammond, P.; Unsal, E. Langmuir 2009, 25, 12591-12603) reported a simplified model for the flow of a surfactant solution into an oil-wet capillary. Results were computed by neglecting the spreading of surfactant molecules ahead of the moving oil/water meniscus onto the hydrophobic surface. We now present a ...
Zheng Shengnai - - 2010
This study was designed to measure the pressure distribution of the intervertebral disc under different degrees of distraction of the interspinous process, because of a suspicion that the degree of distraction of the spinous process may have a close relationship with the disc load share. Six human cadaver lumbar spine ...
Wu H - - 2010
BACKGROUND: Overdistension of the lung causes ventilator-induced lung injury (VILI) accompanied by surfactant abnormalities and inflammatory changes. We investigated the effects of surfactant replacement on overdistension of the terminal airspaces and plasma cytokine levels in VILI. METHODS: VILI was induced by high-pressure ventilation (HPV) in rats anesthetized with pentobarbital, followed ...
Lee Hsin-Ling - - 2009
INTRODUCTION: Most of the glyphosate-surfactant herbicides (GlySH) are formulated commercial products containing isopropylamine (IPA) salt of glyphosate (IPAG), variable amount of a surfactant, and water. Although glyphosate is only slightly toxic to rats, ingestion of GlySH may lead to severe effects, including death, in humans. We conducted a study to ...
Sweet D G - - 2009
Surfactant replacement therapy has been available for about 25 years, revolutionising neonatal respiratory care after its introduction in the 1980s. Along with antenatal steroids, surfactants improve survival for preterm babies and they are now recommended routinely as early in the course of respiratory distress syndrome (RDS) as possible. Prophylactic treatment, ...
Val?rio Alexsandra - - 2010
The aim of this work is to report the production of mono- and diglycerides from olive oil at ambient condition and in pressurized n-butane as solvent medium. For this purpose, a commercial immobilized lipase (Novozym 435) was employed as catalyst and sodium (bis-2-ethyl-hexyl) sulfosuccinate (Aerosol-OT or AOT) as surfactant. The ...
Lyra Joao Cesar - - 2009
Meconium (MEC) is a potent inactivator of pulmonary surfactant. The authors studied the effects of polyethylene glycol addition to the exogenous surfactant over the lung mechanics and volumes. Human meconium was administrated to newborn rabbits. Animals were ventilated for 20 minutes and dynamic compliance, ventilatory pressure, and tidal volume were ...
Thompson M R - - 2009
An in situ study was conducted using an x-ray diffractometer and a specially designed high pressure cell to examine the effects of carbon dioxide at different pressures and temperatures on three different modified montmorillonite species. These organoclays possessed organic pillars of quaternary ammonium surfactant with either one, two, or three ...
Polglase Graeme R - - 2009
Intratracheal lipopolysaccharide (LPS) causes acute inflammation and injurious mechanical ventilation results in pulmonary and systemic inflammation. We aimed to determine in preterm lungs if continuous positive airway pressure (CPAP) protects against pulmonary and systemic inflammation, compared with conventional mechanical ventilation (CMV) after intratracheal LPS. Preterm fetuses were exposed to maternal ...
Geiger Ralf - - 2009
N-chlorotaurine, a long-lived oxidant produced by human leukocytes, can be applied in human medicine as an endogenous antiseptic. Its antimicrobial activity can be enhanced by ammonium chloride. This study was designed to evaluate the tolerability of inhaled N-chlorotaurine (NCT) in the pig model. Anesthetized pigs inhaled test solutions of 1% ...
Kurahashi Kiyoyasu - - 2009
Phagocytes of the reticuloendothelial system are important in clearing systemic infection; however, the role of the reticuloendothelial system in the response to localized infection is not well-documented. The major goals of this study were to investigate the roles of phagocytes in the reticuloendothelial system in terms of bacterial clearance and ...
Chada Martin - - 2008
In acute respiratory distress syndrome (ARDS) with pulmonary hypertension, interleukin-1 beta (IL-1 beta) and interleukin-8 (IL-8) are involved in the pulmonary inflammatory reaction. The purpose of this study was to determine whether systemic and aerosolized administered IL-1 receptor antagonist (IL-1Ra) Anakinra (Kineret) improves lung mechanics and pulmonary artery pressure in ...
Bailey Timothy C - - 2008
BACKGROUND: Ventilation-induced lung injury is often studied in animal models by using ventilation strategies with high-tidal volumes and high-oxygen concentration over a relatively short period of time. The injury induced by these ventilation strategies includes alterations to the surfactant system and up-regulation of inflammatory markers. Whether these responses to ventilation ...
De Luca Daniele - - 2008
PURPOSES: Secretory phospholipase A2 hydrolyzes phosphoglycerides and it has been shown to be involved in alveolar inflammation and surfactant degradation. It plays an important role in acute lung injury but it has never been studied in newborn infants. We were aimed to investigate the phospholipase A2 activity in neonatal lung ...
Polglase Graeme R - - 2008
The effects of lung volume recruitment manouvres on pulmonary blood flow (PBF) during high-frequency oscillatory ventilation (HFOV) in preterm neonates are unknown. Since increased airway pressure adversely affects PBF, we compared the effects of two HFOV recruitment strategies on PBF and oxygenation index (OI). Preterm lambs (128+/-1 day gestation; term ...
McCurnin Donald - - 2008
OBJECTIVE: The goal was to study the pulmonary, biochemical, and morphologic effects of a persistent patent ductus arteriosus in a preterm baboon model of bronchopulmonary dysplasia. METHODS: Preterm baboons (treated prenatally with glucocorticoids) were delivered at 125 days of gestation (term: 185 days), given surfactant, and ventilated for 14 days. ...
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