Search Results
Results 101 - 150 of 656
1 2 3 4 5 6 7 8 9 10 >
Yan Jin-Chuan - - 2005
BACKGROUND: Although it has been hypothesized that hypertension is in part an inflammatory disorder, clinical data linking inflammation with incident hypertension are scarce. There is evidence that have shown that CD40-CD40L interaction plays a pathogenic role in inflammatory disorders. We assessed whether CD40 system expressions were altered in patients including ...
Tsioufis C - - 2005
The role of serum uric acid (SUA) in the context of adverse cardiovascular events in hypertensive subjects is controversial. Additionally, the relationship between SUA and indices of target organ damage is not well defined in this setting. Towards this end, we studied 842 consecutive nondiabetic patients with stage I-II essential ...
M. Lawrence Agius
Arterial hypertension might primarily relate to disturbances of oxygen delivery and of blood flow that arise and progress further as ischemic phenomena of vascular myofibers and of focal regions in tissues of supply. Indeed, one might speak of a centrally operative mechanistic pathway of ischemic phenomena that act as predeterminants ...
Feig Daniel I - - 2005
Hypertension is the most common form of cardiovascular disease. Although it is less common in adolescents than in adults, hypertension and the associated organ damage can and often does begin early in life. Consequently, for many with high blood pressure (BP), measures directed at the long-term prevention of cardiovascular morbidity ...
Silver Burton B - - 2004
A novel technique, using energy dispersive X-ray microanalysis (EXAtm), for noninvasive intracellular (i.c.) measurement of magnesium [Mg2+]i has now been accomplished and proven to be a valuable tool in multiple aspects of normal as well as pathological magnesium metabolism. Since only 1% of total body Mg2+ is found in the ...
Klintenberg Patrik - - 2004
This paper presents development of a first approximation of a Namibian, national level, land degradation monitoring system. The process involved a large number of stakeholders and led to the definition of four primary indicators that were regarded as related to land degradation in Namibia: population pressure, livestock pressure, seasonal rainfall ...
Tikhonoff Valérie - - 2004
Manidipine is a third-generation dihydropyridine calcium antagonist, which causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. In clinical studies, manidipine has been shown to significantly lower office and 24-h blood pressure compared with placebo in patients with essential hypertension. The resulting reduction in blood ...
Cuspidi Cesare - - 2004
BACKGROUND AND PURPOSE: The clinical and prognostic significance of initial retinal alterations in hypertensive patients remains controversial. Therefore, we assessed the relationship of microvascular abnormalities with prognostically validated markers of target organ damage (TOD), such as left ventricular mass (LVM), carotid intima-media thickness (IMT) and microalbuminuria, in early stages of ...
Lee Myung-Suk - - 2004
OBJECTIVES: The purpose of this study was to investigate the impact of practicing qigong on middle-age subjects with essential hypertension. Impacts on blood pressure, reported self-efficacy, perceived benefit, and emotion were observed. DESIGN: Thirty-six (36) adult volunteers were assigned to either a waiting list control or a qigong group that ...
Wilson Dawn K - - 2004
Although previous research has indicated a link between environmental stress and essential hypertension, little is known about the role of violence exposure on risk for developing essential hypertension. Violence exposure, defined as experiencing, witnessing, or hearing about violence in the home, school, or neighborhood, is a serious societal problem. Approximately ...
Beato Cristina V - - 2004
Hypertension is a very common chronic condition that is disproportionately represented in certain populations. Although there have been many past successes in detection, evaluation, treatment, and control of high blood pressure, more successes are needed. Greater collaboration on multiple levels is essential in order to achieve better blood pressure control ...
Dorogovtsev V N - - 2004
The purpose of this research is the study of changes of a systemic hemodynamics under passive orthostatic test for a healthy persons and an ill with Essential Hypertension (EH) and analysis of a possible role of the gravitational factor in a Pathogeny of this disease. For an ill with EH ...
Dosel P - - 2004
Pilots' physiological measurement in conditions of alternating plus and minus Gz (gravitational acceleration) has been done during real flights. The comparison of physiological responses during flights at the safe altitude of 7000 ft and low level flights at the altitude of 900 ft over ground bears on the evaluation of ...
Furumoto Tomoo - - 2004
Increased carotid artery intima-media thickness (IMT), but not necessarily peripheral vessel IMT, accompanies atherosclerosis. We hypothesized that IMT in a peripheral, muscular artery known to be resistant to atherosclerotic changes would increase with hypertension, thereby limiting increases in wall stress and potentially preserving endothelial cell function reflected by flow-mediated dilation ...
Wu Chengde - - 2004
Sitaxsentan (1) (Wu et al. J. Med. Chem. 1997, 40, 1690) is our first endothelin antagonist being evaluated in clinical trials. It has demonstrated biological effects in an acute hemodynamic study in CHF (Givertz et al. Circulation 2000, 101, 2922), an open-label 20-patient pulmonary hypertension trial (Barst et al. Chest ...
Escames Germaine - - 2004
To study the changes in macrophage inducible nitric oxide synthase (iNOS) activity, plasma levels of nitrite, lipid peroxidation (LPO) and melatonin in human essential hypertension before and 6 months after 4 mg/day lacidipine treatment. The study was carried out in a total of 25 subjects--11 healthy subjects and 14 hypertensive ...
Farkas Katalin - - 2004
The aim of the study was to investigate the endothelium-dependent vasodilation in the forearm skin using two non-invasive laser Doppler applications in patients with essential hypertension (EHT) and in normotensive (NT) control subjects. The effect of two consecutive doses of acetylcholine (ACh) and that of sodium nitroprusside (SNP) on the ...
Scheer Frank A J L - - 2004
Patients with essential hypertension have disturbed autonomic cardiovascular regulation and circadian pacemaker function. Recently, the biological clock was shown to be involved in autonomic cardiovascular regulation. Our objective was to determine whether enhancement of the functioning of the biological clock by repeated nighttime melatonin intake might reduce ambulatory blood pressure ...
Larkin Kevin T - - 2004
OBJECTIVE: The purpose of this study was to examine the range of anger-expressive behaviors and social competencies among essential hypertensive patients. METHODS: Behavioral reactions to both neutral and anger-evoking role-play interactions were measured in 26 hypertensive and 15 normotensive patients. Social behaviors were assessed using self-report measures of anger expression, ...
Stoeff S - - 2004
A probable conjunction of hemodynamic- and rheological variables was tested in hypertensive patients. Most pronounced correlation was fixed for some indices (sizable in value for plasma viscosity and small but distinct for blood pressure and ZSR) vs. total peripheral resistance. These results of a small scale elaboration are encouraging to ...
Alebiosu C O CO Department of Medicine, Olabisi Onabanjo University Teaching Hospital, Sagamu, - - 2004
Hypertensives who fail to manifest the normal circadian nocturnal fall in blood pressure have a higher incidence of cardiovascular complications, early glomerular injury and microalbuminuria. This study aims to quantify the proportion of dippers and non-dippers among the essential hypertensive population, and determine the frequency of occurrence of micro-albuminuria among ...
Muda Piibe - - 2003
OBJECTIVE: Intracellular glutathione in its reduced state is a principal cellular biomolecule with antioxidant activity. Glutathione and homocysteine metabolism are closely associated. As both oxidative stress and hyperhomocystinemia are associated with hypertension, we assessed the relationships between these variables. DESIGN AND SETTING: An observation-based case-control study, performed at a university ...
Manzan Anna Carolina C M - - 2003
Curcuma longa [Linn] (turmeric), of the Zingiberaceae family, has a great importance in the food, textile, and pharmaceutical industries. The aim of this work was to identify the best processing conditions to maximize the yields of essential oil and pigments, as well as their content of ar-turmerone, (alpha and beta)-turmerone, ...
Watanabe Sanae - - 2003
High urinary albumin excretion rate (AER) has been associated with the presence of atherosclerotic vascular damages and is an independent risk factor for all causes of death and cardiovascular morbidity and mortality in essential hypertensive patients. Serum cystatin C (s-CC) is a recently identified nonglycosylated 13-kD basic protein that has ...
Marini Ann M - - 2003
Carbamazepine is a well-established, effective treatment of complex partial seizures and is well tolerated in most patients. The adverse effects of carbamazepine include aplastic anemia, agranulocytosis, pancytopenia, bone marrow depression, thrombocytopenia, cardiac conduction abnormalities, congestive heart failure, and peripheral edema. Hypertension or hypotension has also rarely been documented in patients ...
Gong Maolian - - 2003
Essential (primary) hypertension is an important risk factor for cardiovascular morbidity and mortality. Blood pressure is largely heritable; however, the genetic factors contributing to essential hypertension are mostly unknown. We examined a large Chinese kindred (n=387) and selected a subset of 94 individuals for genotyping. An additional 32 Chinese nuclear ...
Touyz Rhian M - - 2003
Endothelin-1 (ET-1) is a pleiotropic hormone produced primarily by the endothelium. Synthesis of ET-1 is stimulated by the major signals of cardiovascular stress, such as vasoactive agents (angiotensin II, norepinephrine, vasopressin, and bradykinin), cytokines (e.g., tumor necrosis factor alpha and transforming growth factor beta), and other factors, including thrombin and ...
Staessen Jan A - - 2003
Hypertension is a frequent, chronic, age-related disorder, which often entails debilitating cardiovascular and renal complications. Blood pressure is usually noted in combination with other cardiovascular risk factors. Diagnosis of hypertension increasingly relies on automated techniques of blood pressure measurement. The pathophysiology of essential hypertension depends on the primary or secondary ...
Rao Murlidhar S - - 2003
Essential hypertension is a global problem with fairly high morbidity and mortality. The pathological mechanisms in hypertension are many and involve sympathetic nervous system, renin-angiotensin-aldersterone system, nitric oxide and a host of vasoactive substances. The consequences of hypertension are related either to hypertension or to atherosclerotic process in the arteries.
Sánchez Ramiro A - - 2003
The aim of this work was to ascertain, in nonmodulating essential hypertension, whether the abnormality in the renal blood supply is extended to the extremities and showed a similar response to ACE inhibition and whether these abnormalities could be identified in normotensive offspring of hypertensives, as non-modulation is a familial ...
Touyz R M - - 2003
Human essential hypertension is a complex, multifactorial, quantitative trait under polygenic control. Although the exact etiology is unknown, the fundamental hemodynamic abnormality in hypertension is increased peripheral resistance, due primarily to changes in vascular structure and function. These changes include arterial wall thickening, abnormal vascular tone and endothelial dysfunction and ...
Cracowski Jean-Luc - - 2003
In contrast with the huge amount of experimental data available, only few and somewhat unconvincing clinical studies support the hypothesis that oxidative stress is involved in the early stages of essential hypertension in humans. Isoprostanes are chemically stable lipid peroxidation products of arachidonic acid, the quantification of which provides a ...
Jonas Michael - - 2003
BACKGROUND: Melatonin plays a role in the biologic regulation of circadian rhythms, including sleep. Melatonin has also been shown to modulate vascular smooth muscle tone and to induce hemodynamic effects in humans. OBJECTIVE: To evaluate whether melatonin plays a role in the circadian rhythm of blood pressure in hypertensive patients. ...
Nakao Mutsuhiro - - 2003
To examine the blood pressure-lowering effects of biofeedback treatment in patients with essential hypertension, a meta-analysis was conducted on studies published between 1966 and 2001. A total of 22 randomized controlled studies with 905 essential hypertensive patients were selected for review. Compared with clinical visits or self-monitoring of blood pressure ...
Mussalo Hanna - - 2002
Baroreceptor reflex regulation has been shown to reset towards a higher blood pressure level and to operate with reduced sensitivity in hypertension. Whether this is secondary to elevated blood pressure or whether it plays a role in the development of hypertension is not known. In addition, only limited data exist ...
Holm Torbjørn - - 2002
BACKGROUND: Most heart transplant (HTx) recipients develop hypertension, characterized by increased peripheral vascular tone and endothelial dysfunction. Reduced levels of nitric oxide (NO) have been found in essential hypertension, and herein we investigated the possible role of altered concentrations of NO in posttransplant hypertension. METHODS: Plasma levels of the NO-derived ...
Deng You-Bin - - 2002
BACKGROUND: Angiotensin II can impair endothelial function, which is mediated by the angiotensin II type 1 receptor subtype. HYPOTHESIS: The study sought to determine whether treatment with the angiotensin II type 1 receptor antagonist losartan would restore the normal dilation of the left main coronary artery (LMCA) by cold pressor ...
Berridge Marc S - - 2002
Large volume low-pressure targets were designed for use on the wide-beam Scanditronix MC-17 cyclotron. The design was optimized experimentally by construction of aluminum test targets. Final production targets were constructed of titanium and niobium. The targets tripled the routine production yield of the previous target, giving up to 90 GBq ...
Ravera Maura - - 2002
BACKGROUND: Microalbuminuria is a marker of hypertensive and atherosclerotic organ damage in essential hypertension and has powerful prognostic value for cerebral and cardiovascular morbidity and mortality. An association between carotid artery intima-media thickness (IMT) and increased urinary albumin excretion (UAE) has been reported in patients with essential hypertension, suggesting a ...
Kumai Yasuhiro - - 2002
In patients with hypertensive encephalopathy, brain edema is frequently distributed in the parieto-occipital white matter. We report a patient with high arterial blood pressure of over 300/160 mmHg on admission, who had extensive MRI-documented reversible lesions throughout the whole brain, including the brainstem, thalami, basal ganglia, and cerebellum. Extraordinarily severe ...
Ferro Charles J - - 2002
The importance of endothelin-1 (ET-1) in the pathophysiology of essential hypertension is unclear. We therefore compared the effects of endothelin ET(A) receptor blockade and the stimulation of ET(A) and ET(B) receptors, and their interaction with the sympathetic nervous system, in the forearm resistance vessels of patients with essential hypertension and ...
Ciuffetti G - - 2002
The pathophysiological significance of hyperviscosity and capillary rarefaction in untreated essential hypertension is unknown. Fifty untreated hypertensive men with capillary rarefaction (intravital capillaroscopy) and 20 age- and sex-matched normotensive controls underwent full haemorheological profiling (blood viscosity at high and low shear, haematocrit, platelet and leukocyte counts, fibrinogen and total protein ...
Giampaolo Bernini - - 2002
OBJECTIVE: Chromogranin A (CgA) is an acidic glycoprotein co-stored in vesicles and co-released with catecholamines. Although currently used as a humoral marker of endocrine tumours, several aspects of CgA secretion still need to be clarified in humans. PATIENTS: Fifty-four controls, 83 essential hypertensive and six adrenalectomized patients were studied. DESIGN: ...
Rivas Miguel - - 2002
Soy-based diets reduce blood pressure in spontaneously hypertensive rats, but apparently not in hypertensive humans. In the present study, the antihypertensive potential of soy milk (500 mL twice daily) compared with cow's milk was investigated in a 3-mo double-blind randomized study of 40 men and women with mild-to-moderate hypertension. Before ...
Di Girolamo G - - 2002
The effects of the angiotensin-converting enzyme inhibitors (ACEIs), may be partially mediated by the kinins' paracrine influence. Their actions may be exerted through nitric oxide and prostacyclin (PGI(2)) synthesis stimulation. The aim of our study was to determine whether the antihypertensive effect of Enalapril correlated with the increment in the ...
Jordan Jens - - 2002
OBJECTIVE: Brainstem neurovascular contact (NVC) may interfere with central autonomic regulation and contribute to essential hypertension. We have previously shown that patients with autosomal-dominant hypertension, brachydactyly, and NVC feature extreme phenylephrine hypersensitivity due to impaired baroreflex buffering. We tested the hypothesis that similar abnormalities are present in patients with essential ...
Sierra Cristina - - 2002
OBJECTIVE: Age, hypertension, diabetes mellitus and a history of cardiovascular disease are the most important factors related to the presence of cerebral white matter lesions (WML), which are a common finding in elderly people. This study investigates which factors related to hypertension per se are associated with the presence of ...
Timms Peter Mclean - - 2002
BACKGROUND: Essential hypertensive patients have an increased heart and arterial collagen concentration. Increased collagen synthesis can be assessed using procollagen III N peptide (PIIINP) and reduced collagen degradation measured using tissue inhibitor of metalloproteinase-1 (TIMP-1). METHODS: Plasma TIMP-1 and PIIINP levels were measured in 31 patients with essential hypertension and ...
Martin Paul - - 2002
Endothelin receptor antagonism lowers blood pressure in patients with essential hypertension, but the contribution of the endothelin system to increased vascular tone in these patients remains controversial. We used strain-gauge venous plethysmography to measure changes in basal and metabolically stimulated (peak reactive hyperemia [PRH]) forearm blood flow (FBF) induced by ...
Hozawa Atsushi - - 2002
We conducted a cross-sectional community survey in northern Japan to assess the relationship between personality and home blood pressure value. The Japanese version of the short-form Eysenck personality questionnaire was used to assess personality. A total of 999 people selected from the general population participated. We showed that the personality ...
1 2 3 4 5 6 7 8 9 10 >