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Results 351 - 400 of 650
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Gonsalves S F - - 1991
Studies were conducted in cats to determine whether this species could serve as an animal model for the therapeutic toxicity of recombinant interleukin-2 in humans, and to establish the role of the area postrema in the causation of recombinant interleukin-2-induced vomiting. Injections of recombinant interleukin-2 (3.6 x 10(6) IU/kg, i.m.), ...
Olsen F - - 1991
The agarose migration technique was used for demonstration of delayed-type hypersensitivity to arterial vessel wall antigens in patients suffering from chronic essential hypertension. By means of this technique, it was demonstrated that the migration indices from the hypertensive patients differed significantly from the normotensive control persons, P less than 0.005. ...
Fredrikson M - - 1991
Psychophysiological theories on the development of essential hypertension are reviewed and evaluated. Two interconnected theories that relate behavior to essential hypertension and account for individual differences in susceptibility to disease are the "hyperreactivity" theory and "the symptom specificity" theory. The "hyperreactivity" theory identifies individual differences in autonomic nervous system reactivity ...
Mensah G A - - 1991
Traditional discussion of the etiology of essential hypertension has often included renal, neural, familial, and genetic theories as well as dietary salt intake. Recent findings suggest a prominent role for abnormal cation metabolism, impaired membrane transport systems, hyperinsulinemia, and psychosocial and behavioral factors. These recent advances in hypertension research suggest ...
Gross G W - - 1991
Most newborns with imperforate anus, except for those with very low varieties, undergo a diverting colostomy performed in the postnatal period, with definitive surgical repair at a later age. Accurate demonstration of the anatomy of any associated fistula between the rectum and urogenital tract is essential for optimal surgical management. ...
West M J - - 1991
1. In renal wrap hypertension in the rabbit and in essential hypertension in humans, non-autonomic components of resistance are the major factors contributing to elevated blood pressure. 2. The central nervous system plays an important role in moment to moment blood pressure control but is not responsible for maintenance of ...
Tamura K - - 1991
Time-associated variations of blood pressure became accessible due to the modern development of pressure monitoring technology. The data collection and analysis should be standardized and formulated. Time-associated changes of pressure were evaluated not only by nonparametric and conventional but also by parametric and rhythmometric estimation. The reference data (chronodesms) are ...
Zhao W G - - 1990
Prostacyclin and thromboxane A2, products of separate branches of the arachidonic acid cascade, can have opposing effects on kidney function and on the vascular musculature. Prostacyclin acts as a vasodilator while thromboxane A2 has a vasoconstrictor effect and the balance between these two compounds appears to contribute to the homeostatic ...
Hamada M - - 1990
This paper updates the current view on clinical significance of systolic time intervals (STI) in estimating the cardiac changes associated with hypertension. The following three intervals were measured as STI: (1) electromechanical systole (QS2 interval); (2) left ventricular ejection time (LVET) and (3) pre-ejection period (PEP). Firstly, the influences of ...
Minuz P - - 1990
1. The effects of non-steroidal anti-inflammatory drugs (NSAID) on prostacyclin and thromboxane biosynthesis and on blood pressure were determined in 46 patients with mild essential hypertension. Patients who had abstained from antihypertensive therapy for 2 weeks before study were treated with either aspirin, ibuprofen, sulindac or placebo for 7 days. ...
Touyz R M - - 1990
Circadian blood pressure and heart rate rhythms were determined in essential and renal hypertensive patients who failed to respond to drug therapy. Indirect ambulatory blood pressure and heart rate recordings were measured in 31 subjects for 24 hours. Essential hypertensive patients exhibit 'white coat hypertension', are normotensive outside the clinic ...
Mongeau J G - - 1990
Erythrocyte cation fluxes were measured in fresh cells, on two different occasions, in 90 children and adolescents suffering from essential hypertension who were followed for a prolonged period. The purpose of the present study was to track the stability of erythrocyte cation fluxes with time, and to determine whether a ...
Picano E - - 1990
In asymptomatic patients with essential hypertension, electrocardiographic changes suggestive of myocardial ischemia can be elicited by rapid pressure lowering or by pronounced coronary arteriolar dilation. The aim of this study was to assess whether dipyridamole infusion might induce ischemic-like electrocardiographic changes in asymptomatic essential hypertensive patients and to describe the ...
Sommers S C - - 1990
Microscopic analysis of over 2,000 renal biopsies taken at surgical sympathectomy operations has been correlated with blood pressures in essential hypertension. Statistically significant relationships exist between the average diastolic pressure and the degree of afferent renal arteriolar thickening and narrowing. Postoperative prognosis was favorable with all but the most severe ...
Williams S A - - 1990
1. Pressure was measured within 28 capillaries of the nailfolds of nine patients with essential hypertension and in 33 capillaries of nine age- and sex-matched normotensive control subjects, using direct micropuncture, a dynamic servo-nulling system and computerized analysis. 2. Average pressure at the apex of the capillary was found to ...
Chamiec T - - 1990
Fifty patients with essential hypertension grade I/II. (WHO) were treated with Nisoldipine (BAY K 5552) or Propranolol for 12 weeks in a single blind, randomised trial. Both drugs similarly reduced mean systolic and diastolic blood pressure. Side effects were rare and usually mild. We conclude that Nisoldipine is safe and ...
Kjeldsen S E - - 1990
The present study aimed at testing the hypothesis of decreased erythrocyte magnesium content and magnesium deficiency in essential hypertension. Atomic absorption was used to measure the erythrocyte content of total magnesium in 50-year-old otherwise healthy white males with essential hypertension (n = 12, blood pressure (mean +/- SE) 155 +/- ...
Saito Y - - 1990
We developed six kinds of monoclonal antibodies against endothelin (ET)-1 recognizing different epitopes with high affinities (5 x 10(10) M-1 to 5 x 10(11) M-1). Using these monoclonal antibodies, we developed radioimmunoassays for ET-1 with different specificities. Cross-reactivities with ET-2 ranged from 80% to 100%, and those with ET-3 ranged ...
Fetkovska N - - 1990
To investigate possible alterations in 5-hydroxytryptamine (5HT) kinetics and sensitivity of blood platelets in patients with essential hypertension, 45 essential hypertensive patients and 45 normotensive healthy subjects matched in pairs for age, sex, and smoking status were compared. There were 18 women and 27 men in each group, ranging from ...
Sechi L A - - 1990
Ketanserin, an antagonist of 5-HT2-serotonergic and alpha 1-adrenergic receptors, has come into use for the therapy of mild to moderate arterial hypertension. Quite recent observations have shown changes in transmembrane sodium (Na) transport after the acute administration of high doses of this drug to normal subjects. It is well known ...
Lewanczuk R Z - - 1990
The pressor responses to dialyzed plasma extracts from normotensive (n = 15) and essential hypertensive (n = 14) human subjects were evaluated in anesthetized Sprague-Dawley rats. Hypertensive but not normotensive plasma raised mean arterial pressure (23.6 +/- 3.6 versus -0.5 +/- 2.5 mmHg, P less than 0.0001), and this effect ...
Reams G P - - 1990
The natural course of essential hypertensive renal disease is characterized by a slowly progressive impairment of renal function. Initially, the changes are functional and reversible; however, structural changes gradually occur, leading to hypertensive nephrosclerosis. Similarities exist between the early functional hemodynamic changes observed in the essential hypertensive kidney and the ...
Martin G - - 1990
Peripheral administration of the neuropeptide Substance P (SP) in rhesus monkeys and baboons caused a long lasting decrease in blood pressure, accompanied by a gradual normalization function of stress-induced bioelectrical activity changes in brain structures, relevant for cardiovascular regulation (frontal cortex, ncl. raphe, locus coeruleus). In addition, SP was found ...
Nityanand S - - 1990
In a study of the kinetics of 5-hydroxytryptamine (5-HT) in platelets in 26 hypertensive subjects with a mean systolic and diastolic blood pressure of 153.9 +/- 26.9 and 106.9 +/- 9.1 mm Hg respectively, it has been observed that in hypertensive platelets there was a marked decrease in 5-HT uptake ...
Brickman A S - - 1990
The relationship between 24-h recumbent blood pressure levels and secretory patterns of catecholamines was investigated in 4 patients with pseudohypoparathyroidism (PsHP) and hypertension and in 9 patients with essential hypertension. A clear circadian rhythm of blood pressure and catecholamines was documented in both groups with lowest levels of blood pressures ...
Mulvany M J - - 1990
This review is concerned with the structure and function of resistance arteries in hypertension. By use of a variety of techniques, results indicate that raised blood pressure, in patients with essential hypertension and in animal models of hypertension, is associated with abnormalities in the structure of small arteries, expressed as ...
Palermo A - - 1989
The aim of this study was to assess the function of the fibrinolytic system at rest and in response to adrenergic stimulation in patients with stable essential hypertension as compared with normotensives. At rest, essential arterial hypertensives were characterized by increased levels of circulating tissue-plasminogen activator, associated with an increased ...
Arosio E - - 1989
The effects of the calcium-entry blocker nicardipine on brachial hemodynamics were studied in 22 patients (18 male, 4 female) with essential hypertension, who were treated with 20 mg tid for 1 year. Compliance, characteristic impedance, vascular resistances, and tangential tension were measured before treatment and after 1, 3, and 12 ...
Weder A B - - 1989
Using the intracellularly trapped pH-sensitive fluorescent dye, BCECF, basal intracellular pH was measured in 18 essential hypertensives and 23 normotensives. The average intracellular pH was slightly, but not significantly, lower in the hypertensives (7.173 +/- 0.017 versus 7.211 +/- 0.014, P = 0.09). Although basal intracellular pH is not significantly ...
Kjeldsen S E - - 1989
In the present study we tested the hypothesis of magnesium deficiency and intracellular magnesium depletion in essential hypertension. Atomic absorption was used to determine the erythrocyte content of magnesium in 50-year-old otherwise healthy white men with never-treated, essential hypertension (n = 12, supine blood pressure 155 +/- 4/109 +/- 2 ...
Hla-Yee-Yee - - 1989
In order to assess whether enhanced fractional sodium reabsorption in the proximal tubule might contribute to the development of essential hypertension, we examined the relationship between arterial blood pressure and lithium clearance (CLi; used as an estimate of end-proximal fluid delivery) or fractional lithium excretion [FELi; measured using the clearances ...
Tang J A - - 1989
The present study demonstrated that the plasma calcitonin gene-related peptide (CGRP) concentration was lower but the CGRP content of abdominal aorta was higher in spontaneously hypertensive rats (SHR) than in normotensive rats (WKY), using specific CGRP radioimmunoassay (P less than 0.01). In eighteen patients with essential hypertension, the concentration of ...
Rizvi S N - - 1989
Fifty patients with essential hypertension were studied for the antihypertensive effect of timolol and propranolol. In 16 out of 25 patients on timolol therapy (64%) blood pressure could be brought well under control (defined as diastolic blood pressure less than 90 mmHg) while with propranolol 13 out of 25 patients ...
London G M - - 1989
An exaggerated reflex response of forearm resistance vessels following stimulation of cardiac mechanoreceptors has been observed in human hypertension. In the present study we analyze the possibility that such an increased response also involves the large brachial artery. For that purpose, the influence of leg elevation in subjects in a ...
Carrière S - - 1989
Clinical and experimental data clearly demonstrate that, at least in some forms of hypertension, removal of the kidney and its replacement by a non-hypertensinogenic organ may counteract the development of this disease. Although their specific involvement has yet to be determined, a number of vasoactive and sodium-retaining systems originating from ...
De la Sierra A - - 1989
The interaction of three different Na+ transport systems (Na+-K+ pump, Na+-K+ cotransport and Na+-Li+ countertransport), with internal Na+ and the passive Na+ leaks, were measured in erythrocytes from 72 Spanish, essential hypertensive patients and 30 normotensive controls. According to the observed abnormalities in Na+ transport pathways, 93.1% of the patients ...
Kimura G - - 1989
Mechanisms of hypotensive action of antihypertensive drugs were theoretically considered using the water tank model on body fluid volume-blood pressure regulation. If a cock is attached to a tank with a base area corresponding to the reciprocal of total peripheral resistance (TPR) and water is poured into this tank at ...
Steiner A - - 1989
We studied the antihypertensive and hypolipidaemic effects of fish oil containing eico-sapentaenoic acid and docosahexaenoic acid in a capsule preparation in patients with mild to moderate essential hypertension and in patients with hypercholesterolaemia. In addition, we used two independent procedures to analyse changes in blood pressure, casual and self-recorded blood ...
Baumgart P - - 1989
Circadian blood pressure rhythms were examined in subjects exhibiting various forms of secondary and essential hypertension and in normotensive subjects with and without renal disease. Indirect ambulatory blood pressure recordings were performed in 284 subjects for 24 h. In contrast to patients with essential hypertension and to normotensive healthy subjects, ...
Knapp H R - - 1989
Both n-3 and n-6 polyunsaturated fats have been suggested to lower blood pressure, an effect ascribed to altered biosynthesis of eicosanoids. To test these hypotheses, we studied blood pressure and eicosanoid production during supplementation of dietary fat for four weeks in 32 men with mild essential hypertension. Supplementation was preceded ...
Spence C D - - 1989
The haemodynamic effects associated with the onset of hypertension induced by infusion of adrenocorticotrophin (ACTH) were investigated in sheep. Analysis of haemodynamic data collected over 24 h by a computer-based monitoring system revealed that mean arterial pressure (MAP) was significantly increased after 4 h. Cardiac output was significantly raised after ...
Cooper W D - - 1989
Although headache is sometimes regarded as a symptom of severe hypertension, its relationship to blood pressure is not clear. In 11,710 patients with mild to moderate essential hypertension we have found that headache was common and may be reduced by treatment. We found a clear relationship between the frequency of ...
Imai Y - - 1989
The effect of glucocorticoid on circadian variations of blood pressure was examined. In untreated patients with essential hypertension, a clear nocturnal fall in blood pressure and heart rate was observed and this was unaffected by combined treatment with antihypertensive drugs. The circadian blood pressure variation in patients with chronic glomerulonephritis ...
Haalboom J R - - 1989
Hypokalaemia is a risk factor for the development of cardiac arrhythmias, at least in patients with a cardiac disease, but it is not known whether this applies to subjects with normal hearts. In the present study, 8 young patients with essential hypertension were treated with chlorthalidone for 12 wk followed ...
Cusi D - - 1989
Essential hypertension is a genetic disease. Its phenotypic expression depends on the interaction between genetic and environmental factors. In prehypertensive rats of the Milan hypertensive strain (MHS) a genetically inherited increase of tubular reabsorption was found, which causes the increase of blood pressure. Studies of ion transport systems in these ...
Whitworth J A - - 1989
Hypothalamic-pituitary-adrenal axis (HPA) function was examined in normotensive (n = 20) and hypertensive (n = 16) men, by measurement of basal cortisol levels, diurnal variation and the response to dexamethasone suppression. Comparison between groups did not reveal any differences in basal cortisol concentrations, in their diurnal variation, or in response ...
Vignocchi G - - 1989
An interaction between pain modulation and arterial pressure control has been proposed on the basis of experimental data in man and animal. Eight hypertensive patients and eight normotensive volunteers were investigated by electrical stimulation of the first trigeminal branch and dental pulp, to evaluate nociceptive sensation and reflex responses. A ...
Radzievsky S A - - 1989
Forty-nine patients with initial stages of essential hypertension (EH) were investigated using phase systole analysis and echocardiography during acupuncture (reflexotherapy) treatment. It was established that even at the initial stages of EH increasing of myocardial mass and the disturbances of contractile and diastolic activity of myocardium take place. As a ...
Aritzi S - - 1989
The hostile personality characteristic of dominance was shown to be significantly lower in a group of 34 male patients with essential hypertension than in a general illness control group (n = 17) in the USA. This replicates a previous finding from research in Greece into this and other conditions of ...
Fariello R - - 1989
Reduced parasympathetic activity has been reported in essential hypertension. Converting enzyme inhibition seems to increase parasympathetic tone. In order to evaluate the effects of enalapril on parasympathetic control of heart rate, the authors studied ten mild-to-moderate essential hypertensive patients (7 F, 3 M), treated for 2 weeks with placebo and ...
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