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Fintel Dan J - - 2009
Clinical trial results indicate that the choice of antihypertensive agent can be a determinant of stroke protection, independent of blood pressure (BP) reduction. Angiotensin-converting enzyme inhibitors (ACE-Is) are effective for BP control and stroke protection, but their use may be limited by patient tolerability. Angiotensin receptor blockers appear to provide ...
Schneck Michael J - - 2009
The Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial is the largest secondary stroke prevention study completed to date. It compared extended-release dipyridamole plus aspirin (eDYP-ASA) versus clopidogrel and telmisartan versus antihypertensive regimens excluding angiotensin receptor blockers (ARBs). No statistical differences were found in either arm for the primary ...
Aiyagari Venkatesh - - 2009
Hypertension is commonly seen in the setting of an acute stroke. Although hypertension is the most important modifiable risk factor for both ischemic and hemorrhagic stroke, the immediate management of elevated blood pressure in this setting is controversial. Questions remain to be definitively answered, such as when to start lowering ...
Ramos Fernando José da Silva FJ Hospital Sírio-Libanês, São Paulo, SP, - - 2009
To assess fluid responsiveness in patients under spontaneous breathing activity ventilation remains a challenge for intensive care physicians. Much of the knowledge on heart-lung interactions and dynamic indexes of fluid responsiveness may not be useful for these patients. Historically, the most frequently used variables to guide fluid responsiveness on this ...
Subramaniam Veeran - - 2009
Hypertension is a leading cause of major adverse cardiovascular outcomes, including heart attacks and stroke. The most visible manifestation of target organ damage related to hypertension is left ventricular hypertrophy (LVH). LVH eventually predisposes to systolic and diastolic heart failure, and is associated with an even greater risk of stroke. ...
Arima Hisatomi - - 2009
High blood pressure is the most important modifiable risk factor for stroke and accumulating evidence indicates that blood pressure levels are likely to be associated with all stroke subtypes. There is also evidence from randomized trials suggesting that blood pressure-lowering treatment provides protection against every stroke subtype in both primary ...
Zhang W W - - 2009
Transient ischemic attack is a medical emergency because early stroke risk after transient ischemic attack is high. Hypertension is the most important modifiable risk factor for stroke and transient ischemic attack. The aims of this review are to provide a summary of the current knowledge concerning the relationship between blood ...
Asayama Kei - - 2009
OBJECTIVE: To compare the predictive power of home blood pressure (HBP) measured in the evening (E-HBP) and that of casual screening BP (CBP) for stroke risk in relation to the number of E-HBP measurements. METHODS: We obtained E-HBP (measured once in the evening just before going to bed for 4 ...
Armario Pedro - - 2009
Stroke remains a common vascular event with high mortality and morbidity. After heart disease, stroke is the second leading cause of death worldwide in adult persons. Silent or subclinical stroke is likely to occur with even greater frequency than clinical stroke and increases the risk of subsequent cerebrovascular events. Hypertension ...
Imano Hironori - - 2009
BACKGROUND AND PURPOSE: Hypertension is a major risk factor for stroke. However, a substantial decrease in blood pressure levels in Japanese during the past 3 decades may have reduced contributions of hypertension to risk of stroke. The population attributable fraction, the percentage of outcomes attributable to exposure, of blood pressure ...
Papademetriou Vasilios - - 2009
Stroke is a major cause of death and disability, and its prevalence is expected to rise as the population continues to age. Most strokes can be prevented through risk-factor modification and application of effective preventive therapies. Although treatment of dyslipidemia, control of diabetes mellitus, smoking cessation and treatment of atrial ...
Mbakwem A C - - 2009
INTRODUCTION: Hypertension is associated with increased morbidity and mortality. Paradigm shift and novel drugs that go beyond blood pressure control have debuted in the last decade globally and in Nigeria. The study therefore proposed to investigate the effect of the above if any on hypertension related acute deaths in patients ...
Jain Anunaya R - - 2009
Blood pressure fluctuation early in the course of ischemic stroke is a proven independent predictor of morbidity and mortality. Both high and low systolic blood pressures have a detrimental effect on the neurologic outcome. Current guidelines support permissive hypertension in the early course of acute ischemic stroke. For patients with ...
Zhou Wei-jun - - 2009
To test the hypothesis that a mobilization of endothelial progenitor cells (EPCs) occurs after acute cerebrovascular diseases, we evaluated the number of EPCs in the process of acute stroke. A total of 203 individuals were examined, including 100 patients with ischemic strokes, 36 patients with hemorrhagic strokes and 67 healthy ...
Cikajlo Imre - - 2009
The aim of the research is to develop an objective evaluation tool for use in stroke rehabilitation clinical practice. Stroke patients are prone to particularly high risk of fall, which may differ for various directions of movement. An apparatus enabling perturbations and postural response assessment in eight directions in transversal ...
Wahab, KW; ;
Background: There is a lot of controversy on the prognostic value of admission blood pressures in acute ischaemic stroke, but in Nigeria, there is no information on this. Objective: The objective of this study was to correlate the effect of blood pressures measured on admission with 30-day mortality and neurological ...
Armario Pedro - - 2009
Stroke, as a clinical manifestation of the cardiovascular diseases, is one of the leading causes of death and disability in both developed and developing countries. Hypertension is by far, the most important risk factor for stroke. Epidemiological data indicate that the risk of stroke increases with both systolic and diastolic ...
Lakhan Shaheen E - - 2009
BACKGROUND: While hypertension is a leading risk factor for an initial stroke, the role of blood pressure lowering to prevent subsequent stroke is less clear. The results of recent large clinical trials investigating effects of antihypertensive agents in patients with a history of stroke have not shown a significant benefit; ...
Seo WhaSook - - 2009
BACKGROUND: Although several factors are known to influence prognosis after acute brain injury, physiologic derangements were found to be associated with, or contributing to, increased mortality and disability in these patients. AIMS: This study was conducted to identify acute physiological parameters that significantly predict outcome and compare the identified parameters ...
Osmond Jessica M JM Department of Physiology, Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd, CB3212A, Augusta, GA 30912, - - 2009
Obesity is a risk factor for stroke, but the mechanisms by which obesity increases stroke risk are unknown. Because microvascular architecture contributes to the outcome of stroke, we hypothesized that middle cerebral arteries (MCAs) from obese Zucker rats (OZRs) undergo inward remodeling and develop increased myogenic tone compared with those ...
Brown Devin L DL The Cardiovascular Center-Stroke Program, University of Michigan Medical School, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-5855, USA. - - 2009
Obstructive sleep apnea is a very common condition after stroke, and it predicts poor outcomes. Unfortunately, stroke patients often do not tolerate continuous positive airway pressure. We hypothesized that a 1-piece head frame headgear would be easier and quicker to use than a traditional strap headgear. A convenience sample of ...
Ishikawa Joji - - 2009
Left ventricular hypertrophy (LVH), assessed by ECG, is associated with an increased risk for cardiovascular events among hypertensive subjects. We evaluated the risks of LVH in a Japanese general population including normotensive and prehypertensive subjects. We measured ECG and blood pressure in 10 755 subjects at baseline. The Cornell product ...
Marquez José J Departments of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, PA, - - 2008
Measures of arterial pulse pressure variation and left ventricular stroke volume variation induced by positive-pressure breathing vary in proportion to preload responsiveness. However, the accuracy of commercially available devices to report dynamic left ventricular stroke volume variation has never been validated. We compared the accuracy of measured arterial pulse pressure ...
Sykora Marek - - 2008
OBJECTIVE: Impaired blood pressure regulation in the acute phase of stroke has been associated with less favorable outcome. Mechanisms and effects of blood pressure dysregulation in stroke are not well understood; however, central autonomic impairment with sympathetic overactivity and baroreflex involvement are discussed. Baroreflex sensitivity (BRS) in spontaneous intracerebral hemorrhage ...
Gommer E D - - 2008
The major purpose of this study was to simultaneously evaluate dCA before and shortly after cerebral vasodilatation evoked by infusion of acetazolamide (ACZ). It was questioned if and to what degree dCA was changed after ACZ infusion. Using 15 mg kg(-1) ACZ infusion cerebrovascular reactivity (CVR) was assessed in 29 ...
Itabashi Ryo - - 2008
OBJECTIVE: Blood pressure lowering in acute intracerebral hemorrhage patients may prevent hematoma growth and neurological deterioration. The optimal goal of hyperacute antihypertensive therapy for intracerebral hemorrhage patients to obtain a favorable early clinical outcome was investigated. METHODS: Of 688 consecutive patients who were admitted to our stroke care units within ...
Carvalho Cristiane C Institute of Neuroscience and Physiology, Section of Clinical Neuroscience and Rehabilitation Medicine, Göteborg University, Göteborg, Sweden. - - 2008
The aim of the present study was to examine the correlation between 1-legged bicycling and the 6-minute walk test (6MWT) in subjects post-stroke. A further aim was to analyse the relationship between specific stroke impairment and walking endurance. Thirty-four subjects (mean age 60 (standard deviation (SD) 4.1) years; mean time ...
Kim Hyung Kook HK Cardiopulmonary Research Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, - - 2008
Both pulse pressure variation and stroke volume variation during intermittent positive-pressure ventilation predict preload responsiveness. However, because ventilatory and cardiac frequencies are not the same, increasing the number of breaths sampled may increase calculated pulse pressure variation and stroke volume variation because larger (max) and smaller (min) pulse pressure and ...
Amarenco Pierre - - 2009
OBJECTIVE: To explore the relative contributions of baseline systolic blood pressure (SBP) and diastolic blood pressure (DBP) and lipoproteins on the risk of recurrent stroke or first major cardiovascular event (MCVE) and their potential impact on the benefit of statin treatment. METHODS AND RESULTS: The SPARCL trial randomized 4731 patients ...
Triantafyllidi Helen - - 2010
A young patient suffered from acute right hemiparesis, facial weakness and Broca's aphasia with multiple brain lesions due to severe hypertension. His evaluation for secondary causes of hypertension revealed hyperaldosteronism due to bilateral adrenal hyperplasia. Treatment is based primarily on spironolactone and ACE inhibitors. Two years later he was in ...
Molina F S - - 2008
OBJECTIVE: To establish reference intervals for fetal heart stroke volume and cardiac output with gestation. METHODS: Fetal heart ventricular volumes were measured using the four-dimensional (4D) spatiotemporal imaging correlation (STIC) ultrasound technique in 140 normal singleton pregnancies at 12-34 weeks' gestation. The Virtual Organ Computer-aided AnaLysis (VOCAL) technique was used ...
Pedelty Laura - - 2008
Cardiovascular disease and stroke disproportionately affect the elderly. The risk for stroke and transient ischemic attack increases exponentially with age. Blood pressure is a potent modifiable target for reducing the risk for stroke in the elderly. In elderly patients with isolated systolic hypertension and those with intracranial atherosclerotic disease, blood ...
Muller Laurent - - 2008
BACKGROUND: The intrathoracic blood volume index (ITBVI) and central venous pressure (CVP) are routinely used to predict fluid responsiveness in critically ill patients with acute circulatory failure (systolic blood pressure < 90 mm Hg or vasopressor requirement). However, they have never been compared. METHODS: In this prospective interventional study, we ...
Voelckel Wolfgang G - - 2008
INTRODUCTION: Heat stroke is still an epidemiologically relevant disease with overall mortality rates as high as 15-33%. In heat stroke, hypotension is caused by relative central hypovolemia. We performed a feasibility study to determine if an inspiratory impedance threshold valve (ITDTM) set to open at -12 cm H2O would reverse ...
Zhang Chun-Bo - - 2008
A series of N-(4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)-2-(piperazin-1-yl)acetamide derivatives were synthesized and their positive inotropic activity was evaluated by measuring left atrium stroke volume on isolated rabbit heart preparations. Several compounds showed favorable activity compared with the standard drug, milrinone, among which N-(1-benzyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)-2-(4-benzylpiperazin-1-yl)acetamide 6j was found to be the most potent with the 13.2% ...
Yang Cheryl C H - - 2008
1. Respiratory related arterial pressure variability may reflect body fluid status and/or cardiac sympathetic function. The underlying mechanism is not clear. 2. In the present study, we used an electromagnetic blood flow meter to measure ascending aortic blood flow, from which stroke volume was integrated, to study respiration-stroke volume coupling ...
Falkstedt Daniel - - 2008
OBJECTIVES: The association between blood pressure measured in late adolescence and early incidence of coronary heart disease and stroke was investigated in Swedish men. We used measures of systolic blood pressure, diastolic blood pressure, mean arterial pressure, and pulse pressure. METHOD: Information on blood pressure at age 18-20 was obtained ...
Zhang Yonghong - - 2008
OBJECTIVES: The association between blood pressure and short-term clinical outcome of acute stroke is inconclusive. We studied the association between admission blood pressure and in-hospital death or disability among acute stroke patients in Inner Mongolia, China. METHODS: A total of 2178 acute ischemic stroke and 1760 hemorrhagic stroke patients confirmed ...
Dahlöf Björn - - 2008
Stroke is a leading cause of death and disability worldwide, and despite improvements in healthcare, its incidence is still rising. Elevated blood pressure (BP) is the single most important modifiable risk factor for stroke, doubling stroke risk for each 20 mm Hg increase in systolic blood pressure (SBP). Although BP ...
Prakash Amit - - 2008
Introduction: EC-IC is a surgical procedure for the treatment and/or prevention of cerebral ischemia in patients with Moya Moya disease, complex cerebral aneurysms and stroke. Perioperatively there is a need for hemodynamic manipulations for cerebral preservation, and for the prevention of bleeding, anastomosis dehiscence and postoperative re-perfusion syndrome. The purpose ...
Bernard Timothy J - - 2008
Traditional risk factors associated with adult arterial ischemic stroke (AIS; ie, hypertension, hyperlipidemia, diabetes, smoking, and atherosclerosis) are relatively rare in children. Childhood AIS is instead associated with a variety of conditions including cerebral arteriopathies, congenital heart disease, infection, head and neck trauma, sickle cell anemia, and prothrombotic abnormalities. Although ...
Nelesen Richard R Department of Psychiatry, University of California San Diego, La Jolla, CA 92093-0804, - - 2008
Although characteristics such as heart rate (HR) and blood pressure (BP) are commonly reported in studies of the relationship between fatigue and cardiac functioning, few reports examine how cardiac function parameters such as cardiac output (CO) and stroke volume (SV) relate to fatigue. This study examined the relationship between self-reported ...
Idicula Titto T - - 2008
BACKGROUND: Body temperature, blood glucose, and blood pressure (BP) may interfere with outcome in patients with acute ischemic stroke treated with thrombolysis. METHODS: We prospectively studied 127 patients who received thrombolysis with tissue plasminogen activator for acute stroke in Bergen, Norway. Body temperature, blood glucose, and BP were measured before ...
Papadopoulos Dimitris P - - 2008
Cerebrovascular disease is a major cause of morbidity and mortality worldwide and its prevalence is expected to increase as a result of projected demographic trends. Stroke is one of the leading causes of disability and death of over 30 million people each year worldwide. Hypertension is the most important modifiable ...
Zheng Liqiang - - 2008
BACKGROUND AND PURPOSE: Information has been sparse on the comparison of pulse pressure (PP) and mean arterial pressure (MAP) in relation to ischemic stroke among patients with uncontrolled hypertension. The present study examined the relation among PP, MAP, and ischemic stroke in uncontrolled hypertensive subjects in China. METHODS: A total ...
Wang Yilong - - 2008
OBJECTIVE: We sought to assess the current status of blood pressure control and the use of antihypertensive drugs in patients with ischemic stroke (IS) or transient ischemic attack (TIA) in China. SUBJECTS AND METHODS: A cross-sectional study (across 19 urban outpatient clinics) on secondary stroke prevention measures was conducted. All ...
Trumble Dennis R - - 2008
A unique biomechanical implant has been developed to convert muscle power into hydraulic energy for the purpose of driving an implanted blood pump. This device, called a muscle energy converter (MEC), is designed to attach to the humeral insertion of the latissimus dorsi (LD) muscle, so that stimulated contractions cause ...
Kubitz Jens C - - 2008
OBJECTIVE: This study was performed to investigate the effect of vasopressor therapy on systolic pressure variation (SPV) and pulse pressure variation (PPV) compared to experimentally measured left ventricular stroke volume variation (SVV). DESIGN AND SETTING: Prospective study in a university laboratory. SUBJECTS: Twelve anesthetized and mechanically ventilated pigs. INTERVENTIONS: Increase ...
Filippatos Gerasimos S GS University of Athens, Athens, - - 2008
Hypertension is a risk factor for heart failure and stroke. However, the effect of hypertension on stroke in patients with heart failure has not been well studied. In the Digitalis Investigation Group trial, 3,674 (47%) of the 7,788 patients had a history of hypertension. Probability or propensity scores for a ...
Papadonikolakis Anastasios - - 2008
The beach-chair position in shoulder surgery provides advantages to the surgeon and anesthesiologist. However, cautious interpretation of the patient's blood pressure is essential, especially when the blood pressure cuff is placed at the calf. The calf pressure should be interpreted relative to the heart-level pressure to avoid iatrogenic cerebral hypoperfusion ...
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