Search Results
Results 501 - 550 of 657
< 4 5 6 7 8 9 10 11 12 13 14 >
Hulthén U L - - 1984
The dependence of arteriolar vasoconstrictor tone on the activity of Na+,K+-ATPase was studied in 17 normotensive subjects (NT) and 28 patients with essential hypertension (EH) by measuring the response in forearm blood flow and vascular resistance to intraarterial infusion of the Na+,K+-ATPase inhibitor ouabain. Basal plasma aldosterone concentrations were elevated ...
Cohen L - - 1984
8 young, untreated, hypomagnesemic patients with a recent onset of high-renin essential hypertension, were treated with 750 mg Mg oxide daily. Only functional (vasospastic) lesions were observed in their retinal vessels. After 3 months of therapy, despite no significant change in blood pressure, complete reversal of the retinal changes was ...
Hulthén U L - - 1983
The forearm vascular resistance (FVR) following intra-arterial infusions of the calcium influx inhibitors nicardipine and verapamil and sodium nitroprusside was compared to that following 10 min arterial occlusion in 10 normotensive (NT) individuals aged 45 +/- 12 years, 12 patients with mild essential hypertension (EH) aged 42 +/- 14 years ...
Martín-Vasallo P - - 1983
In this paper we report the levels of the 4-nitrophenyl phosphate hydrolysing activity of the red blood cell membrane in 46 hypertensive patients as compared to 41 normal controls and eight secondary hypertensives. This activity has at least two components; one of them is dependent on the presence of magnesium ...
Chadha D R - - 1983
Forty-one patients completed a randomized, double-blind, between-group comparison of a combination of penbutolol and frusemide, with penbutolol alone, and frusemide alone in the management of mild to moderate essential hypertension. The results suggest that the combination caused a superior reduction in systolic and diastolic pressure compared with penbutolol and a ...
Levenson J A - - 1983
The efficacy of MK-421 was compared with that of propranolol in patients with mild to moderate essential hypertension, using a placebo-controlled double-blind randomized protocol. The two drugs reduced supine and standing blood pressures, but propranolol, unlike MK-421, reduced heart rate. Using a pulsed Doppler method, brachial artery diameter, blood velocity ...
Garay R P - - 1983
In 50 normotensive controls, the increase in erythrocyte Na+ concentration up to 12.4 +/- 2.0 mmol/l cells (mean +/- SD) ensures half-maximal stimulation of outward Na+,K+ cotransport fluxes. Forty-six out of sixty-five patients with essential hypertension required more than 16 mmol/l cells of internal Na+ concentration to obtain a similar ...
Ando T - - 1983
In order to investigate the antidiuretic hormone (ADH) in essential hypertension and secondary hypertension, plasma ADH levels were measured in normal subjects, in patients with normal and low essential hypertension, and in other patients with various forms of secondary hypertension. Plasma ADH levels were significantly lower in low renin essential ...
Goldstein D S - - 1983
Arterial baroreflex sensitivity, plasma norepinephrine (NE) and epinephrine (E), and pressor and depressor responses were assessed in 25 patients with essential hypertension and 29 normotensive control subjects. Sensitivity of the cardiac limb of the baroreflex was determined by blood pressure and interbeat interval responses associated with the Valsalva maneuver, externally ...
Krogsaa B - - 1983
In a series of 8 patients with recently discovered moderate essential hypertension the blood-retinal barrier permeability to fluorescein was determined by aid of quantitative vitreous fluorophotometry before and after normalization of the systemic blood pressure. The permeability before medical treatment was 1.69 X 10(-7) cm/sec (+/- SEM = 0.14) and ...
Meredith P A - - 1983
The direct-acting vasodilator, endralazine, in combination with a beta-adrenoceptor blocker significantly reduced the blood pressures of normotensive volunteers and of patients with essential hypertension. The mean terminal elimination half-life for endralazine of 136 min in hypertensive patients did not differ significantly from the 155 min in normotensive subjects. In normal ...
Beilin L J - - 1983
Possible adrenal and autonomic mechanisms contributing to the onset of essential hypertension were studied in 18 men selected from the upper and lower extremes of blood pressure distribution within a larger population. In eight of the nine pairs of subjects, who were matched for age and obesity, those with higher ...
Cohen J - - 1983
To examine how various aspects of attentional functioning are affected by autonomic self-regulation procedures, this study compared the effect of two treatment programs (EMG and thermal biofeedback used in conjunction with various somatic and cognitive relaxation/self-regulation strategies, and Benson's Relaxation Response procedure) and a Waiting List control group for essential ...
Reyes A J - - 1983
Fourteen patients with moderately severe essential hypertension were treated for 8 weeks with indapamide 2,5 mg/d. Systolic and diastolic blood pressures fell significantly from the 1st week of treatment; the rapid changes noted thereafter were described mathematically by decreasing power functions of time. Serum potassium and blood glucose values did ...
Saltman P - - 1983
Essential trace elements such as zinc, iron, and copper participate in various enzyme reactions directly related to the regulation of blood pressure and indirectly related to generation of oxidative metabolic energy, alterations in blood lipid levels, and alterations in taste acuity. The toxicological action of several heavy metal ions including ...
Ward D G - - 1983
Hypovolemia increases water intake. Bilateral lesions of a discrete region of the dorsal rostral pons, that contains neurons responding to hypovolemia, markedly increases basal water intake in cats. The critical region appears anteroventral and somewhat medial to the locus coeruleus and is anatomically distinct from a more dorsal region shown ...
Grimm M - - 1983
Fourteen patients with untreated mild to moderate essential hypertension had, on average, an abnormally high cardiovascular reactivity to exogenous noradrenaline and angiotensin II, while plasma noradrenaline, renin activity, exchangeable body sodium, and blood volume were normal. Treatment with a low dose of indapamide (2.5 mg/day) for 6 weeks decreased blood ...
Kjeldsen S E - - 1983
Both arterial and venous plasma adrenaline and noradrenaline concentrations were elevated in 20 middle-aged men with long-standing, untreated essential hypertension compared to 19 normotensive control men (p less than 0.01). The mean a-v (arterial-venous) difference of adrenaline and v-a difference of noradrenaline were increased in the hypertensive (p less than ...
Malinow S H - - 1983
Eighteen patients with essential hypertension uncontrolled by hydrochlorothiazide alone were randomly assigned to receive additional therapy with either guanadrel sulfate or guanethidine sulfate. The frequencies of morning orthostatic faintness, other orthostatic faintness, and diarrhea were twice as high in eight patients treated with guanethidine as in ten patients treated with ...
Hafner R J - - 1983
Twenty-five men and twenty-six women with essential hypertension, and their spouses, were compared with normotensive control couples on a questionnaire measure of marital adjustment. The marriages of the hypertensive men showed significantly raised levels of marital dissatisfaction in the spouses, and an abnormal degree of reciprocal dissatisfaction between spouses. The ...
Kohashi N - - 1983
In order to evaluate how taurine relates to the pathogenesis of essential hypertension, the taurine content of plasma, whole blood and urine was measured in 18 normals and in 79 hypertensive patients. The patients included 32 untreated cases of essential hypertension, 32 treated cases and 15 cases with labile hypertension. ...
Thulesius O - - 1982
Finger systolic blood pressure during cooling was determined in 21 hypertensive, 22 diabetics and 18 control individuals. Blood pressure determination was made using a miniature tourniquet on the middle phalanx and a strain-gauge flow sensor on the finger tip. Pressure was measured at 35 degrees C and upon stepwise local ...
Johnston D W - - 1982
The literature on direct behavioural interventions to reduce two coronary risk factors, Type A behaviour and essential hypertension, is reviewed. It is concluded that there is preliminary evidence that the alteration of Type A behaviour is possible and that such alteration is associated with a reduction in the risk of ...
Ibsen K K - - 1982
This report deals with the possibility that there is a specific change of the lithium transport across the membrane of erythrocytes from patients with essential hypertension. Sodium-lithium countertransport was significantly increased (p less than 0.005) in erythrocytes from 17 males with essential hypertension (mean 0.7 mmole (liter cells X hr)-1, ...
Hafner R J - - 1982
Twenty-one patients with essential hypertension were randomly allocated to eight 1-hour sessions of meditation training, meditation plus biofeedback-aided relaxation, or a no-treatment control group. Statistically significant falls in systolic and diastolic blood pressure occurred after both training programs, although overall reductions in blood pressure were not significantly greater in either ...
Takabatake T - - 1982
The antihypertensive effect of a new calcium antagonist, nicardipine hydrochloride (YC-93), was studied in 47 mild to moderate essential hypertensives. YC-93 (30-60 mg/day) was administered orally alone for 8 weeks (Group I, 31 patients) or in combination with diuretics, beta blockers, or both (Group II, 16 patients). Blood pressure was ...
Mendlowitz M - - 1982
Essential hypertension is fundamentally a genetic disease which emerges because of environmental impact. The genetic factors involve intracellular abnormalities which affect calcium metabolism within smooth muscle cells and possibly within the heart and sympathetic nervous system. These abnormalities are influenced by one or more proteins of which calmodulin is a ...
Frohlich E D - - 1982
Hypertension is not simply an acute elevation of arterial pressure during a laboratory experiment. It is the development of a cardiovascular disorder provoking a variety of physiological adaptions brought about by an imbalance of pressor and depressor mechanisms that serve to control arterial pressure at normal levels in the normotensive ...
Dal Palu C - - 1982
1 Labetalol was administered by intravenous infusion or by the combination of intravenous bolus injection plus infusion to 15 patients with severe essential hypertension and to one with phaeochromocytoma. 2 With the infusion alone the reduction of arterial pressure was slow to develop and limited in degree, but with the ...
Hutton P - - 1982
The accuracy of the Scala Alternans Altera oscillotonometer was investigated by comparison with direct intra-arterial pressures. It was found that the traditional criteria for detecting systolic and diastolic pressures were in error. A slow deflation rate was essential for the accurate measurement of systolic pressure, the maximum amplitude of needle ...
Lebel M - - 1982
To assess the implication of renal prostaglandins in the pathogenesis of essential hypertension, urinary PGE2 and PGF2 alpha were measured in 22 control subjects (11 males) and in 58 patients (33 males) with borderline and sustained essential hypertension under strictly control conditions. Although the mean PGs urinary excretion in essential ...
Kjeldsen S E - - 1982
In 20 middle-aged men with untreated sustained essential hypertension for more than 5 years, both plasma adrenaline and noradrenaline were positively and significantly correlated with blood pressure. In both hypertensives and 19 normotensive control subjects supine arterial adrenaline concentrations were more than twice the venous concentrations consistent with adrenal production ...
Sowers J R - - 1982
Hormonal and mean arterial pressure (MAP) responses to posture, isometric handgrip, angiotensin II (AII), adrenocorticotrophic hormone (ACTH), and metoclopramide (MCP), a dopamine (DA) antagonist, were examined in nine men with essential hypertension and nine age- and weight-matched normotensive men on a constant 100 mEq sodium and 80 mEq potassium intake ...
Davidson J S - - 1982
Sodium-potassium cotransport activity is thought to be defective in essential hypertension and could be a useful genetic marker for susceptibility to essential hypertension. In this study cotransport activity in subjects with hypertension was compared with that in normotensive controls. The effects of ethnic differences, environment, and antihypertensive drugs were also ...
Patel R - - 1982
Serum antinuclear antibody (ANA) and HLA phenotype frequency were studied in 100 black subjects with essential hypertension and 100 normotensive black controls matched for age and sex. 11% of hypertensive individuals had a positive serum ANA test compared with 2% of controls (p less than 0.01). Among the hypertensive patients, ...
Elliott H L - - 1982
Tolmesoxide is a new, direct-acting vasodilator drug for use in the management of both hypertension and cardiac failure. In 6 essential hypertensives inadequately controlled by combined beta-blocker and diuretic therapy (average supine blood pressure 178/103 mmHg) the addition of tolmesoxide (300-900mg daily) was associated with a significant improvement in blood ...
González-Gómez A - - 1982
With the purpose of searching for new clinical features in labile hypertension (LH), systolic time intervals were recorded non-invasively in a group of LH patients. Obtained data were compared with a matched group of normal individuals and also with a group of young patients with chronic essential hypertension. An increase ...
Bühler F R - - 1982
In patients with essential hypertension, plasma adrenaline, regardless of age, was consistently higher than in normotensive controls; adrenaline correlated with heart rate and the vasodilator response in the forearm circulation produced by postjunctional alpha 1-adrenoceptor blockade with prazosin. This dilator response to prazosin was greater in hypertensive patients. Together, this ...
Uhari M - - 1982
The haemodynamic changes in essential hypertension were investigated in 7 girls and 4 boys under the age of 18 years. The Fick method was used for the estimation of cardiac output (CO). The cardiac indices (CIs) ranged form 2.8 to 6.6 litres/min/m2 and the total peripheral resistance (TPR) from 1,100 ...
Sowers J R - - 1981
This study examines the influence of dopamine on recumbent circadian mean arterial blood pressure (MAP) levels and secretory patterns of norepinephrine (NE) in essential hypertension. Nine patients with sustained essential hypertension were studied after they had reached metabolic equilibrium of a constant 100-mmol sodium and 80-mmol potassium intake. MAP measurements ...
Reimann I W - - 1981
1. Two female and two male patients with essential hypertension were given dihydralazine plus saline or dihydralazine plus diclofenac intravenously on two separate occasions. The dihydralazine dose (range: 16.2--32.4 mg/2 h) was chosen individually to reduce systolic blood pressure by 20 mmHg from the control value before the investigation; the ...
Schaadt O - - 1981
1. The complement 3 (C3) phenotype distribution in 112 patients with essential hypertension was compared with the distribution of 316 normotensive control subjects. 2. A significant increased frequency of the C3F-gene was found among the patients (0.2637 vs 0.1721, P = 0.0031), indicating an association between the C3F-gene and essential ...
Hauger-Klevene J H - - 1981
Serum prolactin was measured in 76 patients with essential hypertension: 47.4% had elevated serum prolactin, and those with organ damage had presented higher prolactin than those with Phase I (WHO) hypertension. The effect of prolonged treatment (3 years) with guanfacine, an alpha-adrenoceptor stimulant drug, on blood pressure levels, heart rate, ...
Bing R F - - 1981
1. Plasma and interstitial fluid volumes have been measured simultaneously in men with uncomplicated and untreated essential hypertension. 2. Plasma volume (Evans blue) was reduced in essential hypertension and correlated inversely with blood pressure. 3. Interstitial fluid volume, derived from bromine space and plasma volume, was also reduced in essential ...
Esler M - - 1981
1. The rate of spill-over of noradrenaline to plasma, and neuronal noradrenaline uptake, which influences spill-over, were studied in patients with essential hypertension and depressive illness. 2. Noradrenaline spill-over was increased in seven of thirty-four patients with essential hypertension and five of eleven patients with primary depressive illness, compared with ...
Whitworth J A - - 1981
1. The haemodynamic and volume response to ACTH administration was investigated in six patients with mild, untreated essential hypertension and two patients with Addison's disease on maintenance steroids. Blood pressure, heart rate and weight were recorded daily. Plasma volume (125I-HSA) and cardiac output (thermo-dilution) were measured during the control period ...
Nakamura R - - 1981
To investigate localization of the action on blood pressure in the peptide chain of parathyroid hormone (PTH), we determined the effect of seven fragments of human (h) PTH-(1-34) fragments on blood pressure in anesthetized rats. hPTH-(1-7) and -(28-34) fragments had no effect up to 1 X 10(-6) mole/kg. hPTH-(8-34), -(13-34), ...
Millar-Craig M W - - 1981
Continuous intra-arterial blood pressure recordings during motor car driving were performed in 15 patients with untreated essential hypertension, using the "Oxford" recording technique. Each subject was an experienced driver who used his car every day, and for the study drove from his work place to the hospital during the later ...
Levenson J A - - 1981
Systemic arterial compliance was estimated in 31 men, including 15 patients with sustained essential hypertension and 16 normal subjects of the same age. Values were derived from analysis of the monoexponential blood pressure-time curve during diastole, according to a simple viscoelastic model. In normal subjects, baseline arterial compliance was 2.56 ...
Kuchel O - - 1981
In more than half of 67 patients suspected of having pheochromocytoma, glucagon stimulation increased plasma free norepinephrine (NE) and epinephrine (E) 50% or more, with rising blood pressure or pulse rate; only three patients, however, harbored a pheochromocytoma. A low degree of catecholamine conjugation accounts for most of the false-positive ...
< 4 5 6 7 8 9 10 11 12 13 14 >